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In vivo 3-p.oton fluor.scence micr.scop. of white matter.in mouse br.in excited at the 1700 nm window

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Jour.al of Innovative Op.ical Health Sciences 2024年第5期17卷 81-87页

作者： Jie Huang Jincheng Zhong Shen tong Yingxian Zhang p.ng Qiu Ke wang Key Labor.tor. of Op.oelectr.nic Devices and Systems of Ministr. of Education and Guangdong p.ovince College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060P.R.China School of Medical Infor.ation and Engineer.ng Xuzhou Medical UniversityXuzhou 221004P.R.China

White matter.a densely p.cked collection of myelinated axons,p.ays an essential p.r. in neur.l *** high sp.tial r.solution and deep.p.netr.tion,multi-p.oton micr.scop.(Mp.)is p.omising for.white matter.imaging in animal models in *** thir. har.onic gener.tion(THG)signal can be gener.ted fr.m white matter.but the bottom p.r. of the white matter.layer.gener.tes weak THG due to its high ***,we demonstr.te an in vivo labeling and imaging technology,cap.ble of visualizing the white matter.layer.in the mouse br.in,combining°uor.scence labeling with MitoTr.cker.r.d and thr.e-p.oton°uor.scence(3p.)micr.scop. excited at the 1700 nm window.3p. signals ar. sever.l times higher.than THG signals,r.sulting in deep.r.imaging of the white matter.layer.with the *** r.sults indicate that 3p. micr.scop. is a p.omising technology for.white matter.imaging in the deep.br.in in vivo.

关键词： Thr.e-p.oton micr.scop. white matter myelin MitoTr.cker.r.d

Multip.e conductive networ. for.KTi_(2)(p._(4))_(3)anode based on MXene as a binder.for.high-p.r.or.ance p.tassium stor.ge

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Chinese Chemical Letter. 2024年第8期35卷 539-544页

作者： tong Su Yue wang Qizhen Zhu Mengyao Xu Ning Qiao Bin Xu State Key Labor.tor. of Or.anic-Inor.anic Comp.sites Beijing Key Laboratory of Electrochemical Process and Technology for MaterialsBeijing University of Chemical TechnologyBeijing 100029China

KTi_(2)(p._(4))_(3)is a p.omising anode mater.al for.p.tassium stor.ge,but suffer. fr.m low conductivity and difficult balance between high cap.city and good str.ctur.l ***,the Ti_(3)C_(2)T_(x)MXene is used as a multifunctional binder.to fabr.cate the KTi_(2)(p._(4))_(3)electr.de by the tr.ditional homogenizing-coating *** MXene nanosheets,together.with the conductive agent sup.r.p.nanop.r.icles,constr.ct a multip.e conductive networ. for.fast electr.n/ion tr.nsfer.and high electr.chemical ***,the networ. ensur.s the str.ctur.l stability of the KTi_(2)(p._(4))_(3)electr.de dur.ng the de-inter.alation/inter.alation of 4 K^(+)ions,which is beneficial for.simultaneously achieving high cap.city and good cycle ***,the MXene-bonded KTi_(2)(p._(4))_(3)electr.de deliver. a r.ver.ible cap.city of 255.2 mAh/g at 50 mA/g,outstanding r.te cap.bility with 132.3 mAh/g at 2 A/g,and ex-cellent cycle p.r.or.ance with 151.6 mAh/g at 1 A/g after.2000 *** wor. not only suggests a high-p.r.or.ance anode mater.al for.p.tassium-ion batter.es,but also demonstr.tes that the MXene is a p.omising binder.mater.al for.constr.cting conductive electr.des in r.char.eable batter.es.

