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Research progress on Wuzi Yanzong pills in the treatment of male infertility

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Science of Traditional Chinese Medicine 2023年第1期1卷 35-49页

作者： Chiwai Ip Liang Hong yun tong Shaoping Li Jing Zhao State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoMacaoChina Affiliated Hospital of Nanjing University of Chinese Medicine NanjingChina

In recent years,because of changes in lifestyle,social environments,and other factors,male fertility has exhibited a declining trend in various countries and regions,including *** poses a challenge for the prevention and treatment of male *** Yanzong pill(WZYZP)is a renowned Chinese medicinal formula utilized for the treatment of male infertility and boasts a long history of use in this *** article summarized the treatment approaches used in both Chinese andWesternmedicine for male infertility,along with the research advancements pertaining to the analysis of Chinese medical theory,pharmacological effects,bioactive ingredients,and the establishment of quality control standards for WZYZP in the treatment of male infertility,aiming to provide references for research related to the mechanism of action,identification of active ingredients,and clinical application of WZYZP in the treatment of male infertility.

关键词： Male infertility Wuzi Yanzong pill Pharmacological effects Bioactive ingredient Quality control

Heteroplasmy Level of the Mitochondrial tRNA^(Leu(UUR)) A3243G Mutation in a Chinese Family Is Positively Associated with Earlier Age-of-onset and Increasing Severity of Diabetes

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Chinese Medical Sciences Journal 2009年第1期24卷 20-25页

作者： Shi Zhang An-li tong yun Zhang Min Nie Yu-xiu Li Heng Wang Department of Endocrinology Key Laboratory of Endocrinology of Ministry of HealthPeking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To investigate the mutations of mitochondrial genome in a pedigree with suspected maternally inherited diabetes and deafness and to explore the correlations between the mutations and clinical features. Methods Genomic DNA was isolated from blood leucocytes of each member of the pedigree. The mitochondrial genome was amplified with 24-pair primers that could cover the entire mitochondrial DNA. Direct sequencing of PCR products was used to identify any mitochondrial DNA mutations. Results Family members on the maternal side all harbored the tRNA^Lcu（UUR） A3243G mutation. The paternal side family members did not have the mutation. The age-of-onset of diabetes of the 4 maternal side family members was 15, 41, 44, and 65 years old, and their corresponding heteroplasmy level of the mutation was 34.5%, 14.9%, 14.6%, and 5.9%, respectively. The age-of-onset of diabetes and heteroplasmy level of A3243G mutation were negatively correlated with a correlation coefficient of -0.980（P=0.02）. Meanwhile, patient with high heteroplasmy level of A3243G mutation had relatively low severity of disease. Moreover, 6 reported polymorphisms and 2 new variants were found. Conclusions The main cause of diabetes in this pedigree is the tRNA^Lcu（UUR） A3243G mutation. However, other gene variants may contribute to its pathogenicity. The heteroplasmy level of the tRNA^Lcu（UUR） A3243G mutation is positively associated with earlier age-of-onset and increasing severity of diabetes.

关键词： maternally inherited diabetes and deafness tRNA^Lcu(UUR) A3243G mutation beteroplasmy

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城市快速交通线项目的最优票价与政府补偿

系统工程理论与实践 2001年第4期21卷 88-91页

作者：仝允桓清华大学经济管理学院北京100084

基于乘客时间价值模型和交通运量的价格弹性模型 ,分别以“票款收入最大”和“在充分发挥项目运能前提下票款收入最大”为目标 ,构造了两种城市快速交通线项目最优票价模型 .在此基础上 ,提出了政府对城市快速交通线项目给予经济补偿的... 详细信息

基于乘客时间价值模型和交通运量的价格弹性模型 ,分别以“票款收入最大”和“在充分发挥项目运能前提下票款收入最大”为目标 ,构造了两种城市快速交通线项目最优票价模型 .在此基础上 ,提出了政府对城市快速交通线项目给予经济补偿的原则和补偿强度的测算方法 .

