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Skull metastasis from hepatocellular carcinoma with chronic hepatitis B

World Journal of Gastrointestinal Oncology 2010年第3期2卷 165-168页

作者： Takashi Goto Takahiro Dohmen Kouichi Miura Shigetoshi Ohshima Kazuo Yoneyama tomomi shibuya Ei Kataoka Daisuke Segawa Wataru Sato Yumiko Anezaki Hajime Ishii Daigo Kon Ikuhiro Yamada Kentaro Kamada Hirohide Ohnishi Department of Gastroenterology Akita University School of Medicine

A 56-year-old male visited our hospital for evaluation of an occipital *** computed tomography showed hypervascular enhancement with osteolytic change in the skull and a huge enhanced mass in the *** resonance imaging showed bone metastasis in the thoracic *** for hepatitis B surface antigen and hepatitis B core antibody were positive and his liver condition was Child-Pugh grade *** diagnosis was hepatocellular carcinoma(HCC) with skull and vertebrae metastases on chronic hepatitis *** was treated with radiation therapy for bone metastases and transcatheter arterial chemoembolization for *** he developed acute respiratory failure because of aspiration pneumonia,congestion and oedema with haemorrhage of the lungs and *** showed HCC with multiple bone *** liver tumor was categorized as well-differentiated HCC,Edmondson classification Ⅰ,trabecular type and pseudoglandular *** the liver mild infiltration of lymphocytes was seen in Glisson's capsules which were signif icantly enlarged with well preserved limiting *** necrosis was not *** fibrosis was *** 8 cm × 7 cm × 3 cm metastatic lesion had formed in the left occipitotemporal part of the cranial *** lesion was osteolytic and showed invasion into the dura *** the subdural cavity nor the brain showed involvement from the metastatic ***,skull metastasis from HCC is very rare and it affects the patient's prognosis and the quality of ***,it is very important to make an early diagnosis and carry out proper management of skull metastasis from HCC.

关键词： Hepatocellular carcinoma Skull metastasis Bone metastasis Osteolytic change Chronic hepatitis B

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Effects of Chewing Frequency on Cerebral Blood Flow and Cognitive Function

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Journal of Behavioral and Brain Science 2020年第7期10卷 287-295页

作者： Saya Natsui Megumi Sato tomomi Yokoyama Hiromi Inaba Naomi Kuboyama Kenichi shibuya Graduate School of Health and Welfare Niigata University of Health and Welfare Graduate School Niigata Japan RESCO Corporation Tokyo Japan WELCIA YAKKYOKU CO. LTD. Niigata Japan Department of Health and Nutrition Niigata University of Health and Welfare Niigata Japan Osaka University of Commerce Osaka Japan

The purpose of the present study was to examine the effect of the frequency of mastication on cerebral activation and task scores for computational tasks. Eleven healthy subjects participated in the present study (nine women, two men). Subjects carried out the Uchida-Kraepelin Test for 15 min before and after chewing tasteless gum for five minutes. The oxygenation of the left prefrontal cortex was monitored by near-infrared spectroscopy during the computational tasks. Task scores did not differ significantly according to chewing frequency (p > 0.05). Conversely, the oxygenation value measured after mastication at a chewing frequency of 110 times/minute (Hz) was significantly higher than that observed before mastication (p 0.05 for both). The results of the present study suggest that tasteless mastication does not enhance calculation performance, while a high mastication frequency demonstrates an influence on oxygenation. However, our study indicates that chewing tasteless gum per se does not increase cognitive performance.

关键词： Mastication Frequency Brain Activity Uchida-Kraepelin Test Near-Infrared Spectroscopy

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