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Maintenance treatment with infliximab for ulcerative ileitis after intestinal transplantation: A case report

World Journal of Clinical Cases 2021年第19期9卷 5270-5279页

作者： Takumi Fujimura Yohei Yamada tomoshige umeyama Yumi Kudo Hiroki Kanamori Teizaburo Mori Takahiro Shimizu Mototoshi Kato Miho Kawaida Naoki Hosoe Yasushi Hasegawa Kentaro Matsubara Naoki Shimojima Masahiro Shinoda Hideaki Obara Makoto Naganuma Yuko Kitagawa Ken Hoshino Tatsuo Kuroda Department of Pediatric Surgery National Saitama HospitalWako ShiSaitama 351-0102Japan Department of Pediatric Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Pathology Keio University School of MedicineTokyo 160-8582Japan Center for Diagnostic and Therapeutic Endoscopy Keio University School ofMedicineTokyo 160-8582Japan Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Digestive Diseases Center International University of Health and WelfareMita HospitalTokyo 108-8329Japan Department of Gastroenterology and Hepatology Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Evidence has been published on the successful applications of the anti-tumor necrosis factor alpha antibody infliximab,such as induction therapy,salvage treatment for acute cellular rejection,and treatment for chronic ulcerative inflammation,in intestinal transplant ***,the optimal protocol for the effective use of infliximab remains largely undetermined due to scarcity of available clinical *** report a continuative application of infliximab as maintenance therapy for recurrent chronic ulcerative ileitis in a recipient of isolated intestinal transplantation(ITx).CASE SUMMARY The patient was a 11-year-old boy with intestinal motility disorder classified as a hypogenic type of intestinal *** patient underwent living-donor related intestinal *** immunosuppression regimen consisted of daclizumab,tacrolimus,and *** he did not show rejection while on tacrolimus monotherapy,routine screening endoscopy showed several ulcerative lesions in the distal end of the graft 2 years after the intestinal *** work up to evaluate the progression of anemia revealed stenosis with ulcerative inflammatory changes and multiple longitudinal ulcers in the *** the endoscopic findings suggested ulcerative lesions in Crohn’s disease,infliximab treatment was *** with infliximab and a small dose of oral prednisolone afforded successful withdrawal of total parenteral nutrition and maintenance of a well-functioning graft without infectious complications for 5 years since the administration of the first dose of *** Infliximab is effective as maintenance therapy for recurrent chronic ulcerative ileitis in an isolated ITx patient.

关键词： Intestinal transplantation Chronic ulcer Infliximab Crohn’s disease Tumor necrosis factor alpha Case report

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Microstructural characterization of silicon carbide reinforced dissimilar grade aluminium explosive clads

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Defence Technology（防务技术） 2020年第3期16卷 689-694页

作者： S.Saravanan H.Inokawa R.tomoshige K.Raghukandan Research Centre for Advances in Impact Engineering Sojo UniversityKumamotoJapan Department of Mechanical Engineering Annamalai UniversityTamilnaduIndia Department of Nanoscience Sojo UniversityKumamotoJapan Department of Manufacturing Engineering Annamalai UniversityTamilnaduIndia

Aluminium composites are inevitable in ship building,commercial and defence aircrafts construction due to their light weight,high strength to weight ratio,admirable properties and cost *** this study,the microstructural characteristics of explosive cladded dissimilar grade aluminium(Al 1100-Al 5052) clad composites reinforced with silicon carbide(SiC) particles is *** taken at the interface by optical and scanning electron microscopes(SEM) revealed the formation of a silicon carbide layer between the dissimilar grade aluminium *** reaction layers were witnessed at few locations along the interface,the diffusion of atoms between the participant metals is not visible as confirmed by energy dispersive spectroscopy,elemental mapping,line analysis and X-ray diffraction(XRD).The variation in microhardness at various regions of the silicon carbide reinforced dissimilar aluminium explosive clad is *** increase in tensile strength of the SiC laced clad is also presented.

关键词： Explosive cladding Aluminium Silicon carbide Microstructure Elemental mapping Hardness

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Risk factors for bleeding after endoscopic mucosal resection

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World Journal of Gastroenterology 2005年第46期11卷 7335-7339页

作者： Masatsugu Shiba Kazuhide Higuchi Kaori Kadouchi Ai Montani Kazuki Yamamori Hirotoshi Okazaki Makiko Taguchi Tomoko Wada Atsushi Itani Toshio Watanabe Kazunari Tominaga Yoshihiro Fujiwara tomoshige Hayashi Kei Tsumura Tetsuo Arakawa Department of GastroenterologyOsaka City University Medical School OsakaJapan Department of GastroenterologyOsaka City University Medical School OsakaJapan Department of Preventive Medicine and Environmental HealthOsaka City University Medical SchoolOsakaJapan Department of GastroenterologyOsaka City University Medical School OsakaJapan Department of CardiologyOsaka City University Medical SchoolOsakaJapan