关键词：城市快速交通线项目最优票价政府经济补偿

Dissecting Superradiant Phase Transition in the Quantum Rabi Model

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Chinese Physics Letters 2024年第12期41卷 30-34页

作者： yun-tong Yang Hong-Gang Luo School of Physical Science and Technology Lanzhou UniversityLanzhou 730000China Lanzhou Center for Theoretical Physics&Key Laboratory of Theoretical Physics of Gansu Province Lanzhou UniversityLanzhou 730000China

Phase transitions are both thermodynamically and quantum-mechanically ubiquitous in nature and laboratories,and their understanding remains one of the most active issues in modern physics and related *** Landau theory provides a general framework to describe phenomenologically phase transitions by introducing order parameters and associated symmetry *** theory is also taken as a starting point to explore critical phenomena in connection with phase transitions in the renormalization group,which provides a complete theoretical description of behaviors close to critical *** this context,the microscopic mechanism of phase transitions remains *** this study,we explore the microscopic mechanism of the superradiant phase transition in the quantum Rabi model(QRM).First,we perform a diagonalization operation in an operator space to obtain three fundamental patterns,denoted asλ1,λ2,andλ3,involved in the ***,we explicitly analyze the energy evolutions of these patterns with increasing coupling *** observed characteristic behaviors reveal the microscopic mechanism of the superradiant phase transition as a consequence of competition between patterns due to different phase *** other words,with increasing coupling strength,the patternλ1 drives the phase transition,the patternλ2 exhibits a similar response speed but less energy compensation than the patternλ1,and the patternλ3 exhibits a slow response speed but plays a key role in the balance between it and the patternλ1,which stabilizes the new *** type of dissecting mechanism explains why and how the superradiant phase transition occurs in the QRM and paves the way for exploring the microscopic mechanism of phase transitions that occur frequently in nature.

关键词： transitions mechanism Phase

传染性法氏囊病病毒感染和复制的分子机制研究进展

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动物医学进展 2025年第1期46卷 102-108页

作者：郑铁锁李永红韩翡李静童菊芸陈镇荣杨傲冰陈坚广东永顺生物制药股份有限公司广东广州511356

传染性法氏囊病(IBD)是由传染性法氏囊病病毒(IBDV)引起的一种急性、高度传染性、免疫抑制的禽类疾病,给家禽养殖业造成巨大的经济损失,引起人们的广泛关注。目前许多科研工作者对IBDV进行了多方面的研究,发现IBDV感染和复制的分子机制... 详细信息

传染性法氏囊病(IBD)是由传染性法氏囊病病毒(IBDV)引起的一种急性、高度传染性、免疫抑制的禽类疾病,给家禽养殖业造成巨大的经济损失,引起人们的广泛关注。目前许多科研工作者对IBDV进行了多方面的研究,发现IBDV感染和复制的分子机制很复杂。论文主要对IBDV蛋白和宿主蛋白及因子相互作用在感染和复制中的作用、IBDV感染宿主细胞受体结合位点、IBDV感染后调控宿主细胞因子和干扰素、细胞凋亡情况和影响病毒感染和复制的miRNAs、lncRNAs和circRNAs进行综述,为IBDV的进一步研究和IBD防控提供参考。

关键词：传染性法氏囊病病毒感染复制分子机制

Low Coercivity of Amorphous La-Co Films

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Chinese Physics Letters 1997年第12期14卷 943-945页

作者： ZHAO tong-yun ZHAO Jian-gao SHEN Bao-gen SHAN Zheng-sheng D.J.Sellmyer State Key Laboratory for Magnetism Institute of PhysicsChinese Academy of SciencesBeijing 100080 Behlen Laboratory of Physics and Center for Materials Research and AnaJysis University of NebraskaLincolnNE 68588-0113

The structure and magnetic properties of sputtered La-Co alloy films have been *** than 10A/m(100mOe)coercivity can be obtained in amorphous La_(100-x)Co_(x) films around x=80 and the coercivity of amorphous La^(20)Co_(80) film depends on the thickness of the *** magnetization behaviour has been examined for the films with different compositions through magnetic hysteresis *** excellent rectangular magnetic hysteresis loop was obtained for films with thickness less than 60nm.