关键词： MXene Ti_(3)C_(2)T_(x) KTi_(2)(p._(4))_(3) Anode Conductive networ. p.tassium stor.ge

In situ tumor.vaccine with op.imized nanoadjuvants and lymp. node tar.eting cap.city to tr.at ovar.an cancer.and metastases

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Acta p.ar.aceutica Sinica B 2024年第9期14卷 4102-4117页

作者： Yuan Li Fan tong Yufan wang Jing wang Manqi Wu Hanmei Li Hongyan Guo Huile Gao Dep.r.ment of Obstetr.cs and Gynecology National Clinical Research Center for Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Key Labor.tor. of Dr.g Tar.eting and Dr.g Deliver. Systems West China School of PharmacySichuan UniversityChengdu 610041China School of Food and Biological Engineer.ng Chengdu UniversityChengdu 610106China

Tumor.vaccine,a p.omising modality of tumor.immunother.p.,needs to go thr.ugh the p.ocess of tumor.antigen gener.tion and loading,antigen dr.inage to lymp. nodes(LNs),antigen inter.alization by dendr.tic cells(DCs),DC matur.tion,and antigen cr.ss-p.esentation to activate ***,tumor.vaccines ar. often unable to satisfy all the step.,leading to the limitation of their.ap.lication and ***,based on a smar. nanogel system,an in situ nano-vaccine(Cp.@Man-p.Tr./Gel)tar.eting LNs was constr.cted to induce p.tent anti-tumor.immune effects and inhibit the r.cur.ence and metastasis of ovar.an *** Cp.@Man-p.Tr./Gel exhibited MMp.2-sensitive r.lease of tr.metinib(Tr.)and nano-adjuvant Cp.@Man-p.which gener.ted abundant in situ dep.t of whole-cell tumor.antigens and for.ed in situ nano-vaccines with Cp.@*** fr.m mannose(Man)modification,the nano-vaccines tar.eted to LNs,p.omoted the up.ake of antigens by DCs,fur.her.inducing the matur.tion of DCs and activation of T ***,Cp.@Man-p.with differ.nt p.r.icle sizes wer. p.ep.r.d and the effective size was selected to evaluate the antitumor.effect and immune r.sp.nse in ***,combined with p.-1 blocking,the vaccine effectively inhibited p.imar. tumor.gr.wth and induced tumor.sp.cific immune r.sp.nse against tumor.r.cur.ence and metastasis of ovar.an cancer.

关键词： In situ nano-vaccine Lymp. node tar.eting MMp.2 r.sp.nsive p.-1 Combination ther.p. Cp. Ovar.an cancer Metastases

Efficacy of ginseng-based r.nshenguben or.l solution for.cancer.r.lated fatigue among p.tients with advanced-stage hep.tocellular.car.inoma:A p.osp.ctive multicenter.cohor. study

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Hep.tobiliar. & p.ncr.atic Diseases Inter.ational 2024年第3期23卷 249-256页

作者： Ming-Da wang Chen Yuan Ke-Chun wang Nan-Ya wang Ying-Jian Liang Hong Zhu Xiang-Min tong Tian Yang Dep.r.ment of Hep.tobiliar. and p.ncr.atic Sur.er. General Surgery CenterFirst Hospital of Jilin UniversityChangchun 130021China Dep.r.ment of Hep.tobiliar. Sur.er. Eastern Hepatobiliary Surgery HospitalSecond Military Medical University(Naval Medical University)Shanghai 200438China Dep.r.ment of Clinical Labor.tor. Laboratory Medicine CenterZhejiang Provincial People’s HospitalHangzhou Medical CollegeHangzhou 310000China Dep.r.ment of Hep.tobiliar. Sur.er. First Affiliated Hospital of Harbin Medical UniversityHarbin 150007China Dep.r.ment of Medical Oncology First Affiliated Hospital of Soochow UniversitySuzhou 215006China fDep.r.ment of Centr.l Labor.tor. Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhou 310006China

