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First-line penpulimab(an anti-PD1 antibody)and anlotinib(an angiogenesis inhibitor)with nab-paclitaxel/gemcitabine(PAAG)in metastatic pancreatic cancer:a prospective,multicentre,biomolecular exploratory,phase II trial

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2960-2969页

作者： Huizi Sha Fan tong Jiayao Ni Yi Sun Yahui Zhu Liang Qi Xiaoqin Li Wei Li Yan Yang Qing Gu Xing Zhang Xiaoxuan Wang Chan Zhu Dongsheng Chen Baorui Liu Juan Du The Comprehensive Cancer Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing University&Clinical Cancer Institute of Nanjing UniversityNanjingChina The Comprehensive Cancer Center Nanjing Drum Tower HospitalClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingChina department of Oncology The Affiliated Hospital of Jiangsu UniversityZhenjiangChina department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhouChina department of Oncology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingChina National Institute of Healthcare Data Science at nanjing university NanjingChina State Key Laboratory of Neurology and Oncology Drug Development Jiangsu Simcere Diagnostics Co.Ltd.Nanjing Simcere Medical Laboratory Science Co.Ltd.NanjingChina

Metastatic pancreatic cancer(mPC)has a dismal ***,we conducted a prospective,multicentre,single-arm,phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combination with nab-paclitaxel/gemcitabine(PAAG)in patients with first-line mPC(NCT05493995).The primary endpoints included the objective response rate(ORR)and disease control rate(DCR),while secondary endpoints encompassed progression-free survival(PFS),overall survival(OS),and *** 66 patients analysed for efficacy,the best response,indicated by the ORR,was recorded at 50.0%(33/66)(95%CI,37.4–62.6%),with 33 patients achieving partial response(PR).Notably,the DCR was 95.5%(63/66,95%CI,87.3–99.1%).The median PFS(mPFS)and OS(mOS)were 8.8(95%CI,8.1–11.6),and 13.7(95%CI,12.4 to not reached)months,*** 3/4 treatment-related adverse events(TRAEs)were reported in 39.4%of patients(26/66).In prespecified exploratory analysis,patients with altered SWI/SNF complex had a poorer ***,low serum CA724 level,high T-cell recruitment,low Th17 cell recruitment,and high NK CD56dim cell scores at baseline were potential predicative biomarkers for more favourable *** conclusion,PAAG as a first-line therapy demonstrated tolerability with promising clinical efficacy for *** biomolecular findings identified in this study possess the potential to guide the precise clinical application of the triple-combo regimen.

关键词： CA724 prospective centre

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康德对传统抽象论的批判及其意义

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上海交通大学学报（哲学社会科学版） 2004年第4期12卷 54-59,65页

作者：张荣南京大学哲学系江苏南京210093

抽象论是传统知识论中一个基本的立场 ,然而在《纯粹理性批判》中受到康德尖锐的批判。康德对抽象论的拒斥 ,旨在实现知识论上的“哥白尼式革命”。康德的批判突出了想象力、尤其是先验想象力在知识论中的核心地位。在康德看来 ,先验想... 详细信息

抽象论是传统知识论中一个基本的立场 ,然而在《纯粹理性批判》中受到康德尖锐的批判。康德对抽象论的拒斥 ,旨在实现知识论上的“哥白尼式革命”。康德的批判突出了想象力、尤其是先验想象力在知识论中的核心地位。在康德看来 ,先验想象力生发了知识的两个主干 ,即感性和知性 ,确保了二者的联结 ,克服了传统抽象论关于实在论和观念论之间的疏离。康德对抽象论的批判具有深远的意义 ,对后世哲学产生了深远影响 ,首先在费希特的知识学中取得了实际效应。

关键词：康德抽象论《纯粹理性批判》先验想象力费希特

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AN INCREMENTAL UPDATING ALGORITHM FOR MINING ASSOCIATION RULES

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Journal of Electronics(china) 2002年第4期19卷 403-407页

作者： Xu Baowen Yi tong Wu Fangjun Chen Zhenqiang(department of Computer Science & Engineering, Southeast university, nanjing 210096) (National Key Laboratory of Software Engineering, Wuhan university, Wuhan 430072) department of Computer Science & Engineering Southeast University Nanjing 210096 National Key Laboratory of Software Engineering Wuhan University Wuhan 430072 department of Computer Science & Engineering Southeast University Nanjing 210096

In this letter, on the basis of Frequent Pattern(FP) tree, the support function to update FP-tree is introduced, then an Incremental FP (IFP) algorithm for mining association rules is proposed. IFP algorithm considers not only adding new data into the database but also reducing old data from the database. Furthermore, it can predigest five cases to three *** algorithm proposed in this letter can avoid generating lots of candidate items, and it is high efficient.

