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m6A mRNA methylation controls T cell homeostasis by targeting IL-7/STAT5/SOCS pathway

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m6A mRNA methylation controls T cell homeostasis by targetin...

筑坝渠化河流氮磷迁移特征及其对富营养化的响应

第十二届全国免疫学学术大会

作者： Li Huabing tong jiyu Shu Zhu Yuval Kluger Matthew D.Simon Howard Y.Chang Zhinan Yin Richard A.Flavell Department of Immunobiology Yale University School of Medicine Shanghai Institute of Immunology Department of Microbiology and Immunology The First Affiliated Hospital Biomedical Translational Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering Department of Pathology Yale University School of Medicine Department of Molecular Biophysics & Biochemistry Yale University Dynamic Regulomes Stanford University Howard Hughes Medical Institute

N6-methyladenosine(m6A)is the most common and abundant messenger RNA modification,modulated by‘writers’‘erasers’and‘readers’of this *** vitro data have shown that m6A influences all fundamental aspects of mRNA m... 详细信息

关键词： m6A methylation T cells STAT signaling Inflammation

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生态学杂志 2021年第12期40卷 3998-4007页

作者：鲍林林钱骏佟洪金陈杰纪昱彤辜昊四川省生态环境科学研究院成都610041

闸坝建设显著提高了河流的水资源利用效率,但筑坝致使河流渠道化,是影响氮磷迁移和水体富营养化关键因素之一。本研究以平水期釜溪河流域内威远河、旭水河筑坝渠化河流的4个筑坝河段和1个无闸坝的普通河段为对象,通过河流氮磷通量估算... 详细信息

闸坝建设显著提高了河流的水资源利用效率,但筑坝致使河流渠道化,是影响氮磷迁移和水体富营养化关键因素之一。本研究以平水期釜溪河流域内威远河、旭水河筑坝渠化河流的4个筑坝河段和1个无闸坝的普通河段为对象,通过河流氮磷通量估算和水体营养状态评估,探讨了筑坝渠化河流的氮磷滞留特征及其与水体富营养化的响应关系。结果表明,河流水体存在总磷、铵氮和有机质等污染,特别是支流小流域的污染较为突出。各河段总氮、总磷滞留效率(R_L)平均为101.5和4.7 mg·s^(-1)·km^(-1),其中,旭水河筑坝河段的氮磷滞留效率最高(分别为310.0、12.9 mg·s^(-1)·km^(-1)),为氮磷净滞留(R_(L)>0),其次为威远河筑坝河段(-55.1、-0.2 mg·s^(-1)·km^(-1))和普通河段(-2.3、-1.9 mg·s^(-1)·km^(-1)),为氮磷净输出(R_(L)<0);由于流速和氮磷外源输入、内源释放等影响,釜溪河流域筑坝渠化河流的氮磷滞留效率较水库等拦蓄水体低。筑坝渠化河流的综合营养指数(TLI)平均为54.1,处于轻度富营养化状态,而无闸坝的普通河段水体为中营养(TLI为42.9);浮游植物叶绿素a浓度与流速呈负相关、与营养物质浓度呈正相关,氮磷污染较重的筑坝渠化河流富营养化风险较高。因此,应加强釜溪河流域内外污染源控制,优化河流水动力条件,以减轻富营养化风险。

关键词：釜溪河流域船闸堰渠化河流滞留效率富营养化

抗体技术研究进展(2):小分子抗体及功能复合化抗体

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暨南大学学报（自然科学与医学版） 2013年第5期34卷 556-563页

作者：向军俭童吉宇王宏广东省分子免疫与抗体工程重点实验室广东广州510632 暨南大学抗体工程研究中心广东广州510632

随着分子生物学的发展,基因工程小分子抗体以及纳米抗体由于其分子质量小、结构简单、异源性低、组织穿透能力强及易于大量生产等优点而越来越受到人们的关注,并且其与毒素、酶、细胞因子等生物活性物质融合可产生功能复合化抗体——抗... 详细信息

随着分子生物学的发展,基因工程小分子抗体以及纳米抗体由于其分子质量小、结构简单、异源性低、组织穿透能力强及易于大量生产等优点而越来越受到人们的关注,并且其与毒素、酶、细胞因子等生物活性物质融合可产生功能复合化抗体——抗体融合蛋白,在肿瘤的诊断和治疗中具有广阔的应用前景.本研究主要就小分子抗体、功能复合化抗体以及纳米抗体近几年的发展与应用进行综述.

关键词：小分子抗体抗体融合蛋白功能复合化抗体纳米抗体

Long time Cola beverages consumption aggravates the pathogenesis of EAE through modulating intestinal microbiota.

