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Revitalizing Time-Honored tong ren Tang

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New insight into the oncogenic mechanism of the retroviral oncoprotein Tax

CHINA TODAY 2021年第10期

作者： tong XUAN

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Protein & Cell 2012年第8期3卷 581-589页

作者： Hua Cheng tong ren Shao-cong Sun Penn State Hershey Cancer Institute HersheyPA 17033USA Microbiology and Immunology Penn State University College of MedicineHersheyPA 17033USA Department of Immunology The University of Texas M.D.Anderson

Human T cell leukemia virus type 1(HTLV-1),an etio-logical factor that causes adult T cell leukemia and lym-phoma(ATL),infects over 20 million people *** 1 million of HTLV-1-infected patients develop ATL,a highly aggressive non-Hodgkin's lymphoma without an effective *** pX region of the HTLV-1 viral genome encodes an oncogenic protein,Tax,which plays a central role in transforming CD4+ T lymphocytes by deregulating oncogenic signaling pathways and promoting cell cycle *** of Tax following viral entry is critical for promoting survival and proliferation of human T cells and is required for initiation of *** exhibits diverse functions in host cells,and this oncoprotein primarily targets IκB kinase complex in the cytoplasm,resulting in persistent activation of NF-κB and upregulation of its responsive gene expressions that are crucial for T cell survival and cell cycle *** here review recent advances for the pathological roles of Tax in modulating IκB kinase *** also discuss our recent observation that Tax connects the IκB kinase complex to autophagy *** Tax-mediated pathogenesis will provide insights into development of new therapeutics in controlling HTLV-1-associated diseases.

关键词： human T cell leukemia virus type 1 IκB kinase complex NF-κB lipid raft microdomains autophagy Beclin1-PI3KC3-Bif1 complex

Novel gripper module and method for automated assembly of miniature parts

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Advances in Manufacturing 2023年第2期11卷 295-310页

作者： Zhi-Yong Zhang Xiao-Dong Wang tong-Qun ren Tian-Lun Jin Key Laboratory for Micro/Nano Technology and System of Liaoning Province Dalian University of TechnologyDalian116024LiaoningPeople's Republic of China Key Laboratory for Precision and Non-traditional Machining of Ministry of Education Dalian University of TechnologyDalian116024LiaoningPeople's Republic of China

During assembly process,the miniature part needs to be fixed in its assembly *** some occasions where adhesive is used,the joining force is not established due to the adhesive curing process,in that case the locking of parts is *** locking is difficult to meet the increasing demand for mass *** solve this problem and realize fully automatic assembly,a novel gripper module was designed and corresponding locking method was *** to the functional integration,the gripper module is capable of manipulating and locking the *** module is integrated into the assembly system and plays a crucial role in automatic *** locking method for automatic assembly is based on the integration of the part picking up and the locking unit *** being placed accurately at its desired position,the miniature part can be automatically locked by releasing the locking *** innovative structure and mechanism of the gripper module convert the spring force into the locking force of the miniature part,ensuring non-rigid locking and suitable small locking *** principle,flexibility and limitations of the proposed method were clarified in ***,an effective compensation strategy was used to achieve accurate and stable pickup of the part,which increased the reliability of the assembly *** automatic locking,the disturbances to the part due to the eccentric load were *** effectiveness of the gripper module and proposed method was verified by *** results indicated that the modular system integrated with the gripper module could meet the requirements of fully automatic *** locking is replaced by automatic locking,and workers are liberated from tedious manual *** improvement of automation level enables assembly equipment to be applied to mass production scenarios.

关键词： Fully automatic assembly Miniature parts Automatic locking Gripper module

Prognosis of gestational choriocarcinoma diagnosed incidentally during laparoscopy for a presumed cornual pregnancy:a report of five cases

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Cancer Biology & Medicine 2017年第2期14卷 191-193页

作者： Shiping Liu Chenchen Fan Fengzhi Feng Yang Xiang Xirun Wan tong ren Peking University First Hospital Peking Union Medical College Hospital

The clinical presentations of gestational choriocarcinoma vary markedly, and a misdiagnosis could be made in atypical patients if simply relying on clinical features. Laparoscopic resection of uterine mass lesion is rarely used in gestational choriocarcinoma diagnosis because of the fear of heavy blood loss and distant metastasis. Five patients who were preoperatively diagnosed as having cornual pregnancy underwent laparoscopic resection of mass lesion and then proved to have gestational choriocarcinoma based on pathological examinations. Chemotherapy was started within two days after surgery, and the rate of complete remission was 100%. The mean follow-up time was 29.8±19.1 months, and no patient showed signs of relapse. Laparoscopic resection of uterine mass followed by timely postoperative chemotherapy may be an effective and safe way to obtain pathologic results in patients with suspected gestational choriocarcinoma.

