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Selenium deficiency exacerbates ROS/ER stress mediated pyroptosis and ferroptosis induced by bisphenol A in chickens thymus

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Journal of Environmental Sciences 2025年第2期148卷 13-26页

作者： Kun wang Xu Shi Hongjin lin tong Xu Shiwen Xu College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Harbin 150030China

Bisphenol A(BPA)is an industrial pollutant that can cause immune *** acts as an antioxidant,as selenium deficiency often accompanies oxidative stress,resulting in organ *** study is the first to demonstrate that BPA and/or selenium deficiency induce pyroptosis and ferroptosis-mediated thymic injury in chicken and chicken lymphoma cell(MDCC-MSB-1)via oxidative stress-induced endoplasmic reticulum(ER)*** established a broiler chicken model of BPA and/or selenium deficiency exposure and collected thymus samples as research subjects after 42 *** results demonstrated that BPA or selenium deficiency led to a decrease in antioxidant enzyme activities(T-AOC,CAT,and GSH-Px),accumulation of peroxides(H2O2 and MDA),significant upregulation of ER stress-relatedmarkers(GRP78,IER 1,PERK,EIF-2α,ATF4,and CHOP),a significant increase in iron ion levels,significant upregulation of pyroptosis-related gene(NLRP3,ASC,Caspase1,GSDMD,IL-18 and IL-1β),significantly increase ferroptosis-related genes(TFRC,COX2)and downregulate GPX4,HO-1,FTH,*** vitro experiments conducted in MDCC-MSB-1 cells confirmed the results,demonstrating that the addition of antioxidant(NAC),ER stress inhibitor(TUDCA)and pyroptosis inhibitor(Vx765)alleviated oxidative stress,endoplasmic reticulum stress,pyroptosis,and ***,this study concludes that the combined effects of oxidative stress and ER stress mediate pyroptosis and ferroptosis in chicken thymus induced by BPA exposure and selenium deficiency.

关键词： Bisphenol A Selenium deficiency ROS/ER stress Pyroptosis Ferroptosis Thymic injury

Visible light promoted polyhalomethylation of alkenes: alkylation and cyclization

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Organic Chemistry Frontiers 2022年第4期9卷 1004-1009页

作者： tong-lin wang Bo-Sheng Zhang Jing-Jiang Liu Xiao-Jun Liu Xi-Cun wang Zheng-Jun Quan Laboratory of Eco-Environment-Related Polymer Materials Ministry of EducationChina.College of Chemistry and Chemical EngineeringNorthwest Normal UniversityLanzhouGansu 730070People’s Republic of China

We report a visible light promoted carbochloromethylation of 2-bromomethyl acrylate and N-arylmethacrylamide,and a series of trihalomethyl substituted allylic acid esters and indolone derivatives were *** reaction used common and inexpensive chloroform and tribromomethane as tri-halomethyl reagents,iodobenzene diacetate(PIDA)as an oxidant and Eosin Y as a *** reaction conditions are mild and the substrate scope is wide.

关键词： promoted light cyclization

Nighttime reactions of a series of unsaturated alcohols with NO_(3)•:Kinetics,products and mechanisms study

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Journal of Environmental Sciences 2025年第5期151卷 331-346页

作者： Yanyong Xu Shengrui tong Weiran Li Meifang Chen lin Hu Hailiang Zhang Sufan wang Maofa Ge State Key Laboratory for Structural Chemistry of Unstable and Stable Species Chinese Academy of Sciences Research/Education Center for Excellence in Molecular SciencesInstitute of Chemistry Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China College of Chemistry and Material Science Anhui Normal UniversityWuhu 241000China College of Ecology and Environment Xinjiang UniversityUrumqi 830017China

Unsaturated alcohols are a class of Biogenic volatile organic compounds(BVOCs)emitted in large quantities by plants when damaged or under adverse environmental conditions,and studies on their atmospheric degradation at night are still *** used chamber experiments to study the gas-phase reactions of three unsaturated alcohols,E-2-penten-1-ol,Z-2-hexen-1-ol and Z-3-hepten-1-ol,with NO_(3)radicals(NO_(3)•)during the *** rate constants of these reactions were(11.7±1.76)×10^(−13),(8.55±1.33)×10^(−13)and(6.08±0.47)×10^(−13)cm^(3)/(molecule·s)at 298K and 760 Torr,*** contrast,the reaction rate of similar substances with ozone was about 10^(−18)cm^(3)/(molecule·s),which indicates that the reaction with NO_(3)•is themain oxidation pathway for unsaturated alcohols at *** molecule aldehydes and ketones were the main gas-phase organic products of the reaction of three aldehydes and ketones with NO_(3)•,and the total small molecule aldehydes and ketones yields can reach between 45%-60%.They mainly originate from the breakage of alkoxy radicals,and different breakage sites determine different product *** addition,the SOA yields of the three unsaturated alcohols with NO_(3)•were 7.1%±1.0%,12.5%±1.9%and 30.0%±4.5%,respectively,whichweremuch higher than those of similarly structured substances with O_(3)or OH radicals(•OH).The results of high-resolution mass spectrometry shows that the main components of Secondary organic aerosol(SOA)of the three unsaturated alcohols are dimeric compounds containing several nitrate groups,which are formed through the polymerization of oxyalkyl radicals.