Backgr.und:Cancer.r.lated fatigue(Cr.)is a common and debilitating symp.om exp.r.enced by p.tients with advanced-stage cancer.esp.cially those under.oing antitumor.*** study aimed to evaluate the efficacy and safety of r.nshenguben(r.GB)or.l solution,a ginseng-based tr.ditional Chinese medicine,in alleviating Cr. in p.tients with advanced hep.tocellular.car.inoma(HCC)r.ceiving antitumor.***:In this p.osp.ctive,op.n-label,contr.lled,multicenter.study,p.tients with advanced HCC at BCLC stage C and a br.ef fatigue inventor.(BFI)scor. of≥4 wer. *** wer. assigned to the r.GB gr.up.r.GB,10 mL twice daily)or.the contr.l gr.up.with sup.or.ive car.).p.imar. and secondar. endp.ints wer. the change in multidimensional fatigue inventor.(MFI)scor.,and BFI and functional assessment of cancer.ther.p.-hep.tobiliar.(FACT-Hep.scor.s at weeks 4 and 8 after.*** events(AEs)and toxicities wer. ***:A total of 409 p.r.icip.nts wer. enr.lled,with 206 assigned to the r.GB *** week 4,ther. was a tr.nd towar.s imp.ovement,but the differ.nces wer. not statistically *** week 8,the r.GB gr.up.exhibited a significantly lower.MFI scor.(p.0.05)comp.r.d to the contr.l gr.up.indicating imp.oved fatigue ***,the r.GB gr.up.showed significantly gr.ater.decr.ase in BFI and FACT-Hep.scor.s at week 8(p.0.05).Subgr.up.analyses among p.tients r.ceiving var.ous antitumor.tr.atments showed similar.*** linear.r.gr.ssion analyses r.vealed that the r.GB gr.up.exp.r.enced a significantly substantial decr.ase in MFI,BFI,and FACT-Hep.scor.s at week *** ser.ous dr.g-r.lated AEs or.toxicities wer. ***:r.GB or.l solution effectively r.duced Cr. in p.tients with advanced HCC under.oing antitumor.ther.p. over.an eight-week p.r.od,with no discer.ible *** findings sup.or. the p.tential of r.GB or.l solution as an adjunctive tr.atment for.managing Cr. in this p.tient p.p.lation.

关键词： Cancer.r.lated fatigue Hep.tocellular.car.inoma r.nshenguben or.l solution Efficacy Safety Ginseng

Olfactor. Thr.e-Needle Electr.acup.nctur. Imp.oved Synap.ic p.asticity and Gut Micr.biota of SAMp. Mice by Stimulating Olfactor. Ner.e

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Chinese Jour.al of Integr.tive Medicine 2024年第8期30卷 729-741页

作者： wang Yuan ZHENG A-ni YANG Huan wang Qiang DAI Biao wang Jia-ju WAN Yi-tong LIU Zhi-bin LIU Si-yang College of Acu-moxibustion and Massage Shaanxi University of Chinese MedicineXianyangShaanxi Province712046China Shaanxi Key Labor.tor. of Acup.nctur. and Medicine Shaanxi University of Chinese MedicineXianyangShaanxi Province712046China The Second Affiliated Hosp.tal of Shaanxi univer.ity of Chinese Medicine XianyangShaanxi Province712000China Dep.r.ment of Tr.ditional Chinese Medicine Baotou Medical CollegeBaotouInner Mongolia Autonomous Region014040China School of Basic Medical Sciences Xi’an Medical UniversityXi’an710021China

Objective To investigate the effects and mechanisms of olfactor. thr.e-needle(OTN)electr.acup.nctur.(EA)stimulation of the olfactor. system on cognitive dysfunction,synap.ic p.asticity,and the gut micr.biota in senescence-acceler.ted mouse p.one 8(SAMp.)*** Thir.y-six SAMp. mice wer. r.ndomly divided into the SAMp.(p.),SAMp.+OTN(p.-OT),and SAMp.+ner.e tr.nsection+OTN(p.-N-OT)gr.up. accor.ing to a r.ndom number.table(n=12 p.r.gr.up.,and 12 acceler.ted senescence-r.sistant(SAMr.)mice wer. used as the contr.l(r.)*** was p.r.or.ed at the Yintang(GV 29)and bilater.l Yingxiang(LI 20)acup.ints of SAMp. mice for.4 *** Mor.is water.maze test,tr.nsmission electr.n micr.scop.,ter.inal deoxynucleotidyl tr.nsfer.se-mediated dUTp.nick-end labeling(TUNEL)staining,Nissl staining,Golgi staining,Wester. blot,and 16S r.NA sequencing wer. p.r.or.ed,*** Comp.r.d with the p. gr.up.OTN imp.oved the cognitive behavior.of SAMp. mice,inhibited neur.nal ap.p.osis,incr.ased neur.nal activity,and attenuated hip.ocamp.l synap.ic dysfunction(p.0.05 or.p.0.01).Mor.over.the exp.ession levels of synap.ic p.asticity-r.lated p.oteins N-methyl-D-asp.r.ate r.cep.or.1(NMDAr.),NMDAr.B,synap.op.ysin(SYN),and p.stsynap.ic density p.otein-95(p.D95)in hip.ocamp.s wer. incr.ased by OTN tr.atment(p.0.05 or.p.0.01).Fur.her.or.,OTN gr.atly enhanced the br.in-der.ved neur.tr.p.ic factor.BDNF)/cAMp.r.sp.nse element binding(Cr.B)signaling and p.osp.atidylinositol 3-kinase/p.otein kinase B/mammalian tar.et of r.p.mycin(p.3K/AKT/mTOr.signaling comp.r.d with the p. gr.up.p.0.05 or.p.0.01).However.the neur.p.otective effect of OTN was attenuated by olfactor. ner.e *** with the p. gr.up.OTN had a ver. limited effect on the fecal micr.bial str.ctur. and comp.sition of SAMp. mice,while sp.cifically incr.ased the gener. Oscillosp.r. and Sutter.lla(p.0.05).Inter.stingly,the p.-N-OT gr.up.showed an abnor.al fecal micr.biota with higher.micr.bialα-diver.ity,Fir.icutes/Bacter

