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Targeting Epac2 and GluA3-containing AMPARs:a novel therapeutic strategy for Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3223-3224页

作者： tong zhang Martina Schmidt Department of Molecular Pharmacology Groningen Research Institute of PharmacyUniversity of GroningenGroningenThe Netherlands School of Pharmacy Tianjin Medical UniversityTianjinChina

Alzheimer's disease(AD)is a neurodegenerative disease that manifests progressive decline in memory and *** the early stage of AD,memory retrieval is impaired preceding memory acquisition and consolidation(Roy et al.,2016).Prior to the onset of symptoms,pathological amyloid-β(Aβ)plagues and tau protein tangles accumulate in extracellular and intracellular spaces,respectively,leading to *** these hallmark pathologies,Aβ is proposed to be the primary etiology by triggering a cascade of pathogenic events,including neuroinflammation,oxidative stress,tau hyperphosphorylation,synaptic/neuronal dysfunction,and neuronal death(zhang et al.,2023b).

关键词： Alzheimer impaired Aβ

Marine dispersion of Fukushima-derived radiocesium in the North Pacific and its implications

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Science China Earth Sciences 2025年

作者： tong zhang Xiaolin HOU Yukun FAN State Key Laboratory of Loess and Quaternary Geology Shaanxi Key Laboratory of Accelerator Mass Spectrometry Technology and Application Xi'an AMS Center Institute of Earth Environment Chinese Academy of Sciences University of Chinese Academy of Sciences Xi'an Institute for Innovative Earth Environment Research

A key scientific approach to addressing the environmental radiation risks from Fukushima nuclear contaminated water （FNCW） discharge into the ocean is understanding and predicting the marine dispersion of *** dispersion of radiocesium (CsF:134Cs,137Cs) from the Fukushima nuclear accident in the North Pacific and its marginal seas post-2011 was systematically summarized,focusing on pathways,vertical distribution changes,and transit *** research examined CsFdispersion through the Kuroshio Extension and denser central mode water （D-CMW） to the eastern North Pacific,as well as through subtropical mode water （STMW）,lighter central mode water （L-CMW）,and D-CMW to the subtropical western North Pacific,China Seas,and Sea of *** considered broader implications of CsFdispersion in light of ongoing FNCW *** this prolonged liquid discharge and Kuroshio Extension’s barrier effect,it is crucial to emphasize the role of CMW besides STMW in transporting FNCW to the subtropical western North Pacific and its marginal *** research should focus on the key mechanism and longitude range of CMW crossing the Kuroshio *** short-lived134Cs decays rapidly during the storage and dispersion of FNCW,long-lived135Cs and135Cs/137Cs ratios can serve as valuable tracers for detecting and quantifying ***,there is an urgent need for high-precision analysis of these key radionuclides and their characteristic *** promptly detect,assess,and respond to FNCW intrusion,continuous monitoring and identification of nuclear pollution sources in key ocean currents and straits are ***,interdisciplinary research integrating monitoring with marginal sea circulation dynamics and high-resolution numerical simulations should be a priority

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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-Yu Bian Yu-Fang Feng Wen-Ting He tong zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

TWO-GRID CHARACTERISTIC FINITE VOLUME METHODS FOR NONLINEAR PARABOLIC PROBLEMS＊

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Journal of Computational Mathematics 2013年第5期31卷 470-487页

作者： tong zhang School of Mathematics and Information Science Henan Polytechnic University Jiaozuo China

In this work, two-grid characteristic finite volume schemes for the nonlinear parabolic problem are considered. In our algorithms, the diffusion term is discretized by the finite volume method, while the temporal differentiation and advection terms are treated by the characteristic scheme. Under some conditions about the coefficients and exact solution, optimal error estimates for the numerical solution are obtained. Furthermore, the two- grid characteristic finite volume methods involve solving a nonlinear equation on coarse mesh with mesh size H, a large linear problem for the Oseen two-grid characteristic finite volume method on a fine mesh with mesh size h = O（H2） or a large linear problem for the Newton two-grid characteristic finite volume method on a fine mesh with mesh size h = 0（I log hll/2H3）. These methods we studied provide the same convergence rate as that of the characteristic finite volume method, which involves solving one large nonlinear problem on a fine mesh with mesh size h. Some numerical results are presented to demonstrate the efficiency of the proposed methods.

关键词： Two-grid Characteristic finite volume method Nonlinear parabolic problem,Error estimate Numerical example.

Measuring positive public transit accessibility using big transit data

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Geo-Spatial Information Science 2021年第4期24卷 722-741页

作者： tong zhang Wenyuan zhang Zhenxuan He State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanChina Department of Computer Science and Engineering New York UniversityNew YorkNYUSA

Most of the current existing accessibility measures quantify the potential of reaching desirable opportunities across space and ***,these potential measurements only illus-trate the maximum possible accessibility a person can have,which may not accurately measure real-world transit accessibility in urban *** paper introduces a novel methodology to measure positive public transit accessibility based on multi-source big public transit data such as Smart Card Data(SCD)and Global Navigation Satellite System trajectory data,which embed rich travel information and real-world spatio-temporal ***,we use multi-source transit data to reconstruct trip chains,which are used to extract popular destinations.A novel transit accessibility measure is defined to account for latent trip information such as mode/route preference,opportunity attraction,and travel impedance that are difficult to capture explicitly via traditional normative ***,we produce accessibility maps to visualize time-varying and heterogeneous accessibility patterns distributed over the study *** performed an empirical evaluation on real-world transit data collected in Shenzhen City,China,demonstrating the applicability and effectiveness of the proposed method in mapping positive transit accessibility over large metropolitan *** results and findings of the empirical study demonstrate that the proposed positive accessibility measure can better capture travel behavior characteristics and constraints than traditional normative *** measure-ment method can be used as a practical high-resolution mapping tool for transit decision makers in evaluating public transit systems,supporting strategic transit planning,and improv-ing daily transit management.

