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An association between Helicobacter pylori and upper respiratory tract disease: Fact or fiction?

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World Journal of Gastroenterology 2014年第6期20卷 1470-1484页

作者： Shin Kariya Mitsuhiro Okano Kazunori nishizaki Department of Otolaryngology-Head and Neck Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Helicobacter pylori(H. pylori) is a major cause of chronic gastritis and gastric ulcers and considerable evidence supports the notion that infection with this bacterium is also associated with gastric malignancy in addition to various other conditions including pulmonary, vascular and autoimmune disorders. Gastric juice infected with H. pylori might play an important role in upper respiratory tract infection. Although direct and/or indirect mechanisms might be involved in the association between H. pylori and upper respiratory tract diseases, the etiological role of H. pylori in upper respiratory tract disorders has not yet been fully elucidated. Although various studies over the past two decades have suggested a relationship between H. pylori and upper respiratory tract diseases, the findings are inconsistent. The present overview describes the outcomes of recent investigations into the impact of H. pylori on upper respiratory tract and adjacent lesions.

关键词： Paranasal sinus Ear Adenoid Oral cavity Pharynx Larynx Upper respiratory tract Cancer

A study on quality evaluation for bituminous mixture using X-ray CT

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Frontiers of Structural and Civil Engineering 2013年第2期7卷 89-101页

作者： Satoshi TANIGUCHI Keiichiro OGAWA Jun OTANI Itaru nishizaki Public Works Research Institute Tsukuba 305-8516Japan School of Science and Technology Kumamoto UniversityKumamoto 860-8555Japan

The objective of this paper is to propose a new quality evaluation method for asphalt concrete mixture using X-ray CT *** achieve this aim,asphalt mixtures should be subjected to the X-ray CT scanning and its characteristics should be *** approach employed in this study was as follows:1)Coarse aggregate,fine aggregate,filler and bitumen were prepared;2)dense-graded,coarse-graded and porous asphalt mixtures were made;3)materials and mixtures were subjected to the X-ray CT scanning;4)frequency of CT-value,threshold value,average slice CT-value,average segment CT-value were *** the material examination,CT-value of aggregate becomes smaller in the order of coarse aggregate,fine aggregate and filler and CT image of bitumen was nearly *** the mixture examination,histograms of CT-value and four segmentation images made from CT images expressed the material and mixture characterization such as particle size and the difference in bitumen content and mixture type visibly and the bitumen content varies with the threshold *** addition,the average segment CT-value without threshold value by dividing the fine aggregate from the coarse aggregate and average CT-value of the coarse aggregate,especially is highly correlated with average CT-value of the bitumen.

关键词： asphalt concrete mixture aggregate bitumen bitumen content quality evaluation X-ray CT

Taurolithocholate impairs bile canalicular motility and canalicular bile secretion in isolated rat hepatocyte couplets

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World Journal of Gastroenterology 2006年第33期12卷 5320-5325页

作者： Norihito Watanabe Tatehiro Kagawa Sei-ichiro Kojima Shinji Takashimizu Naruhiko Nagata Yasuhiro nishizaki Tetsuya Mine Division of Gastroenterology Department of In-ternal Medicine Tokai University School of Medicine Japan

AIM: To investigate the effects of taurolithocholate (TLC)on the canalicular motility in isolated rat hepatocyte cou-plets (IRHC).METHODS: TLC was added to IRHC at concentrationsof 10 and 50 μmol/L, respectively. In each group, fi vetime-lapse movies containing 3 representative bile cana-liculi were taken under phase-contrast microscopy for12 h. The number of bile canalicular contractions andthe intervals between consecutive canalicular contrac-tions were calculated. Furthermore, the effects of TLC onIRHC were examined by transmission electron ***: The bile canalicular contractions were spon-taneous and forceful in the controls. Active vesicularmovement was observed in the pericanalicular *** after the addition of TLC, the bile canaliculiwere deformed, and canalicular bile was incorporatedinto the vacuoles. The canaliculi were gradually dilated,and canalicular contractions were markedly inhibited byTLC. The vesicular movements became extremely slowin the pericanalicular region. The number of canalicularcontractions significantly decreased in the TLC-treatedgroups, as compared with that in the controls. The timeintervals were prolonged, as the TLC dosage increased,indicating that bile secretion into the canaliculi wasimpaired with TLC. Transmission electron microscopyrevealed the lamellar transformation of the canalicularmembranes in IRHC treated with ***: TLC impairs both the bile canalicularcontractions and the canalicular bile secretion, possiblyby acting directly on the canalicular membranes in TLC-induced cholestasis.

