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H pylori seropositivity and cytokine gene polymorphisms

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World Journal of Gastroenterology 2007年第33期13卷 4445-4451页

作者： Yasuaki Saijo Eiji Yoshioka tomonori fukui Mariko Kawaharada Fumihiro Sata Hirokazu Sato Reiko Kishi Department of Health Science Asahikawa Medical College Midorigaoka E2-1-1-1 Asahikawa Hokkaido 078-8510 Japan Department of Public Health Hokkaido University Graduate School of Medicine Kita 15 Nishi 7 Kita-ku Sapporo 060-8638 Japan Health Administration Department Sapporo Railway Hospital Kita 3 Higashi 1 Cyuo-ku Sapporo 060-0033Japan

AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to influence infection with H ***: The subjects were 410 Japanese transit company employees. C-reactive protein and conventional cardiovascular risk factors were evaluated. Serum anti-H pylori antibodies were measured. The genotypes of IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G polymorphisms were determined by allelic discrimination using fluorogenic probes and a 5′nuclease ***: In gender- and age-adjusted logistic analyses, the subjects with TNF-857T/T had a significantly lower odds ratio (OR) for H pylori seropositivity (reference -857C/C; OR = 0.15, 95% CI: 0.03-0.59, P = 0.007). After stratification according to smoking and drinking status, among never-smokers, the subjects with IL1B-511C/T had a significantly lower OR (reference -511C/C; OR = 0.30, 95% CI: 0.10-0.90, P = 0.032). Among drinkers in the 1-5 times/wk category, the subjects with IL1B-511T/T had a significantly lower OR (reference C/C; OR = 0.38, 95% CI: 0.16-0.95, P = 0.039), and the subjects with IL1B-31C/T and T/T had a significantly higher OR (reference C/C; C/T: OR = 2.59, 95% CI, P = 0.042: 1.04-6.47; C/C: OR = 3.17, 95% CI: 1.23-8.14, P = 0.017). Among current smokers, the subjects withIL6-634C/G had a significantly higher OR (reference C/C; OR = 2.28, 95% CI: 1.13-4.58, P = 0.021). However, the interactions terms between the aforementioned genotypes and lifestyles were not statistically ***: Contrary to previous findings, the results herein suggest that the TNF-857T/T genotype may be protective against chronic infection with H pylori. Drinking and smoking habits may influence the effect of cytokine gene polymorphisms. Further studies are required to clarify the effects of the pro- and anti-inflammatory cytokine

关键词：细胞活素类细胞基因医学研究

Phosphorylated protein chip combined with artificial intelligence tools for precise drug screening

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Journal of Biomedical Research 2024年第3期38卷 195-205页

作者： Katsuhisa Horimoto Yuki Suyama Tadamasa Sasaki Kazuhiko fukui Lili Feng Meiling Sun Yamin Tang Yixuan Zhang Dongyin Chen Feng Han SOCIUM Inc. Tokyo 1350064Japan International Medical Center Saitama Medical UniversitySaitama 350-1298Japan Artificial Intelligence Research Center National Institute of Advanced Industrial Science and TechnologyTokyo 1350064Japan Department of Informatics and Data Science Sanyo-Onoda City UniversityYamaguchi 7560884Japan International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China Department of Physiology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Gusu School Nanjing Medical UniversitySuzhouJiangsu 215001China National Vaccine Innovation Platform Nanjing Medical UniversityNanjingJiangsu 211166China

We have developed a protein array system,named"Phospho-Totum",which reproduces the phosphorylation state of a sample on the *** protein array contains 1471 proteins from 273 known signaling *** to the activation degrees of tyrosine kinases in the sample,the corresponding groups of substrate proteins on the array are phosphorylated under the same *** addition to measuring the phosphorylation levels of the 1471 substrates,we have developed and performed the artificial intelligence-assisted tools to further characterize the phosphorylation state and estimate pathway activation,tyrosine kinase activation,and a list of kinase inhibitors that produce phosphorylation states similar to that of the *** Phospho-Totum system,which seamlessly links and interrogates the measurements and analyses,has the potential to not only elucidate pathophysiological mechanisms in diseases by reproducing the phosphorylation state of samples,but also be useful for drug discovery,particularly for screening targeted kinases for potential drug kinase inhibitors.