关键词： Gestational choriocarcinoma cornual pregnancy laparoscopy

Enhanced growth of crystalline-amorphous core-shell silicon nanowires by catalytic thermal CVD using in situ generated tin catalyst

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Science China Chemistry 2012年第12期55卷 2573-2579页

作者： CHENG ShiMin ren tong YING PinLiang YU Rui ZHANG WenHua ZHANG Jian LI Can State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian National Laboratory for Clean EnergyDalian 116023China Graduate University of Chinese Academy of Sciences Beijing 100049China

In this work,we prepared silicon nanowires(Si NWs) on both fluorine-doped SnO 2(FTO) coated glass substrate and common glass substrate by catalytic thermal chemical vapor deposition(CVD) using indium film as the *** is confirmed that indium can catalyze the growth of Si *** importantly,we found that tin generated in situ from the reduction of SnO 2 by indium can act as catalyst,which greatly enhances the growth of Si NWs on FTO *** obtained Si NWs have a uniform crystalline-amorphous core-shell structure that is formed via vapor-liquid-solid and vapor-solid growth of silicon *** work provides a strategy to prepare Si NWs in high yield by catalytic thermal CVD using the low melting point metal catalysts.

关键词： crystalline-amorphous core-shell silicon nanowires catalytic thermal CVD in situ tin catalyst indium catalyst

Hydrodynamics of the Semi-Immersed Cylinder by Forced Oscillation Model Testing

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China Ocean Engineering 2018年第1期32卷 110-116页

作者： SONG Chun-hui FU Shi-xiao TANG Xiao-ying HU Ke MA Lei-xin ren tong-xin State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center for Advanced Shipand Deep-Sea Exploration Shanghai 200240China School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Tianjin Research Institute for Water Transport Engineering Tianjin 300000China Massachusetts Institute of Technology CambridgeMA 02139USA

In this paper, the hydrodynamic coefficients of a horizontal semi-immersed cylinder in steady current and oscillatory flow combining with constant current are obtained via forced oscillation experiments in a towing tank. Three nondimensional parameters(Re, KC and Fr) are introduced to investigate their effects on the hydrodynamic *** experimental results show that overtopping is evident and dominates when the Reynolds number exceeds 5×105 in the experiment. Under steady current condition, overtopping increases the drag coefficient significantly at high Reynolds numbers. Under oscillatory flow with constant current condition, the added mass coefficient can even reach a maximum value about 3.5 due to overtopping while the influence of overtopping on the drag coefficient is minor.

关键词： semi-immersed cylinder hydrodynamic coefficient forced oscillation experiment overtopping

Alterations in the human oral microbiome in cholangiocarcinoma

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Military Medical Research 2023年第5期10卷 726-729页

作者： Ben-Chen Rao Gui-Zhen Zhang Ya-Wen Zou tong ren Hong-Yan ren Chao Liu Zu-Jiang Yu Zhi-Gang ren Department of Infectious Diseases the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Jinan Microecological Biomedicine Shandong Laboratory Jinan 250000China Gene Hospital of Henan Province Precision Medicine Centerthe First Affiliated Hospital of Zhengzhou Univer‑sityZhengzhou 450052China Department of Pharmacy the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Shanghai Mobio Biomedical Technology Co. Ltd.Shanghai 201111China

Dear Editor,Alterations in the human microbiome are closely related to various hepatobiliary *** microbial dysbiosis has been found in patients with cholangiocarcinoma(CCA)[1].However,the characteristics of oral micro... 详细信息

关键词： Cholangiocarcinoma Oral microbiome Diagnostic biomarker Random forest model 16S rRNA MiSeq sequencing

Expression and functional analyses of the mitogen-activated protein kinase (MPK) cascade genes in response to phytohormones in wheat ( Triticum aestivum L.)