关键词： Data mining Association rules Support function Frequent pattern tree

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Prefrontal Cortex Homer Expression in an Animal Model of Attention Deficit/Hyperactivity Disorder

Prefrontal Cortex Homer Expression in an Animal Model of Att...

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第六届江浙沪儿科学术会议暨儿科学基础与临床研究进展学术班

作者： Qin Hong Xia Chi Xi-rong Guo Mei-ling tong Rong-hua Chen Min Zhang Xiao-qin Pan Mei Guo Li Fei Corresponding Author’s Institution department of Pediatrics nanjing Maternity and Child Health Hospital of nanjing Medical university nanjing 210004 china

Background Attention-deficit/hyperactivity disorder(ADHD) is apervasiveneurobeha vioral disorder affecting approximately 5%of children and adolescents and 3%of adults,and the prefrontal cortex(PFC) may play the most critical role in the expression of *** previous studies indicate a potential role of Homer-a scaffolding protein family localized at the postsynaptic density(PSD) of glutamatergic excitatory synapses-in behavioral pathologies associated with neuropsychiatric disorders. Accordingly,we speculate that these Homer isoforms might contribute to the etiology and development of *** We investigated the differential expressions of several Homer isoforms in the PFC of the spontaneous hypertensive rat/Wistar-Kyoto rats(SHR/WKY),the most frequently used animal model of ***,we examined the effects of methylphenidate(MPH) exposure on the behaviors and the expression of different Homer isoforms in the PFC of *** Homer 1 a and Homer 2a/b,but not Homer lb/c,were expressed at a significantly lower levels in the PFC of SHR compared with *** exposure decreased the locomotor activity and non-selective attention of SHR,and it up regulated the expression of Homer la and Homer 2a/b,but not Homer lb/c,in the PFC of *** It is plausible that Homer 1a and Homer 2a/b may be involved in the etiology and pathogenesis of *** work will focus on elucidating the specific mechanisms of Homer 1a and Homer 2a/b in ADHD.

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SEM in-situ Fracture Observation and the Reinforcing Effect of Composite SiC_p/ZA22

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Journal of Materials Science & Technology 2001年第6期17卷 649-652页

作者： Jun WANG, Baode SUN and Yaohe ZHOU School of Materials Science and Engineering, Shanghai Jiaotong university, Shanghai 200030, china Lining ZHANG and Feng CHEN department of Materials Science and Engineering, Southeast university, Shanghai Jiao tong Univ Sch Mat Sci & Engn Shanghai 200030 Peoples R China SE Univ Dept Mat Sci & Engn Nanjing 210096 Peoples R China

The strengthening effect of a Zn alloy reinforced by SiC particulate was examined. Based on the results of SEM in-situ fracture observation and stress field analysis by finite element method, it is believed that the r... 详细信息

关键词： SiC SEM in-situ Fracture Observation and the Reinforcing Effect of Composite SiC_p/ZA22

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Spatial Variation and Trend of Extreme Precipitation in Africa during 1981-2019 and Its Projected Changes at the End of 21^st Century

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Journal of Geoscience and Environment Protection 2024年第3期12卷 192-221页

作者： Fabien Habiyakare tong Jiang Ibrahim Yahaya Daudi Ndabagenga James Kagabo Buda Su School of Atmospheric Sciences Key Laboratory of Meteorological Disaster of Ministry of Education Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and Technology Nanjing China Rwanda Meteorology Agency (Meteo Rwanda) Kigali Rwanda Institute for Disaster Risk Management/School of Geographical Sciences Nanjing University of Information Science & Technology Nanjing China department of Geography Gombe State University Gombe State Nigeria

