检索结果-南通市图书馆

Precise Orientational Control of Electroactive Units Using a Tripodal Triptycene Scaffold to Direct Noncovalent Pairing at the Single Molecular Level

引用

Precision Chemistry 2023年第6期1卷 388-394页

作者： Colin J.Martin tomoya fukui Ryosuke Takehara Shintaro Fujii Takanori Fukushima Laboratory for Chemistry and Life Science Institute of Innovative ResearchTokyo Institute of TechnologyYokohama 226-8503Japan Department of Chemistry School of ScienceTokyo Institute of TechnologyTokyo 152-8551Japan

A break junction technique has been established to explore conductive behavior at the single molecular level,and recent interest has shifted toward the evaluation of bimolecular systems interacting through noncovalent intermolecular *** requires precise control over the orientation of the two molecules so that they can adapt an appropriate face-to-face arrangement between two ***,we present an approach using a tripodal triptycene scaffold that allows for accurate positioning of electroactive subunits with an upright configuration on substrate *** incorporated electron-donating tetrathiafulvalene or electron-accepting anthraquinone into the molecular scaffold and confirmed that the resulting molecules retain the electronic properties particular to their attached ***-assembled monolayers(SAMs)of these molecules were prepared on Au(111)and characterized by XPS and *** break junction techniques were applied to the SAMs,revealing two electrical conduction regimes;one arises from single-molecules sandwiched between two electrodes,and the second from intermolecularly interacting homodimers that bridge between *** observation demonstrates the validity of the approach of using tripodal triptycene scaffolds to precisely direct electroactive subunits to undergo intermolecular *** believe that the present work will provide a new avenue for evaluating the heterodimers at the single molecular level.

关键词： STM break junction self-assembled monolayers supramolecular scaffold noncovalent interactions triptycene

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deep belief network-hidden Markov model based nonlinear equalizer for VCSEL based optical interconnect

引用

Science China(Information Sciences) 2020年第6期63卷 155-163页

作者： fukui TIAN Chuanchuan YANG State Key Laboratory of Advanced Optical Communication Systems and Networks School of Electronics Engineering and Computer Science Peking University

The data center has developed rapidly over the past few years, leading to the demand for high speed data transmission. Vertical cavity surface emitting lasers(VCSELs) based optical interconnect is evolving to 100 Gb/s and beyond, which makes nonlinear distortions difficult to be compensated or equalized by conventional equalizers. Moreover, the challenge becomes very complicated for conventional equalizers because of the presence of inter-symbol interference(ISI) together with the nonlinear distortions. So many neural network based DSP algorithms such as artificial neural network(ANN) have been proposed to mitigate the distortions. However, ANN has the limitations that sample's relevant information is not considered,leading to degradation in ANN's performance and high computational complexity. In this paper, in order to maintain an excellent capability of mitigating nonlinear distortions like other neural network based equalizers while considering the sample's relevant information to reduce the computational complexity, we propose a deep belief network-hidden Markov model(DBN-HMM) based nonlinear equalizer which is tested in a PAM-4 modulated VCSEL and multimode fiber(MMF) optical interconnect link experimentally. The BER performance can be greatly improved compared with conventional DSP algorithms. In addition, the computational complexity of DBN-HMM based equalizer can be about 41% lower than that of ANN based method with a similar BER performance.

关键词： short-range optical interconnect vertical cavity surface emitting laser(VCSEL) nonlinear equalizer deep belief network(DBN) hidden Markov model(HMM)

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Do vasopressin V2 receptor antagonists benefit cirrhotics with refractory ascites?

引用

World Journal of Gastroenterology 2015年第41期21卷 11584-11596页

作者： Hiroshi fukui Department of Gastroenterology Endocrinology and Metabolism Nara Medical University

Hyponatremia is a frequent complication of advanced cirrhosis with ascites associated with increased morbidity and mortality. It is caused by an impairment in the renal capacity to eliminate solute-free water and is considered to be related to persistent secretionof vasopressin despite low serum osmolality. This nonosmotic release of vasopressin is mediated by the autonomic nervous system, which senses the underfilling of arterial vascular component. This reduction of effective arterial blood volume is closely related to the development of ascites. Although the short-time effects of vasopressin V2 receptor antagonists(vaptans) on hyponatremia and ascites have been repeatedly reported, their effects on the long-term management of cirrhotic ascites have not been established yet. Considering that their effects on water diuresis and their safety are limited by severe underfilling state of patients, cautious approaches with adequate monitoring are needed to advanced cirrhosis. Proper indication, adequate doses and new possibility of combination therapy should be explored in the future controlled study. As hyponatremia is frequent obstacle to ascites management, judicious combination with low-dose diuretics may decrease the incidence of refractory ascites. Although vaptans show much promise in the treatment of advanced cirrhosis, the problem of high cost should be solved for the future.