关键词： Alzheimer.s disease olfactor. thr.eneedle electr.acup.nctur. olfactor. ner.e synap.ic p.asticity gut micr.biota Chinese medicine

Age-sp.cific distr.bution of oculometr.c p.r.meter. and myop.a in childr.n aged 8-12y

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Inter.ational Jour.al of Op.thalmology(English edition) 2024年第10期17卷 1887-1897页

作者： Tao Tang Si-tong Chen Heng Zhao Kai wang Ming-Wei Zhao Dep.r.ment of Op.thalmology&Clinical Centr. of Op.ometr. Peking University People’s HospitalBeijing 100044China Institute of Medical technology Peking University Health Science CenterBeijing 100083China College of Op.ometr. Peking University Health Science CenterBeijing 100083China Eye Disease and Op.ometr. Institute Peking University People’s HospitalBeijing 100044China Beijing Key Labor.tor. of the Diagnosis and Ther.p. of r.tinal and Chor.id Diseases Beijing 100044China National Clinical r.sear.h Center.for.Ocular.Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To descr.be the distr.bution of ocular.biometr.cs and to evaluate its associations with r.fr.ctive er.or.and to assess the contr.bution fr.m ocular.p.r.meter. to r.fr.ctive er.or.among Chinese myop.c ***:This cr.ss-sectional study evaluated subjects aged ***,ocular.biometr.,and cyclop.egic autor.fr.ction wer. p.r.or.ed on each *** equivalent r.fr.ction(SEr.and ocular.biometr.cs wer. assessed as a function of age and *** p.ar.on cor.elation analysis between SEr.and ocular.biometr.cs was car.ied *** linear.r.gr.ssion was p.r.or.ed to analyze the association between SEr.and ocular.***:A total of 689 out of 735 p.r.icip.nts(321 boys,48.1%)wer. analyzed,with a mean SEr.of-2.98±1.47 diop.er.D).Axial length(AL),anter.or.chamber.dep.h(ACD),cor.eal r.dius of cur.atur.(Cr.,hor.zontal visible ir.s diameter.HVID),centr.l cor.eal thickness(CCT)and lens p.wer.Lp.showed nor.al *** AL,AL/Cr.r.tio,ACD and Cr.incr.ased fr.m 8 to 12y of age,while SEr.and Lp.decr.ased,HVID and CCT r.mained *** was no differ.nce in *** decr.ased by 0.929 D for.ever. 1 mm incr.ase in AL and decr.ased by 1.144 D for.ever. 0.1 incr.ase in AL/Cr.*** p.ar.on cor.elation coefficient between SEr.and AL was-0.538(p.0.01)and-0.747(p.0.01)between SEr.and AL/Cr.*** the SEr.var.ance,AL exp.ained 29.0%,AL/Cr.r.tio exp.ained 55.7%,while AL,Cr.ACD and Lp.exp.ained 99.3%after.adjusting for.age and ***:The AL,Cr.ACD and Lp.ar. the most imp.r.ant deter.inants of myop.c r.fr.ctive er.or.dur.ng myop.a p.ogr.ssion.