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Journal of Integrative Agriculture 2017年第1期16卷 27-35页

作者： YAO Su-fei WANG Yan-xia YANG tong-ren HAO Lin LU Wen-jing XIAO Kai College of Agronomy Agricultural University of Hebei Baoding 071001 P.R. China College of Life Sciences Agricultural University of Hebei Baoding 071001 P.R. China Shijiazhuang Academy of Agriculture and Forestry Sciences Shijiazhuang 050041 P.R. China

Mitogen-activated protein kinase （MPK） cascades consist of a set of kinase types （MPKKKs, MPKKs, MPKs） to establish conserved signal-transducing modules mediating plant growth, development as well as responses to internal and external cues. In this study, the expression patterns of six MPKKK, two MPKK, and 11 MPK genes in wheat in responses to external treatments of phytohormones, including naphthylacetic acid （NAA）, abscisic acid （ABA）, 6-benzyladenine （6-BA）, gibber- ellin （GA3）, salisylic acid （SA）, jasmonic acid （JA）, and ethylene （ETH）, were investigated. Expression analysis revealed that several of the MPK cascade genes are responses to the external phytohormone signaling. Of which, TaMPKKKA;3 is induced by 6-BA and NAA while TaMPK4 repressed by ETH, GA3, SA, and JA; TaMPKKKA, TaMPKKKA;3 and TaMPK1 are down-regulated by ETH and GA3whereas TaMPK9 and TaMPK12 repressed by ETH and JA in addition that TaMPK12 also repressed by GA3; TaMPK12;1 is down-regulated by ABA, GA3 and SA while TaMPK17 repressed by all exogenous phytonormones examined. TaMPK4, a MPK type gene previously characterized to mediate tolerance to phosphate （Pi） deprivation, was functionally evaluated for its role in mediation of responses of plants to exogenous GA3, ETH, SA, and JA. Results indicated that overexpression and antisense expression of TaMPK4 in tobacco dramatically modify the growth of seedlings upon treatments of GA3, SA and JA, in which the overexpressors behaved deteriorated growth feature whereas the seedlings with antisense expression of TaMPK4 exhibited improved seedling phenotype. The growth behaviors in lines overexpressing or antisensely expressing TaMPK4 are closely associated with the biomass and the corresponding hormone-associated parameters. These results demonstrated that TaMPK4 acts as a critical player in mediating the phyto- hormone signaling. Our findings have identified the phytohormone-responsive MPK cascade genes in wheat and provided a connection between the phy

关键词： wheat (Triticum aestivum L.) phytohormone mitogen-activated protein kinase (MPK) cascade expression iransgene analysis

Sensitivity analysis of single-angle polarization reflectance observed by satellite

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Chinese Science Bulletin 2014年第14期59卷 1519-1528页

作者： Guangming Shi Chengcai Li tong ren Department of Atmospheric and Oceanic Sciences School of PhysicsPeking University Department of Geological Sciences Jackson School of GeosciencesUniversity of Texas at AustinAustinTX 78712USA

Two channels of the Cloud Aerosol Polarimetric Imager,onboard the TanSat-Chinese carbon dioxide observation satellite,are designed to detect the polarization state of radiation reflected by the earth-atmosphere system in a single-viewing *** to understand how the earth and atmospheric parameters affect the polarization state of radiation,we conduct a sensitivity analysis of the polarized reflectance at the top of atmosphere(TOA)with respect to the aerosol microphysical parameters,atmospheric profiles,and surface polarization *** is found that(1)the TOA polarization reflectance at 0.66 lm is most sensitive to the real part of the aerosol complex refractive index,the mean radius of the fine mode aerosol particles,as well as atmospheric pressure and temperature profiles;(2)the TOA polarization reflectance at 1.64 lm is sensitive to the volume ratio between the coarse mode and fine mode particles as well,but it is not sensitive to atmospheric profiles;and(3)surface polarization properties have a relatively weak influence on the TOA polarization reflectance at both 0.66 and 1.64 lm.

关键词：敏感性分析偏振反射卫星观测地球大气系统气溶胶粒子复数折射率 TOA 观测卫星