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Therapeutic efficacy of ramucirumab after lenvatinib for post-progression treatment of unresectable hepatocellular carcinoma

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Gastroenterology Report 2021年第2期9卷 133-138,I0002页

作者： Atsushi Hiraoka Takashi Kumada Toshifumi Tada Chikara Ogawa Joji Tani Shinya Fukunishi Masanori Atsukawa Masashi Hirooka Kunihiko Tsuji Toru Ishikawa Koichi Takaguchi Kazuya Kariyama Ei Itobayashi Kazuto Tajiri Noritomo Shimada Hiroshi shibata Hironori Ochi Kazuhito Kawata Hidenori Toyoda Hideko Ohama Kazuhiro Nouso Akemi Tsutsui Takuya Nagano Norio Itokawa Korenobu Hayama Taeang Arai Michitaka Imai Yohei Koizumi Shinichiro Nakamura Kojiro Michitaka Yoichi Hiasa Masatoshi Kudo Gastroenterology Center Ehime Prefectural Central HospitalEhimeJapan Department of Gastroenterology and Hepatology Ogaki Municipal HospitalGifuJapan Department of Internal Medicine Himeji Red Cross HospitalHyogoJapan Department of Gastroenterology and Hepatology Takamatsu Red Cross HospitalTakamatsuJapan Department of Gastroenterology and Hepatology Kagawa universityKagawaJapan Department of Gastroenterology Osaka Medical CollegeOsakaJapan Division of Gastroenterology and Hepatology Department of Internal MedicineNippon Medical SchoolTokyoJapan Department of Gastroenterology and Metabology Ehime University Graduate School of MedicineEhimeJapan Center of Gastroenterology Teine Keijinkai HospitalSapporoJapan Department of Gastroenterology Saiseikai Niigata HospitalNiigataJapan Department of Hepatology Kagawa Prefectural Central HospitalTakamatsuJapan Department of Gastroenterology Okayama City HospitalOkayamaJapan Department of Gastroenterology Asahi General HospitalAsahiJapan Department of Gastroenterology Toyama University HospitalToyamaJapan Division of Gastroenterology and Hepatology Otakanomori HospitalKashiwaJapan Department of Gastroenterology Tokushima Prefectural Central HospitalTokushimaJapan Hepato-biliary Center Matsuyama Red Cross HospitalMatsuyamaJapan Department of Hepatology Hamamatsu University School of MedicineHamamatsuJapan Department of Gastroenterology Kindai UniversityOsakaJapan

Background:Lenvatinib is used for unresectable hepatocellular carcinoma(u-HCC)as first-line,as well as second-and third-line therapy in *** evaluated the therapeutic efficacy of newly developed ramucirumab when given after lenvatinib for post-progression ***:Of 385 patients with u-HCC and treated with lenvatinib at 16 different institutions in Japan between May 2018 and January 2020,28 who received ramucirumab as the next treatment were enrolled and therapeutic responses were evaluated in a retrospective ***:The median age of the 28 patients given ramucirumab was 70 years and the median albumin-bilirubin score *** the 28 patients,23 were male,21 were classified as Child-Pugh A and 7 as Child-Pugh B,and 25 were Barcelona Clinic Liver Cancer Stage *** was given as second-line therapy in 14,third-line in 9,and fourth-line in *** response was obtained in only 26 patients;the objective response rate was 3.8%(1/26)and the disease-control rate was 42.3%(11/26),with a median period to progression of 2.0 *** reasons for discontinuation of ramucirumab were progression of disease in 16 and Grade 3 adverse events(gastrointestinal bleeding,ascites)in ***:The anticipated therapeutic efficacy of ramucirumab for post-progression treatment following lenvatinib was not seen in our early experience.

关键词： hepatocellular carcinoma ramucirumab lenvatinib sorafenib

Prevalence of Chronic Pain, Especially Headache, and Relationship with Health-Related Quality of Life in Middle-Aged Japanese Residents

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Health 2016年第1期8卷 116-124页

作者： Junko Mitoma Masami Kitaoka Hiroki Asakura Enoch Olando Anyenda Daisuke Hori Nguyen Thi Thu Tao Toshio Hamagishi Koichiro Hayashi Fumihiko Suzuki Yukari Shimizu Hiromasa Tsujiguchi Yasuhiro Kambayashi Yuri Hibino Tadashi Konoshita Takiko Sagara Aki shibata Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Science Kanazawa University Ishikawa Japan Third Department of Internal Medicine Fukui University School of Medicine Fukui Japan