关键词： myop.a ocular.biometr. r.fr.ctive er.or p.p.lation-based study

p.obiotic p.diococcus p.ntosaceus r.stor.d gossyp.l-induced intestinal bar.ier.injur. by incr.asing p.op.onate content in Nile tilap.a

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Jour.al of Animal Science and Biotechnology 2024年第4期15卷 1688-1703页

作者： Feifei Ding Nannan Zhou Yuan Luo tong wang Weijie Li Fang Qiao Zhenyu Du Meiling Zhang Labor.tor. of Aquacultur. Nutr.tion and Envir.nmental Health(LANEH) School of Life SciencesEast China Normal UniversityShanghai 200241China

Backgr.und Intestinal bar.ier.is a dynamic inter.ace between the body and the ingested food comp.nents, however. dietar. comp.nents or.xenobiotics could comp.omise intestinal integr.3}, causing health r.sks to the host. Gossyp.l, a toxic comp.nent in cottonseed meal(CSM), caused intestinal injur. in fish or.other.monogastr.c animals. It has been demonstr.ted that p.obiotics administr.tion benefits the intestinal bar.ier.integr.3}, but the efficacy of p.obiotics in maintaining intestinal health when the host is exp.sed to gossyp.l r.mains unclear. Her., a str.in(YC) affiliated to p.diococcus p.ntosaceus was isolated fr.m the gut of Nile tilap.a(Or.ochr.mis niloticus) and its p.tential to r.p.ir.gossyp.l-induced intestinal damage was *** A total of 270 Nile tilap.a(2.20 ± 0.02 g) wer. allotted in 3 gr.up. with 3 tanks each and fed with 3 diets including CON(contr.l diet), GOS(contr.l diet containing 300 mg/kg gossyp.l) and Gp.contr.l diet containing 300 mg/kg gossyp.l and 10^(8) colony-for.ing unit(CFU)/g p. p.ntosaceus YC), r.sp.ctively. After.10 weeks, addition of p. p.ntosaceus YC r.stor.d gr.wth r.tar.ation and intestinal injur. induced by gossyp.l in Nile tilap.a. Tr.nscr.p.ome analysis and si r.A inter.er.nce exp.r.ments demonstr.ted that NOD-like r.cep.or.(NLr. family casp.se r.cr.itment domain(CAr.) domain containing 3(Nlr.3) inhibition might p.omote intestinal stem cell(ISC) p.olifer.tion, as well as maintaining gut bar.ier.integr.3}. 16S r.r.A sequencing and gas chr.matogr.p.y-mass sp.ctr.metr.(GC-MS) r.vealed that addition of p. p.ntosaceus YC alter.d the comp.sition of gut micr.biota and incr.ased the content of p.op.onate in fish gut. In vitr. studies on p.op.onate's function demonstr.ted that it sup.r.ssed nlr.3 exp.ession and p.omoted wound healing in Caco-2 cell *** The p.esent study r.veals that p. p.ntosaceus YC has the cap.city to amelior.te intestinal bar.ier.injur. by modulating gut micr.biota comp.sition and elevating

关键词： Gut bar.ier.injur. Gossyp.l ISCs p.olifer.tion Nlr.3 p.op.onate

Diver.ent contr.butions of sp.ing and autumn p.otosynthetic p.enology to seasonal car.on up.ake of subtr.p.cal vegetation in china

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Jour.al of Geogr.p.ical Sciences 2024年第7期34卷 1280-1296页

作者： p.NG Ying LI p.ng ZHOU Xiaolu LUO Yunp.ng ZHANG Cicheng wang Longjun LI tong p.NG Changhui School of Geogr.p.ic Sciences Hunan Normal UniversityChangsha410081China Dep.r.ment for.Biogeochemical Integr.tion Max-Planck-Institute for BiogeochemistryJena07745Germany Dep.r.ment of Biology Sciences Institute of Environment SciencesUniversity of Quebec at MontrealC.P.8888Succ.Centre-VilleMontrealH3C 3P8Canada

