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Babao Dan Inhibits Gastric Cancer Progression in vivo Through Multiple Signaling Pathways

World Journal of Traditional Chinese Medicine 2024年第1期10卷 14-21页

作者： Hai-Xia Shang Yi Fang Bin Guan Jian-Hua Guan Jun Peng Jin-Yan Zhao jiu-Mao Lin Institute of Oncology of Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhouFujianChina Key Laboratory of Integrative Medicine of Fujian Province University Fujian University of Traditional Chinese MedicineFuzhouFujianChina Fujian Key Laboratory of Integrative Medicine on Geriatric Fujian University of Traditional Chinese MedicineFuzhouFujianChina Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhouFujianChina Xiamen Traditional Chinese Medicine Co. Ltd.XiamenFujianChina

Objective:The aim of this study was to explore the effects of Babao dan(BBD),a traditional Chinese medicine,on gastric cancer(GC)progression in *** and Methods:A subcutaneous xenograft mouse model of GC was established using MGC80-3 *** terminal deoxynucleotidyl transferase-mediated dUTP:2'-deoxyuridine 5'-triphosphate-biotin nick-end labeling method was adopted to detect cell apoptosis in *** expression levels of proteins associated with proliferation,apoptosis,and angiogenesis were measured by immunohistochemical staining or western blotting(WB).The activation and protein levels of p-c-Jun N-terminal kinase(JNK),p-p38,p-extracellular-regulated kinase 1/2,p-nuclear factor-κB(NF-κB),and p-STAT3 were examined by Bio-plex and ***:BBD significantly inhibited tumor growth in GC mouse models with no adverse effect on body weight or organ *** was also found that BBD significantly suppressed the proliferation of GC tumor cells,induced the apoptosis of tumor cells,and inhibited angiogenesis through inactivating with mitogen-activated protein kinase,NF-κB,and STAT3 ***:BBD exerts suppressive effects on GC tumor growth by regulating multiple pathways in vivo,which may provide a novel treatment option for GC therapy.

关键词： Babao dan gastric cancer multiple signaling pathways proliferation traditional Chinese medicine

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Electrodeposition of rare refractory metals in low-temperature ionic liquids

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Rare Metals 2024年第10期43卷 4921-4933页

作者： Lin-Lin Wang Han-Dong Jiao Rui Yuan Le-Yang Li Man-Peng Lin Rui-Yang Sun jiu-San Xiao Shu-Qiang Jiao Institute of Advanced Structure Technology Beijing Institute of Technology State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing

Rare refractory metals(RRMs) play a significant role in fundamental industries, including electronics,chemical industry, machinery, etc., and future advanced fields, such as aerospace and superconductivity. However,the traditional production processes of RRMs based on high-temperature thermal reduction cannot meet the requirements of low-energy consumption. This dilemma could be addressed efficiently by using a low-temperature electrodeposition strategy in ionic liquids(ILs). This review summarizes a panoramic view of the latest developments on the electrodeposition of RRMs in ILs after a brief review on the current industrial production methods of RRMs. Based on this, the electrochemical mechanism occurring at the cathode during the electrodeposition process of RRMs in different electrolytes and under different conditions is thoroughly discussed, because it is crucial for the successful production of pure RRMs. In addition, this review not only analyses the main challenges that hinder the industrial application of the electrodeposition of RRMs in ILs, but also proposes corresponding solutions. We hope this review can provide a valuable guidance for the fundamental research and industrial development of lowtemperature electrodeposition of RRMs.

关键词： Chemical industry

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政治世界的祛魅与复魅——论诺瓦利斯“诗性国家”中的共和主义与世界主义

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哲学动态 2024年第6期 54-65页

作者：罗久西安交通大学哲学系

德国浪漫主义在西方政治思想发展史中具有不容忽视的重要性。早期浪漫派引领了对现代市民社会的利己主义观念的批判,对社会契约理论和作为自由主义政治基础的个人主义预设提出了质疑,发展了一种新的有机的国家观念;他们强调内心的情感,... 详细信息