关键词： Unsaturated alcohols Reaction rate Aldehyde and ketone products Secondary organic aerosol components Reaction mechanism

Synthesis of Quinoline-2-thiones and Its' Derivatives

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Synthesis of Quinoline-2-thiones and Its' Derivatives

Recent advances of cerium compounds in functional coatings:Principle,strategies and applications

中国化学会·第十五届全国有机合成化学学术研讨会

作者： Xi Zhang tong-lin wang Xi-Cun wang 权正军 College of Chemistry and Chemical Engineering Northwest Normal University 西北师范大学

Quinoline is a common structure in a lot of bioactive natural products, drugs, *** these privileged scaffolds, quinoline-2-thione and 2-aminoquinoline derivatives represent one of the important classes of heterocycles, which has been applied as synthetic intermediates and possess a broad spectrum of biological and pharmacological *** synthesized quinoline-2-thione compounds through the cyclization reaction of metal-free, base-catalyzed/promoted vinylaromatic amines with CS/***, the quinoline motif can be constructed by reaction of vinylaromatic amines with acetophenone or KS/*** starting vinyl aromatic amine can be synthesized from aniline and *** method has the advantages of chemical selectivity, and high product *** have explored the great potential of quinoline-2-thione as an organic synthesis nucleophile, including its application in transition metal-catalyzed C-C, C-S-C cross-coupling processes, trifluoromethylation, methylation, and catalytic Michael reactions.

关键词： quinoline-2-thiones trifluoromethylation methylation Michael addition C-C coupling reaction

来源： cnki会议评论

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Journal of Rare Earths 2025年第2期43卷 227-245页

作者： Kai An Youqiang wang Yi Sui Yongquan Qing Wei tong Xuezhao wang Changsheng Liu School of Mechanical and Automotive Engineering Qingdao University of Technology State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare Earths School of Materials Science and Engineering Northeastern University Center for Nano and Micro Mechanics Tsinghua University

Cerium(Ce) compounds have attracted considerable attention as key components in functional coatings due to their many outstanding *** work provides a comprehensive review of recent advances in the application of Ce in functional *** role of Ce in the improvement of functional properties such as corrosion-resistance,self-healing,superhydrophobicity,wear-resistance,and UV shielding is reviewed from the perspective of functional mechanism and applied ***,the strategies,processes,practical problems,and current challenges in the research of functional coatings containing Ce are summarized and *** objective is to highlight the great potential of Ce in functional coatings,and to explore new applications of Ce in the development of novel ***,this work aims to enhance the application value of Ce,solving the problem of unbalanced application of rare-earth elements.

关键词： Cerium Functional coatings Corrosion Superhydrophobicity UV resistance Rare earths

Isospin splitting of the Dirac mass probed using the relativistic Brueckner-Hartree-Fock theory

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Nuclear Science and Techniques 2025年第2期36卷 123-130页

作者： Pianpian Qin Qiang Zhao Hui tong Chencan wang Sibo wang Department of Physics and Chongqing Key Laboratory for Strongly Coupled Physics Chongqing UniversityChongqing 401331China Center for Exotic Nuclear Studies Institute for Basic ScienceDaejeon 34126Korea Helmholtz-Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universität BonnBonn D-53115Germany School of Physics and Astronomy Sun Yat-Sen UniversityZhuhai 519082China

The isospin splitting of the Dirac mass obtained using the relativistic Brueckner-Hartree-Fock(RBHF)theory was thor-oughly *** the perspective in the full Dirac space,the long-standing controversy between the momentum-independent approximation(MIA)method and the projection method on the isospin splitting of the Dirac mass in asymmetric nuclear matter was analyzed in *** found that the assumption procedure of the MIA method,which assumes that single-particle potentials are momentum independent,is not a sufficient condition that directly leads to the opposite sign of the isospin splitting of the Dirac mass,whereas the extraction procedure of the MIA method,which extracts single-particle potentials from single-particle potential energy,changes the sign.A formal expression of the Dirac mass was obtained by approximately solving a set of equations involved in the extraction *** opposite isospin splitting of the Dirac mass was mainly caused by the extraction procedure,which forcibly assumed that the momentum dependence of the single-particle potential energy was in a quadratic form,in which the strength was solely determined by a constant scalar *** understanding of the isospin splitting of the Dirac mass from ab initio calculations could enhance our knowledge of neutron-rich systems,such as exotic nuclei and neutron stars.