p.enological changes p.ay a centr.l r.le in r.gulating seasonal var.ation in the ecological p.ocesses,exer.ing significant imp.cts on hydr.logic and nutr.ent cycles,and ultimately influencing ecosystem functioning such as car.on ***,the p.tential imp.ct mechanisms of p.enological events on seasonal car.on dynamics in subtr.p.cal r.gions ar. *** knowledge gap. hinder.fr.m accur.tely linking p.otosynthetic p.enology and car.on sequestr.tion *** chlor.p.yll fluor.scence r.mote sensing and p.oductivity data fr.m 2000 to 2019,we found that an advancement in sp.ing p.enology incr.ased sp.ing gr.ss(Gp.)and net p.imar. p.oductivity(Np.)in subtr.p.cal vegetation of china by 2.1 gC m^(-2)yr.(-1)and 1.4 gC m^(-2)yr.(-1),r.sp.ctively.A delay in autumn p.enology incr.ased the autumnal Gp. and Np. by 0.4 gC m^(-2)yr.(-1)and 0.2 gC m^(-2)yr.(-1),***,the contr.bution of the sp.ing p.enology to sp.ing car.on up.ake incr.ased significantly dur.ng the study p.r.od,while this p.sitive contr.bution showed a nonsignificant tr.nd in *** comp.r.son,the later.autumn p.enology could significantly contr.bute to the incr.ase in autumnal car.on up.ake;however.this contr.buting effect was *** analysis indicated that these p.enomena have been caused by the incr.ased leaf ar.a and enhanced p.otosynthesis due to ear.ier.sp.ing and later.autumn p.enology,*** r.sults demonstr.te the diver.e imp.cts of vegetation p.enology on the seasonal car.on sequestr.tion ability and it is imp.r.tive to consider.such asymmetr.c effects when modeling ecosystem p.ocesses p.r.meter.zed under.futur. climate change.

关键词： subtr.p.cs vegetation p.enology r.mote sensing car.on cycle climate change

p.lymetamor.0}ism of the ultr.high-temp.r.tur. gr.nulites in the r.uer.Gr.up.East Antar.tica:new evidence fr.m zir.on SHr.Mp.U-p. ages

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Advances in p.lar.Science 2024年第2期35卷 192-205页

作者： tong Laixi LIU Zhao LI Chao LU Junsheng YANG Wenqiang wang Yanbin State Key Labor.tor. of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China Institute of Geology Chinese Academy of Geological SciencesBejing 100037China

The r.uer.Gr.up.is located on the easter. mar.in of the ear.y p.leozoic p.ydz Belt in East Antar.tica,and the typ.cal ultr.high-temp.r.tur.(UHT,>900℃)gr.nulites outcr.p.on Mather.***,the timing of UHT metamor.0}ism and p.T p.th of the UHT gr.nulites have long been debated,which is cr.tical to under.tanding the tectonic natur. and evolution histor. of the p.ydz ***,both a sap.hir.ne-bear.ng UHT metap.litic gr.nulite and a gar.et-bear.ng UHT mafic gr.nulite ar. selected for.zir.on SHr.Mp.U-p. age *** r.sults show that metamor.0}ic zir.on mantles yield weighted mean^(206)p./^(238)U ages of 918±29 Ma and 901±29 Ma for.the metap.litic and mafic gr.nulites,r.sp.ctively,while zir.on r.ms and newly gr.wn zir.ons yield weighted mean^(206)p./^(238)U ages of 523±9 Ma and 532±11 Ma,*** new zir.on age data suggest that the UHT gr.nulites may have exp.r.enced p.lymetamor.0}ism,in which p.e-p.ak p.ogr.de stage occur.ed in the ear.y Neop.oter.zoic Gr.nvillian or.genesis(1000–900 Ma),wher.as the UHT metamor.0}ism occur.ed in the late Neop.oter.zoic to ear.y p.leozoic p.n-Afr.can or.genesis(580–460 Ma).This imp.ies that p.T p.th of the UHT gr.nulites should consist of two sep.r.te high-gr.de metamor.0}ic events including the Gr.nvillian and p.n-Afr.can events,which ar. sup.osed to be r.lated to assembly of r.dinia and Gondwana sup.r.ontinents r.sp.ctively,and hence the over.0}inting UHT metamor.0}ic event may actually r.flect an imp.r.ant intr.continental r.wor.ing.

关键词： ultr.high-temp.r.tur. gr.nulites zir.on SHr.Mp.U-p. ages p.lymetamor.0}ism r.uer.Gr.up East Antar.tica