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Improvement in symptoms after H_2-receptor antagonist-based therapy for eradication of H pylori infection

World Journal of Gastroenterology 2007年第28期13卷 3836-3840页

作者： Takeshi Hagiwara Mototsugu Kato tomonori anbo Akimichi Imamura Toshihiro Suga Takumi Uchida Akira Fujinaga Manabu Nakagawa Soichi Nakagawa Yuichi Shimizu Jyunji Yamamoto Hiroshi Takeda Masahiro Asaka Department of Gastroenterology Sapporo-Kosei General HospitalSapporoHokkaido 060-4876Japan Division of Endoscopy Hokkaido University HospitalSapporoHokkaido 060-4876Japan Department of Internal Medicine Abashiri-Kosei General HospitalAbashiriJapan Department of Gastroenterology Graduate School of Medicine Hokkaido UniversitySapporoHokkaido 060-4876Japan

AIM: To investigate the therapeutic effects of triple therapy combining lafutidine with clarithromycin and amoxicillin on H pylori infection and the resolution of gastroesophageal symptoms after eradication. METHODS: We conducted a randomized, multicenter, open-label controlled trial to compare the effective-ness of a triple therapy of lafutidine, clarithromycin, and amoxicillin (lafutidine group) with that of a triple therapy of lansoprazole, clarithromycin, and amoxicillin (lansopra- zole group) in patients with H pylori infection. The study group comprised 22 patients with gastric ulcers and 18 patients with duodenal ulcers who had H pylori infection. RESULTS: H pylori eradication rates were similar in the lafutidine group (14/20, 70%) and the lansoprazole group (14/20, 70%). Gastroesophageal reflux and ab-dominal symptoms improved after eradication therapy in both groups, whereas abdominal discomfort, diarrhea, and constipation were unchanged. H pylori status had no apparent effect on improvement of gastroesophageal reflux or abdominal symptoms after treatment. Adverse events were similar in both groups. CONCLUSION: The triple therapy including lafutidine is equivalent to triple therapy including lansoprazole in terms of H pylori eradication rates and improvement in gastroesophageal reflux and abdominal *** results are attributed to the fact that lafutidine has strong, continuous antisecretory activity, unaffected by CYP2C19 polymorphisms.

关键词： Hpylori Gastroesophageal symptoms Lafutidine Lansoprazole

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Stresses in the Scapular Fossa Do Not Exceed the Yield Stress When Elevated up to 135 Degrees of Abduction after Reverse Shoulder Arthroplasty

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Journal of Biomedical Science and Engineering 2024年第2期17卷 35-40页

作者： Rina Sakai tomonori Kenmoku Ryo Tazawa Kazuhiro Yoshida Tomomi Mizuhashi Masanobu Ujihira Department of Medical Engineering and Technology Kitasato University School of Allied Health Sciences Sagamihara Japan Department of Orthopedic Surgery Kitasato University School of Medicine Sagamihara Japan Kitasato University Graduate School of Medical Sciences Sagamihara Japan

Reverse shoulder arthroplasty (RSA) is an effective treatment for rotator cuff tears. Despite its advantages, complications occur at a high rate. Complications requiring revision include a high rate of base plate failure, 38% of which are due to instability. The primary stability the base plate ensures is a crucial factor and, thus, is the subject of much debate in clinical studies and biomechanical research. This study is aimed to provide data that will contribute to the base plate’s pri-mary stability and glenoid longevity by clarifying the stresses at the scapular fossa and base plate interface associated with elevation after RSA. A 3D finite element model was created from the DICOM data for the scapulohumeral joint and SMR shoulder system. For loading conditions, 30 N was applied for each posi-tion with abduction angles of 0, 45, 90, and 135 degrees. A three-dimensional fi-nite element analysis was performed using the static implicit method with LS-DYNA. The von Mises stresses in the scapular fossa were found not to exceed the yield stress on the bone even after elevation to an abduction angle of 135 de-grees after RSA. It is rough to uniformly compare the yield stress and the von Mises stress, but it was inferred that the possibility of fracture is low unless a large external force is applied. A maximum von Mises stress showed 0 degrees of abduction, suggesting that the lowered position is in a more severe condition than the elevated position. If better improvement is desired, it may be necessary to devise ways to reduce the stress on the upper screw. .