关键词： Dirac mass Relativistic Brueckner-Hartree-Fock theory Single-particle potential Momentum dependence

Preface to the Special Topic on Air Pollution Complex Research in China:Recent Advances

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Advances in Atmospheric Sciences 2025年第4期42卷 593-596页

作者： tong ZHU Mingjin TANG Hong LIAO Yele SUN lin wang Minghuai wang Xuemei wang Peking University Beijing 100871China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China Nanjing University of Information Science and Technology Nanjing 210044China Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China Fudan University Shanghai 200438China Nanjing University Nanjing 210023China Jinan University Guangzhou 510632China

*** Air pollution is a global environmental problem and has serious impacts on human health,climate change,and ecological *** the lessons learned by developed countries,the use of various energy types can result in different types of air pollution,such as smoke from coal burning and photochemical smog from gasoline/diesel vehicle ***,in China,rapid development in the last several decades has led to a drastic increase in coal consumption and the number of vehicles;and consequently,air pollution in China is complicated by the coexistence of high concentrations of primary and secondary trace gases and aerosol particles from multiple *** concept of an“air pollution complex”was first proposed by Xiaoyan TANG in 1997 to characterize the complexity of the formation mechanisms of air pollution,and calls for science-based control strategies(Zhu,2005).

关键词： pollution smoke aerosol

An ionic liquid assisted hydrogel functionalized silica stationary phase for mixed-mode liquid chromatography

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Chinese Chemical Letters 2025年第1期36卷 491-495页

作者： tong Zhang Xiaojing Liang Licheng wang Shuai wang Xiaoxiao Liu Yong Guo Lanzhou Institute of Chemical Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Lanzhou Institute for Food and Drug Control Key Laboratory of Pesticide and Veterinary Drug Monitoring for State Market RegulationLanzhou 730050China

An ionic liquid assisted hydrogel modified silica was synthesized using a one-pot polymerization and physical coating technique and subsequently applied to mixed-mode liquid *** techniques,including Fourier transform infrared spectroscopy(FT-IR),X-ray photoelectron spectroscopy(XPS),and elemental analysis,etc.,confirmed the successful prepared of this innovative stationary *** unique combination of amide,long alkyl chain,and imidazole ring in the hydrogel coating enables the stationary phase to function effectively in hydrophilic/reversed-phase/ion exchange liquid ***,the stationary phase exhibited superior separation performance owing to the synergistic effect of the ionic liquid and *** was particularly evident when analyzing various analytes such as organic acids,nucleosides/bases,polycyclic aromatic hydrocarbons(PAHs)and ***,under our operating conditions,an excellent column efficiency of 53,642.9 plates/m was achieved for *** summary,we have proposed a straightforward strategy to enhance the separation performance of hydrogel coatings in liquid chromatography,thereby broadening the potential applications of hydrogels in the field of separation.

关键词： Ionic liquid Hydrogel Functionalized silica Synergistic effect Stationary phase

Study on the One-year Accuracy of Pulsar Time-scale

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Research in Astronomy and Astrophysics 2025年第1期25卷 282-296页

作者： linlin wang Zhehao Zhang Chengshi Zhao Zongke Li Minglei tong National Time Service Center Chinese Academy of Sciences Key Laboratory of Time Reference and Applications Chinese Academy of Sciences University of Chinese Academy of Sciences

Determining accurate pulsar timing model parameters is essential for establishing TT(PT), a realization of Terrestrial Time (TT) based on a pulsar timescale (PT). This study discusses the impact of different data spans on the accuracy of pulsar timing model parameters when determining pulsar timing model parameters. Using observations of PSR J0437-4715, J1909-3744, J1713+0747, and J1744-1134 from the second data release of the International Pulsar Timing Array (IPTA II, Version A), we compare the accuracy of the timing model parameters determined by these observations with different data spans. The results show for PSR J0437-4715, J1713+0747,and J1909-3744, the amplitude fluctuations of rotational frequency remain within 10-15, 10-14, and 10-14Hz,respectively, when the data spans for determining pulsar timing model parameters exceed 13, 14, and 6 ***, the one-year accuracy of TT(PT) is crucial for its application in timekeeping. By comparing the frequency deviations of TT(PT) relative to TT(BIPM) under both ideal (kr) and actual (kp) conditions across different data spans, we find that when the data span reaches the duration above, the accuracy of TT(PT) surpasses that of TT(TAI) under ideal conditions, slightly inferior under actual conditions. This suggests with improved observational technologies, the accuracy of TT(PT) can be further enhanced.

关键词： (stars:) pulsars: individual (PSRs J1909-3744, J1713+0747, J0437-4715, J1744-1134) methods: data analysis time