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浙江省125MW机组通流改造相关问题的分析与处理

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汽轮机技术 2005年第1期47卷 71-72,75页

作者：童小忠浙江省电力试验研究所杭州310014

对浙江省 12台国产 125MW机组通流部分改造后出现的振动、主汽门无法正常关闭、推力轴承瓦温高等直接影响运行的缺陷进行了分析和讨论,并介绍了处理方法,可供同类机组参考。

关键词： 125MW机组通流改造故障分析与处理

Construction of a Survivability Evaluation System for Military Aircraft

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International Journal of Plant Engineering and Management 2007年第2期12卷 79-86页

作者： LUO Guang-qi SONG Wen-yan tong zhong-xiang LI Shou-an College of Power and Energy Northwestern Polytechnical University Xi＇an 710072 P. R. China College of Engineering Air Force Engineering University Xi＇an 710038 P. R. China College of Aeronautics Northwestern Polytechnical University Xi＇an 710072 P. R. China

The evaluation indexes system of aircraft survivability is constructed for the first time from three aspects： susceptibility, vulnerability and combat resilience; the bargaining weight method is proposed to determine the weights of the indexes and evaluate aircraft survivability. The bargaining weight method brings different opinions into accord under the constraint of minimum loss, it can overcome the partial subjectivity in determining weights and evaluation, and has objectivity. The example testifies rationality and feasibility of the evaluation system.

关键词： aircraft survivability evaluation index bargaining weight susceptibility vulnerability

EFFICACY AND SAFETY OF GEFITINIB AS MONOTHERAPY FOR CHINESE PATIENTS WITH ADVANCED NON-SMALL CELL LUNG CANCER

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Chinese Medical Journal 2006年第1期119卷 63-68页

作者： WANG Meng-zhao LI Long-yun WANG Shu-lan ZHANG Xiao-tong zhong Wei ZHANG Li Department of Respiratory Diseases Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China

Platinum-based chemotherapy can improve the survival and quality of life of patients with locally advanced and metastatic lung cancer. Second-line docetaxel monotherapy can improve overall survival following the failure of first line chemotherapy. However, many limiting factors such as poor performance status, advanced age, adverse effects of chemotherapy and reluctance to receive cytotoxic chemotherapeutic agents render patients unable to accept chemotherapy.

关键词： non-small cell lung cancer gefitinib treatment

乳腺癌耐药蛋白表达与晚期非小细胞肺癌铂类为主的化疗疗效及预后的关系

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实用肿瘤杂志 2009年第1期24卷 27-30页

作者：汪旭佟仲生天津医科大学肿瘤医院化疗科天津市肿瘤防治重点实验室天津300060

目的探讨乳腺癌耐药蛋白(BCRP)表达与晚期非小细胞肺癌(NSCLC)以铂类为主的化疗疗效及预后的关系。方法回顾性分析本院初治的B或期NSCLC患者86例,应用免疫组化方法检测每位患者肿瘤标本中的BCRP表达水平,应用SPSS 16.0进行统计分析,探讨... 详细信息

目的探讨乳腺癌耐药蛋白(BCRP)表达与晚期非小细胞肺癌(NSCLC)以铂类为主的化疗疗效及预后的关系。方法回顾性分析本院初治的B或期NSCLC患者86例,应用免疫组化方法检测每位患者肿瘤标本中的BCRP表达水平,应用SPSS 16.0进行统计分析,探讨BCRP表达水平与化疗疗效、无进展生存期(PFS)以及总生存期(OS)的关系。结果BCRP表达阴性患者的化疗有效率为44.0%,而表达阳性的患者为19.4%,两者之间差异有统计学意义(P=0.017)。BCRP表达阴性患者的PFS及OS较表达阳性的患者长,并且差异有统计学意义(P值分别为0.000和0.000)。多因素分析表明BCRP是独立影响PFS及OS的指标。结论BCRP表达水平与晚期NSCLC以铂类为主的化疗疗效及预后密切相关,对于进一步研究晚期NSCLC耐药机制,制定个体化治疗方案,延长患者生存期具有重要意义。

关键词：癌非小细胞肺药物疗法药物耐受性预后回顾性研究

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多复变数Bergman空间的支配集

数学学报（中文版） 2022年第1期65卷 25-32页

作者：宋鑫仝策中河北工业大学数学系天津300401

本文利用伪双曲度量球对单位球上的Bergman空间的支配集给出完整刻画.证明方法是将Luecking在单位圆盘上的三个重要引理推广到单位球上,从而刻画单位球上的Bergman空间的支配集.