德国浪漫主义在西方政治思想发展史中具有不容忽视的重要性。早期浪漫派引领了对现代市民社会的利己主义观念的批判,对社会契约理论和作为自由主义政治基础的个人主义预设提出了质疑,发展了一种新的有机的国家观念;他们强调内心的情感,重视历史和传统,尤其是爱和共同体的价值。在他们看来,原子化的占有性个体主义和以保障抽象的个人权利为基础与目的的契约论国家观的兴起,是随着自然的理性化和祛魅一道发生的政治世界的祛魅和理性重构的产物。以诺瓦利斯为代表的早期浪漫主义者试图重新唤起一种以情感、精神和人类之间的具体联系为中心的共和主义和世界主义理想,以取代启蒙运动对理性知识、物质财富、道德和法律原则的关注;他们用具有象征意义的中世纪的形象来唤起关于人类重新统一的黄金时代的理想,并引出对一个世界性的精神共同体的渴望。

关键词：德国浪漫主义诗性国家共和主义世界主义

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从康德的浪漫主义到早期浪漫派的康德主义——再思康德与德国浪漫主义的内在联系

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复旦学报（社会科学版） 2024年第1期66卷 132-143页

作者：罗久西安交通大学哲学系西安710049

拘泥于对德国古典哲学的教条化理解,许多哲学史家常常倾向于切断德国浪漫主义与德国古典哲学之间的联系,将其视为与德国古典哲学相对立的非理性主义思潮,甚至不承认德国浪漫主义的哲学价值。然而,像诺瓦利斯这样的早期浪漫主义者和其他... 详细信息

拘泥于对德国古典哲学的教条化理解,许多哲学史家常常倾向于切断德国浪漫主义与德国古典哲学之间的联系,将其视为与德国古典哲学相对立的非理性主义思潮,甚至不承认德国浪漫主义的哲学价值。然而,像诺瓦利斯这样的早期浪漫主义者和其他大多数德国古典哲学家一样共享了康德批判哲学的问题意识。康德的独特之处在于他既是启蒙理性的捍卫者,又是启蒙理性深刻的批判者,他试图通过对理性自身的批判限制知识的范围,防止无节制的理性反思对一切无条件者和不朽价值的虚无化;同时又从理性的实践应用出发,证明了一个具有内在价值和目的的道德世界的现实性。康德对自然的理性化和祛魅过程的限制及其对自然的合道德性的证成,构成了德国浪漫主义的先声。而早期浪漫主义者正是受康德“哥白尼式的革命”的启发,进一步证明了存在之于意识的优先性,并用诗意原则取代了康德的实践原则,揭示了无条件者的超越性与内在性的统一。

关键词：康德哥白尼式的革命实践理性浪漫主义诺瓦利斯诗意

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康德道德教育思想中的先验主义与目的论

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教育学报 2024年第5期20卷 39-51页

作者：罗久西安交通大学人文社会科学学院西安710049

虽然康德在教育学讲座中对教育和教育之于人的道德发展所具有的重要作用进行了系统考察,但是他的先验主义的自由和道德理论本身似乎没有为通向自由与道德的教育的可能性留下空间。在康德的先验哲学中,道德发展的经验性与道德本身的纯粹... 详细信息

虽然康德在教育学讲座中对教育和教育之于人的道德发展所具有的重要作用进行了系统考察,但是他的先验主义的自由和道德理论本身似乎没有为通向自由与道德的教育的可能性留下空间。在康德的先验哲学中,道德发展的经验性与道德本身的纯粹性似乎是不能兼容的。不过,康德的道德哲学和教育哲学是在不同的理论范式中发展起来的:前者处于先验主义框架内,而后者则依赖于一种目的论的人性观。在康德那里,道德的自律性和道德意识作为一种理性事实并不意味着道德教育和道德发展是不可能与不必要的。相反,康德对人性的目的论观点恰恰表明,作为人的规定与使命的人性只有通过教育才能获得其合目的的实现。道德的纯粹性与道德教育的经验性能够在康德的目的论框架中兼容。

关键词：康德道德教育人性先验主义目的论

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Microvascular structural changes in esophageal squamous cell carcinoma pathology according to intrapapillary capillary loop types under magnifying endoscopy

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3471-3480页

作者： Wei-Yang Shu Yan-Yan Shi jiu-Tian Huang Ling-Mei Meng He-Jun Zhang Rong-Li Cui Yuan Li Shi-gang Ding Department of Gastroenterology Peking University Third HospitalBeijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 10019China Department of Gastroenterology Pathology Laboratory Peking University Third HospitalBeijing 100191China Department of Gastroenterology Peking University International HospitalBeijing 102206China