关键词： Liver cirrhosis Ascites Hyponatremia Pathophysiolo

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantifying the impacts of the COVID-19 pandemic lockdown and the armed conflict with Russia on Sentinel 5P TROPOMI NO_(2)changes in Ukraine

引用

Big Earth Data 2024年第1期8卷 58-81页

作者： Anh Phan Hiromichi fukui Graduate School of Engineering Chubu UniversityKasugaiJapan Chubu Institute for Advanced Studies and International Digital Earth Applied Science Research Center(IDEAS) Chubu UniversityKasugaiJapan

This study investigated variations in nitrogen dioxide(NO_(2))levels in Ukraine during two significant periods:the COVID-19 pandemic lockdown in 2020 and the armed conflict with Russia in *** and reprocessed Sentinel 5P data products were utilized for the analysis.A machine learning model was employed to generate a business-as-usual NO_(2)time series that accounted for meteorological *** the nine most populous cities in Ukraine,during the lockdown in 2020 we observed a moderation of increases in NO_(2)levels during the lockdown compared to the pre-lockdown *** at the same months during the conflict period in 2022,we identified much more significant reductions in NO_(2)level in these cities,averaging 12.1%for original and 18.1%for reprocessed *** our examination of major urban areas,we observed reductions in NO_(2)levels in areas surrounding coal power plants damaged or destroyed by the *** the major urban areas in Ukraine,we conclude that changes in daily anthropogenic activities due to the conflict-related events had more substantial impacts on NO_(2)levels than did COVID-19 lockdown.

关键词： NO_(2) COVID-19 Russia-Ukraine armed conflict weather-normalization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of water saturation and loading rate on direct shear tests of andesite

引用

Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 653-662页

作者： Tianshu Bao Kimihiro Hashiba Katsunori fukui Department of Systems Innovation The University of TokyoTokyo113-8656Japan

For estimating the long-term stability of underground framework,it is vital to learn the mechanical and rheological characteristics of rock in multiple water saturation ***,the majority of previous studies explored the rheological properties of rock in air-dried and water saturated conditions,as well as the water effects on compressive and tensile *** this study,andesite was subjected to direct shear tests under five water saturation conditions,which were controlled by varying the wetting and drying *** tests were conducted at alternating displacement rates under three vertical *** results reveal that the shear strength decreases exponentially as water saturation increases,and that the increase in shear strength with a tenfold increase in displacement rate is nearly constant for each of the vertical *** on the findings of the shear tests in this study and the compression and tension tests in previous studies,the influences of both water saturation and loading rate on the Hoek-Brown failure criterion for the andesite was *** results indicate that the brittleness index of the andesite,which is defined as the ratio of uniaxial compressive strength to tensile strength,is independent of both water saturation and loading rate and that the influences of the water saturation dependence and the loading rate dependence of the failure criterion can be converted between each other.

关键词： Direct shear test Water saturation Loading rate dependence Failure criterion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On improving strigolactone mimics for induction of suicidal germination of the root parasitic plant Striga hermonthica

引用

aBIOTECH 2021年第1期2卷 1-13页

作者： Ikuo Takahashi Kosuke fukui Tadao Asami Graduate School of Agricultural and Life Sciences The University of TokyoTokyo 113-8657Japan

Strigolactones(SLs)are plant hormones that regulate the branching of plants and seed germination stimulants of root parasitic *** root parasites are a great threat to agricultural production,the use of SL agonists could be anticipated to provide an efficient method for regulating root parasites as suicidal germination inducers.A series of phenoxyfuranone-type SL mimics,termed debranones,has been reported to show potent bioactivities,including reduction of the tiller number on rice,and stimulation of seed germination in the root parasite Striga *** exert both activities,two substituents on the phenyl ring of the molecules were important but at least a substituent at the 2-position must be an electron-withdrawing ***,little is known about the effect of the properties of the substituents at the 2-position on ***,we found that different substituents at the 2-position give different preferences for *** debranones were more effective than the others and SL agonist GR24 for inhibiting rice tiller but far less effective in the induction of *** ***,nitrile and methyl derivatives clearly stimulated the germination of *** *** their IC_(50) values were 100 times higher than that of GR24 in the receptor competitive binding assay,their physiological activities were approximately 1/10 of *** differences could be due to their uptake in plants and/or their physicochemical stability under our experimental *** findings could support the design of more potent and selective SL agonists that could contribute to solving big agricultural issues.

关键词： Agonist Rice Root parasitic weed Seed germination Strigolactone Tillering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Selective Mimics of Strigolactone Actions and Their Potential Use for Controlling Damage Caused by Root Parasitic Weeds

引用

Molecular Plant 2013年第1期6卷 88-99页

作者： Kosuke fukui Shinsaku Ito Tadao Asami Graduate School of Agricultural and Life Sciences University of Tokyo 1-1-1 Yayoi Bunkyo Tokyo Japan 113-8657 JST CREST 1-1-1 Yayoi Bunkyo Tokyo Japan 113-8657

