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Multi-endpoint assays reveal more severe toxicity induced by chloraminated effluent organic matter than chloraminated natural organic matter

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Journal of Environmental Sciences 2024年第1期135卷 310-317页

作者： Hai-Yan Wang De-Xiu Wu Ye Du Xiao-tong lv Qian-Yuan Wu State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Environmental Protection Key Laboratory of Microorganism Application and Risk Control Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental SafetyTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China College of Architecture and Environment Sichuan UniversityChengdu 610000China

Disinfection by chloramination produces toxic byproducts and the difference in toxicity of reclaimed and drinking water treated by chloramination remains *** study investigated cytotoxic effects at the same concentrations of dissolved organic matter and showed that chloraminated effluent organic matter(EfOM)induced 1.7 times higher cytotoxicity than chloraminated natural organic matter(NOM)applied to simulate drinking *** EfOM induced more reactive nitrogen species than chloraminated NOM,and chloraminated EfOM and NOM induced similar and higher levels of reactive oxygen species than the negative control,***,intracellular macromolecule damage indicated by DNA/RNA damage marker 8–hydroxy-(deoxy)guanosine and the intracellular protein carbonyl concentration induced by chloraminated EfOM was higher and slightly more than that induced by chloraminated NOM,*** data were consistent with the effects on cell physiological *** cycle arrest mainly occurred in G2 phase by chloraminated EfOM and *** apoptotic cells,which could return to normal,increased upon exposure to high concentrations of chloraminated EfOM and ***,necrotic cells were significantly increased from 0.5%to 2.5%when the concentration increased from 20-to 60-fold chloraminated EfOM,but were not obviously changed by chloraminated *** results indicated that the comprehensive intracellular changes induced by toxic substances in chloraminated EfOM were more irreversible and induced more cell death than chloraminated NOM.

关键词： Cytotoxicity Intracellular active nitrogen/oxygen Intracellular oxidative damage Cell necrosis Reclaimed water

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High critical current density in Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12) electrolyte via interfacial engineering with complex hydride

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Rare Metals 2024年第2期43卷 692-701页

作者： Ying-tong lv Teng-Fei Zhang Zhao-tong Hu Guang-Lin Xia Ze-Ya Huang Zhen-Hua Liu Li-Hua Que Cai-Ting Yuan Fang-Qin Guo Takayuki Ichikawa Xue-Bin Yu College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing210016China Centre for Hydrogenergy College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing210016China Department of Materials Science Fudan UniversityShanghai200433China Graduate School of Advanced Science and Engineering Hiroshima University1-4-1 KagamiyamaHigashi-Hiroshima739-8527Japan

Garnet-type solid-state batteries(SSBs)are considered to be one of the most promising candidates to realize next-generation lithium metal batteries with high energy density and ***,the dendrite-induced short-circuit and the poor interfacial contact impeded the practical ***,interface engineering to achieve low interfacial resistance without high temperature calcination was developed,which Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO)was simply coated with complex hydride(Li_(4)(BH_(4))_(3)I(3L1L))in various mass ratios n(Li_(4)(BH_(4))_(3)I)-(100−n)LLZTO(10≤n≤40).The interfacial conductivity increases by more than three orders of magnitude from 8.29×10^(−6)S·cm^(−1)to 1.10×10^(−2)S·cm^(−1).Symmetric Li cells exhibit a high critical current density(CCD)of 4.0 mA·cm^(−2) and an excellent cycling stability for 200 h at 4.0 mA·cm^(−2).SSBs with polymeric sulfur-polyacrylonitrile(SPAN)cathode achieve a high discharge capacity of 1149 mAh·g^(−1) with a capacity retention of 91%after 100 cycles(0.2 C).This attempt guides a simple yet efficient strategy for obtaining a stable Li/LLZTO interface,which would promote the development of solid-state batteries.

