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Essence of"Shen(Kidney)Controlling Bones":Conceptual Analysis Based on Hypothalamic-Pituitary-Adrenal-Osteo-Related Cells Axis

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Chinese Journal of Integrative Medicine 2018年第11期24卷 806-808页

作者： XU Tao-tao JIN Hong-ting tong pei-jian First Clinical Medical College of Zhejiang Chinese Medical University Hangzhou(310053)China Institute of Orthopaedicsand Traumatology First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou(310006)China Departmentof Orthopaedics First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou(310006)China

As a traditional concept of Chinese medicine（CM）, the theory of ＂Shen（Kidney） controlling bones＂ has been gradually proven. And in modern allopathic medicine, the multiple mechanisms of bone growth, development and regeneration align with the theory. Shen deficiency as a pathological condition has a negative effect on the skeleton of body, specifically the disorder of bone homeostasis. Present studies indicate that Shen deficiency shares a common disorder characterized by dysfunction of hypothalamic-pituitary-adrenal（HPA） axis. HPA axis may be an important regulator of bone diseases with abnormal homeostasis. Therefore, we posit the existence of hypothalamic-pituitary-adrenal-osteo-related cells axis： cells that comprise bone tissue（osteo-related cells） are targets under the regulation of HPA axis in disorder of bone homeostasis. Chinese herbs for nourishing Shen have potential in the development of treatments for disorder of bone homeostasis.

关键词： Chinese medicine Shen (Kidney) controlling bones hypothalamic-pituitary-adrenal axis bone homeostasis osteoporosis

10E8-like neutralizing antibodies against HIV-1 induced using a precisely designed conformational peptide as a vaccine prime

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Science China(Life Sciences) 2014年第1期57卷 117-127页

作者： YU Yang tong pei LI Yu LU ZhiFeng CHEN YingHua Laboratory of Immunology School of Life Sciences Tsinghua University Beijing Key Laboratory for Protein Therapeutics MOE Key Laboratory for Protein Sciences

Recent studies have demonstrated that the membrane-proximal external region （MPER） of human immunodeficiency virus 1 （HIV-1） glycoprotein 41 contains a series of epitopes for human monoclonal antibodies, including 2F5, Zl3el, 4El0, and 10E8, which were isolated from HIV-l-infected individuals and show broad neutralizing activities. This suggests that MPER is a good target for the development of effective HIV-1 vaccines. However, many studies have shown that it is difficult to induce antibodies with similar broad neutralizing activities using MPER-based peptide antigens. Here, we report that 10E8-1ike neu- tralizing antibodies with effective anti-HIV-1 activity were readily induced using a precisely designed conformational immu- nogenic peptide containing the 10E8-specific epitope. This immunogenic peptide （designated T10HE） contains a 15-mer MPER-derived 10E8-specific epitope fused to T-helper-cell epitopes from tetanus toxin （tt）, which showed a significantly sta- bilized a-helix structure after a series of modifications, including substitution with an （S）-c^-（2＇-pentenyl） alanine containing an olefin-bearing tether and ruthenium-catalyzed olefin metathesis, compared with the unmodified T10E peptide. The stabilized （x-helix structure of T10HE did not affect its capacity to bind the 10E8 antibody, as evaluated with an enzyme linked immuno- sorbent assay （ELISA） and surface plasmon resonance binding assay （SPR assay）. The efficacies of the T10HE and T10E epitope vaccines were evaluated after a standard vaccination procedure in which the experimental mice were primed with ei- ther the T10HE or T10E immunogen and boosted with HIV-1 JRFL pseudoviruses. Higher titers of 10E8-1ike antibodies were induced by T10HE than that by T10E. More importantly, the antibodies induced by T10HE showed enhanced antiviral potency against HIV-1 strains with both X4 and R5 tropism and a greater degree of broad neutralizing activity than the antibodies in- duced by T10E. These results indic

关键词： MPER peptide immunogen vaccine prime neutralizing antibody

Understanding the mechanisms of resistance to tomato leaf mold:A review

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Horticultural Plant Journal 2022年第6期8卷 667-675页