BACKGROUND The intrapapillary capillary loop(IPCL)characteristics,visualized using magnifying endoscopy,are commonly assessed for preoperative evaluation of the infiltration depth of esophageal squamous cell carcinoma(ESCC).Japan Esophageal Society(JES)classification is the most widely used *** structural changes are evaluated by magnifying endoscopy for the presence or absence of each morphological factor:tortuosity,dilatation,irregular caliber,and different ***,the pathological characteristics of IPCLs have not been thoroughly investigated,especially the microvascular structures corresponding to the deepest parts of the lesions'*** To investigate differences in pathological microvascular structures of ESCC,which correspond to the deepest parts of the lesions'*** Patients with ESCC and precancerous lesions diagnosed at Peking University Third Hospital were enrolled between January 2019 and April *** first underwent magnified endoscopic examination,followed by endoscopic submucosal dissection or surgical *** images were scanned using a threedimensional slice scanner,and the pathological structural differences in different types,according to the JES classification,were analyzed using nonparametric tests and *** The 35 lesions were divided into four groups according to the JES classification:A,B1,B2,and *** analyses revealed significant differences(aP0.05).However,significant differences in the short calibers,long calibers,and area of IPCL were observed between types B1 and B3(aP0.05).CONCLUSION Pathological structures of IPCLs in the deepest infiltrating regions differ among va

关键词： Esophageal squamous cell carcinoma Intrapapillary capillary loop The Japan Esophageal Society classification Magnifying endoscopy Pathological characteristics

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Adrenocorticotropic hormone combined with magnesium sulfate therapy for infantile epileptic spasms syndrome:a real-world study

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World Journal of Pediatrics 2024年第8期20卷 834-847页

作者： Wen He Qiu-Hong Wang jiu-Wei Li Yang-Yang Wang Xiao-Mei Luo Lin Wan Jing Wang Xiu-Yu Shi Wei-Hua Zhang Fang Fang Li-Ping Zou Senior Department of Pediatrics the Seventh Medical Center of Chinese PLA General HospitalDepartment of Pediatricsthe First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Neurology Beijing Children’s HospitalCapital Medical UniversityBeijingChina Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

Background Infantile epileptic spasms syndrome(IESS)is a serious disease in infants,and it usually evolves to other epilepsy types or syndromes,especially refractory or super-refractory focal *** adrenocorticotropic hormone(ACTH)is one of the first-line and effective treatment plans for IESS,it has serious side effects and is not sufficiently *** A retrospective study of the clinical outcomes of ACTH combined with magnesium sulfate(MgSO4)therapy for IESS in two hospital centers was *** major outcome of the single and combined treatment was evaluated by changes in seizure frequency and improvements in hypsarrhythmia electroencephalography(EEG).To reduce the confounding bias between the two groups,we used SPSS for the propensity score matching(PSM)*** We initially recruited 1205 IESS patients from two Chinese hospitals and treated them with ACTH combined with MgSO4 and ACTH *** 1005 patients were enrolled in the treatment(ACTH combined with MgSO4:744,ACTH:261),and both treatment plans had a more than 55%response ***,compared to patients treated with ACTH alone,those patients treated with ACTH combined with MgSO4 had better performance in terms of the seizure frequency and hypsarrhythmia *** PSM,the two groups also showed significant differences in responder rate[70.8%(95%confidence interval,CI)=66.7%–74.8%)vs.53.8%(95%CI=47.4%–60.2%),P3 months(P<0.05).In addition,the overall incidence of adverse reactions in the ACTH combined with MgSO4 group was much lower than that in the ACTH group(31.4%vs.63.1%,P<0.001).During the treatment,only

关键词： Adrenocorticotropic hormone Clinical trial Infantile epileptic spasms syndrome Magnesium sulfate Real-world study

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Strong metal-support interactions between highly dispersed Cu^(+) species and ceria via mix-MOF pyrolysis toward promoted water-gas shift reaction

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Journal of Energy Chemistry 2024年第4期91卷 475-483页

