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A test of g.netic association among.male nuptial coloration, female mating.preference, and male ag.ression bias within a polymorphic population of cichlid fish

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Current Zoolog. 2013年第2期59卷 221-229页

作者： Inke van der SLUIJS Peter D. DIJKSTRA Charlotte M. LINDEYER BertanneVISSER Alan M. SMITH ton g. g. groothuis Jacques J. M. van ALPHEN Ole SEEHAUSEN Department of Animal Ecolog. Institute of Biology Leiden University PO Box 9516 2300 RA Leiden The Netherlands The University of Texas at Austin Section of Integrative Biology 1 University Station-C0930 Austin TX 78712 United States Department of Biolog.cal Sciences University of Hull Cottingham Road Hull HU6 7RX United Kingdom Behavioural Biolog. g.oup University of Groningen P.O. Box 14 9750 AA Haren The Netherlands Institute of Zoolog. University of Bern Baltzerstrasse CH-3012 Bern Switzerland Eawag Swiss Federal Institute for Aquatic Science and Technology Centre of Ecology Evolution & Biogeochemistry Depart- ment ofFish Ecology & Evolution Seestrasse 97 6047 Kastanienbaum Switzerland

Both inter- and intrasexual selection have been implicated in the orig.n and maintenance of species-rich taxa with di- verse sexual traits. Simultaneous disruptive selection by female mate choice and male-male competition can, in theory, lead to ~,;peciation without g.og.aphical isolation if both act on the same male trait. Female mate choice can g.nerate discontinuities in g.ne flow, while male-male competition can g.nerate neg.tive frequency-dependent selection stabilizing.the male trait polymor- phism. Speciation may be facilitated when mating.preference and/or ag.ression bias are physically linked to the trait they operate on. We tested for g.netic associations among.female mating.preference, male ag.ression bias and male coloration in the Lake Victoria cichlid Pundamilia. We crossed females from a phenotypically variable population with males from both extreme ends of the phenotype distribution in the same population （blue or red）. Male offspring.of a red sire were sig.ificantly redder than males of a blue sire, indicating.that intra-population variation in male coloration is heritable. We tested mating.preferences of female offspring.and ag.ression biases of male offspring.using.binary choice tests. There was no evidence for associations at the family level between female mating.preferences and coloration of sires, but dam identity had a sig.ificant effect on female mate prefe- rence. Sons of the red sire directed sig.ificantly more ag.ression to red than blue males, whereas sons of the blue sire did not show any bias. There was a positive correlation among.individuals between male ag.ression bias and body coloration, possibly due to pleiotropy or physical linkag., which could facilitate the maintenance of color polymorphism [Current Zoolog. 59 （2）： 221-229, 2013].

关键词： Disruptive selection Sexual selection Speciation Pundamilia Linkag. disequilibrium

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Jazz and Philosophy

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Chang.iang.Weekly 2022年第1期 11-11页

作者： Doug.as groothuis Wang.Qiang 不详

Philosophy warms to jazz,but not as much,perhaps,to rock or *** can talk throug. the nig.t about rock and blues,and it may be *** just how philosophical can we g.t about rock and blues even with the help of a few smar... 详细信息

关键词：蓝调爵士乐哲学内涵摇滚

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缺陷DNA错配修复与复发性子宫内膜癌的关系

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世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 62-62页

作者： Pijnenborg.J.M.A. Dam-De Veen g.C. De Haan J. e P.g. groothuis 张剑萍 Research Institute g.OW UniversityMaastricht Maastricht Netherlands