作者： Tingting Zhao tong pei Jingbin Jiang Huanhuan Yang He Zhang Jingfu Li Xiangyang Xu Key Laboratory of Biology and Genetic Improvement of Horticultural Crops(Northeast Region) Ministry of Agriculture and Rural AffairsCollege of Horticulture and Landscape ArchitectureNortheast Agricultural UniversityHarbin 150030China

Tomato leaf mold is a common disease in tomato production and severely impacts the growth,fruit quality and yield of tomato *** on tomato leaf mold has a long history and has focused mainly on the differentiation of pathogen races,the structure and function of pathogen Avr gene products,the cloning of Cf resistance genes and the analysis of disease resistance *** between Cf and Avr are in accordance with the"gene-for-gene"hypothesis and typical Cf/Avr interactions are part of effector-triggered immunity(ETI).However,an increasing number of studies have proven that pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI)is involved in the disease resistance response system mediated by Cf *** addition,different Cf genes have both similar and different roles in the disease resistance response,indicating that the disease resistance mechanism of Cf genes is *** this paper,progress in tomato leaf mold research was reviewed,and the regulatory mechanism underlying the Cf-mediated disease resistance response was thoroughly *** hope this summary will lay a foundation for research on tomato leaf mold disease resistance mechanisms and is applicable to breeding for disease resistance.

关键词： Tomato leaf mold Cf genes Disease resistance Cf/Avr interactions

Vapor deposition of aluminium oxide into N-rich mesoporous carbon framework as a reversible sulfur host for lithium-sulfur battery cathode

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Nano Research 2021年第1期14卷 131-138页

作者： Fei Sun Zhibin Qu Hua Wang Xiaoyan Liu tong pei Rui Han Jihui Gao Guangbo Zhao Yunfeng Lu School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Department of Chemistry Shanghai Normal UniversityShanghai 150001China Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesCA 90095USA

Restraining the shuttle effects of lithium polysulfides is the key to improve the cycling reversibility and stability of lithium-sulfur(Li-S)batteries for which design of robust sulfur hosts has been regarded as the most effective *** this work,we report a new type of hybrid sulfur host which is composed of Al_(2)O_(3) homogenously decorated in nitrogen-rich mesoporous carbon framework(NMC-Al_(2)O_(3)).The NMC-Al_(2)O_(3) hybrid host features a poly-dispersed spherical morphology and a mesoporous configuration with high surface area and large pore volume that can accommodate a high sulfur content up to 73.5 wt.%.As a result,the fabricated NMC-Al_(2)O_(3)-S cathode exhibits all-round improvements in electrochemical properties in term of capacities(1,212 mAh·g^(-1)at 0.2 C;755 mAh·g^(-1)at 2 C),cycling charge-discharge reversibility(sustainably 100%efficiencies)and stability(1,000 cycles with only 0.023%capacity decay per cycle at 0.5 C).By contrast,the Al_(2)O_(3)-free NMC-S cathode shows both decreased capacities and rapidly descending Coulombic efficiencies during *** functional theory(DFH")calculations further reveal that the implanted Al_(2)O_(3) can greatly enhance the chemical adsorption and catalytic conversion for various lithium polysulfides and thereby effectively prevent the polysulfide shuttling and significantly improve the utilizability,reversibility and stability of sulfur cathode.

关键词： lithium-sulfur battery aluminium oxide sulfur host nitrogen-rich carbon mesoporous structure

Response of axillary bud development in garlic(Allium sativum L.) to seed cloves soaked in gibberellic acid(GA3) solution

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Journal of Integrative Agriculture 2020年第4期19卷 1044-1054页

作者： LIU Hong-jiu HUANG Cai-ping tong pei-jiang YANG Xue CUI Ming-ming CHENG Zhi-hui College of Horticulture Northwest A&F UniversityYangling 712100P.R.China College of Plant Protection Northwest A&F UniversityYangling 712100P.R.China