Strigolactones （SLs） are a novel class of plant hormones and rhizosphere communication signals, although the molecular mechanisms underlying their activities have not yet been fully determined. Nor is their application in agriculture well developed. The importance of plant hormone agonists has been demonstrated in both basic and applied research, and chemicals that mimic strigolactone functions should greatly facilitate strigolactone research. Here, we report our discovery of a new phenoxyfuranone compound, 4-Br debranone （4BD）, that shows similar activity to that of the major strigolactone （SL） analog GR24 in many aspects of a biological assay on plants. 4BD strongly inhibited tiller bud outgrowth in the SL-deficient rice mutant d10 at the same concentration as GR24, with no adverse effects, even dur- ing prolonged cultivation. This result was also observed in the Arabidopsis thaliana SL-deficient mutants max1, max3, and max4. However, the application of 4BD to the Arabidopsis SL-insensitive mutant max2 induced no morphological changes in it. The expression of SL biosynthetic genes was also reduced by 4BD treatment, probably via negative feed- back regulation. However, in a seed germination assay on Striga hermonthica, a root parasitic plant, 4BD showed far less activity than GR24. These results suggest that 4BD is the first plant-specific strigolactone mimic.

关键词： strigolactones plant growth regulator Arabidopsis rice debranone branching tillering.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CONSERVATION LAWS IN FINITE MICROCRACKING BRITTLE SOLIDS

引用

Acta Mechanica Solida Sinica 2005年第3期18卷 189-199页

作者： Wang Defa Chen Yiheng fukui Takuo Department of Civil Engineering Xi＇an University of Technology Xi＇an 710048 China Department of Engineering Mechanics Xi＇an Jiaotong University Xi＇an 710049 China Department of Architecture and Civil Engineering Fukui University Fukui 910-8507 Japan

This paper addresses the conservation laws in finite brittle solids with microcracks. The discussion is limited to the 2-D cases. First, after considering the combination of the Pseudo-Traction Method and the indirect Boundary Element Method, a versatile method for solving multi-crack interacting problems in finite plane solids is proposed, by which the fracture parameters （SIF and path-independent integrals） can be calculated with a desirable accuracy. Second, with the aid of the method proposed, the roles the conservation laws play in the fracture analysis for finite microcracking solids are studied. It is concluded that the conservation laws do play important roles in not only the fracture analysis but also the analysis of damage and stability for the finite microcracking system. Finally, the physical interpretation of the M-integral is discussed further. An explicit relation between the M-integral and the crack face area, i.e., M = GS, has been discovered using the analytical method, which can shed some light on the Damage Mechanics issues from a different perspective.

关键词： conservation laws finite microcracking solids pseudo-traction method boundary element method stress intensity factors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gut-liver axis in liver cirrhosis: How to manage leaky gut and endotoxemia

引用

World Journal of Hepatology 2015年第3期7卷 425-442页

作者： Hiroshi fukui Department of Gastroenterology and Metabolism Nara Medical University

A "leaky gut" may be the cutting edge for the passage of toxins, antigens or bacteria into the body, and may play a pathogenic role in advanced liver cirrhosis and its complications. Plasma endotoxin levels have been admitted as a surrogate marker of bacterial translocation and close relations of endotoxemia to hyperdynamic circulation, portal hypertension, renal, cardiac, pulmonary and coagulation disturbances have been reported. Bacterial overgrowth, increased intestinal permeability, failure to inactivate endotoxin,activated innate immunity are all likely to play a role in the pathological states of bacterial translocation. Therapeutic approach by management of the gut-liver axis by antibiotics, probiotics, synbiotics, prebiotics and their combinations may improve the clinical course of cirrhotic patients. Special concern should be paid on anti-endotoxin treatment. Adequate management of the gut-liver axis may be effective for prevention of liver cirrhosis itself by inhibiting the progression of fibrosis.

关键词： Gut-liver axis Liver cirrhosis Pathogenesis Complications Endotoxemia Bacterial translocation Leaky gut Toll-like receptors Selective intestinal decontamination Probiotics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

DYNAMICS OF LOCALIZED TRAVELING WAVE CONVECTION IN BINARY FLUID MIXTURE

引用

Journal of Hydrodynamics 1998年第2期10卷 29-39页

作者： Ning Li-zhongDepartment of Applied Physics, Fakulty of Engineering, fukui University, Bunkyo 3-9-1,fukui 910, JapanYoshifumi HaradaDepartment of Applied Physics, Fakulty of Engineering, fukui University, Bunkyo 3-9-1,fukui 910, JapanHideo YahataDepartment fukui Univ Fukui Japan

The dynamical behavior of a localized traveling wave (LTW) in a binary fluid layer heated from below confined in a rectangular cell with the intermediate aspect ratio Γ=12 and the separation ratio ψ=-0. 11 is studied by using the two-dimensional numerical simulation of the full hydrodynamic equations. We find that a counterpropa-gating wave (CPW) occurs at the onset of convection and is modulated in space-time. The modulated traveling wave (MTW) plays an important role in the transition to the LTW state, and the LTW state depends on the fluid parameters and exists in a narrow interval of the reduced Rayleigh number. The transition from LTW to an extended traveling wave (ETW) or stationary overturning convection (SOC) state occurs when r exceeds a certain critical value. Our results agree with those observed in experiments.

关键词： convection localized traveling wave,binary fluid mixture simulation nonlinear.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：