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Long time Cola beverages consumption aggravates the pathogen...

炎症负荷在预测老年上皮性卵巢癌患者预后中的价值

第十届全国免疫学学术大会

作者： Guangchao Cao Wanjun Huang Zonghua Liu jiyu tong Hao Cheng Yiming Wen Hengwen Yang Zhenzhou Wu Liqing Zhao Richard A.Flavell Zhinan Yin State Key Laboratory of Medicinal Chemical Biology College of Life Sicences Nankai University Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering Biomedical Translational Innovative Entrepreneurial Team of Pearl River Talent ProgramBiomedical Translational Research Institute Jinan University Department of Immunology Yale School of Medicine

Epidemiological evidence has linked dietary changes,which may greatly disturb the homeostasis between immune system and microbiota,to the increasing incidence of autoimmune diseases in developed countries over recent *** Cola beverages had dramatically changed the dietary component all over the world in the past *** hypothesized that these commercial drinks may affect the pathogenesis of autoimmune diseases via modulating the composition of microbiota.

关键词： Cola beverages Microbiota EAE ATP

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肿瘤防治研究 2024年第5期51卷 361-367页

作者：杨丹妮赵梦娜冯晓叶童继玉王华蔡红兵武汉大学中南医院妇科肿瘤科武汉430071

目的探讨血液炎症负荷在预测老年上皮性卵巢癌患者预后中的价值。方法回顾性分析诊断为上皮性卵巢癌的老年(初诊年龄≥65岁)患者的临床资料和相关外周血参数。应用单变量和多变量Cox回归构建炎症相关的血液评分系统,使用Kaplan-Meier法... 详细信息

目的探讨血液炎症负荷在预测老年上皮性卵巢癌患者预后中的价值。方法回顾性分析诊断为上皮性卵巢癌的老年(初诊年龄≥65岁)患者的临床资料和相关外周血参数。应用单变量和多变量Cox回归构建炎症相关的血液评分系统,使用Kaplan-Meier法进行生存分析,采用Cox风险比例回归分析确定独立预后影响因素,基于独立预后影响因素构建列线图模型并使用ROC曲线、C指数及校准曲线评价列线图模型。结果血液中炎症负荷高的患者预后更差(P=0.002)。与炎症负荷低组相比,炎症负荷高的上皮性卵巢癌患者临床分期更晚、腹水量更多(P<0.05)。Cox风险比例回归分析显示ACCI、CA125值、残留病灶和血液中炎症负荷是影响总生存期的独立预后因素(P<0.05)。结论血液中的炎症负荷是老年上皮性卵巢癌患者预后的生物标志物,通过对血液中炎症负荷评分可为卵巢癌患者的疗效监测和治疗干预提供帮助。

关键词：炎症卵巢癌老年预后

Nanomechanical Behaviour of the Membranous Wings of Dragonfly Pantala flavescens Fabricius

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Journal of Bionic Engineering 2016年第3期13卷 388-396页

作者： Yanru Zhao Dongsheng Wang Jin tong jiyu Sun The College of Mechanical and Power Engineering Henan Polytechnic University Jiaozuo 454000 China The Key Laboratory of Bionic Engineering (Ministry of Education China) and the College of Biological and Agricultural Engineering Jilin University (Nanling Campus) Changchun 130022 China

The dragonfly has excellent flying capacity and its wings are typical 2-dimensional composite materials in micro-scale or nano-scale. The nanomechanical behavior of dragonfly membranous wings was investigated with a nanoindenter. It was shown that the maxima of the reduced modulus and nanohardness of the in-vivo and fresh dragonfly wings are about at position of 0.7L, where L is the wing length. It was found that the reduced modulus and nanohardness of radius of the wings of dragonfly are large. The reduced modulus and nanohardness of Costa, Radius and Postal veins of the in-vivo dragonfly wings are larger than those of the fresh ones. The deformation, stress and strain under the uniform load were analyzed with finite element simulation software ANSYS. The deformation is little and the distribution trend of the strain is probably in agreement with that of the stress. It is shown that the main veins have better stabilities and load-bearing capacities. The understanding of dragonfly wings＇ nanomechanical properties would provide some references for improving some properties of 2-dimentional composite materials through the biomimetic designs. The realization of nanomechanical properties of dragonfly wings will provide inspirations for designing some new structures and materials of mechanical parts.