关键词： Taurolithocholate Bile canaliculi Canalicularcontraction Bile secretion Isolated rat hepatocyte couplets Canalicular membrane Contractile protein

Interactive Fuzzy Approaches for Solving Multiobjective Two-Person Zero-Sum Games

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Applied Mathematics 2016年第5期7卷 387-398页

作者： Hitoshi Yano Ichiro nishizaki Graduate School of Humanities and Social Sciences Nagoya City University Nagoya Japan Graduate School of Engineering Hiroshima University Higashi-Hiroshima Japan

In this paper, we consider multiobjective two-person zero-sum games with vector payoffs and vector fuzzy payoffs. We translate such games into the corresponding multiobjective programming problems and introduce the pessimistic Pareto optimal solution concept by assuming that a player supposes the opponent adopts the most disadvantage strategy for the self. It is shown that any pessimistic Pareto optimal solution can be obtained on the basis of linear programming techniques even if the membership functions for the objective functions are nonlinear. Moreover, we propose interactive algorithms based on the bisection method to obtain a pessimistic compromise solution from among the set of all pessimistic Pareto optimal solutions. In order to show the efficiency of the proposed method, we illustrate interactive processes of an application to a vegetable shipment problem.

关键词： Multiobjective Two-Person Zero-Sum Games LR Fuzzy Numbers Fuzzy Payoff Matrices Fuzzy Goals Possibility Measure Pareto Optimal Solutions Linear Programming

Relationship between chronic rhinosinusitis and lower airway diseases: An extensive review

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World Journal of Otorhinolaryngology 2015年第2期5卷 44-52页

作者： Shin Kariya Mitsuhiro Okano Kazunori nishizaki Department of Otolaryngology-Head and Neck Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Signifcant links between allergic rhinitis and asthma have been reported, and the united airway disease hypothesis is supported by numerous findings in epidemiologic, physiologic, pathologic, and immunologic studies. The impact of allergic rhinitis on asthma has been esta-blished. On the other hand, the relationship between chronic rhinosinusitis and lung diseases has been under investigation. Chronic rhinosinusitis is a common disease, and the high prevalence of chronic rhinosinusitis in some kinds of lung diseases has been reported. Recent studies suggest that the treatment of chronic rhinosinusitis has beneficial effects in the management of asthma. Here, we present an overview of the current research on the relationship between chronic rhinosinusitis and lower airway diseases including asthma, chronic obstructive pul-monary disease, cystic fibrosis, diffuse panbronchiolitis, primary ciliary dyskinesia, idiopathic bronchiectasis, and allergic bronchopulmonary aspergillosis.

关键词： Chronic rhinosinusitis Sinusitis Asthma Chronic obstructive pulmonary disease Cystic fbrosis Diffuse panbronchiolitis Primary ciliary dyskinesia Idiopathic bronchiectasis Allergic bronchopulmonary aspergillosis

A Two-Level Purchase Problem for Food Retailing in Japan

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American Journal of Operations Research 2012年第4期2卷 482-494页

作者： Masatoshi Sakawa Ichiro nishizaki Takeshi Matsui Tomohiro Hayashida Faculty of Engineering Hiroshima University Higashi-Hiroshima Japan

In this paper, we deal with a purchase problem for food retailing, and formulate a two-level linear programming problem with a food retailer and a distributer. The food retailer deals with vegetables and fruits which are purchased from the distributer;the distributer buys vegetables and fruits ordered from the food retailer at the central wholesale markets in several cities, and transports them by truck from each of the central wholesaler markets to the food retailer’s storehouse. We solve the two-level linear programming problem in which the profits of the food retailer and the distributer are maximized.