The aim of this study was to evaluate the prevalence of chronic pain (CP) and the relationship between CP, especially headache adjusted for CP at other sites, and health-related quality of life (HRQoL) in middle-aged Japanese residents. We examined the prevalence of CP (defined as pain persisting for 3 months or more) and HRQoL (SF-36) in 1117 middle-aged residents of Japan. We assessed the eight dimensions of health status and the 3 component SF-36 summary score to evaluate HRQoL. The prevalence of CP was 15.3% among men and 15.1% among women. Multiple linear regression analysis demonstrated that lumbar pain (p β = -0.132), knee pain (p β = -0.115), foot pain (p = 0.042, β = -0.065), and age (p β = -0.154) were independently correlated with a lower physical component score (PCS). Older age (ppβ = -0.096), knee pain (p β = -0.109), upper limb pain (p β = -0.098), and lumbar pain (p = 0.022, β = -0.077) all showed a significant negative correlation with MCS. The presence of chronic headache (p = 0.011, β = -0.082) was the only factor significantly correlated with a lower role component score (RCS). We identified a negative correlation between chronic headache and RCS, unlike the relation between musculoskeletal pain and PCS or MCS, suggesting that RCS was an independently influenced by CP differently from PCS or MCS in Japanese residents.

关键词： Quality of Life Chronic Pain Headache SF-36 Pain

HIV-1包膜蛋白V2区突变对V3区特异的中和抗体的影响

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中华微生物学和免疫学杂志 2011年第7期31卷 613-617页

作者：刘沐桑松下修三柴田润二刘维达中国医学科学院北京协和医学院皮肤病研究所南京210042 日本熊本大学艾滋病中心

目的研究HIV－1包膜蛋白、吃区突变对V3区特异中和抗体与HIV－1中和作用的影响。方法使用假病毒中和试验测定L175P突变对于V3区中和抗体对HIV-1中和能力的影响，ELISA方法测定上述中和抗体对gp120蛋白单体的结合力。结果V2区突变L175P... 详细信息

目的研究HIV－1包膜蛋白、吃区突变对V3区特异中和抗体与HIV－1中和作用的影响。方法使用假病毒中和试验测定L175P突变对于V3区中和抗体对HIV-1中和能力的影响，ELISA方法测定上述中和抗体对gp120蛋白单体的结合力。结果V2区突变L175P可以改变多个V3区特异性中和抗体对病毒的中和能力，但这些中和抗体对gp120蛋白单体的结合力不因V2区突变而改变。结论V2区的L175P突变改变了gp120蛋白天然三聚体的结构，促进了V3区抗体的中和能力。

关键词： HIV V2区 V3区突变中和抗体

HB型步进电动机一体式分割型阻尼减振方式的提案

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微特电机 1994年第4期22卷 2-5页

作者：程树康郑萍寇宝泉柴田岩夫哈尔滨工业大学哈尔滨150001 千叶工业大学

结合HB型步进电动机的结构特点提出一种一体式分割型阻尼方式。定性分析了这种方式的原理,并在具体样机上实施,进行了实验研究,说明这种方式的有效性。

关键词：步进电动机一体式分割型电机

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柴田文江:从生活中的那道光开始

艺术与设计 2022年第2期11卷 114-117页

作者：吉丽柴田文江(图) 不详

我喜欢亲手创造的感觉,手工艺和创造力是我成长过程的一部分,也是我的热爱,能让我沉迷其中无法自拔。--柴田文江柴田文江,日本知名女性设计师,毕业于武藏野艺术学院,被称为“经久不衰的设计师”。2021年底,柴田文江凭借Bonbori系列灯具... 详细信息

我喜欢亲手创造的感觉,手工艺和创造力是我成长过程的一部分,也是我的热爱,能让我沉迷其中无法自拔。--柴田文江柴田文江,日本知名女性设计师,毕业于武藏野艺术学院,被称为“经久不衰的设计师”。2021年底,柴田文江凭借Bonbori系列灯具获得了2021EDIDA(ELLE DECORATION INTERNATIONAL DESIGN AWARDS)设计大奖灯具设计类金奖,温柔的灯光从波点状的玻璃凹面里透出来,给生活带来仪式感。

关键词：仪式感灯具设计无法自拔武藏野女性设计师手工艺创造力

Recycling of Sludge From Chemical-Mechanical Polishing （CMP） Waste Water Treatment

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Recycling of Sludge From Chemical-Mechanical Polishing （CMP...

Mineralogy of individual dust particles in the free troposphere and near the ground in Dunhuang, China