AIM: To clarify the risk factors for bleeding after endoscopic mucosal resection (EMR).METHODS: A total of 297 consecutive patients who underwent EMR were enrolled. Some of the patients had multiple lesions. Bleeding requiring endoscopic treatment was defined as bleeding after EMR. Odds ratios (OR) with 95% confidence intervals (CI), calculated by logistic regression with multivariate adjustments for covariates,were the measures of ***: Of the 297 patients, 57 (19.2%) patients with bleeding after EMR were confirmed. With multivariate adjustment, the cutting method of ENR, diameter, and endoscopic pattern of the tumor were associated with the risk of bleeding after ENR. The multivariate-adjusted OR for bleeding after EMR using endoscopic aspiration mucosectomy was 3.07 (95%CI, 1.59-5.92) compared with strip biopsy. The multiple-adjusted OR for bleeding after EMR for the highest quartile (16-50 mm) of tumor diameter was 5.63 (95%CI, 1.84-17.23) compared with that for the lowest (4-7 mm). The multiple-adjusted OR for bleeding after EM R for depressed type of tumor was 4.21 (95%CI, 1.75-10.10) compared with elevated ***: It is important to take tumor characteristics (tumor size and endoscopic pattern) and cutting method of EMR into consideration in predicting bleeding after ENR.

关键词：内窥镜治疗损伤致病因子

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腹腔内脂肪变化可预测日裔美国人高血压的发生风险

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中华高血压杂志 2015年第6期23卷 521-521页

作者：刘莉叶鹏 Catherine AS Steven EK Wilfred YF tomoshige H Donna LL Edward JB

研究表明,CT测量出的腹内脂肪面积与日裔美国人高血压的患病率和发病率相关。其他人群中的证据也表明,腹腔外的脂肪面积可能有一定的保护作用。研究人员试图确定特定的脂肪组织变化能否预测高血压的发展。方法：该研究为前瞻性研究,对... 详细信息

研究表明,CT测量出的腹内脂肪面积与日裔美国人高血压的患病率和发病率相关。其他人群中的证据也表明,腹腔外的脂肪面积可能有一定的保护作用。研究人员试图确定特定的脂肪组织变化能否预测高血压的发展。方法：该研究为前瞻性研究,对日裔美国人社区糖尿病研究中的286名受试者（平均年龄49.5岁,男性占50.4%）进行10年随访。基线时,受试者均无高血压、未服降压或降糖药物。

关键词：高血压美国人腹腔内发生风险日裔预测脂肪变脂肪面积

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Treatment of Asthma in the Elderly: Questionnaire Survey in Japan

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International Journal of Clinical Medicine 2017年第4期8卷 236-247页

作者： Sahoko Chiba Kimitake Tsuchiya Tomoyuki Ogata Reina Imase Tamon Yagi Yuka Mishima Torahiko Jinta Kazuhito Saito Reiko Taki Susumu Isogai Yasuto Jinn Tsutomu Kawasaki Ichiro Natsume Yoshihiro Miyashita Jun Takagiwa Nobuo Ishiwata tomoshige Chiaki Masato Kishi Yoshikazu Tsukada Motohisa Yamasaki Naohiko Inase Department of Respiratory Medicine Tokyo Medical and Dental University Tokyo Japan JA Toride Medical Center Ibaraki Japan St. Luke’s International Hospital Tokyo Japan Tsuchiura Kyoudou General Hospital Ibaraki Japan Japanese Red Cross Musashino Hospital Tokyo Japan Ome Municipal General Hospital Tokyo Japan Hiratsuka Kyosai Hospital Kanagawa Japan Yokohama City Minato Red Cross Hospital Kanagawa Japan Yokosuka Kyosai Hospital Kanagawa Japan Yamanashi Prefectural Central Hospital Yamanashi Japan Tokyo Kyosai Hospital Tokyo Japan Kudanzaka Hospital Tokyo Japan Hokushin General Hospital Nagano Japan Mishima General Hospital Shizuoka Japan Soka Municipal Hospital Saitama Japan Nitobe Memorial Nakano General Hospital Tokyo Japan

Introduction: The prevalence of asthma in the elderly has been increasing due to the aging of the global population. Appropriate treatment for asthma in the elderly is now a major issue, as the disease is often fatal and incurs high medical costs in the elderly population. There have been few recent reports on asthma treatment for the elderly in the real-world clinical settings. Objectives: This study was performed to assess how respiratory physicians manage asthma in elderly patients in clinical settings in Japan. Methods: Respiratory physicians in 16 Japanese hospitals responded to a questionnaire survey on asthma and COPD treatment between December 2014 and February 2015. The analysis was performed using data collected from medical records on 2041 asthma patients. Results: The mean patient age was 61.2 years, and 36.6% of the patients were men. In the breakdown by age, 1018 (49.9%) of the patients were elderly (≥ 65 years). Compared to the non-elderly, the elderly patients had a significantly lower BMI, greater smoking history in pack-years, and poorer pulmonary function. There were no significant differences between the elderly and non-elderly in the prescription rates of common medications such as inhaled corticosteroids, long-acting beta-agonists (LABA) administered via inhaler or transdermal patch, long-acting muscarinic antagonists, or leukotriene receptor antagonists. In contrast, mucoactive drugs (18.7% vs. 12.3%, P P P = 0.02). Conclusions: According to this survey, the prescription rates of mucoactive drugs, macrolides, and transdermal LABA were significantly higher in the elderly than in the non-elderly.

关键词： Asthma Elderly Transdermal LABA Aging

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