关键词： Phospho-Totum protein array signal transduction pathways artificial intelligence tools drug screening

Zn含量对于Cu-Mn-Zn/ZrO_(2)催化剂CO_(2)加氢合成甲醇性能的影响研究

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燃料化学学报（中英文） 2024年第3期52卷 293-304页

作者：王世威杨金海周宏利肖福魁赵宁中国科学院山西煤炭化学研究所煤炭高效低碳转化全国重点实验室山西太原030001 中国科学院大学北京100049

通过溶胶-凝胶方法制备了一系列不同Zn含量的Cu-Mn-Zn/ZrO_(2)催化剂,并通过XRD、BET、TPR、N_(2)O吸附、XPS、TPD和in-situ DRIFTS进行了表征。结果表明,随着Zn含量增加,催化剂上CO_(2)加氢反应的活性增加。在所有样品中,Cu_(3)MnZn_(0... 详细信息

通过溶胶-凝胶方法制备了一系列不同Zn含量的Cu-Mn-Zn/ZrO_(2)催化剂,并通过XRD、BET、TPR、N_(2)O吸附、XPS、TPD和in-situ DRIFTS进行了表征。结果表明,随着Zn含量增加,催化剂上CO_(2)加氢反应的活性增加。在所有样品中,Cu_(3)MnZn_(0.5)Zr_(0.5)(CMZZ-0.5)在250℃和5 MPa条件下具有最高的CO_(2)转化率(6.5%)和甲醇选择性(73.7%)。表征结果表明,Zn进入Cu_(1.5)Mn_(1.5)O_(4)尖晶石结构,形成ZnOx,导致催化剂表面羟基含量的增加,同时增加了Cu0和Cu^(α+)的含量,改善了H_(2)和CO_(2)的活化能力。此外,通过原位漫反射红外光谱研究了CO_(2)转化为甲醇的途径。

关键词： CO_(2)加氢甲醇 Cu-基催化剂表面羟基

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铁路隧道套衬加固施工技术

江苏建材 2024年第1期 106-107页

作者：张福奎中铁十六局集团第二工程有限公司天津300162

结合贵广客运专线怀集至肇庆东贵广场段隧道套衬整治施工案例,详细阐述了隧道套衬加固等一系列的整治技术,并在套衬施工阶段按照隧道现场整治情况及施工工艺持续进行优化调整。该段隧道经套衬加固整治效果显著,达到了预期目标,为类似的... 详细信息

结合贵广客运专线怀集至肇庆东贵广场段隧道套衬整治施工案例,详细阐述了隧道套衬加固等一系列的整治技术,并在套衬施工阶段按照隧道现场整治情况及施工工艺持续进行优化调整。该段隧道经套衬加固整治效果显著,达到了预期目标,为类似的隧道套衬加固施工提供了经验参考。

关键词：铁路隧道套衬施工技术

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钙铈基催化剂上碳酸丙烯酯和甲醇制备碳酸二甲酯的研究

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燃料化学学报（中英文） 2024年第4期52卷 545-552页

作者：郭炯杨金海史依琳赵宁肖福魁姜新东沈阳化工大学辽宁/沈阳功能染颜料重点实验室辽宁沈阳110142 中国科学院山西煤炭化学研究所煤炭高效低碳转化全国重点实验室山西太原030001

采用溶胶凝胶法制备了不同比例的钙铈基催化剂,并研究了其对于碳酸丙烯酯和甲醇制备碳酸二甲酯的酯交换反应性能。结果表明,Ca∶Ce=9的催化剂在反应时间2 h,温度40℃,甲醇与碳酸丙烯酯物质的量比为15∶1,催化剂用量为碳酸丙烯酯用量4%... 详细信息

采用溶胶凝胶法制备了不同比例的钙铈基催化剂,并研究了其对于碳酸丙烯酯和甲醇制备碳酸二甲酯的酯交换反应性能。结果表明,Ca∶Ce=9的催化剂在反应时间2 h,温度40℃,甲醇与碳酸丙烯酯物质的量比为15∶1,催化剂用量为碳酸丙烯酯用量4%的条件下,碳酸丙烯酯转化率达到91.1%,碳酸二甲酯选择性达到91.7%。采用XRD、N2吸附-脱附、FT-IR、XPS和CO_(2)-TPD对催化剂进行了表征。结果表明,催化剂表面的氧空穴越多,中等碱性位数量越多,越有利于甲醇的活化,催化剂的活性越好。

关键词：钙铈基催化剂碳酸二甲酯酯交换固体碱

Effects of water saturation and loading rate on direct shear tests of andesite

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 653-662页

作者： Tianshu Bao Kimihiro Hashiba Katsunori fukui Department of Systems Innovation The University of TokyoTokyo113-8656Japan

For estimating the long-term stability of underground framework,it is vital to learn the mechanical and rheological characteristics of rock in multiple water saturation ***,the majority of previous studies explored the rheological properties of rock in air-dried and water saturated conditions,as well as the water effects on compressive and tensile *** this study,andesite was subjected to direct shear tests under five water saturation conditions,which were controlled by varying the wetting and drying *** tests were conducted at alternating displacement rates under three vertical *** results reveal that the shear strength decreases exponentially as water saturation increases,and that the increase in shear strength with a tenfold increase in displacement rate is nearly constant for each of the vertical *** on the findings of the shear tests in this study and the compression and tension tests in previous studies,the influences of both water saturation and loading rate on the Hoek-Brown failure criterion for the andesite was *** results indicate that the brittleness index of the andesite,which is defined as the ratio of uniaxial compressive strength to tensile strength,is independent of both water saturation and loading rate and that the influences of the water saturation dependence and the loading rate dependence of the failure criterion can be converted between each other.