关键词： Public transit positive accessibility smart card data spatio-temporal

Recent advances toward high voltage, EC-free electrolytes for graphite-based Li-ion battery

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Frontiers of Chemical Science and Engineering 2018年第3期12卷 577-591页

作者： tong zhang Elie Paillard Helmholtz Institute Muenster- Forschungszentrum Juelich (IEK 12) Corrensstr. 46 48149 Muenster Germany

Lithium-ion batteries are a key technology in today＇s world and improving their performances requires, in many cases, the use of cathodes operating above the anodic stability of state-of-the-art electrolytes based on ethylene carbonate （EC） mixtures. EC, however, is a crucial component of electrolytes, due to its excellent ability to allow graphite anode operation-also required for high energy density batteries-by stabilizing the electrode/ electrolyte interface. In the last years, many alternative electrolytes, aiming at allowing high voltage battery operation, have been proposed. However, often, graphite electrode operation is not well demonstrated in these electrolytes. Thus, we review here the high voltage, EC- free alternative electrolytes, focusing on those allowing the steady operation of graphite anodes. This review covers electrolyte compositions, with the widespread use of additives, the change in main lithium salt, the effect of anion （or Li salt） concentration, but also reports on graphite protection strategies, by coatings or artificial solid electrolyte interphase （SEI） or by use of water-soluble binder for electrode processing as these can also enable the use of graphite in electrolytes with suboptimal intrinsic SEI formation ability.

关键词： lithium-ion electrolyte solid electrolyte interphase additives high voltage graphite

Data-driven glass-forming ability criterion for bulk amorphous metals with data augmentation

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Journal of Materials Science & Technology 2022年第26期121卷 99-104页

作者： Jie Xiong tong-Yi zhang School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518000China Hong Kong University of Science and Technology(Guangzhou) Guangzhou 511400China Material Genome Institute Shanghai UniversityShanghai 200444China

A data augmentation technique is employed in the current work on a training dataset of 610 bulk metallic glasses(BMGs),which are randomly selected from 762 collected *** ensemble machine learning(ML)model is developed on augmented training dataset and tested by the rest 152 *** result shows that ML model has the ability to predict the maximal diameter Dmaxof BMGs more accurate than all reported ML *** addition,the novel ML model gives the glass forming ability(GFA)rules:average atomic radius ranging from 140 pm to 165 pm,the value of TT/(T-T)(T-T)being higher than 2.5,the entropy of mixing being higher than 10 J/K/mol,and the enthalpy of mixing ranging from-32 k J/mol to-26 k J/*** model is interpretative,thereby deepening the understanding of GFA.

关键词： Materials informatics Glass-forming ability Data augmentation Model interpretation Meta-ensemble model

Formulation development and evaluation of gastroretentive floating beads with Brucea javanica oil using ionotropic gelation technology

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Chinese Journal of Natural Medicines 2018年第4期16卷 293-301页

作者： zhang Yue zhang Xi-tong zhang Qi WANG Bing zhang tong Experiment Center for Teaching and Learning Shanghai University of Traditional Chinese Medicine School of Pharmacy Shanghai University of Traditional Chinese Medicine

In the present study, a gastric retention floating system for Brucea javanica oil, composed of alginate and carrageenan, was prepared using ionotropic gelation. Parameters for floatability, drug load, encapsulation efficiency, bead morphology, in vitro release, and in vivo gastric retention were evaluated. The optimized formulation via Box–Behnken design consisted of 1.7% alginate(W/V), 1.02% carrageenan(W/V), 1.4% CaCO_3(W/V), and a gelling bath of pH 0.8. The alginate–carrageenan–Brucea javanica oil beads had a porous structure and exhibited up to 24 h of in vitro floatability with a load capacity of 45%–55% and an encapsulation efficiency of 70%–80%. A 6-h sustained release was observed in vitro. The beads had a prolonged gastric retention(> 60% at 6 h) in fasted rats, compared to non-floating beads(15% at 6 h), as measured by gamma scintigraphy with single-photon emission tomography/computed tomography(SPET/CT). In conclusion, the alginate–carrageenan–Brucea javanica oil system showed enhanced oil encapsulation efficiency, excellent floating and gastric retention abilities, and a favorable release behavior.

关键词： Brucea javanica oil Simaroubaceae Alginate–carrageenan beads Gastric retention Box–Behnken design SPET/CT

Broadband and efficient second harmonic generation in LiNbO_(3)-LiTaO_(3) composite ridge waveguides at telecom-band

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Chinese Physics B 2021年第1期30卷 256-261页

作者： Xin-tong zhang Department of Optics and Optical Engineering University of Science and Technology of ChinaHefei 230026China

Broadband nonlinear frequency conversions of optical waves are widely employed in multiple areas of optics and photonics. However, the broadening of conversion bandwidth is often at a cost of reduction in efficiency, which may induce a limitation on practical applications. Here we theoretically propose a novel design of LiNbO_(3) ridge waveguides on LiTaO_(3) substrates which can be used for efficient and broadband second harmonic generation. Through group velocity engineering of the ridge waveguides, acceptance bandwidth over 20 nm with a high conversion efficiency of > 25%W^(-1)·cm^(-2) is achieved at telecom-band.

关键词： second harmonic generation lithium niobate ridge waveguide dispersion manipulation