关键词： Hydrides Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO) Critical current density Solid-state electrolytes(SSEs) Lithium-sulfur batteries

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综采面片帮冒顶机理及处理技术现状与展望

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江西煤炭科技 2024年第1期 11-14页

作者：郝彦李陈加胜张艳飞吕通安徽理工大学机械工程学院安徽淮南232001

综采工作面片帮冒顶后,为保证综采工作面安全快速通过片帮冒顶区域,采取高效的片帮冒顶处理技术是确保冒顶区域得到安全处置的重要手段。现有研究表明,采煤工作面片帮冒顶是受到煤岩应力分布、采动矿压分布、支架设备性能等多方面因素... 详细信息

综采工作面片帮冒顶后,为保证综采工作面安全快速通过片帮冒顶区域,采取高效的片帮冒顶处理技术是确保冒顶区域得到安全处置的重要手段。现有研究表明,采煤工作面片帮冒顶是受到煤岩应力分布、采动矿压分布、支架设备性能等多方面因素的影响。总结了大倾角、大采高及松软煤层工作面片帮冒顶机理,分析归纳了片帮冒顶处理技术,分析了基于视觉感知、机器人的创新处理技术。总结现阶段学者研究成果中存在的问题,提出未来研究中需要突破的技术难点、需要深入研究的方向。

关键词：综采工作面片帮冒顶大倾角松软煤层处理技术

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Vehicle-to-grid service development logic and management formulation

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Journal of Modern Power Systems and Clean Energy 2019年第4期7卷 935-947页

作者： Lefeng SHI tong lv Yandi WANG School of Economics and Management Chongqing Normal UniversityChongqing 401331China School of Electrical Engineering Shandong UniversityJinan 250061China

Vehicle-to-grid(V2G)is regarded as the effective way to reconcile contradictions between an electric power system and electric vehicles(EVs).A lot of research has been carried out to affect this,often based on different technical and trade model *** value of theresearch is dependent on how reasonable the assumptions it makes *** paper presents a framework for analyzing V2G service development from a coevolutionary perspective in which the interactive relation between the diffusion of EVs and the upgrade of the distribution grid system is considered.A V2G service development logic and its management formulation are put ***,the motivations and contradictions of developing V2G services are *** a development phase division of the V2G services is proposed in view of the coevolution relation between the grid upgrade and the development of the ***,taking into account the characteristics of each phase,the physical trade structures and corresponding management hierarchies,management relations as well as management measures,are *** paper provides a new perspective of V2G service development,answers the core question on how to make the V2G vision come true in synergy with the development of EVs,and gives some advice on future V2G management paradigms.

关键词： Electric vehicle Vehicle-to-grid service Smart grid Aggregator

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Numerical manifold method for thermo-mechanical coupling simulation of fractured rock mass

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 1977-1992页

作者： Jiawei Liang Defu tong Fei Tan Xiongwei Yi Junpeng Zou Jiahe lv Faculty of Engineering China University of GeosciencesWuhan430074China Department of Civil Engineering Monash UniversityClaytonVIC3800Australia Badong National Observation and Research Station of Geohazards China University of GeoscienceWuhan430074China

As a calculation method based on the Galerkin variation,the numerical manifold method(NMM)adopts a double covering system,which can easily deal with discontinuous deformation problems and has a high calculation *** at the thermo-mechanical(TM)coupling problem of fractured rock masses,this study uses the NMM to simulate the processes of crack initiation and propagation in a rock mass under the influence of temperature field,deduces related system equations,and proposes a penalty function method to deal with boundary *** examples are employed to confirm the effectiveness and high accuracy of this *** the thermal stress analysis of a thick-walled cylinder(TWC),the simulation of cracking in the TWC under heating and cooling conditions,and the simulation of thermal cracking of the SwedishÄspöPillar Stability Experiment(APSE)rock column,the thermal stress,and TM coupling are *** numerical simulation results are in good agreement with the test data and other numerical results,thus verifying the effectiveness of the NMM in dealing with thermal stress and crack propagation problems of fractured rock masses.

关键词： Heat conduction Fractured rock mass Crack propagation Galerkin variation Numerical manifold method(NMM)

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Temporospatial inhibition of Erk signaling is required for lymphatic valve formation

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Signal Transduction and Targeted Therapy 2023年第10期8卷 4850-4866页

作者： Yaping Meng tong lv Junfeng Zhang Weimin Shen Lifang Li Yaqi Li Xin Liu Xing Lei Xuguang Lin Hanfang Xu Anming Meng Shunji Jia State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBejing 100084China Guangzhou Laboratory Guangzhou 510320 Guangdong ProvinceChina State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Intraluminal lymphatic valves(lvs)and lymphovenous valves(lvs)are critical to ensure the unidirectional flow of lymphatic *** abnormalities in these valves always cause lymph or blood reflux,and result in lymphedema.

