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A strategy for strengthening chaotic mixing of dual shaft eccentric mixers by changing non-Newtonian fluids kinetic energy distribution

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Chinese Journal of Chemical Engineering 2024年第5期69卷 122-134页

作者： Songsong Wang tong meng Qian Zhang Changyuan Tao Yundong Wang Zequan Li Zuohua Liu School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 400044China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing 400044China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

Efficiently modulating the velocity distribution and flow pattern of non-Newtonian fluids is a critical challenge in the context of dual shaft eccentric mixers for process intensification,posing a significant barrier for the existing technologies.Accordingly,this work reports a convenient strategy that changes the kinetic energy to controllably regulate the flow patterns from radial flow to axial flow.Results showed that the desired velocity distribution and flow patterns could be effectively obtained by varying the number and structure of baffles to change kinetic energy,and a more uniform velocity distribution,which could not be reached normally in standard baffle dual shaft mixers,was easily obtained.Furthermore,a comparative analysis of velocity and shear rate distributions is employed to elucidate the mechanism behind the generation of flow patterns in various dual-shaft eccentric mixers.Importantly,there is little difference in the power number of the laminar flow at the same Reynolds number,meaning that the baffle type has no effect on the power consumption,while the power number of both unbaffle and U-shaped baffle mixing systems decreases compared with the standard baffle mixing system in the transition flow.Finally,at the same rotational condition,the dimensionless mixing time of the U-shaped baffle mixing system is 15.3%and 7.9%shorter than that of the standard baffle and the unbaffle mixing system,respectively,which shows the advantage of the U-shaped baffle in stirring rate.

关键词： Dual shaft “U-shaped”baffle Flow pattern Mixing time Power demand

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长三角绿色低碳循环发展的创新驱动机理及效应识别

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长江流域资源与环境 2024年第2期33卷 254-270页

作者：田时中童梦梦安徽大学经济学院安徽合肥230601

探究绿色技术创新如何驱动长三角绿色低碳循环发展,有利于加快实现长三角高质量一体化发展目标。基于多维指标体系和主成分分析方法,测度长三角41个城市绿色低碳循环发展指数,运用广义最小二乘法、空间面板和门槛模型,实证检验绿色技术... 详细信息

探究绿色技术创新如何驱动长三角绿色低碳循环发展,有利于加快实现长三角高质量一体化发展目标。基于多维指标体系和主成分分析方法,测度长三角41个城市绿色低碳循环发展指数,运用广义最小二乘法、空间面板和门槛模型,实证检验绿色技术创新对长三角绿色低碳循环发展的驱动机理及其效应,研究发现:(1)从基准回归结果看,绿色技术创新显著促进长三角绿色低碳循环发展,且存在区域异质性。产业结构升级、政府竞争和人力资本水平在绿色技术创新对长三角绿色低碳循环发展的影响中发挥正向调节作用。(2)从空间效应来看,绿色技术创新对长三角绿色低碳循环发展存在正向空间相关和空间溢出效应。(3)从门槛效应来看,随着金融发展水平的提升,绿色技术创新对长三角绿色低碳循环发展的促进作用不断增强。以上结论,对于加快长三角绿色低碳循环发展和一体化进程,具有重要的政策启示。

关键词：长三角绿色技术创新绿色低碳循环驱动机理调节效应

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采用AD654芯片的直流电压传感器及其温度漂移补偿

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激光杂志 2024年第1期45卷 43-48页

作者：孟通李长胜北京航空航天大学仪器科学与光电工程学院北京100191

提出一种基于电压-频率变换的光电式电压传感器及电压传感信号温度漂移的补偿方法。电压传感系统主要包括电阻分压器、电压-频率变换芯片、发光二极管、光纤、光电探测与信号处理单元等。利用两块AD654型芯片分别作为被测电压和温度传... 详细信息

提出一种基于电压-频率变换的光电式电压传感器及电压传感信号温度漂移的补偿方法。电压传感系统主要包括电阻分压器、电压-频率变换芯片、发光二极管、光纤、光电探测与信号处理单元等。利用两块AD654型芯片分别作为被测电压和温度传感单元,通过对两路光传感信号进行非线性数据拟合等方式实现了对电压传感信号温度漂移的实时补偿。实验测量了0.6 kV~5.0 kV范围内的直流电压,并实现了电压传感信号的温度漂移补偿,在-40℃~+60℃的温度范围内,电压传感信号温度漂移的平均相对误差约为±0.7%。

关键词：光电式电压传感器电压-频率变换 AD654芯片温度漂移补偿

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Multiaxial fatigue life prediction of composite laminates

