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基于变步长扫描策略的FBG高速解调

红外与激光工程 2024年第4期53卷 233-242页

作者：梁磊张宇宁杜尚明童晓玲武汉理工大学光纤传感技术国家工程实验室湖北武汉430070 武汉理工大学信息工程学院湖北武汉430070 武汉理工大学三亚科教创新园海南三亚572000

现有的FBG高速解调方法都各有优缺点,其中扫描式光谱分析系统通用性好、成本较低,在速度和精度上的表现较为均衡。针对扫描激光器型光纤布拉格光栅波长解调仪在实际应用中调谐次数多、扫描耗时久等问题,设计了一种变步长扫描策略,使用... 详细信息

现有的FBG高速解调方法都各有优缺点,其中扫描式光谱分析系统通用性好、成本较低,在速度和精度上的表现较为均衡。针对扫描激光器型光纤布拉格光栅波长解调仪在实际应用中调谐次数多、扫描耗时久等问题,设计了一种变步长扫描策略,使用较少的波长调谐次数实现光谱局部峰值的检出。实验表明,在通道内只有单个光栅的情况下,使用变步长扫描策略需要扫描的点数降低了至少90%,扫描耗时减少了90%,解调速度提高至10倍。在上位机对传输的局部光谱数据进行高斯拟合解调,并对变步长扫描策略进行信噪比仿真实验测试,仿真证明变步长扫描策略适用于信噪比高于9.23 dB的情况且对后续解调的精度和平均误差几乎没有影响,具有一定的应用价值。

关键词：光纤光栅高速解调可调谐激光器波长调谐

Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori

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Journal of Pharmaceutical Analysis 2021年第3期11卷 374-382页

作者： Jiangbo Song Lian Liu Kaige Hao Shuang Mao Yongxi Tang xiaoling tong Fangyin Dai State Key Laboratory of Silkworm Genome Biology Key Laboratory for Sericulture Biology and Genetic BreedingMinistry of Agriculture and Rural AffairsCollege of BiotechnologySouthwest UniversityNo.2 Tiansheng RoadBeibei DistrictChongqing400715China

A number of research has shown that the plant polyphenol resveratrol,one of the most prominent small molecules,has beneficial protective effects in multiple organisms,including worms,flies,and *** understand the effects of resveratrol on lifespan,we evaluated its effects in the silkworm Bombyx *** this study,we found that lifespan was significantly prolonged in both female and male silkworms treated with *** larval weight was significantly increased from day 3 of the 5th larval instar(L5D3)to day 7 of the 5th larval instar(L5D7).However,the weight of the pupa,cocoon,and total cocoon was not significantly different in female silkworms with resveratrol treatment than that in ***,resveratrol significantly improved the thermotolerance of the silkworms,which enhanced their survival ***,antioxidant activity was increased by resveratrol in both female and male ***,an antioxidant-related signalling pathway,SIRT7-FoxO-GST,was activated in silkworms with resveratrol ***,these results help us to understand the molecular pathways underlying resveratrol induced pro-longevity effects and indicate that silkworm is a promising animal model for evaluating the effects of lifespan-extending drugs.

关键词： Resveratrol Bombyx mori Lifespan Antioxidant activity SIRT7-FoxO-GST pathway

基于光纤光栅加速度传感器的管道流量实时监测方法研究

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数字制造科学 2024年第1期 66-71页

作者：彭汉修何祖清梁磊童晓玲程必强中石化石油工程技术研究院有限公司北京102211 武汉理工大学光纤传感技术与网络国家工程研究中心湖北武汉430070 武汉理工大学机电工程学院湖北武汉430070

在高温、高压、腐蚀等极端恶劣环境的油气井下,光纤传感器相比传统电类传感器具有更高的可靠性。管道振动的标准偏差与流动湍流引起的管壁压力波动成正比,因此基于光纤光栅传感原理及传感器几何形状优化方法设计了一种高灵敏度的光纤加... 详细信息

在高温、高压、腐蚀等极端恶劣环境的油气井下,光纤传感器相比传统电类传感器具有更高的可靠性。管道振动的标准偏差与流动湍流引起的管壁压力波动成正比,因此基于光纤光栅传感原理及传感器几何形状优化方法设计了一种高灵敏度的光纤加速器传感器以感受管壁压力波动,进行非侵入式管道流量测量。搭建了实验平台进行相关实验,采用指数拟合及二次拟合方法拟合振动标准差与流速实验数据,拟合度均高达98%,流速拟合误差在±5%范围内,指数拟合方法更优,可测最低流速为0.37 m/s。经实验证明,此种加速器传感器能够较好实现井下管道非侵入式实时测量。