This study comprehensively examines the patterns and regional variation of severe rainfall across the African continent, employing a suite of eight extreme precipitation indices. The analysis extends to the assessment of projected changes in precipitation extremes using five General Circulation Models (GCMs) from Coupled Model Intercomparison Project Phase 6 (CMIP6) under four Shared Socioeconomic Pathways (SSPs) scenarios at the long-term period (2081-2100) of the 21st century. Furthermore, the study investigates potential mechanisms influencing precipitation extremes by correlating extreme precipitation indices with oceanic system indices, specifically Ni?o 3.4 for El Ni?o-Southern Oscillation (ENSO) and Dipole Mode Index (DMI) for the Indian Ocean Dipole (IOD). The findings revealed distinct spatial distributions in mean trends of extreme precipitation indices, indicating a tendency toward decreased extreme precipitation in North Africa, Sahel region, Central Africa and the Western part of South Africa. Conversely, West Africa, East Africa and the Eastern part of South Africa exhibit an inclination toward increased extreme precipitation. The changes in precipitation extreme indices indicate a general rise in both the severity and occurrence of extreme precipitation events under all scenarios by the end of the 21st century. Notably, our analysis projects a decrease in consecutive wet days (CWD) in the far-future. Additionally, correlation analysis highlights significant correlation between above or below threshold rainfall fluctuation in East Africa and South Africa with oceanic systems, particularly ENSO and the IOD. Central Africa abnormal precipitation variability is also linked to ENSO with a significant negative correlation. These insights contribute valuable information for understanding and projecting the dynamics of precipitation extreme in Africa, providing a foundation for climate adaptation and mitigation efforts in the region.

关键词： Extreme Precipitation Mann-Kendall Trend Projections Oceanic System Africa

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Distribution of Vasoative Intestinal Polypeptide in CranialParasym pathetic Ganglion of the Rat

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The Journal of Biomedical Research 1999年第2期23卷 95-97,110页

作者： Wang Heming(王鹤鸣)\ Knyazeva LA\+1 tong Xinkang(童鑫康) Han Qunying(韩群颖) Fang Shibang(方实邦) [WT5,5”BZ]department of Anatomy, nanjing Medical university, nanjing 210029, P. R. china \+1department of Morphology, Russia State Medical university, Moscow 117869, Russia

Immunoreactivity (IR) for vasoactive intestinal polypeptide (VIP) of cranial parasympathetic ganglia of the rat was observed with indirect immunofluorescent method. It was found that there were VIP IR principal neurons in the ciliary, pterygopalatine, and otic ganglia. The highest positive ratio of VIP IR cells was located in the ciliary ganglia (34.8%), followed by that in the pterygopalatine ganglia(17.0%), and the lowest was found in the otic ganglia (15.4%). VIP IR small intensely fluorescent (SIF) cells and nerve fibers were not observed. Distributive characteristics of neuropeptides and functional significance of VIP in cranial parasympathetic ganglia were discussed.

关键词： vasoactive intestinal polypeptide ciliary ganglion pterygopalatine ganglion otic ganglion

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A Prospective Cohort Study of Antimony Exposure and Cognitive Impairment in Older Adults—china,2017–2021

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china CDC weekly 2024年第23期6卷 537-541,I0001-I0007页

作者： Yidan Qiu Saisai Ji Chen Chen Jinhui Zhou Jun Wang Bing Wu Yuan Wei Fangyu Li Xulin Zheng Lanjing Xu Zheng Zhang Feng Zhao Guangdi Chen John SJi Yuebin Lyu Shilu tong Xiaoming Shi department of Big Data in Health Science School of Public HealthZhejiang UniversityHangzhou CityZhejiang ProvinceChina china CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Center for Global Health School of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina department of Epidemiology and Biostatistics School of Public HealthJilin UniversityChangchun CityJilin ProvinceChina School of Public Health China Medical UniversityShenyang CityLiaoning ProvinceChina Institute of Environmental Health School of Public Healthand Bioelectromagnetics LaboratorySchool of MedicineZhejiang UniversityHangzhou CityZhejiang ProvinceChina Environmental Research Center Duke Kunshan UniversityKunshan CityJiangsu ProvinceChina Nicholas School of the Environment Duke UniversityDurhamNCUSA School of Public Health Institute of Environment and Population HealthAnhui Medical UniversityHefei CityAnhui ProvinceChina School of Public Health and Social Work Queensland University of TechnologyBrisbaneAustralia

What is already known about this topic?Antimony(Sb)has been identified as a new neurotoxicant that impacts neurological functions in animal ***,its effects on the human population remain *** is added by this report?The study reveals that there is an association between exposure to Sb and a higher incidence of cognitive impairment in older *** dose-response curve demonstrates that the risk of cognitive impairment consistently increased with higher levels of Sb exposure without a discernible *** are the implications for public health practice?Reducing exposure to Sb may have a beneficial effect in delaying or preventing the onset of cognitive *** intervention has the potential to significantly decrease the disease burden associated with cognitive impairment,ultimately contributing to social development.