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Chinese Journal of Aeronautics 2021年第12期34卷 227-237页

作者： Jingmeng WENG tong meng Weidong WEN Shaodong WENG Xi'an Aerospace Propulsion Institute Xi'an 710100China Academy of Space Electronic Information Technology Xi'an 710100China College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Mechcmo-Electronic Engineering Xidian UniversityXi'an 710071China

A study of composite laminates under tension–torsion biaxial loading is presented.The focus is placed on fatigue lives of composite laminates under different tension–torsion biaxial fatigue loading paths.A macro-meso model used to predict multiaxial fatigue life of composite laminates is also presented in this paper.Firstly,a macro-scale 3 D RVE corresponding to composite laminates is established to determine strain components in the material principal direction of each layer for each biaxial stress ratio.Secondly,a meso-scale 3 D RVE corresponding to each layer with fibers distributed randomly is established,with progressive damage prediction method,biaxial strength of composite laminates can be predicted,and the final failure layer can be confirmed.Thirdly,select any one of fatigue loading path at which the final failure of composite laminates is fiber failure(matrix failure)to establish the reference curve for fiber(matrix).Finally,with reference curve,fatigue life of composite laminates under any biaxial loading path can be predicted.And numerical results show good agreements with experimental data.

关键词： Composite laminates Fatigue damage parameter Life prediction Multiaxial fatigue Multiaxial strength

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The role of ubiquitination in tumorigenesis and targeted drug discovery

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2294-2321页

作者： Lu Deng tong meng Lei Chen Wenyi Wei Ping Wang College of Animal Science and Technology Northwest A&F UniversityYangling Shaanxi 712100China Division of Spine Department of OrthopedicsTongji Hospital Affiliated to Tongji University School of Medicine389 Xincun RoadShanghaiChina Division of Laboratory Safety and Services Northwest A&F UniversityYangling Shaanxi 712100China Department of Pathology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215USA tongji University Cancer Center Shanghai Tenth People’s Hospital of Tongji UniversitySchool of MedicineTongji UniversityShanghai 200092China

Ubiquitination,an important type of protein posttranslational modification(PTM),plays a crucial role in controlling substrate degradation and subsequently mediates the“quantity”and“quality”of various proteins,serving to ensure cell homeostasis and guarantee life activities.The regulation of ubiquitination is multifaceted and works not only at the transcriptional and posttranslational levels(phosphorylation,acetylation,methylation,etc.)but also at the protein level(activators or repressors).When regulatory mechanisms are aberrant,the altered biological processes may subsequently induce serious human diseases,especially various types of cancer.In tumorigenesis,the altered biological processes involve tumor metabolism,the immunological tumor microenvironment(TME),cancer stem cell(CSC)stemness and so on.With regard to tumor metabolism,the ubiquitination of some key proteins such as RagA,mTOR,PTEN,AKT,c-Myc and P53 significantly regulates the activity of the mTORC1,AMPK and PTEN-AKT signaling pathways.In addition,ubiquitination in the TLR,RLR and STING-dependent signaling pathways also modulates the TME.Moreover,the ubiquitination of core stem cell regulator triplets(Nanog,Oct4 and Sox2)and members of the Wnt and Hippo-YAP signaling pathways participates in the maintenance of CSC stemness.Based on the altered components,including the proteasome,E3 ligases,E1,E2 and deubiquitinases(DUBs),many molecular targeted drugs have been developed to combat cancer.Among them,small molecule inhibitors targeting the proteasome,such as bortezomib,carfilzomib,oprozomib and ixazomib,have achieved tangible success.In addition,MLN7243 and MLN4924(targeting the E1 enzyme),Leucettamol A and CC0651(targeting the E2 enzyme),nutlin and MI‐219(targeting the E3 enzyme),and compounds G5 and F6(targeting DUB activity)have also shown potential in preclinical cancer treatment.In this review,we summarize the latest progress in understanding the substrates for ubiquitination and their special functions in tumor metabolism regulation,TME modulation a

关键词： metabolism ubiquitin targeted

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医疗网络中无证书并行密钥隔离聚合签名方案

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计算机工程与应用 2024年第1期60卷 289-300页

作者：蒙彤郭瑞王翊丞刘颖菲西安邮电大学网络空间安全学院西安710121 西安邮电大学无线网络安全技术国家工程实验室西安710121

无线传感器网络在医疗领域的应用,为医生和患者带来了极大的便利。由于传输过程中会导致患者隐私信息被破坏,医疗数据的真实性和完整性成为了医疗行业一大难题。为解决此难题,无证书聚合签名方案被提出保护患者隐私信息。然而,大多数方... 详细信息