Gibberellins(GAs) are important phytohormones that regulate many developmental processes in plants. Clove, as the reproductive organ of garlic, dramatically affected garlic bulb development. Considering the potential of gibberellins in plant development and our previous studies, we investigated the effect of soaking two types of seed cloves(seed clove-I: without root/shoot sprouting;seed clove-II: with root/shoot sprouting) in GA3 solution on axillary bud development and examined the effect of soaking seed cloves in GA3 solution on bulb development, phytohormone level and sugar content in this *** indicated seed clove types, soaking liquids and their interaction significantly affected the number of cloves per bulb and the rate of single-clove bulb. Moreover, soaking seed cloves in 1 mmol L^-1 GA3 solution for 24 h not only promoted axillary bud formation and secondary plant growth(equal to tillering or branching), but also slightly increased the number of cloves per bulb and changed bulb structure with a low yield and marketable quality. On the 40 th day after GA3 treatment(at axillary bud outgrowth stage), zeatin riboside(ZR) and soluble protein in stem were sharply increased with the increase of GA3, sucrose, fructose and soluble protein in leaf. However, GA3, indole-3-acetic acid(IAA), soluble sugar and sucrose in stem(3.52 ng g^-1 fresh weight(FW), 19.88 ng g^-1 FW, 237.3 mg g^-1 FW, and 8.24 mg g^-1 FW, respectively) were significantly decreased on the 40 th day after GA3 treatment, compared to the control of water treatment(5.56 ng g^-1 FW, 32.96 ng g^-1 FW, 263.6 mg g^-1 FW, and 10.37 mg g^-1 FW, respectively). To our knowledge, these novel results indicate seed cloves soaked in GA3 solution promotes axillary bud formation and outgrowth that caused the changes in plant architecture and bulb structure. Meanwhile, our findings suggest that the level of endogenous plant hormone(GA3, IAA and ZR) cooperates with the content of sugar(sucrose and fructose)

关键词： garlic(Allium sativum) gibberellic acid seed clove axillary bud plant hormone sugar

Chinese Medicine Treatment Prolonged Survival in Small Cell Lung Cancer Patients:A Clinical Observation

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Chinese Journal of Integrative Medicine 2021年第7期27卷 496-501页

作者： XU Xiao-qing DENG Wen-qi WANG Da-yang LI Meng KOU Dong-lei ZHANG pei-tong Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Beijing University of Chinese Medicine Beijing100029China

Objective To evaluate the effect of Chinese medicine(CM)treatment on survival time and quality of life(QOL)in patients with small cell lung cancer(SCLC).Methods This was an exploratory and prospective clinical *** diagnosed with SCLC receiving CM treatment were included and followed up every 3 *** primary outcome was overall survival(OS),and the secondary outcomes were progression-free survival(PFS)and *** A total of 136 patients including 65 limited-stage SCLC(LS-SCLC)patients and 71 extensive-stage SCLC(ES-SCLC)patients were *** median OS of ES-SCLC patients was 17.27 months,and the median OS of LS-SCLC was 40.07 *** survival time was 16.27 months for SCLC patients with brain metastasis,9.83 months for liver metastasis,13.43 months for bone metastasis,and 18.13 months for lung *** age,pleural fluid,liver and brain metastasis were risk factors,while longer CM treatment duration was a protective *** assessment indicated that after 6 months of CM treatment,scores increased in function domains and decreased in symptom *** CM treatment might help prolong OS of SCLC ***,CM treatment brought the trend of symptom amelioration and QOL *** results provide preliminary evidence for applying CM in SCLC multi-disciplinary treatment.

关键词： small cell lung cancer Chinese medicine survival time follow-up quality of life

Effects of combined rTMS and visual feedback on the rehabilitation of supernumerary phantom limbs in a patient with spinal cord injury:A case report

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World Journal of Clinical Cases 2019年第19期7卷 3120-3125页

作者： Yin-Shan Lu pei tong Tie-Cheng Guo Xin-Hua Ding Song Zhang Xiu-Juan Zhang Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Rehabilitation Medicine Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Rehabilitation Medicine Taikang Tongji(Wuhan)HospitalWuhan 430000Hubei ProvinceChina Department of Rehabilitation Medicine Chengdu Second People's HospitalChengdu 610011Sichuan ProvinceChina