关键词： Antimony development. exposure

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氨曲南治疗60例老年下呼吸道细菌感染的多中心随机对照研究

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中国新药与临床杂志 2004年第1期23卷 13-17页

作者：唐英春张扣兴张月莉殷凯生戴令娟庞仲华张德平戴山林中山大学第三附属医院呼吸内科广东广州510630 华东医院呼吸内科上海200040 南京大学附属一院呼吸内科江苏南京210029 南京大学附属鼓楼医院呼吸内科江苏南京210008

目的 :评价氨曲南治疗老年下呼吸道细菌感染的疗效和安全性。方法 :老年人下呼吸道细菌感染 12 1例 ,随机分氨曲南组 6 0例 ,用氨曲南2 .0 g ,加入氯化钠注射液 10 0mL中 ,iv ,gtt ,q 12h ,疗程 7～ 14d ;头孢他啶组 6 1例 ,用头孢他啶2... 详细信息

目的 :评价氨曲南治疗老年下呼吸道细菌感染的疗效和安全性。方法 :老年人下呼吸道细菌感染 12 1例 ,随机分氨曲南组 6 0例 ,用氨曲南2 .0 g ,加入氯化钠注射液 10 0mL中 ,iv ,gtt ,q 12h ,疗程 7～ 14d ;头孢他啶组 6 1例 ,用头孢他啶2 .0 g,加入氯化钠注射液 10 0mL中 ,iv ,gtt ,q 12h ,疗程 7～ 14d。结果 :氨曲南组和头孢他啶组有效率分别为 83%和 80 % ,痊愈率分别为 5 8%和5 4% ,差异无显著意义 (P >0 .0 5 )。 2组细菌清除率分别为 85 %和 82 % ,细菌阴转率分别为 82 %和82 % ,差异无显著意义 (P >0 .0 5 ) ;2组不良反应发生率分别为 2 %和 3% ,实验室检查异常发生率分别为 3%和 3% ,均系轻度呈一过性 ,差异无显著意义 (P >0 .0 5 )。结论 :氨曲南治疗老年下呼吸道细菌感染的安全。

关键词：细菌感染老年人多中心研究随机对照试验氯曲南头孢他啶

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基于癌毒理论探讨胃癌前病变的辨治思路

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南京中医药大学学报 2024年第10期40卷 1109-1113页

作者：於丙寅李文婷吴勉华南京中医药大学第一临床医学院江苏南京210029 南京市秦淮区夫子庙社区卫生服务中心中医科江苏南京210000 南京中医药大学吴勉华全国名中医传承工作室江苏南京210023

胃癌前病变是一类具有明显癌变危险的胃部慢性疾病,早期干预胃癌前病变,是胃癌二级预防的重要手段。吴勉华教授基于脾胃功能特点和癌毒理论,认为情志不畅是胃癌前病变的诱发因素,脾胃虚弱是基本病机,痰瘀互结是关键病机,癌毒蓄积是病理... 详细信息

胃癌前病变是一类具有明显癌变危险的胃部慢性疾病,早期干预胃癌前病变,是胃癌二级预防的重要手段。吴勉华教授基于脾胃功能特点和癌毒理论,认为情志不畅是胃癌前病变的诱发因素,脾胃虚弱是基本病机,痰瘀互结是关键病机,癌毒蓄积是病理特征;辨证以辨病位、辨病理因素、辨病性为要点;治疗以疏肝利胆为先,运脾和胃为本,化痰祛瘀为治疗核心,抗癌解毒贯穿始终;注重病机的兼夹转化;遣方用药以理气不伤阴、滋阴不碍脾、化瘀不伤正、补益不助邪为主要原则,从而发挥中医药优势与特色,为胃癌前病变的临床诊治提供思路与借鉴。

关键词：胃癌前病变癌毒理论辨治思路病机中医理论

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