无线传感器网络在医疗领域的应用,为医生和患者带来了极大的便利。由于传输过程中会导致患者隐私信息被破坏,医疗数据的真实性和完整性成为了医疗行业一大难题。为解决此难题,无证书聚合签名方案被提出保护患者隐私信息。然而,大多数方案都无法抵御完全选择密钥攻击,并存在密钥暴露问题。为此,提出了可抵御完全选择密钥攻击的无证书并行密钥隔离聚合签名方案。该方案基于区块链技术进行数据共享和身份追踪,利用边缘计算的实时性处理无线传感器网络中高延迟问题,同时使用并行密钥隔离方法解决密钥暴露问题。在随机谕言机模型下,基于椭圆曲线离散对数问题证明该方案的不可伪造性,基于哈希的强抗碰撞性证明方案可抵御完全选择密钥攻击。使用MIRACL库进行效率分析,表明该方案在各阶段运行效率要优于其他相关方案,同时具有较低的通信开销。

关键词：边缘计算无证书聚合签名并行密钥隔离完全选择密钥攻击

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移动医疗系统中的可撤销无证书代理重签名方案

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信息安全学报 2024年第3期9卷 1-18页

作者：郭瑞刘颖菲王翊丞蒙彤西安邮电大学网络空间安全学院西安710121 西安邮电大学无线网络安全技术国家工程实验室西安710121

代理重签名在保证委托双方私钥安全的前提下,通过半可信代理实现了双方签名的转换,在本文方案中,通过代理重签名实现了在通信过程中终端用户对于身份的隐私要求。移动医疗服务系统因为其有限的计算和存储能力,需要借助云服务器来对医疗... 详细信息

代理重签名在保证委托双方私钥安全的前提下,通过半可信代理实现了双方签名的转换,在本文方案中,通过代理重签名实现了在通信过程中终端用户对于身份的隐私要求。移动医疗服务系统因为其有限的计算和存储能力,需要借助云服务器来对医疗数据进行计算和存储。然而,在将医疗数据外包给云服务器后,数据便脱离了用户的控制,这给用户隐私带来了极大地安全隐患。现有的无证书代理重签名方案大多都不具有撤销功能,存在着密钥泄露等安全性问题。为了解决这一问题,本文提出了一种可撤销的无证书代理重签名方案,在不相互信任的移动医疗服务系统中,实现了医疗数据传输过程以及云存储过程中的用户匿名性,同时,本文方案具有单向性和非交互性,更适合在大规模的移动医疗系统中使用。此外,当用户私钥泄露时,本文利用KUNode算法实现了对用户的高效撤销,并利用移动边缘计算技术将更新密钥和撤销列表的管理外包给移动边缘计算设备,降低了第三方的计算成本,使其具有较低的延迟。最后,在随机谕言机模型下证明了所构造的方案在自适应选择消息攻击下的不可伪造性,并利用JPBC库与其他方案进行计算与通信开销的对比。其结果表明,本方案在具备更优越的功能的同时,具有较小的计算成本、通信成本和撤销成本。

关键词：无证书代理重签名随机谕言机模型外包撤销移动医疗系统云计算

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Identification of the genetic central dogma in osteogenic differentiation of MSCs by osteoinductive medium from transcriptional data sets

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Chronic Diseases and Translational Medicine 2022年第3期8卷 218-228页

作者： tong-meng Jiang School of Materials Science and Engineering Zhejiang UniversityHangzhouZhejiang 310027China

Background:The genetic central dogma(GCD)has been demonstrated its essential function in many biological processes and diseases.However,its roles in the process of osteogenic differentiation of mesenchymal stem cells(MSCs)remain unclear.Methods:In this project,we analyzed an online database of osteogenic differentiation of MSCs after 14 days and 28 days by osteoinductive medium(GSE83770).The differentially expressed genes were screened by GEO2R,with further conducting of KEGG pathways using DAVID.In addition,protein-protein interactions of the enriched pathways were performed using STRING with marked hub genes measured by the CytoHubba.Hub genes were verified by quantitative reverse-transcription polymerase chain reaction.Results:Results showed that six pathways related to GCD,including DNA replication,Aminoacyl-tRNA biosynthesis,Mismatch repair,Ribosome,Spliceosome,and RNA degradation pathways enriched in the early stage(14 days vs.undifferentiated MSCs)of osteogenesis.The Lysosome pathway was highly enriched in the late stage(28 vs.14 days)of osteogenesis,and Ribosome pathway plays a key role throughout the entire process(28 days vs.undifferentiated MSCs)of osteogenesis.Conclusion:Both DNA replication and protein translation were functionally worked in the early stage of osteogenesis,whereas the Lysosome pathway was the only GCD-related one in the late stage of osteogenesis.The GCD-related Ribosome pathway occupied the entire process of osteogenesis.