BACKGROUND Supernumerary phantom limb(SPL)caused by spinal cord injury(SCI)has previously been reported in several ***,the mechanisms and management of SPL in SCI patients are still not fully ***,we report a rare case of SPL in a patient with incomplete *** SUMMARY A 46-year-old man complained of four hands 7 d after *** was diagnosed with SPL complicated with actual limb neuropathic *** a period of treatment with neurotrophic agents and Chinese traditional and analgesic medications,SPL symptoms and actual limb pain did not ***,his symptoms gradually lessened after combined treatment with high-frequency repetitive transcranial magnetic stimulation(rTMS),a promising neuromodulation technique,over the M1 cortex and visual *** 7 wk of this treatment,SPL disappeared completely and actual limb pain was significantly *** Cerebral plasticity changes may be a mechanism underlying the occurrence of non-painful SPL in SCI patients,and high-frequency rTMS applied to the M1 cortex could be a promising treatment method for SPL.

关键词： Supernumerary phantom limb Spinal cord injury Repetitive transcranial magnetic stimulation Visual feedback Case report

Different Survival Benefits of Chinese Medicine for Pancreatic Cancer:How to Choose?

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Chinese Journal of Integrative Medicine 2018年第3期24卷 178-184页

作者： LI Meng WANG Miao-miao GUO Xiu-wei WU Chao-yong LI Dao-rui ZHANG Xing ZHANG pei-tong Department of Oncology Guang'anmen HospitalChina Academy of Chinese Medical Sciences Graduate School Beijing University of Chinese Medicine

Objective：To assess the efficacy of Chinese medicine（CM） on patients with pancreatic cancer（PC） in a retrospective population-based ***：Between January 1,2013,and August 30,2016,according to whether received Western medicine treatment,the patients were included into either integrative medicine（IM） group or CM *** enrolled patients were orally administrated with Gexia Zhuyu Decoction（膈下逐瘀汤） or Liujun Ermu Decoction（六君二母汤） by syndrome differentiation,twice a day,last for at least 2 *** primary end point was overall survival（OS）.Results：A total of 174 patients with PC were enrolled in this *** stage Ⅰ/Ⅱ,the median OS was 20.5 months in the IM group [95% confidence interval（CI）,12.499 to 28.501] and 11.17 months in the CM group（95% CI,5.160 to 17.180,P=0.015）.The 1-and 2-year survival rates for the two groups were 47.0%,40.0% and 21.0%,21.0%,*** stage Ⅲ/Ⅳ,median OS was 13.53 months（95% CI,8.665 to 18.395） in the IM group versus 6.4 months（95% CI,0.00 to 15.682） in the CM group,respectively（P=0.32）.The 1-and 2-year survival rate for the IM and CM groups were 27.0%,7.0% and 20.0%,2.0%,***：Intervention of CM contributes to the different survival benefits for PC in different *** treatment might be a promising strategy for PC patients in early ***,in advanced stage,CM might be an alternative candidate for PC patients.

关键词： survival benefit Chinese medicine integrative medicine pancreatic cancer treatment selection

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瓮模型中多粒子动力学的研究

物理学报 2005年第12期54卷 5554-5558页

作者：陈波童培庆南京邮电大学通达学院南京210003 南京师范大学物理科学与技术学院南京210097

研究了处于热库中的多颗粒在两个和多个瓮中的运动.通过求解含噪声项的一维朗之万方程,获得颗粒的位置和速度,并分析了其运动状态.研究发现,在高温下系统处于对称态的时间较长,反之系统将会出现多个定态.所有运动颗粒的速率分布都满足Ga... 详细信息

研究了处于热库中的多颗粒在两个和多个瓮中的运动.通过求解含噪声项的一维朗之万方程,获得颗粒的位置和速度,并分析了其运动状态.研究发现,在高温下系统处于对称态的时间较长,反之系统将会出现多个定态.所有运动颗粒的速率分布都满足Gauss分布,非对称态的有效温度T2与弹性恢复系数r有良好的指数关系.

关键词：多颗粒多瓮速率分布有效温度