关键词： Bergman空间支配集对合自同构伪双曲度量

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大地电磁法小极值有用信息提取及数值模拟

中国有色金属学报 2013年第9期23卷 2444-2449页

作者：杨立功谢维童孝忠中南大学地球科学与信息物理学院长沙410083 北京矿产地质研究院北京100012

以大地电磁测深理论公式为基础,给出了提取小极值信息的具体方法。然后以第二层断面为例,编程计算小极值在不同断面类型、不同地电参数条件下的视电阻率曲线。通过数值模拟分析小极值出现频率、曲线特征、幅度大小与断面参数的关系,发... 详细信息

以大地电磁测深理论公式为基础,给出了提取小极值信息的具体方法。然后以第二层断面为例,编程计算小极值在不同断面类型、不同地电参数条件下的视电阻率曲线。通过数值模拟分析小极值出现频率、曲线特征、幅度大小与断面参数的关系,发现这些小极值的特征含有关于地电断面参数的丰富信息,而且只需要观测较窄的频段,与观测包括全部渐近线的完整视电阻率曲线相比,其观测频点可减少很多;对于其他地电构造,根据视电阻率曲线的左支渐近线和小极值特征也能够提取到关于断面参数信息。只要测准小极值幅值和频率,就能提取断面信息。结果表明:该方法能极大地提高物探结果的准确性和稳定性,节省野外观测时间,提高野外工作效率,降低成本。

关键词：大地电磁小极值有用信息数值模拟

MicroRNA Profiling of Transgenic Mice with Myocardial Overexpression of Nucleolin

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Chinese Medical Journal 2018年第3期131卷 339-346页

作者： Qing-Lan Lyu Bi-Mei Jiang Bin Zhou Li Sun zhong-Yi tong Yuan-Bin Li Yu-Ting Tang Hui Sun Mei-Dong Liu Xian-zhong Xiao Department of Pathophysiology Xiangya School of Basic Medical Sciences Central South University Changsha Hunan 410078 China Department of Rheumatology Xiangya Hospital Central South University Changsha Hunan 410008 China Department of Pathology The Second Xiangya Hospital Central South University Changsha Hunan 410000 China

Background：Nucleolin （NCL） is the most abundant RNA-binding protein in the cell nucleolus and plays an important role in chromatin stability,ribosome assembly,ribosomal RNA maturation,ribosomal DNA transcription,nucleocytoplasmic transport,and regulation of RNA stability and translation *** addition to its anti-apoptotic properties,the underlying mechanisms associated with NCL-related roles in different cellular processes remain *** this study,the effect of NCL on microRNA （miRNA） expression was evaluated by generating transgenic mice with myocardial overexpression of NCL and by analyzing microarrays of mature and precursor miRNAs from ***：Using microinjection ofalpha-MyHc clone 26-NCL plasmids,we generated transgenic mice with myocardial overexpression of NCL firstly,and then mature and precursor miRNAs expression profiles were analyzed in NCL transgenic mice （n =3） and wild-type （WT） mice （n =3） by miRNA *** Package for the Social Sciences version 16.0 software （SPSS,Inc.,Chicago,IL,USA） was used to perform Student＇s t-test,and statistical significance was determined at P 〈 ***：Several miRNAs were found to be differentially expressed,of which 11 were upregulated and 4 were downregulated in transgenic mice with myocardial overexpression of NCL compared to those in WT *** differentially expressed miRNAs were subsequently confirmed and quantified by real-time quantitative reverse transcription-polymerase chain *** analysis was used for the prediction of miRNA ***,in vitro experiments showed that NCL regulated miR-21 expression following hydrogen peroxide ***：Myocardial-protection mechanisms exerted by NCL might be mediated by the miRNAs identified in this study.

关键词： MicroRNA microarray Myocardium Nucleolin Transgenic mice