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Z-shaped incision without epithelial resection in pterygium surgery

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1262-1266页

作者： Satoru Kase shinki Chin Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan

AIM:To introduce a novel surgical technique using a Z-shaped incision without epithelial resection in ophthalmic ***:This was a prospective *** pterygium surgery,all proliferative tissues were separated from the cornea and conjunctiva without resection of the *** unaffected conjunctiva was incised in a *** upper(or lower)conjunctival flap was sutured to the lower(or upper)normal conjunctiva on the limbal sclera,while the proliferative tissue was sutured to the upper conjunctiva(or lower)near the ***:Ten patients with pterygia were eligible for this *** patients with primary pterygia and 2 with recurrent pterygia were *** age of patients at surgery ranged from 47 to 90y(average:71.9y).Five patients each showed right and left-sided *** postoperative follow-up periods were from 8 to 78mo(average:25.0mo).The surgery was successfully conducted and wounds were favorably reconstructed in all *** proliferative tissues sutured to the normal conjunctiva showed palor and attenuated neovessles,and never showed re-growth after *** patients did not show *** pterygium was noted in 1 patient,but additional treatments were not ***:The procedure involves the reconstruction of pterygial tissue and normal conjunctiva using a Z-shaped *** scleral limbal wound can be covered with nonaffected conjunctiva without any excision of conjunctival epithelia in patients with primary or recurrent pterygia.

关键词： pterygium surgery Z-shape non-resection

Histological observation of trabecular meshwork in a patient with Axenfeld-Rieger syndrome——a new theory for the mechanism of ectropion uvea in congenital glaucoma

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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1167-1169页

作者： Satoru Kase shinki Chin Teruhiko Hamanaka Yasuhiro Shinmei Takeshi Ohguchi Susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo CityHokkaido 060-8638Japan Department of Ophthalmology Japan Red Cross Medical CenterTokyo 150-8935Japan

Dear Editor,I am *** Kase,from the Department of Ophthalmology,Faculty of Medicine and Graduate School of Medicine,Hokkaido University.I write to present the case of clinicopathological findings in Axenfeld-Rieger syn... 详细信息

关键词： Medicine Rieger congenital

Treatment of secondary glaucoma by new trabeculotomy

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Treatment of secondary glaucoma by new trabeculotomy

Protective effect of fermented papaya preparation on stress-induced acute gastric mucosal lesion

中华医学会第十二届全国眼科学术大会

作者： shinki Chin Hokkaido University Graduate School of Medicine

Conventional 360—degrees suture trabeculotomy is an ef- fective method for treating primary congenital *** procedure avoids many of the difficulties encountered with

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Journal of Biophysical Chemistry 2012年第4期3卷 311-316页

作者： shinki Murakami Fusako Takayama Toru Egashira Mitsuko Imao Akitane Mori Department of Brain Science Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama Department of Brain Science Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan Department of Clinical Pharmaceutical Science Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan SAIDO Corporation Fukuoka Japan

Stress ulceration is single or multiple mucosal defects with/without bleeding from the gastric mucosa during the physiologic stress. Oxidative stress (OS) is a key pathogenic factor in psychogenic stress-induced acute gastric mucosal lesion (AGML). Fermented papaya preparation (FPP) is reported to have oxygen radical scavenging activity and is effective in OS-related diseases. Here, we investigated the protective effects and the mechanism of action of FPP on stress-induced AGML in rats, induced by water immersion restraint stress (WIRS). Exposure of rats to 6-hour WIRS resulted in the appearance of splinter hemorrhages and mucosal lesions in the stomach. WIRS induced significant increase in lipid peroxidation and decrease in superoxide dismutase-like activity in both the plasma and gastric mucosa. WIRS also significantly increased myeloperoxidase activity together with Nuclear factor-kappaB (NF-kB) activation in gastric mucosa. FPP reduced all the above changes. The results suggest that oral administration of FPP provides protection against WIRS-induced acute gastric mucosal lesions through its anti-oxidative and anti-inflammatory properties.

关键词： Acute Gastric Mucosal Lesion Fermented Papaya Preparation Oxidative Stress Inflammation

Fermented papaya preparation halts the progression of non-alcoholic steatohepatitis in rats

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Journal of Biophysical Chemistry 2013年第2期4卷 84-90页

作者： shinki Murakami Fusako Takayama Toru Egashira Mitsuko Imao Akitane Mori Department of Brain Science Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan Department of Clinical Pharmaceutical Science Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan SAIDO Corporation Fukuoka Japan

Non-alcoholic steatohepatitis (NASH) can progress to cirrhosis or hepatocellular carcinoma. Oxidative stress is implicated in NASH progression. Fermented papaya preparation (FPP) has oxygen radical scavenging activity and is effective in oxidative stress-related diseases. We investigated the effects of FPP on NASH progression using a rat NASH model. Plasma biochemical parameters and lipid peroxidation in the liver were elevated in NASH rats. Histologically, the liver of NASH rats showed liver fibrosis, mitochondrial dysfunction and over-expression of microsomal CYP2E1. Myeloperoxidase activity and nuclear factor-kappaB activation were also markedly increased in NASH. Oral administration of FPP ameliorated these changes in NASH rats. These results suggest that FPP halts NASH progression through its anti-oxidative and antiinflammatory properties.