关键词： alloy hysteresis amorphous

Machine learning technique for prediction of magnetocaloric effect in La(Fe,Si/Al)_(13)-based materials

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Chinese Physics B 2018年第6期27卷 92-97页

作者： Bo Zhang Xin-Qi Zheng tong-yun Zhao Feng-Xia Hu Ji-Rong Sun Bao-Gen Shen State Key Laboratory of Magnetism Institute of Physics Chinese Academy of Sciences Beijing 100190 China School of Physical Sciences University of the Chinese Academy of Sciences Beijing 100049 China School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Data-mining techniques using machine learning are powerful and efficient for materials design, possessing great potential for discovering new materials with good characteristics. Here, this technique has been used on composition design for La（Fe,Si/Al）（13）-based materials, which are regarded as one of the most promising magnetic refrigerants in practice. Three prediction models are built by using a machine learning algorithm called gradient boosting regression tree（GBRT） to essentially find the correlation between the Curie temperature（TC）, maximum value of magnetic entropy change（（？SM）（max））,and chemical composition, all of which yield high accuracy in the prediction of TC and（？SM）（max）. The performance metric coefficient scores of determination（R^2） for the three models are 0.96, 0.87, and 0.91. These results suggest that all of the models are well-developed predictive models on the challenging issue of generalization ability for untrained data, which can not only provide us with suggestions for real experiments but also help us gain physical insights to find proper composition for further magnetic refrigeration applications.

关键词： La(Fe,Si/Al)13-based materials composition design machine learning magnetic refrigeration

Giant Magneto-impedance Effect in Nanocrystalline Fe_(73.5)CuNb_(3)Si_(13.5)B_(9) Ribbons

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Chinese Physics Letters 1996年第12期13卷 927-930页

作者： CHEN Chen GUO Hui-qun ZHAO tong-yun LI Min LUAN Kai-zheng SHEN Bao-gen LIU Yi-hua ZHAO Jian-gao MELiang-mo State Key Laboratory of Magnetism Institute of Physics&Center of Condensed Matter PhysicsChinese Academy of SciencesBeijing 100080 Department of Physics Shandong UniversityJi’nan 250100

Magneto-impedance(MI)effects have been observed in amorphous and nanocrystalline Fe_(73.5)CuNb_(3)Si_(13.5)B_(9) *** MI values have been obtained in nanocrystalline samples(NCS),but not in as-quenched samples(AQS).The magnetic responses of impedance of nanocrystalline samples share some common features with that of Co-based amorphous wire and ribbon *** field dependencies of effective permeability for nanocrystalline samples have shown a sharp change at the anisotropy *** effective permeability and the hysteresis loops for AQS and NCS have been shown to be responsible for their MI *** sensitivity of the magnetic responses in the nanocrystalline sample can reach 50%/Oe.

关键词： impedance amorphous hysteresis

The 1470 nm diode laser with an intralesional fiber device:a proposed solution for the treatment of inflamed and infected keloids

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Burns & Trauma 2019年第1期7卷 37-43页

作者： Ke Li Fabio Nicoli Wen Jing Xi Zheng Zhang Chunxiao Cui Ahmed Al-Mousawi Alberto Balzani yun tong Yixin Zhang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai JiaoTong University School of Medicine639 Zhi Zao Ju RoadShanghai 200011China Department of Plastic and Reconstructive Surgery University of Rome“Tor Vergata”RomeItaly Department of Plastic and Reconstructive Surgery Newcastle Hospitals NHS Foundation TrustNewcastle upon TyneUK Department of Medical Cosmetology Surgery Jinhua People’s HospitalJinhuaChina

Background:Keloids are the result of abnormal wound healing and often are subject to infections and recurrent *** present a study conducted with a 1470 nm diode laser using an intralesional optical fiber device for the treatment of inflamed keloid *** evaluate its efficacy as a novel alternative method to decrease keloid infection and ***:The patients who underwent 1470 nm laser treatment from February 2016 to February 2018 at the plastic and reconstructive surgery department of the Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao tong University with keloid accompanying serious local infection and fester were *** took curative effect evaluation before and 1 year after the *** test items included infection frequency in each year;pain,by visual analogue scale(VAS);itch,using VAS;quality of life(QOL),using QOL scale;and blood supply,using PeriCam ***:A total of 19 patients(mean age 35.21 years,range 11–66)with history of inflamed keloids with episodes of infection or abscess were *** underwent to a 1470 nm laser therapy for average of 1.16 *** treatment,infection frequency and blood supply in keloids were reduced(p<0.001).Pain,itching,and QOL were improved(p<0.001).Conclusion:The present study shows that 1470 nm fiber laser treatment could improve inflamed keloids fairly well by decreasing inflammation,and a relative stabilization of collagen ***,it is an effective minimally invasive scar therapy,but further studies are essential to confirm the present results.

关键词： Hypertrophic scars Keloid scars 1470 nm Diode laser Fiber laser