关键词： Purchase Problem Food Retailing Stackelberg Solution Two-Level Linear Programming Problem

Cooperative Particle Swarm Optimization in Distance-Based Clustered Groups

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Journal of Software Engineering and Applications 2017年第2期10卷 143-158页

作者： Tomohiro Hayashida Ichiro nishizaki Shinya Sekizaki Shunsuke Koto Faculty of Engineering Hiroshima University Hiroshima Japan

TCPSO (Two-swarm Cooperative Particle Swarm Optimization) has been proposed by Sun and Li in 2014. TCPSO divides the swarms into two groups with different migration rules, and it has higher performance for high-dimensional nonlinear optimization problems than traditional PSO and other modified method of PSO. This paper proposes a particle swarm optimization by modifying TCPSO to avoid inappropriate convergence onto local optima. The quite feature of the proposed method is that two kinds of subpopulations constructed based on the scheme of TCPSO are divided into some clusters based on distance measure, k-means clustering method, to maintain both diversity and centralization of search process are maintained. This paper conducts numerical experiments using several types of functions, and the experimental results indicate that the proposed method has higher performance than the TCPSO for large-scale optimization problems.

关键词： Particle Swarm Optimization Different Migration Rules Clustering

Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C

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World Journal of Gastroenterology 2004年第5期10卷 733-736页

作者： Kaori Mochizuki Tatehiro Kagawa Shinji Takashimizu Kazuya Kawazoe Sei-Ichiro Kojima Naruhiko Nagata Atsushi Nakano Yasuhiro nishizaki Koichi Shiraishi Masaru Itakura Norihito Watanabe Tetsuya Mine Shohei Matsuzaki Department of Internal Medicine Division of GastroenterologyTokai University School of MedicineBohseidaiIsehara 259-1193Japan

AIM:To test whether in vitro incubation of peripheral blood mononuclear cells (PBMC) with interferon (IFN) could efficiently decrease hepatitis C virus-RNA (HCV-RNA) amount and to analyze whether this effect was associated with clinical response to ***:Twenty-seven patients with histologically proven chronic hepatitis C were given intravenous administration of 6 million units (MU) IFN-β daily for 6 weeks followed by three times weekly for 20 weeks. PBMC collected before IFN therapy were incubated with IFN-β and HCV-RNA in PMBC was semi-quantitatively ***: Twenty-five patients completed IFN *** patients (32%) had sustained loss of serum HCV-RNA with normal serum ALT levels after IFN therapy (complete responders).HCV-RNA in PBMC was detected in all patients,whereas it was not detected in PBMC from healthy *** vitro administration of IFN-β decreased the amount of HCV-RNA in PMBC in 18 patients (72%). Eight of these patients obtained complete response. On the other hand,none of the patients whose HCV-RNA in PBMC did not decrease by IFN-β was complete responders. Multiple logistic regression analysis revealed that the decrease of HCV-RNA amount in PBMC by IFN-β was the only independent predictor for complete response (P<0.05).CONCLUSION:The effect of in vitro IFN-β on HCV in PBMC reflects clinical response and would be taken into account as a predictive marker of IFN therapy for chronic hepatitis C.

关键词： Adult Antiviral Agents dosage Drug Resistance, Viral Female Hepacivirus Hepatitis C, Chronic Humans In Vitro Interferon-beta Leukocytes, Mononuclear Male Middle Aged Predictive Value of Tests RNA, Viral

Evaluation and Advice System for Improving the Manner of Speaking in Lectures Using Features of Filled Pauses

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Evaluation and Advice System for Improving the Manner of Spe...