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Self-supported transition metal oxide electrodes for electrochemical energy storage

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Tungsten 2020年第4期2卷 337-361页

作者： Xiao‑Ling Teng Xi‑tong sun Lu Guan Han Hu Ming‑Bo Wu State Key Lab of Heavy Oil Processing Institute of New EnergyCollege of Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China

Electrode materials are of decisive importance in determining the performance of electrochemical energy storage(EES)***,the electrode materials are physically mixed with polymer binders and conductive additives,which are then loaded on the current collectors to function in real *** a configuration inevitably reduces the content of active species and introduces quite some undesired interfaces that bring down the energy densities and power *** viable solution to address this issue is to construct self-supported electrodes where the active species,for example transition metal oxides(TMOs),are directly integrated with conductive substrates without polymer binders and conductive *** this review,the recent progress of self-supported TMO-based electrodes for EES devices including lithium-ion batteries(LIBs),sodium-ion batteries(SIBs),aluminum-ion batteries(AIBs),metal-air batteries,and supercapacitors(SCs),is discussed in great *** focused attention is firstly concentrated on their structural design and controllable ***,the mechanism understanding of the enhanced electrochemical performance is ***,the challenges and prospects of self-supported TMO-based electrodes are summarized to end this review.

关键词： Self-supported electrodes Transition metal oxides Metal-ion batteries Metal-air batteries Supercapacitors

Effect of low high-density lipoprotein levels on mortality of septic patients: A systematic review and meta-analysis of cohort studies

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World Journal of Emergency Medicine 2020年第2期11卷 109-116页

作者： Shao-hua Liu Huo-yan Liang Hong-yi Li Xian-fei Ding tong-wen sun Jing Wang General ICU the First Affi liated Hospital of Zhengzhou UniversityHenan Key Laboratory of Critical Care MedicineZhengzhou 450052China Department of Respiratory Critical Care Medicine the First Affi liated Hospital of Zhengzhou UniversityZhengzhou 450052China

BACKGROUND:An increase in high-density lipoprotein(HDL)is well associated with a decreased cardiovascular risk,especially *** studies suggest that lower levels of HDL may also be associated with an increased risk of sepsis and an increased rate of mortality in septic ***,this conclusion remains ***:MEDLINE,EMBASE,and CENTRAL databases were searched from inception to September 30,*** studies were conducted to evaluate the correlation of lipoprotein levels and the risk and outcomes of sepsis in adult *** primary outcomes were the risk and mortality of ***:Seven studies comprising 791 patients were *** levels of HDL had no marked relevance with the risk of sepsis(odds radio[OR]for each 1 mg/dL increase,0.94;95%CI 0.86–1.02;P=0.078),whereas lower HDL levels were related to an increased mortality rate in septic patients(OR for below about median HDL levels,2.00;95%CI 1.23–3.24;P=0.005).CONCLUSION:This meta-analysis did not reveal a signifi cant association between lower HDL levels and an increase in the risk of sepsis,whereas it showed that lower HDL levels are associated with a higher mortality rate in septic adult *** findings suggest that HDL may be considered as a promising factor for the prevention and treatment of sepsis in the future.

关键词： High-density lipoprotein Sepsis Mortality Meta-analysis

Adult-onset Still's disease evolving with multiple organ failure and death:A case report and review of the literature

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World Journal of Clinical Cases 2021年第4期9卷 886-897页

作者： Zhong-Bin Han Ju Wu Jing Liu He-Ming Li Kai Guo tong sun Department of Surgery Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001Liaoning ProvinceChina Department of ICU Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001Liaoning ProvinceChina Department of Oncology Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001Liaoning ProvinceChina Department of Surgery Second People's Hospital of Jinzhong CityJinzhong 030600Shanxin ProvinceChina