第八届东亚资源再生技术国际会议

作者： E.shibata M.Maeda T.Nakamura H.Umezawa M.Iseki D.Takaoka M.Yasuda M.Tsuihiji K.Hara Institute of Multidisciplinary Research for Advanced Materials Tohoku University 11 Katahira 2-Chome AobakuSendai 980-8577 Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University 11 Katahira 2-Chome AobakuSendai 980-8577 Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University 11 Katahira 2-Chome AobakuSendai 980-8577 Japan SANYO ELECTRIC Co. Ltd. 1-1-1 Sakata Oizumi-Machi Ora-Gun Gunma 370-0596 Japan SANYO ELECTRIC Co. Ltd. 1-1-1 Sakata Oizumi-Machi Ora-Gun Gunma 370-0596 Japan SANYO ELECTRIC Co. Ltd. 1-1-1 Sakata Oizumi-Machi Ora-Gun Gunma 370-0596 Japan SANYO ELECTRIC Co. Ltd. 1-1-1 Sakata Oizumi-Machi Ora-Gun Gunma 370-0596 Japan SANYO Aqua Technology Co. Ltd. 1-1-1 Sakata Oizumi-Machi Ora-Gun Gunma 370-0596 Japan SANYO Aqua Technology Co. Ltd. 1-1-1 Sakata Oizumi-Machi Ora-Gun Gunma 370-0596 Japan

＜正＞In order to obtain the basic knowledge needed for an efficient flat membrane filtration system for the wastewater from chemical-mechanical polishing （CMP）, we have investigated the formation mechanisms of silica gel from a colloidal silica slurry using a membrane filtration system. And besides, for recycling the wet silica gel as a fine silica powder, the experimentally formed wet silica gel was heat-dried and also freeze -dried, and then the micromorphology, specific surface area and pore size distribution of the obtained powders were investigated. The basic mechanisms of slurry filtration, including the effects of vacuum pressure and slurry volume, can be explained by Darcy’s Law. The freeze-dried gel sample was transformed to a fine powder, however the heat-dried one became a sintered solid. Our results indicate that, in the plant, the recovered wet silica gel can be recycled as a fine silica powder by a freeze-dry treatment. The specific surface area and the pore size distribution of the powders were significantly affected by the slurry pH.

关键词： CMP slurry Flat membrane filtration Silica gel Freeze-dry

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Mineralogy of individual dust particles in the free troposph...

Fighting neglected infectious diseases:Medicinal Structure Genomics of Pathogenic Protozoa

第三届国际沙尘暴与降尘天气专题学术研讨会

作者： D. Trochkine Y. Iwasaka A. Matsuki M.Yamada Y.-S. Kim T. Nagatani T. shibata M. Nagatani H. Nakata Kanazawa University Institute of Nature and Environmental Technology Institute for Water and Environmental Problem Siberian Branch Russian Academy of Science Russia Kanazawa University Institute of Nature and Environmental Technology Kanazawa University Institute of Nature and Environmental Technology Kanazawa University Institute of Nature and Environmental Technology Kanazawa University Institute of Nature and Environmental Technology Nagoya University Graduate School of Environmental Studies Nagoya University Graduate School of Environmental Studies Solar-Terrestrial Environment Laboratory Nagoya University Toyokawa Japan Solar-Terrestrial Environment Laboratory Nagoya University Toyokawa Japan

＜正＞ Knowing of chemical composition of the individual dust particles in the atmosphere near their source is very important due to the different behavior of various kinds of particles during the long-range transport...

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Fighting neglected infectious diseases:Medicinal Structure G...

中国化学会第二十五届学术年会

作者： Tracy Arakaki Erica Boni Juergen Bosch Fred Buckner Wim Hol Ethan Merritt Natascha Mueller Alberto J Napuli Jenni Ross Sayaka shibata Wesley Van Voorhis Christophe Verlinde Frank Zucker Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA Department of Biochemistry University of Washington Seattle WA 98195 USA

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新型汽油机双喷嘴系统喷雾概念的开发

汽车与新动力 2019年第1期2卷 50-54页

作者： [日]H.shibata T.Mizobuchi M.Iwamuro A.Koda H.Omura 武涛(译) 不详

为了应对全球环境和能源安全问题,汽油直接喷射(GDI)系统是主要发展热点。与此同时,深入开发多点燃油气道喷射系统(MPI),使这种简单可靠的燃烧系统能适应全球油品是非常重要的。在新兴国家的汽车市场,特别是A级和B级车有一定的MPI发动... 详细信息

为了应对全球环境和能源安全问题,汽油直接喷射(GDI)系统是主要发展热点。与此同时,深入开发多点燃油气道喷射系统(MPI),使这种简单可靠的燃烧系统能适应全球油品是非常重要的。在新兴国家的汽车市场,特别是A级和B级车有一定的MPI发动机需求。重点研究了MPI系统开发的关键技术,即在低温条件下减少燃油湿壁,以及在大负荷工况下通过燃油气化最大限度地降低混合气的温度(防止爆燃)。提出了一种新MPI双喷嘴系统,不仅保留了MPI系统均质混合气的优点,而且增加了直接进入燃烧室的喷雾数量,从而获得了类似GDI的部分优点。这种MPI双喷嘴系统需要有更好的雾化效果和进气气流的稳定性。开发了独特的雾化技术并优化了喷雾形态,以此改善了雾化效果和相对进气气流的稳定性,实现了开阀喷射的收益。

关键词：双喷系统多点喷射汽油机燃油喷射系统颗粒排放