关键词： genetic central dogma lysosome mesenchymal stem cells osteogenic differentiation ribosome

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Predicting bioactive compounds and cancer-related molecular targets of lotus seedpod (Receptaculum Nelumbinis) based on network pharmacology and molecular docking

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Food and Health 2024年第2期6卷 14-41页

作者： Jian-Lin Shen meng-tong Zhang Fei Li Jia-Yu Huang Quan-Sheng Xu Han-Yue Zhang Jun Zhang Jing Li Yan-Ping Li Qi Zou Xiao-Yin Wang School of Public Health and Health Management Gannan Medical UniversityGanzhou 341000China Scientific Research Center Gannan Medical UniversityGanzhou 341000China Key Laboratory of Development and Utilization of Gannan Characteristic Food Function Component of Ganzhou Gannan Medical UniversityGanzhouChina

Background:Lotus seedpod(Receptaculum Nelumbinis)is the abundant by-products produced during lotus seed processing,and the sources are usually considered to be wastes and are abandoned outdoors or incinerated.This study aims at predicting its bioactive compounds and cancer-related molecular targets against six cancers,including lung cancer,gastric cancer,liver cancer,breast cancer,ovarian cancer and cervical cancer.Methods:Network pharmacology and molecular docking methods were performed.Results:Network pharmacology results indicated that 14 core compounds(liensinine,tetrandrine,lysicamine,tricin,sanleng acid,cireneol G,ricinoleic acid,linolenic acid,5,7-dihydroxycoumarin,apigenin,luteolin,morin,quercetin and isorhamnetin)and 10 core targets(AKT1,ESR1,HSP90AA1,JUN,MAPK1,MAPK3,PIK3CA,PIK3R1,SRC and STAT3)were screened for lotus seedpod against the six cancers.Molecular docking analysis suggested that the binding abilities between the core compounds and the core targets were mostly strong.GO analysis revealed that the intersected targets between the bioactive compounds of lotus seedpod and the six cancers were significantly related to biological processes,cell compositions and molecular functions.KEGG analysis showed that PI3K-Akt,TNF,Ras,MAPK,HIF-1 and C-type lectin receptor signaling pathways were notably involved in the anti-cancer activities of lotus seedpod against the six cancers.Conclusions:14 core compounds and 10 core targets were screened for lotus seedpod against lung cancer,gastric cancer,liver cancer,breast cancer,ovarian cancer and cervical cancer.This study supports the application of lotus seedpod in treating cancers,and promotes the recycling and the high-value utilization.

关键词： Lotus seedpod Anti-cancer Bioactive compounds Molecular targets Network pharmacology Molecular docking.

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磁脱扣器动作响应分析及储能电容匹配设计

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电力自动化设备 2024年第1期44卷 167-173页

作者：李奎佟盟武一卢志伟胡博凯徐子健河北工业大学河北省电磁场与电器可靠性重点实验室天津300401 河北工业大学省部共建电工装备可靠性与智能化国家重点实验室天津300401

驱动电路与磁脱扣器是电磁式漏电保护器的核心组件,磁脱扣器需与储能电容匹配。在电磁式漏电保护器基本工作原理分析的基础上,建立磁脱扣器的数学模型与有限元计算模型,根据激磁安匝变化进行衔铁响应状态分析,仿真不同线圈激励形式下磁... 详细信息

驱动电路与磁脱扣器是电磁式漏电保护器的核心组件,磁脱扣器需与储能电容匹配。在电磁式漏电保护器基本工作原理分析的基础上,建立磁脱扣器的数学模型与有限元计算模型,根据激磁安匝变化进行衔铁响应状态分析,仿真不同线圈激励形式下磁脱扣器动作响应状态。研究衔铁角动量与角位移变化特征,根据无激励时衔铁释放临界角动量与角位移关系,确定不同线圈激励形式下的衔铁临界释放条件。研究电容电压激励源下衔铁所受力矩冲量的变化规律,分析电容及其储能对衔铁释放响应状态的影响,根据临界储能最小的原则确定电容匹配,可以降低衔铁可靠释放所需储能。通过对磁脱扣器样机进行实验测试,验证了理论分析与仿真计算的正确性。

关键词：电磁式漏电保护器磁脱扣器临界释放条件电容电压激励储能电容匹配

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