关键词： Reverse Shoulder Arthroplasty Finite Element Analysis Yield Stress Glenoid

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Prediction of the Curie temperature considering the dependence of the phonon free energy on magnetic states

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npj Computational Materials 2020年第1期6卷 140-146页

作者： tomonori Tanaka Yoshihiro Gohda Department of Materials Science and Engineering Tokyo Institute of TechnologyYokohama 226-8502Japan

Prediction of the Curie temperature is of significant importance for the design of ferromagnetic *** of the most widely used methods to estimate the Curie temperature from first principles relies on a spin Hamiltonian,for example,the Heisenberg Hamiltonian,and exchange coupling parameters obtained by first-principles calculations at zero *** though there have been attempts to include the effects of magnetism on phonons,the influence of magnetism-dependent phonons on magnetism has been disregarded in the theoretical estimation of the Curie ***,we propose a first-principles thermodynamic approach to minimise the total free energy considering both the influences of magnetism on phonons and the feedback effect from phonons to *** applying our scheme to body-centered cubic Fe,we find a significant reduction of the Curie temperature due to the feedback *** result indicates the importance of the feedback effect for a quantitative description of finite-temperature *** addition,we point out that the reduction in the theoretical Curie temperature arises in a wide range of ferromagnetic materials that exhibit phonon softening due to magnetic disordering.

关键词： temperature effect phonon

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Effects of Pulsation on Separated Flow and Heat Transfer in Enlarged Channel

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Journal of Thermal Science 2011年第1期20卷 70-75页

作者： Hiroyuki YOSHIKAWA tomonori KAI Mizue MUNEKATA Hideki OHBA Dept.of Mechanical System Engineering Kumamoto University2-39-1 KurokamiKumamoto 860-8555Japan Graduate School of Science and Technology Kumamoto University2-39-1 KurokamiKumamoto 860-8555Japan Kikuyo KikuchiKumamoto 869-1101Japan

Numerical results of three-dimensional separated flow and heat transfer in an enlarged rectangular channel are presented in this *** expansion ratio and aspect ratio of the channel are 2.0 and 16.0,*** number of the flow is 200 and it is over the critical Reynolds *** the critical Reynolds number,the flow in the symmetric channel becomes asymmetric and deflects to one side of the *** of the pulsating fluctuation at the inlet upon the flow in the channel are *** is clarified that the inlet flow with a pulsating fluctuation of Strouhal number 0.05 and 0.10 strongly affects on the flow in the channel,and heat transfer on the walls is enhanced,especially on the wall surface covered with long separation *** the other hand,the pulsation of St=0.0125 oscillates the shear layer more weakly than that of St=0.05,0.10 and the enhancement of heat transfer is smaller,though some vortices are shed from the vicinity of the side wall near the reattachment *** oscillation of the main flow calms down gradually as the Strouhal number of the pulsation increases over *** influence of pulsation of St=0.20 on the flow is restricted in the near downstream of the step,and heat transfer on the walls is almost similar to that of the steady flow in the channel.

关键词： Pulsating Fluctuation Symmetric Enlarged Channel Separated Flow Heat Transfer

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Integrated view of plant metabolic defense with particular focus on chewing herbivores

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Journal of Integrative Plant Biology 2022年第2期64卷 449-475页

作者： David Wari Takako Aboshi tomonori Shinya Ivan Galis Institute of Plant Science and Resources Okayama UniversityKurashiki710-0046 Japan Faculty of Agriculture Yamagata UniversityWakaba-machiTsuruoka997-8555 Japan

Success of plants largely depends on their ability to defend against *** emergence of the first voracious consumers,plants maintained adapting their structures and chemistry to escape from *** constant pressure was further accelerated by adaptation of herbivores to plant defenses,which all together sparked the rise of a chemical empire comprised of thousands of specialized metabolites currently found in *** diversity in the plant kingdom is truly amazing,and although many plant metabolites have already been identified,a large number of potentially useful chemicals remain unexplored in plant ***,biosynthetic routes for plant metabolites involve many enzymes,some of which still wait for identification and biochemical ***,regulatory mechanisms that control gene expression and enzyme activities in specialized metabolism of plants are scarcely ***,understanding of how plant defense chemicals exert their toxicity and/or repellency against herbivores remains limited to typical examples,such as proteinase inhibitors,cyanogenic compounds and *** this review,we attempt summarizing the current status quo in metabolic defense of plants that is predominantly based on the survey of ubiquitous examples of plant interactions with chewing herbivores.