BACKGROUND Adult-onset Still’s disease(AOSD)is a rare systemic inflammatory disease,which is characterized by daily fever and arthritis,with an evanescent rash and neutrophilic *** date,there has been no definite laboratory or imaging test available for diagnosing AOSD;the diagnosis is one of exclusion,which can be very *** particular,AOSD patients may experience different complications affecting their clinical picture,management,and *** treatment of AOSD remains largely empirical and involves therapeutic *** SUMMARY We report the case of a 36-year-old woman who presented with fever,red rash,arthralgia,and sore *** serum ferritin level and white blood cell count were markedly elevated,and the first diagnosis 22 years prior was"juvenile rheumatoid arthritis of systemic type".The patient was treated with prednisone,sulfasalazine,methotrexate,and *** remission of her symptoms,the patient stopped taking the medications,and the disease ***,the patient was diagnosed with adult-onset Still's *** occurred several times due to self-medication withdrawal,and an interleukin-6 antagonist(tocilizumab/Actemra)was administered to control the ***,she was hospitalized because an incision did not heal,and the patient suddenly developed high fever and diarrhea during *** patient's disease progressed violently and quickly developed into macrophage activation syndrome,disseminated intravascular coagulation,shock,and multiple organ *** patient had sudden cardiac arrest,and she died despite emergency rescue *** AOSD patients need regular follow-up in the long-term treatment process,and must press formulary standard medication,and do not voluntarily withdraw or reduce the *** it may cause disease back-and-forth or serious lifethreatening ***,strict management of trauma,infections,tumors,and other diseases may contribute

关键词： Adult-onset Still's disease Macrophage activation syndrome Disseminated intravascular coagulopathy Multiple organ failure Death Case report

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中国医疗卫生人员超重/肥胖危险因素研究

中国全科医学 2025年第3期28卷 320-329页

作者：郭馨月巩少青侯晓辉孙桐文建强王志耀何景阳孙雪竹王素芳田向阳冯雪安徽医科大学公共卫生学院营养与食品卫生系安徽省合肥市230031 漯河医学高等专科学校河南省漯河市462002 中国健康教育中心北京市100011 山东省疾病预防控制中心山东省济南市250013 甘肃省中医药发展中心甘肃省兰州市741020 新疆维吾尔自治区卫生健康宣传教育中心新疆维吾尔自治区乌鲁木齐市830000 河南省疾病预防控制中心健康教育所河南省郑州市450003 中国医学科学院阜外医院心脏康复中心北京市100037 国家心血管病中心健康生活方式医学中心北京市100037

背景医疗卫生人员在预防和控制COVID-19大流行方面发挥了关键作用。高感染风险和密集的工作不仅导致医疗卫生人员职业倦怠,并且严重影响了他们的心理健康和生活方式,大量国外研究表明,新型冠状病毒感染疫情导致医疗卫生人员出现膳食不... 详细信息