关键词： Direct shear test Water saturation Loading rate dependence Failure criterion

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旋翼近水面效应影响因素

空气动力学学报 2024年第1期42卷 86-99,I0002页

作者：白兴之吴文华林泽铖范召林张代贤高福奎中国空气动力研究与发展中心跨介质飞行器研究中心绵阳621000 中国空气动力研究与发展中心空天技术研究所绵阳621000 中国空气动力研究与发展中心绵阳621000

旋翼在近水面高速旋转产生的水气交混流场会引发近水面效应,为了解近水面效应对飞行器介质跨越造成的潜在风险,通过近水面与地面实验详细对比了不同直径的碳纤维旋翼桨叶在无地效、地面效应与近水面效应工况下的气动特性。研究分析了旋... 详细信息

旋翼在近水面高速旋转产生的水气交混流场会引发近水面效应,为了解近水面效应对飞行器介质跨越造成的潜在风险,通过近水面与地面实验详细对比了不同直径的碳纤维旋翼桨叶在无地效、地面效应与近水面效应工况下的气动特性。研究分析了旋翼近水面效应关键影响因素,指出了旋翼在近水面工作时拉力、扭矩与功率剧烈变化的原因,初步认识了液滴对于旋翼的作用,揭示了近水面效应影响规律:对于直径0.56 m桨叶,在高油门、低水面距离工况下,近水面效应具有非线性增升、增阻、转速降低、需用功率增大的效果;低油门、高水面距离工况下具有增升、减阻的效果;同时近水面效应又受旋翼直径、桨叶类型、转速影响。对于直径0.25 m桨叶,在不同工况下近水面效应都具有增升、减阻的效果。

关键词：近水面效应跨介质飞行器旋翼自由面地面效应液滴

国际标准ISO 4301-1:2016《起重机-分级-第1部分:总则》比对

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起重运输机械 2024年第8期 74-79页

作者：皮君丽林夫奎北京起重运输机械设计研究院有限公司北京100007 北京市自动化物流装备工程技术研究中心北京100007 机械工业起重机械轻量化技术重点实验室北京100007

文中通过对比国际标准ISO 4301-1:2016《起重机—分级—第1部分:总则》与ISO 4301-1:1986《起重机和起重机械—分级—第1部分:总则》,分析了ISO 4301-1:2016的4个主要技术内容变化,即细化整机级别划分、变更机构分级参数、新增平均位移... 详细信息

文中通过对比国际标准ISO 4301-1:2016《起重机—分级—第1部分:总则》与ISO 4301-1:1986《起重机和起重机械—分级—第1部分:总则》,分析了ISO 4301-1:2016的4个主要技术内容变化,即细化整机级别划分、变更机构分级参数、新增平均位移分级方法及零部件分级规定,阐述了在ISO 4301系列其他国际标准中引用及国内外标准中采用情况,为我国标准化组织、企业及社会各方提供参考。

关键词：起重机分级国际标准国内外标准引用采用

Applications of image analysis in plant chromosome and chromatin structure study

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Quantitative Biology 2022年第3期10卷 226-238页

作者： Nobuko Ohmido Astari Dwiranti Seiji Kato Kiichi fukui Graduate School of Human Development and Environment Kobe UniversityKobe 657-8501Japan Cellular and Molecular Mechanisms in Biological System(CEMBIOS)Research Group Department of BiologyFaculty of Mathematics and Natural SciencesUniversitas IndonesiaDepok CampusWest Java 16424Indonesia Graduate School of Pharmaceutical Sciences Osaka UniversitySuitaOsaka 565-0871Japan

Background:The use of image analysis to understand the structure of chromosome and chromatin is critical to the study of genetic evolution and ***,a detailed chromosome map and the structure of chromatin in the nucleus may contribute to the plant breeding and the study of fundamental biology and genetics in ***:In plants with a fully annotated genome project,such as the Leguminosae species,the integration of genetic information,including DNA sequence data,a linkage map,and the cytological quantitative chromosome map could further improve their genetic *** numerical parameters of chromocenters in 3D can provide useful genetic information for phylogenetic studies of plant diversity and heterochromatic markers whose epigenetic changes may explain the developmental and environmental changes in the plant *** DNA fibers combined with fluorescence in situ hybridization revealed the highest spatial resolution of the obtained genome ***,image analysis at the nano-scale level using a helium ion microscope revealed the surface structure of chromatin,which consists of chromatin fibers compacted into plant ***:The studies described in this review sought to measure and evaluate chromosome and chromatin using the image analysis method,which may reduce measurement time and improve ***,we discussed the development of an effective image analysis to evaluate the structure of chromosome and *** effective application study of cell biology and the genetics of plants using image analysis methods is expected to be a major propeller in the development of new applications.

关键词： CHIAS chromosome chromatin extended DNA fiber helium ion microscopy nucleus plants