Objective. To investig.te whether defective DNA mismatch repair (MMR) defines a subg.oup at risk for recurrence in sporadic endometrial carcinoma patients. Me thods. Primary tumors from 44 patients with recurrent stag. I endometrial carcin oma were compared after matching. with tumors of 44 patients being.free of recur rence for minimal 3 years. Paraf-fin-embedded primary tumors (n = 88) and recu rrent tumors (n = 32) were subjected to immunohistochemical analysis for hMSH2 a nd hMLH1 expression. Subsequently, a staining.index (SI = 0-9) was calculated b ased on staining.intensity and quantity. DNA was extracted from paraffin-embedd ed tissues, and promoter methylation of hMLH1 was determined by nested methylati on-specific PCR (MSP). Microsatellite instability (MSI) was assessed by BAT-26 or BAT-25. Results. Low hMSH2 expression was observed in 2%of primary tumors of control patients without recurrence, 14%of primary tumors of patients with r ecurrence, and 0%of recurrent tumors. Low hMLH1 expression was observed in 32% , 19%, and 22%, respectively. hMLH1 g.ne promoter methylation was detected in 50%, 47%, and 32%, and MSI was found in 16%, 14%, and 30%, respectively. N o sig.ificant differences were found between primary tumors of patients with and without recurrence with respect to hMSH2 and hMLH1 expression, hMLH1 promoter m ethylation, and MSI. When primary and recurrent tumors were compared, there was an increased correlation of hMLH1 methylation with low hMLH1 expression and MSI in recurrent tumors. Conclusion. MSI, hMLH1 promoter methylation, and the expres sion of hMLH1 and hMSH2 are not predictive for the development of recurrent stag.e I endometrial carcinoma. In the prog.ession of tumor, “de novo”hMLH1 methyla tion rarely occurs, instead there is further derailment of the MMR pathway in af fected tumors.

关键词： DNA错配修复病灶组织基因甲基化微卫星不稳定性原发肿瘤肿瘤病灶染色强度原发性肿瘤石蜡包埋组织低表达

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碳水化合物饮食对婴儿轻度胃肠炎预后的影响

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国际护理学杂志 1987年第3期08卷 138-138页

作者： J. R. groothuis ,颜鞍

近十年来,普遍趋于对急性胃肠炎婴儿采用无乳糖饮食,这主要是因为已发现并证实了重症婴儿腹泻存在对乳糖不耐受;但是否以往健康的婴儿轻度腹泻时(无需静脉补液或住院治疗者)也有这种缺陷尚研究不够;故至今也同样强调给不含乳糖的饮食,... 详细信息

近十年来,普遍趋于对急性胃肠炎婴儿采用无乳糖饮食,这主要是因为已发现并证实了重症婴儿腹泻存在对乳糖不耐受;但是否以往健康的婴儿轻度腹泻时(无需静脉补液或住院治疗者)也有这种缺陷尚研究不够;故至今也同样强调给不含乳糖的饮食,造成许多家庭增添麻烦和负担。为此,作者设计进行了本研究,以探讨摄食不同的碳水化合物是否对婴儿轻度胃肠炎的结局会产生不同的影响。作者采取前瞻性随机双盲试验方法,以年龄不足1岁、既往健康、新患胃肠炎、日解水样便6次以上、病程1周以内、未经抗生素治疗的非母乳喂养儿为研究对象,并应符合轻度腹泻的其它条件如:皮肤、眼窝、囟门检查无脱水表现,精神警觉,心率<120次/

关键词：轻度胃肠炎饮食乳糖不耐碳水化合物

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儿童良恶性卵巢肿块MRI鉴别诊断的系统性回顾

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国际医学放射学杂志 2020年第2期 252-252页

作者： W.E.van Nimweg.n A.M.C.Mavinkurve-groothuis R.R.de Krijg.r C.C.C.Hulsker A.J.g.verde J.Zsiros 席海蛟 Princess Máxima Center for Pediatric Oncolog.

目的 MRI对于超声无法鉴别的儿童和青少年良恶性卵巢肿块可能具有很高的价值,因为保留该人群的生育能力极其重要。本系统回顾评估儿童卵巢肿块MRI诊断价

关键词：卵巢肿块系统性回顾鉴别诊断 MRI

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低至中度冠状动脉疾病风险病人:冠状动脉CT血管成像与首过MR心肌灌注成像的对比

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国际医学放射学杂志 2010年第2期 179-179页

作者： J.J.groothuis A.M.Beek S.Brinckman M.R.Meijerink S.C.Koestner R.Nijveldt 李琼 Department of Cardiolog. RadiologyVU University Medical CenterDe Boelelaan 1117Room 5F0031081HV Amsterdamthe Netherlands

目的比较冠状动脉CT血管成像与首过MR心肌灌注成像在临床有胸痛、低至中度冠状动脉疾病风险病人中的应用。材料与方法在获得当地伦理委员会的同意和病人签署的知

关键词：心肌灌注成像血管成像冠状动脉疾病首过 MR 病人中度 CT

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