背景医疗卫生人员在预防和控制COVID-19大流行方面发挥了关键作用。高感染风险和密集的工作不仅导致医疗卫生人员职业倦怠,并且严重影响了他们的心理健康和生活方式,大量国外研究表明,新型冠状病毒感染疫情导致医疗卫生人员出现膳食不合理、运动减少、睡眠障碍等情况,增加了超重和肥胖的风险。截至目前,有关新型冠状病毒感染疫情对中国医疗卫生人员体重及生活方式变化影响的研究较少,影响体重变化的主要生活方式因素尚不清楚。目的通过构建贝叶斯网络模型,分析新型冠状病毒感染疫情对中国医疗卫生人员超重/肥胖的影响及其危险因素,为重大传染病疫情期间预防和控制超重/肥胖提供科学依据。方法于2022年8月,随机抽取5个省/自治区/直辖市的100家医疗卫生机构中的医疗卫生人员,采用课题组自行编写的调查问卷[Cronbach'sα=0.820,公因子累积方差贡献率(AVCR)=63.55%],调查对象通过扫描“问卷星”平台生成的电子问卷二维码,填写并提交问卷。使用SPSS 25.0软件进行描述性统计分析,使用R 4.3.0软件的“bnlearn”包构建贝叶斯网络模型,并使用Netica 6.09软件进行贝叶斯网络模型概率预测。结果本研究共调查医疗卫生人员20261名,其中女性占67.57%(13690/20261);平均年龄(40.2±9.2)岁;文化程度为大专或本科的占73.28%(14848/20261)。2019、2022年超重/肥胖率分别为43.06%(8726/20261)和45.71%(9262/20261)。2019—2022年,12.64%(1458/11535)的调查对象BMI由消瘦/正常变为超重/肥胖。贝叶斯网络模型共纳入15个节点,其中,吃蔬菜水果、吃早餐频次、饮酒、饭量为调查对象BMI由消瘦/正常变为超重/肥胖的父节点,当吃蔬菜水果“有所减少”、吃早餐频次“无变化”、饮酒“无变化”且饭量“增加很多”时,BMI由消瘦/正常变为超重/肥胖的风险最高,为75.00%。当吃蔬菜水果为“增加很多”、吃早餐频次为“有所增加”、饮酒为“从不或很少”且饭量为“有所减少”时,BMI由消瘦/正常变为超重/肥胖的风险最低,为2.04%。贝叶斯网络概率预测模型发现,当调查对象熬夜及持续性压力/焦虑/抑郁情绪“有所增加”、睡眠时间及吃蔬菜水果“有所减少”、吃早餐频次“减少很多”、饮酒“无变化”且饭量“有所增加”时,BMI由消瘦/正常变为超重/肥胖的风险为26.70%,如果该研究对象吃早餐频次“增加很多”时,则BMI由消瘦/正常变为超重/肥胖的发生风险降低为14.30%。结论吃蔬菜水果、吃早餐频次、饮酒以及饭量是医疗卫生人员超重/肥胖的直接预测因素,新冠疫情等重大传染病疫情期间,在确保医疗卫生机构正常运转的前提下,实行合理的轮休制度,提供心理支持和生活方式行为干预服务,有利于医疗卫生人员肥胖防控。

关键词：超重肥胖医疗卫生人员生活方式贝叶斯网络

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Body Weight Misperception and Weight Disorders among Chinese Children and Adolescents:A Latent Class Analysis

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Current Medical Science 2019年第5期39卷 852-862页

作者： Ting-ting QIN Huang-guo XIONG Ming-ming YAN tong sun Ling QIAN Ping YIN Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute for Health Education Shandong Provincial Center for Disease Control and PreventionJinan 250000China Center for Health Education The Ministry of Health of the People's Republic of ChinaBeijing 100011China

Body misperception plays an important role in the development of weight and dietary disorders among children and adolescents.A school-based health promotion program(2014-2015)was conducted to promote the school health education and improve the teenagers'physical health among Chinese children and *** on this program,we intended to examine weight status and weight misperception among Chinese children and adolescents and to explore the relationship between weight misperception and lifestyle behaviors.A total of 10708 Chinese children and adolescents in 3rd and 7th grade from Shandong and Qinghai province participated in the *** participants,dietary and activity patterns were clustered by latent class analysis(LCA).Logistic regression analysis was undertaken to explore the relationship between weight perception and demographic factors or dietary and activity *** the gender-specific difference of children and adolescents,analyses were separately conducted among boys and *** total prevalence of weight misperception was 44.50%.Boys,especially those in higher grade and living in wealthier district,were more likely to misperceive body *** were more likely to overestimate their weight(26.10%)while boys tended to underestimate the weight(28.32%).Three latent dietary and activity patterns including obesogenic pattern,malnourished pattern and healthy pattern were *** participants who had weight misperception were more likely to choose unhealthy dietary and exercise *** high prevalence of weight misperception was closely related to the unhealthy weight pattern and unhealthy dietary or exercise *** research found that most children and adolescents failed to perceive their weight correctly and boys tended to underestimate their weight while girls were subjected to ***,comprehensive intervention programs should focus on improving self-weight awareness,and appropriate guidance should be made to