关键词：光纤光栅加速度传感器井下管道流量监测管壁压力

Bmelo12,an elongase of very long-chain fatty acids gene,regulates silk yield in Bombyx mori

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Journal of Genetics and Genomics 2022年第9期49卷 909-911页

作者： Weidong Zuo Chunlin Li Yanyu Liu Rui Gao Yue Luan Bili Zhang Hai Hu Minjin Han xiaoling tong Cheng Lu Fangyin Dai State Key Laboratory of Silkworm Genome Biology Key Laboratory of Sericultural Biology and Genetic BreedingMinistry of Agriculture and Rural AffairsCollege of SericultureTextile and Biomass SciencesSouthwest UniversityChongqing 400715China

In silkworm,cocoon shell weight(CSW),an index of silk yield,is a quantitative trait(Nagaraju and Goldsmith,2002),and multiple quantitative trait loci(QTLs)located on different chromosomes have been found(Zhan et al.,2... 详细信息

关键词： Bombyx trait silk

The Hox genes and body plan of silkworm,Bombyx mori

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The Hox genes and body plan of silkworm,Bombyx mori

Genomic dissection of gastrointestinal and lung neuroendocrine neoplasm

中国蚕学会第十届青年学术研讨会

作者： xiaoling tong Songzhen He Southwest University China

Hox genes encoding homeodomain-containing transcription factors control the embryogenesis and the specification of various tissue structures during animal *** specific regional functions of individual Hox genes largely reflect their restricted expression patterns,the disruption of which can lead to developmental defects and *** silkworm,there are more than 30 mutants（E pseudoalleles） exhibiting profound morphological alterations during development,such as extra color markings,supernumerary or defective legs,abnormal silkgland,defective wings and embryonic ***,we found that the deficiencies in Hox gene cluster were responsible for the E *** mutations in the gene coding region destroyed the encoded protein,while,mutations in the intergenic region affected the Hox gene expression *** long non-coding RNAs（lncRNAs） and mi RNAs within the Hox cluster were supposed to regulate Hox gene expression as *** characterize the lepidopteran-specific Hox cluster genes,six special homeobox（Shx） genes were cloned and their tissue-specific expression pattern were identified by in situ in *** analyzed the role of Hox genes during silkworm development,some new findings in the silkworm were opposed to previous reports in Drosophila and other *** instance,the Antp gene does not affect the wing identity in Drosophila and Tribolium castaneuma,while,the BmAntp gene was found to be involved the wing development in *** the inhibition of Abd-A gene in leg development by repressing distal-less（dll） in Drosophila,the silkworm BmAbd-A gene promotes the proleg development,which was supported by the fact that ectopic expressed Abd-A gene in the abdominal segment（A2） activated the ectopic dll expression and thereby induced extra *** of the Hox genes expression and their roles in establishing the body structures in silkworm promise to shed light on the regulatory mechanisms of Hox genes during vertebrate evolut

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Chinese Journal of Cancer Research 2019年第6期31卷 918-929页

作者： Haixing Wang Li Sun Hua Bao Ao Wang Panpan Zhang Xue Wu xiaoling tong Xiaonan Wang Jie Luo Lin Shen Yang WShao Ming Lu Department of Endoscopy Center The First Affiliated Hospital of Xiamen UniversityXiamen 361003China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China Translational Medicine Research Institute Geneseeq Technology Inc.Toronto M5G 1L7Canada Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Medical Department Nanjing Geneseeq Technology Inc.Nanjing 210032China Department of Pathology China-Japan Friendship HospitalBeijing 100029China School of Public Health Nanjing Medical UniversityNanjing 210029China

Objective:Neuroendocrine neoplasms(NENs)are relatively rare and heterogeneous malignancies with two major subtypes:low-grade neuroendocrine tumor(NET)and high-grade neuroendocrine carcinoma(NEC).Comprehensive molecular characterization of NENs is needed to refine our understanding of the biological underpinnings of different NEN subtypes and to predict disease progression more ***:We performed whole-exome sequencing(WES)of NEN samples from 49 patients(25 NETs and 24 NECs)arising from the stomach,intestines or *** features were assessed and associated with molecular ***:NENs generally harbor a low mutation burden,with TP53 being the top mutated gene found in 31%of *** with other studies,p53 signaling pathway dysfunction is significantly enriched in NECs compared to NETs(P<0.01).Other than TP53,tissue type-specific mutation profiles of NENs were observed in our cohort compared to those reported in pancreatic ***,we observed significant genomic instability,with increased copy number alterations observed across the NEN genome,which was more profound in NECs and independently correlated with poor overall survival(OS)(P<0.001).NECs could be further stratified into two molecular subtypes based on OS(P<0.001)and the chromosomal instability score(CIS).Interestingly,we discovered that the gain of whole chromosome 5 occurred at the early stage of NEN development,followed by the loss of 5 q exclusively in NECs(P<0.001).Conclusions:These findings provide novel insights into the molecular characteristics of NENs and highlight the association of genomic stability with clinical outcomes.