关键词： Pantala flavescens Fabricius membranous wing experimental optimization design nanoindentation nanome-chanieal property

Kinematics of Chinese toad Bufo gargarizans

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Science China(Technological Sciences) 2010年第11期53卷 2936-2941页

作者： WANG ChaoFei tong Jin SUN jiyu Key Laboratory of Engineering Bionics Ministry of EducationJilin UniversityChangchun 130022China College of Biological and Agricultural Engineering Jilin UniversityChangchun 130022China

A three-dimensional motion force tester for animal was used to measure the reaction forces of the feet of a Chinese toad (B. gargarizans) against a horizontal solid surface on which it crawled. The motion behavior of the Chinese toad was recorded by a high-speed camera on line. The motor function of every foot was analyzed. It was found that the lateral force represents the control ability of side-to-side locomotion, controls the lateral movement, and maintains a stable state for the sustainable creeping gesture. The forefeet play the assistant role and the hind feet play the main role in driving. The normal force of the forefeet is significantly greater than that of the hind feet, so the forefeet play the main role in supporting the body and the hind feet play the assistant role. The normal force is significantly greater than the lateral force and the driving force as well. There is little change for the friction force and the support angle of the all four feet. The average value of the support angle is 70°–80°. The Chinese toad’s vola friction coefficient of the forefeet is less than that of the hind feet. The above results indicate that the difference in kinematics and the material characteristic of the contact skin of the Chinese toad. The results could be useful to the structure design and gait optimization of some robots.

关键词： Chinese toad Bufo gargarizans kinematics 3-D motion force

三种常见肝脏血管铸型剂比较及温度对混合铸型剂影响

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西南医科大学学报 2020年第6期43卷 560-563页

作者：袁浩杨秋语童继玉高云陈波西南医科大学四川泸州646000 西南医科大学基础医学院解剖学教研室四川泸州646000

目的:比较三种常见肝脏血管铸型剂优劣以及温度对混合铸型剂的溶解时间和凝固时间的影响。方法:18只雄性家兔随机平分为3组,用三种铸型剂分别灌注家兔门静脉和后腔静脉,比较肝脏铸型标本及混合铸型剂不同温度下溶解和凝固时间。结果:过... 详细信息

目的:比较三种常见肝脏血管铸型剂优劣以及温度对混合铸型剂的溶解时间和凝固时间的影响。方法:18只雄性家兔随机平分为3组,用三种铸型剂分别灌注家兔门静脉和后腔静脉,比较肝脏铸型标本及混合铸型剂不同温度下溶解和凝固时间。结果:过氯乙烯铸型标本气泡少、完整度高、末梢充盈佳、韧性佳,制作周期长;自凝牙托剂铸型标本气泡极少,制作周期短,韧性佳、完整性可,末梢充盈较差;混合材料铸型标本气泡稍多,制作周期短、韧性、完整性和末梢充盈度俱佳。过氯乙烯-牙托粉混合铸型材料的溶解和凝固时间皆随温度升高而加快。Pearson相关性检验显示:混合铸型材料的溶解时间与温度呈负相关(r=-0.8964,P=0.0026);混合铸型材料的凝固时间与温度亦成负相关(r=-0.95346,P=0.0009)。混合铸型材料的溶解及凝固时间随温度增加而降低,最佳铸型温度约在26℃。结论:乙酸乙酯-自凝牙托材料混合铸型剂制作肝脏血管灌注标本简便易行,铸型效果好,最佳铸型温度约在26℃。

关键词：铸型自凝牙托材料过氯乙烯材料肝脏温度

Bio-inspirations for the Development of Light Materials based on the Nanomechanical Properties and Microstructures of Beetle Dynastes tityus

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Journal of Bionic Engineering 2019年第1期16卷 154-163页

作者： jiyu Sun Wei Wu Zelai Song Jin tong Shujun Zhang Key Laboratory of Bionic Engineering (Ministry of Education China)Jilin UniversityChangchun 130022China School of Computing and Technology Gloucestershire UniversityCheltenham GL50 2HRUK

Dynastes tityus(***)is a typical beetle whose elytra are light and *** primary function of elytra is to protect beetle's *** this paper,*** elytra were selected as the biological prototype for the investigation to obtain bio-inspirations for the design and development of light materials with high ratio of strength to ***,the microstructure investigation and quasi-static nanoindentation tests have been carried out on the ten samples of the selected elytra *** to reveal their mechanical properties and ***,based on the fmdings from the microstructure investigation and nanoindentation tests,three models of bio-inspired materials have been proposed for further study to gain the deep understanding of the relationships between the special mechanical characteristics and *** Finite Element Analysis(FEA)simulations have been performed on the three models for harvesting the bio-inspirations for the initial design of light ***,through comparative analysis of the findings from the microstructure investigation,the nanoindentation tests and the simulations,some meaningful bio-inspirations have been reaped for the future optimization of the design and development of light materials with high ratio of strength to mass.

关键词： beetle elytra bio-inspirations nano-mechanical properties microstructures light-weight materials with high strength