关键词： weight perception children and adolescents obesity lifestyle behavior pattern latent class analysis

Structural Variability and Rifting Process of the Segmented Cenozoic Pearl River Mouth Basin,Northern Continental Margin of the South China Sea

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Acta Geologica Sinica(English Edition) 2022年第6期96卷 2074-2092页

作者： MA Bingshan QI Jiafu WU Guanghui REN Jianye YANG Linlong sun tong CHEN Shi CHEN Weichang GE Jiawang School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China College of Marine Science and Technology China University of GeosciencesWuhan 430074China Working Station for Postdoctoral Scientific Research Shengli OilfieldDongyingShandong 257001China Research Institute of Petroleum Exploration Dagang Oilfield CompanyTianjin 300450China College of Geography Jining Normal UniversityUlanqabInner Mongolia 012000China

The Pearl River Mouth Basin(PRMB)is an important area for studying the evolution of continental marginal basins in the northern South China Sea(SCS),but the structural variability and spatiotemporal rifting process remains poorly *** study investigates the differential structural features of the eastern,middle and western PRMB,as well as the extensional deformation laws in operation during the rifting stage,according to an integrated analysis of geometric characteristics and kinematic parameters,i.e.,horizontal displacement and stretching factors of basin and *** PRMB underwent at least three phases of intense extension,which varied in time and space.(1)During the middle Eocene,most sags in the PRMB were intensely stretched and high-angle planar to listric boundary faults controlled the wedge-shaped stratigraphic geometry.(2)During the late Eocene-to-early Oligocene,the stratigraphic geometry of the sags was slightly wedge-shaped and continuously controlled by boundary faults,however,the extensional strength decreased relatively in the Northern depression zone,but increased in the Southern depression zone.(3)During the late Oligocene,the extension was extremely weak in the northeast PRMB,but relatively strong in the southwest PRMB,leading to tabular stratigraphic geometry in the northeast PRMB,but localized slightly wedge-shaped stratigraphic geometry in the *** southwest PRMB still underwent relatively strong extension during the early *** southwest PRMB that was induced by a small-scale localized mantle convection system constantly rifted during the late Oligocene,controlled by the weak lithosphere,westward(southwestward)diachronous opening and southward jump of the ocean *** applied quantitative parameters and spatiotemporal rifting process may be used as a reference with which to study the segmented continental margin rifts.

关键词： basin structure extensional feature rifting process Pearl River Mouth Basin northern South China Sea

Multiple bilateral and symmetric C1-2 ganglioneuromas: A case report

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World Journal of Clinical Cases 2022年第31期10卷 11549-11554页

作者： Shuang Wang Jun-Xiong Ma Liang Zheng Shao-tong sun Liang-Bi Xiang Yu Chen Department of Orthopedics General Hospital of Northern Theater CommandShenyang 110006Liaoning ProvinceChina

BACKGROUND Ganglioneuromas are rare tumors of the sympathetic nervous system that originate from neural crest *** the cervical spine has rarely been reported as a site for ganglioneuroma,we present a case report on this uncommon *** SUMMARY A 34-year-old male presented with a 4-month history of progressive paralysis of both upper limbs along with an unsteady *** touch sensitivity of both hands was reduced,and there was conspicuously high muscle tonus in his upper and lower limbs,along with hyperactive physiological reflection and deep *** resonance imaging showed several nodules around the C2-7 intervertebral foramena,among which the masses lying between C1 and C2 were obviously bilaterally compressing the spinal *** posterior decompression was performed without fixation and the tumors in the upper cervical spine were removed intact,with rapid relief of *** pathological diagnosis was *** Multiple and bilateral ganglioneuroams are a rare occurrence in the cervical *** this case report,timely resection of the neoplasms around C1 and C2 resulted in spinal cord decompression,with rapid relief of symptoms and a good *** the current case,we are aware of only seven such cases in the literature,of which four arose from Japan,one from China,and one from *** suppose that ethnicity and geographic associations with this rare disease presentation may be an aspect for future consideration and investigation.