关键词： Neuroendocrine carcinoma whole-exome sequencing chromosomal instability

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河南省高校知识女性群体健康锻炼调查

河南师范大学学报（自然科学版） 2013年第4期41卷 180-182页

作者：佟小玲新乡学院体育系河南新乡453003

以河南省高校知识女性群体为研究对象,通过对研究对象对健康概念的认知度、自身健康状况的自我评价、健康锻炼态度的调查、各年龄段健康状况以及不同年龄段锻炼的理想度的调查统计,针对该群体在健康锻炼方面存在认识程度上差异、亚健康... 详细信息

以河南省高校知识女性群体为研究对象,通过对研究对象对健康概念的认知度、自身健康状况的自我评价、健康锻炼态度的调查、各年龄段健康状况以及不同年龄段锻炼的理想度的调查统计,针对该群体在健康锻炼方面存在认识程度上差异、亚健康状态人数居多等问题,提出了一些合理化建议.

关键词：河南省高校知识女性健康锻炼调查

The Mechanism of Chemokine Receptor 9 Internalization Triggered by Interleukin 2 and Interleukin 4

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Cellular & Molecular Immunology 2009年第3期6卷 181-189页

作者： xiaoling tong Lijun Zhang Li Zhang Meng Hu Jun Leng Beibei Yu Beibei Zhou Yi Hu Qiuping Zhang Department of Immunology College of Basic Medical Sciences Wuhan University Donghu Road 185 Wuchang Wuhan 430071 China Department of Geriatrics Renmin Hospital Wuhan University Jiefang Road 238 Wuchang Wuhan 430060 China

In previous study, we found that the chemokine receptor 9 （CCR9） was highly expressed on CD4^＋T cells from patients with T-cell lineage acute lymphocytic leukemia （T-ALL） and mediated leukemia cell infiltration and metastasis. Combined use of interleukin 2 （IL-2） and IL-4 promoted the internalization of CCR9 and therefore attenuated leukemia cell infiltration and metastasis. In this study, we preliminarily investigated the mechanism of internalization of CCR9 on MOLT4 cell model （a human leukemia T-cell line, naturally expresses CCR9） and found that IL-2 upregulated the cell surface expression of IL-4Rα （CD124） greatly, whereas IL-4 had no significant influence on α （CD25） and β subunits （CD122） of IL-2R. Moreover, specific inhibitors, such as staurosporine, H89 and heparin, inhibited internalization of CCR9, which indicated a role of protein kinase C （PKC） and G protein-coupled kinase 2 （GRK2）, respectively. Furthermore, GRK2 was upregulated and translocated to cell membrane in IL-2 and IL-4 treated cells which indicated that PKC could be a prerequisite for GRK2 activity.

关键词： CCR9 IL-2 IL-4 PKC GRK2

基于东中西部地区吸收能力的区域外包技术外溢效应研究

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华中师范大学学报（自然科学版） 2014年第3期48卷 425-430页

作者：童晓玲武汉理工大学机电工程学院武汉430070

利用1992年～2011年度间的省级面板数据,运用广义矩估计方法实证研究了东部、中部和西部地区的吸收能力对外包的技术外溢效应影响,得出了以下结论：一是东部、中部和西部地区存在外包的技术外溢效应,但该效应均较小;二是东部地区制约外... 详细信息

利用1992年～2011年度间的省级面板数据,运用广义矩估计方法实证研究了东部、中部和西部地区的吸收能力对外包的技术外溢效应影响,得出了以下结论：一是东部、中部和西部地区存在外包的技术外溢效应,但该效应均较小;二是东部地区制约外包的技术吸收能力的主要因素是人力资本;三是经济开放度和金融发展水平是中西部地区制约外包技术吸收能力的主要因素.

关键词：外包技术外溢效应吸收能力实证研究