关键词： lymphatic Morphological edema

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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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Military Medical Research 2024年第1期11卷 34-49页

作者： Yi-Qun Li Fang-Zhou Sun Chun-Xiao Li Hong-Nan Mo Yan-tong Zhou Dan lv Jing-tong Zhai Hai-Li Qian Fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor *** the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment *** evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully *** Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of *** investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo *** signaling pathway components were evaluated using multi-omics *** were performed to elucidate the regulation of lipid metabolic reprogramming of *** We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic ***,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain *** Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of ***2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 Lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

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Ruin Probabilities for a Risk Model with Two Classes of Claims

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Acta Mathematica Sinica,English Series 2010年第9期26卷 1749-1760页

作者： tong Ling lv Jun Yi GUO Xin ZHANG Department of Mathematics China Agricultural University Beijing 100083 P. R. China School of Mathematical Sciences Nankai University Tianjin 300071 P. R. China

In this paper we consider a risk model with two kinds of claims, whose claims number processes are Poisson process and ordinary renewal process respectively. For this model, the surplus process is not Markovian, however, it can be Markovianized by introducing a supplementary process, We prove the Markov property of the related vector processes. Because such obtained processes belong to the class of the so-called piecewise-deterministic Markov process, the extended infinitesimal generator is derived, exponential martingale for the risk process is studied. The exponential bound of ruin probability in iafinite time horizon is obtained.

关键词： Markov vector process piecewise-deterministic Markov process (PDMP) infinitesimal generator exponential martingale ruin probability

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Random change point model with an application to the China Household Finance Survey

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Science China Mathematics 2024年

作者： Meng Li Lingxi Gao Guangming lv Xingwei tong School of Statistics Beijing Normal University

We consider a linear model with a change point according to the unknown random threshold of a covariate. We give the expectation-maximization(EM) estimation of the regression and change point parameters. The existence of the random change point is detected by the supremum(SUP) test of score statistics. Theoretically, we establish the convergence and asymptotic distribution of the estimation and show that the EM estimates converge in distribution to a normal distribution. In addition, the numerical performance of the proposed approach is demonstrated through simulation studies. Finally, applying our methodology to household financial decisions, we see that the average debt tolerance of Chinese households is estimated to be 1.1364 times the sum of total household income and financial assets. The effect of assets and income on consumption shows a rapid decline if the household exceeds the average debt tolerance.

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Current progress of computational modeling for guiding clinical atrial fibrillation ablation

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2021年第10期22卷 805-817页

作者： Zhenghong WU Yunlong LIU lv tong Diandian DONG Dongdong DENG Ling XIA College of Biomedical Engineering&Instrument Science Zhejiang UniversityHangzhou 310027China School of Biomedical Engineering Dalian University of TechnologyDalian 116024China

Atrial fibrillation(AF)is one of the most common arrhythmias,associated with high morbidity,mortality,and healthcare costs,and it places a significant burden on both individuals and ***-arrhythmic drugs are the most commonly used strategy for treating ***,drug therapy faces challenges because of its limited efficacy and potential side *** ablation is widely used as an alternative treatment for ***,because the mechanism of AF is not fully understood,the recurrence rate after ablation remains *** addition,the outcomes of ablation can vary significantly between medical institutions and patients,especially for persistent ***,the issue of which ablation strategy is optimal is still far from *** modeling has the advantages of repeatable operation,low cost,freedom from risk,and complete control,and is a useful tool for not only predicting the results of different ablation strategies on the same model but also finding optimal personalized ablation targets for clinical reference and even *** review summarizes three-dimensional computational modeling simulations of catheter ablation for AF,from the early-stage attempts such as Maze III or circumferential pulmonary vein isolation to the latest advances based on personalized substrate-guided ***,we summarize current developments and challenges and provide our perspectives and suggestions for future directions.

关键词： Atrial fibrillation Catheter ablation Computational modeling Atrial fibrosis

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