关键词： Ganglioneuroma Cervical cord Dumbbell tumor Symmetric Surgery Case report

UBE2C affects breast cancer proliferation through the AKT/mTOR signaling pathway

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Chinese Medical Journal 2021年第20期134卷 2465-2474页

作者： Zi-Nan Lu Jia Song tong-Hui sun Gang sun Department of Mammary/Head and Neck Surgery The Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830011China Department of Institute for Cancer Research The Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqiXinjiang 830011China

Background:Ubiquitin-conjugating enzyme E2C(UBE2C)has been shown to be associated with the occurrence of various cancers and involved in many tumorigenic *** study aimed to investigate the specific molecular mechanism through which UBE2C affects breast cancer(BC)***:BC-related datasets were screened according to filter criteria in the Gene Expression Omnibus(GEO)database and The Cancer Genome Atlas(TCGA)*** differentially expressed genes(DEGs)were identified using Venn diagram *** using DEGs,we conducted the following analyses including Gene ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG),protein-protein interaction(PPI),and survival analysis,and then validated the function of the hub geneUBE2C using quantitative reverse transcription-polymerase chain reaction(RT-qPCR),cell counting kit-8(CCK-8)assay,transwell assay,and Western blot ***:In total,151 DEGs were identified from the GEO and TCGA *** results of GO analysis demonstrated that the DEGs were significantly enriched with mitotic nuclear division,lipid droplet,and organic *** analysis showed that the peroxisome proliferators-activated receptor(PPAR)signaling pathway,regulation of lipolysis in adipocytes,and proximal tubule bicarbonate reclamation were significantly enriched in the signal transduction pathway *** top three hub genes that resulted from the PPI network wereFOXM1,UBE2C,*** results of survival analysis showed a close relationship between UBE2C and *** results of CCK-8 and transwell assays suggested that the proliferation and invasion ofUBE2C knockdown cells were significantly inhibited(P<0.050).The results of Western blot assay showed that the level of phosphorylated phosphatase and tensin homology deleted on chromosome 10(p-PTEN)was obviously increased(P<0.050),whereas the levels of phosphorylated protein kinase B(p-AKT),phosphorylated mammalian target of rapamycin(p-mTOR),and hypoxia-in

关键词： AKT/mTOR Breast cancer Invasion Proliferation Ubiquitin-conjugating enzyme E2C

RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations

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Genes & Diseases 2024年第1期11卷 87-90页

作者： Hongxia Zhang Yueya Zhong Yuanming He Yujia Xu Ying Ren Haixia Zhuang tong sun Zhigang Zhu Xinliang Mao Institute of Clinical Pharmacology Science and Technology Innovation CenterGuangzhou University of Chinese MedicineGuangzhouGuangdong 510403China Guangdong Provincial Key Laboratory of Protein Modification and Degradation School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouGuangdong 511436China Department of Pharmacology College of Pharmaceutical SciencesSoochow UniversitySuzhouJiangsu 215123China Division of Hematology&Oncology Department of GeriatricsGuangzhou First People's HospitalCollege of MedicineSouth China University of TechnologyGuangzhouGuangdong 510180China

Chronic myelogenous leukemia(CML)is a malignancy from bone marrow myeloid stem cells mainly driven by the fusion gene *** addition to BCR-ABL,other genes including RNF6 are also dysregulated in CML cells.1 RNF6,a ubiquitin ligase of the RING family,promotes various cancer cell proliferation,chemoresistance,and tumor growth in vivo by targeting various proteins for ubiquitination and degradation,including SHP1,TLE3,FOXA1,and MAD1.^(2) However,its specific mechanism in CML is not known.

关键词： ubiquitin myelogenous leukemia