作者： Xiao-Chen Sun Xing-Chi Li Ze-Wei Xie Chen-Yue Yuan De-jiu Wang Qian Zhang Xiao-Yu Guo Hao Dong Hai-Chao Liu Ya-Wen Zhang Beijing National Laboratory for Molecular Sciences(BNLMS) State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing National Laboratory for Molecular Sciences(BNLMS) College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Beijing National Laboratory for Molecular Sciences(BNLMS) State Key Laboratory for Structural Chemistry of Stable and Unstable SpeciesCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The modulation of metal-support interfacial interaction is significant but challenging in the design of high-efficiency and high-stability supported ***,we report a synthetic strategy to upgrade Cu-CeO_(2)interfacial interaction by the pyrolysis of mixed metal-organic framework(MOF)*** obtained highly dispersed Cu/CeO_(2)-MOF catalyst via this strategy was used to catalyze water-gas shift reaction(WGSR),which exhibited high activity of 40.5μmolCOgcat^(-1).s^(-1)at 300℃and high stability of about 120 *** on comprehensive studies of electronic structure,pyrolysis strategy has significant effect on enhancing metal-support interaction and then stabilizing interfacial Cu^(+)species under reaction *** Cu^(+)species and generated oxygen vacancies over Cu/CeO_(2)-MOF catalyst played a key role in CO molecule activation and H2O molecule dissociation,*** collaborated closely and then promoted WGSR catalytic performance in comparison with traditio nal supported *** study shall offer a robust approach to harvest highly dispersed catalysts with finely-tuned metal-support interactions for stabilizing the most interfacial active metal species in diverse heterogeneous catalytic reactions.

关键词： Cu-based catalyst MOF derivative Water-gas shift reaction Metal-support interaction

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A novel transformer-embedded lithium-ion battery model for joint estimation of state-of-charge and state-of-health

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Rare Metals 2024年第11期 5637-5651页

作者： Shang-Yu Zhao Kai Ou Xing-Xing Gu Zhi-Min Dan jiu-Jun Zhang Ya-Xiong Wang School of Mechanical Engineering and Automation Fuzhou University Chongqing Key Laboratory of Catalysis and New Environmental Materials College of Environment and ResourcesChongqing Technology and Business University Contemporary Amperex Technology Co Limited (CATL) College of Materials Science and Engineering Fuzhou University

The state-of-charge(SOC) and state-of-health(SOH) of lithium-ion batteries affect their operating performance and *** coupled SOC and SOH are difficult to estimate adaptively in multi-temperatures and *** paper proposes a novel transformer-embedded lithium-ion battery model for joint estimation of state-ofcharge and *** battery model is formulated across temperatures and aging,which provides accurate feedback for unscented Kalman filter-based SOC estimation and aging *** open-circuit voltages(OCVs) are corrected globally by the temporal convolutional network with accurate OCVs in time-sliding *** equation is combined with estimated SOH for temperature-aging migration.A novel transformer model is introduced,which integrates multiscale attention with the transformer's encoder to incorporate SOC-voltage differential derived from battery *** model simultaneously extracts local aging information from various sequences and aging channels using a self-attention and depth-separate *** leveraging multi-head attention,the model establishes information dependency relationships across different aging levels,enabling rapid and precise SOH ***,the root mean square error for SOC and SOH under conditions of 15℃dynamic stress test and 25℃ constant current cycling was less than 0.9% and 0.8%,***,the proposed method exhibits excellent adaptability to varying temperature and aging conditions,accurately estimating SOC and SOH.

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Increasing the toughness while reducing the viscosity of carbon nanotube/ polyether imide/polyether ether ketone nanocomposites

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新型炭材料（中英文） 2024年第4期39卷 715-728页

作者： SONG jiu-peng ZHAO Yan LI Xue-kuan XIONG Shu LI Shuang WANG Kai School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Polyether ether ketone(PEEK)has good mechanical ***,its high viscosity when molten limits its use because it is hard to *** nanocomposites containing both carbon nanotubes(CNTs)and polyether imide(PEI)were pre-pared by a direct wet powder blending method using a vertical injection molding *** addition of an optimum amount of PEI lowered the viscosity of the molten PEEK by approximately 50%while producing an increase in the toughness of the nanocom-posites,whose strain to failure increased by 129%,and fracture energy increased by 97%.The uniformly dispersed CNT/PEI powder reduced the processing difficulty of PEEK nanocomposites without affecting the thermal *** improvement of the strength and viscosity of PEEK facilitate its use in the preparation of thermoplastic composites.

关键词： Nanocomposites Mechanical properties Rheological properties Microstructural analysis

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