关键词： defense herbivore mode of action plant specialized metabolism

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Pneumonia and seizures due to hypereosinophilic syndrome—organ damage and eosinophilia without synchronisation:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6325-6332页

作者： Tetsuro Ishida tomonori Murayama Seiju Kobayashi Department of Psychiatry Hokujinkai Ishibashi HospitalOtaru 047-8585Japan Department of Psychiatry Kushiro Red Cross HospitalKushiro 085-8512Japan Department of Psychiatry Shinyukai Nakae HospitalSapporo 001-0022Japan

BACKGROUND Hypereosinophilic syndrome(HES)is a condition characterized by increased eosinophil proliferation in the bone marrow,as well as tissue eosinophilia,often causing organ *** cause of the disease is *** symptoms include fatigue,cough,shortness of breath,myalgia,angioedema,fever,and *** addition to the respiratory symptoms,damage to the central nervous system can lead to severe ***,we report a case with pneumonia and complex partial seizures secondary to *** SUMMARY A 94-year-old woman was admitted to our hospital for heart failure and bloody *** admission,she also showed symptoms of ***-contrast computed tomography of the chest showed pleural effusion and infiltrative *** gastrointestinal endoscopy showed multiple ulcers in the sigmoid *** analyses showed marked eosinophilia(eosinophils 1760/mm3,total leukocytes 6850/mm3).Initial treatment with furosemide 20 mg/d and prednisolone 25 mg/d relieved these ***,the patient subsequently experienced localised epileptic seizures characterized by bilateral eyelid twitching and eyes rolling upwards,without generalized convulsions,and respiratory arrest *** showed spikes and ***-contrast magnetic resonance imaging of the brain showed extensive periventricular *** administration of levetiracetam 1000 mg/d the epileptic seizures ***,the patient’s consciousness remained impaired,and her pneumonia worsened *** weeks later,she died of *** HES symptoms are variable and atypical,and the level and timing of eosinophilia and organ damage are often discordant.

关键词： Case report Hypereosinophilic syndrome Pneumonia Seizures Prednisolone Levetiracetam

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Molecular evidence for biochemical diversification of phenolamide biosynthesis in rice plants

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Journal of Integrative Plant Biology 2016年第11期58卷 903-913页

作者： Kimiaki Tanabe Yuko Hojo tomonori Shinya Ivan galis Institute of Plant Science and Resources Okayama University Kurashiki 710-0046 Japan

Two phenolamides （PAs）, p-coumaroylputrescine and feruloylputrescine strongly accumulate in rice （Oryza sativa cv. Nipponbare） leaves subjected to attack of chewing and sucking herbivores. Here we identified and characterized in vitro three novel rice genes that mediated coumaroyI-CoA/ feruloyI-CoA conjugation to polyamines, putrescine and agmatine. Interestingly, two genes were highly specific for their polyamine substrates, encoding putresdne N-hydrox- ycinnamoyltransferase and agmatine N-hydroxycinnamoyl- transferase, while the third enzyme could use both polyamines and it was therefore annotated as putrescine/ agmatine N-hydroxycinnamoyltransferase. All genes were preferentially expressed in rice roots and developing flowers, and in addition, the putrescine/agmatine N-hydroxycinnamoyl- transferase transcripts were strongly induced by wounding in the young rice leaves. Because the wound response of this gene was only partially suppressed in the jasmonoyI-L-isoleucine deficient plants （Osjarl）, it suggests that its upregulation （as well as inducible PAs in rice） may be largely independent of jasmonoyI-L-isoleucine signaling pathway. The finding of three closely related genes with a similar and/or overlapping activity in PA biosynthesis provides another striking example of rapid diversification of plant metabolism in response to environmental stresses in nature.

关键词： Acyltransferase p-coumaroylputrescine defense feruloylputrescine phenolamides rice (Oryza sativa)

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Integrated biological–physical process for biogas purification effluent treatment

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Journal of Environmental Sciences 2019年第9期31卷 110-122页

作者： Roslan Noorain tomonori Kindaichi Noriatsu Ozaki Yoshiteru Aoi Akiyoshi Ohashi Department of Civil and Environmental Engineering Graduate School of Engineering Hiroshima University 1-4-1 Kagamiyama Higashihiroshima Hiroshima 739-8527 Japan Section of Environmental Engineering Technology Malaysia Institute of Chemical & Bioengineering Technology University Kuala Lumpur Lot 1988 Kawasan Perindustrian Bandar Vendor Taboh Naning 78000 Alor Gajah Melaka Malaysia Department of Molecular Biotechnology Graduate School of Advanced Sciences of Matter Hiroshima University 1-3-1 Kagamiyama Higashihiroshima 739-8530 Japan