关键词： Fermented Papaya Preparation Non-Alcoholic Steatohepatitis Oxidative Stress Antioxidant Activity Inflammation

乳腺摄影中肿块密度为乳腺癌有意义的预估表现

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国际医学放射学杂志 2011年第2期 178-179页

作者： R.W.Woods G.S.Sisney L.R.Salkowski K.shinki E.S.Burnside 唐光健 Department of Radiology School of Medicine and Public HealthUniversity of Wisconsin600 Highland AveE3/366 Clinical Science Center

目的确定非钙化性乳腺肿块在乳腺照摄影中的密度与恶性是否相关,并测算前瞻性与回顾性评价的一致性。材料与方法研究经学院评审委员会批准并免除病人知

关键词：肿块密度数据组乳腺肿块回顾性评价

膝关节大采样各向同性投影稳态自由进动序列成像:诊断作用并与常规MR对照

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国际医学放射学杂志 2009年第3期 291-291页

作者： R.Kijowski D.G.Blankenbaker J.L.Klaers K.shinki A.A.De Smet W.F.Block 杨卉 Department of Radiology University of Wisconsin HospitalClinical Science Center-E3/311600 Highland AveMadisonWI 53792-3252USA

目的将大采样各向同性投影稳态自由进动(VIPR-SSFP)序列与常规MR成像序列进行比较,评估两者在症状性膝关节病人中显示关节软骨、韧带、半月板和骨质结构方面的作用。方法本项前瞻性研究得到了所有受试者的书面同意及机构审查委员会的批... 详细信息

目的将大采样各向同性投影稳态自由进动(VIPR-SSFP)序列与常规MR成像序列进行比较,评估两者在症状性膝关节病人中显示关节软骨、韧带、半月板和骨质结构方面的作用。方法本项前瞻性研究得到了所有受试者的书面同意及机构审查委员会的批准,并符合HIPAA。VIPR-SSFP序列检查在1.5T MR设备上进行,共有95例有临床症状病人进行了检查(52例男性,43例女性,平均年龄41.6岁),随后进行了膝关节镜手术。所有MR检查由2位骨关节放射专家独立观察2次。首先观察常规MR序列,其次是VIPR-SSFP序列,包括软骨病变、前后十字交叉韧带撕裂、

关键词：稳态自由进动 MR 膝关节半月板撕裂常规序列

髋关节MR成像:IDEAL-SPGR容积序列与标准MR序列对软骨病变检测和分级的比较

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国际医学放射学杂志 2012年第1期 85-85页

作者： D.G.Blankenbaker S.R.Ullrick R.Kijowski K.W.Davis A.A.De Smet K.shinki 管宇 Department of Radiology University of Wisconsin School of Medicine and Public Health600 Highland AveE3/311MadisonWI 53792

目的比较不对称回波和最小二乘估计对水脂迭代分离的扰相梯度回波序列(IDEAL-SPGR)与标准MR关节成像序列对检测髋关节软骨病变及分级的诊断效能。材料与方法该研究获得伦理委员会批准,3名骨骼肌肉系统放射学家及1名骨骼肌肉系统的研究... 详细信息

目的比较不对称回波和最小二乘估计对水脂迭代分离的扰相梯度回波序列(IDEAL-SPGR)与标准MR关节成像序列对检测髋关节软骨病变及分级的诊断效能。材料与方法该研究获得伦理委员会批准,3名骨骼肌肉系统放射学家及1名骨骼肌肉系统的研究员独立地回顾性分析了67例

关键词：软骨病变 MR 髋关节 IDEAL-SPGR 序列

1.5T与3.0T MRI评估膝关节软骨对比

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国际医学放射学杂志 2009年第3期 282-282页

作者： R.Kijowski D.G.Blankenbaker K.W.Davis K.shinki L.D.Kaplan A.A.De Smet 胡睿 Department of Radiology University of Wisconsin Hospital600 Highland AveClinical Science Center-E3/311MadisonWI 53792-3252USA

目的回顾性比较1.5T及3.0T MRI在评估有相关症状病人膝关节软骨的诊断价值。方法此研究符合HIPAA,经伦理委员会同意,在病人不知情情况下进行。研究组(包括200例有相关症状的病人)接受MRI膝关节扫描,采用1.5T(61例男性,39例女性;平均年龄... 详细信息

目的回顾性比较1.5T及3.0T MRI在评估有相关症状病人膝关节软骨的诊断价值。方法此研究符合HIPAA,经伦理委员会同意,在病人不知情情况下进行。研究组(包括200例有相关症状的病人)接受MRI膝关节扫描,采用1.5T(61例男性,39例女性;平均年龄38.9岁)或3.0T(52例男性,48例女性;平均年龄39.1岁)设备,病人随后行膝关节镜手术治疗。所有1.5T及3.0T MR扫描均采用多层面快速自旋回波序列,并应用相似的组织对比度。

关键词：膝关节软骨相关症状病人 MRI 特异度