Biogas purification via water scrubbing produces effluent containing dissolved CH4, H2S,and CO2, which should be removed to reduce greenhouse gas emissions and increase its potential for water regeneration. In this study, a reactor built with air supplies at the top and bottom was utilized for the treatment of biogas purification effluent through biological oxidation and physical stripping processes. Up to 98% of CH4 was removed through biological treatment at a hydraulic retention time of 2 hr and an upper airflow rate of 2.02 L/day. Additionally, a minimum CH4 concentration of 0.04% with no trace of H2S gas was detected in the off gas. Meanwhile, a white precipitate was captured on the carrier showing the formation of sulfur. According to the developed mathematical model, an upper airflow rate of greater than 2.02 L/day showed a small deterioration in CH4 removal performance after reaching the maximum value, whereas a 50 L/day bottom airflow rate was required to strip the CO2 efficiently and raise the effluent p H from 5.64 to 7.3. Microbiological analysis confirmed the presence of type 1 methanotroph communities dominated by Methylobacter and Methylocaldum. However, bacterial communities promoting sulfide oxidation were dominated by Hyphomicrobium.

关键词： Biogas purification effluent Dissolved methane pH elevation Biological oxidation CO2 stripping

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ILES of an array of three subsonic counter-flow jets issuing from a wing leading edge exposed to hypersonic aerodynamic heating

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Advances in Aerodynamics 2020年第1期2卷 236-249页

作者： tomonori Shimada Taku Ohwada Department of Aeronautics and Astronautics Graduate School of EngineeringKyoto UniversityKyoto 615-8530Japan

The flow of an active thermal protection system exploiting subsonic counter-flow jets for wing leading edges of hypersonic vehicles is numerically studied on the basis of the three dimensional Navier-Stokes *** coolant air issuing from around the stagnation point as an array of three jets spreads over both the upper and the lower sides of the cylinder surface and about 40~60%cooling effectiveness is achieved in the range up to 5 degrees angle of attack despite the occurrence of various three-dimensional fluid-dynamic *** numerical scheme is second order accurate but simple inclusion of high order polynomial approximation in the reconstruction enables the capturing of finer structure of the flow field.

关键词： Subsonic jet Counter-flow Aerodynamic heating TPS Rayleigh-Taylor Kelvin-Helmholtz Near-wall streaks

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Current research of idiopathic normal pressure hydrocephalus:Pathogenesis,diagnosis and treatment

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World Journal of Clinical Cases 2023年第16期11卷 3706-3713页

作者： Tetsuro Ishida tomonori Murayama Seiju Kobayashi Department of Psychiatry Japan Health Care CollegeSapporo 062-0053HokkaidoJapan Department of Psychiatry Asahikawa Keisenkai HospitalAsahikawa 078-8208HokkaidoJapan Department of Psychiatry Shinyukai Nakae HospitalSapporo 001-0022HokkaidoJapan

Idiopathic normal pressure hydrocephalus(iNPH)is caused by impaired cerebrospinal fluid absorption in the elderly;it is a surgically treatable form of *** disturbance,dementia,and urinary incontinence are the triad of signs for *** addition to these clinical findings,imaging studies show characteristic ventricular *** Evans Index and‘disproportionately enlarged subarachnoid hydrocephalus’are other well-known imaging findings of *** the tap test shows improved symptoms,shunt surgery is *** disease was first described by Hakim and Adams in 1965,followed by the publication of the first,second,and third editions of the guidelines in 2004,2012,and 2020,*** studies signal the glymphatic system and classical cerebrospinal fluid(CSF)absorption from the dural lymphatics as aetiological mechanisms of CSF *** is also underway on imaging test and biomarker developments for more precise diagnosis,shunting technique options with fewer sequelae and complications,and the influence of ***,the newly introduced‘suspected iNPH’in the third edition of the guidelines may be useful for earlier ***,less well-studied areas remain,such as pharmacotherapy in non-operative indications and neurological findings other than the triadic *** review briefly presents previous research on these and future issues.

关键词： Review Idiopathic normal pressure hydrocephalus Treatable dementia Shunt surgery Drug therapy

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