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Higgs Mechanism and New Propagator of Massive Vector Bosons

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Journal of Modern Physics 2012年第7期3卷 619-624页

作者： Takehisa Fujita Naohiro kanda Kazuhiro Tsuda Department of Physics Faculty of Science and Technology Nihon University Tokyo Japan

discuss a serious problem related to the Higgs mechanism and show that the unitary gauge which imposes the condition of ф=ф÷ on the Higgs fields does not correspond to a proper gauge fixing. Instead, this is simply a procedure for producing the massive vector boson fields by hand. This suggests that the Lagrangian density of the weak interactions should be reconsidered by starting from the massive vector boson fields which couple to the fermion currents as the initial ingredients. Here, it is shown that the new renormalization scheme with massive vector bosons has no intrinsic problem and the massive vector boson fields do not give rise to any divergences for the physical observables in the renormalization scheme.

关键词： Higgs Mechanism

Direct-acting Antivirals and Host-targeting Agents against the Hepatitis A Virus

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Journal of Clinical and Translational Hepatology 2015年第3期3卷 205-210页

作者： Tatsuo kanda Shingo Nakamoto Shuang Wu Masato Nakamura Xia Jiang Yuki Haga Reina Sasaki Osamu Yokosuka Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine Inohana Chuo-ku Chiba Japan

Hepatitis A virus (HAV) infection is a major cause of acute hepatitis and occasionally leads to acute liver failure in both developing and developed *** effective vaccines for HAV are available,the development of new antivirals against HAV may be important for the control of HAV infection in developed countries where no universal vaccination program against HAV exists,such as *** are two forms of antiviral agents against HAV:direct-acting antivirals (DAAs) and host-targeting agents (HTAs).Studies using small interfering ribonucleic acid (siRNA) have suggested that the HAV internal ribosomal entry site (IRES) is an attractive target for the control of HAV replication and *** the HTAs,amantadine and interferon-lambda 1 (IL-29) inhibit HAV IRES-mediated translation and HAV *** kinase (JAK) inhibitors inhibit La protein expression,HAV IRES activity,and HAV *** on this review,both DAAs and HTAs may be needed to control effectively HAV infection,and their use should continue to be explored.

关键词： Amantadine DAA HAV HTA La protein Drug overview

海洋可燃冰采掘利用系统设计及储层尺度的数值模拟

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科学通报 2018年第31期63卷 3241-3250页

作者：陈林冯永昌 Hikaru Yamada Yuki kanda Junnosuke Okajima Atsuki Komiya Shigenao Maruyama 中国科学院工程热物理研究所北京100190 Institute of Fluid Science Tohoku UniversitySendai 980-8577Japan National Institute of Technology Hachinohe CollegeTamonokiHachinohe 039-1192Japan

近年来,海洋可燃冰的开发利用已经成为国际能源研究领域的重要新兴课题.本文介绍了一种利用海洋可燃冰系统的低碳排放的开采,并进行了经济性论证和开采策略的数值分析工作.以日本南部海域海槽和中国神狐海域的开采情景为例,着重针对近... 详细信息

近年来,海洋可燃冰的开发利用已经成为国际能源研究领域的重要新兴课题.本文介绍了一种利用海洋可燃冰系统的低碳排放的开采,并进行了经济性论证和开采策略的数值分析工作.以日本南部海域海槽和中国神狐海域的开采情景为例,着重针对近年中日两国的开采活动及其开采策略进行了分析.研究表明:单一的降压开采和注热开采会遇到复杂的井口效应和能效问题,策略性组合设计能够获得较好的开采效率.研究确证了地层热管理和注热水、地层热流对可燃冰储层分解过程的影响.总结了当前海洋可燃冰开采方式的利弊,提出了低碳排放的开采方法,以期为未来进一步的海洋可燃冰试采工作和规模化利用提供有益的参考.

关键词：可燃冰天然气多孔介质热管理数值模型

Genetic and epigenetic aspects of initiation and progression of hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第37期21卷 10584-10597页

作者： Mitsuro kanda Hiroyuki Sugimoto Yasuhiro Kodera Department of Gastroenterological Surgery (Surgery Ⅱ) Nagoya University Graduate School of Medicine

Hepatocellular carcinoma(HCC) is a primary cancer of the liver that is predominant in developing countries and is responsible for nearly 600000 deaths each year worldwide. Similar to many other tumors, the development of HCC must be understood as a multistep process involving the accumulation of genetic and epigenetic alterations in regulatory genes, leading to the activation of oncogenes and the inactivation or loss of tumor suppressor genes. Extensive research over the past decade has identified a number of molecular biomarkers, including aberrant expression of HCCrelated genes and microRNAs. The challenge facing HCC research and clinical care at this time is to address the heterogeneity and complexity of these genetic and epigenetic alterations and to use this information to direct rational diagnosis and treatment strategies. The multikinase inhibitor sorafenib was the first molecularly targeted drug for HCC to show some extent of survival benefits in patients with advanced tumors. Although the results obtained using sorafenib support the importance of molecular therapies in the treatment of HCC, there is still room for improvement. In addition,no molecular markers for drug sensitivity, recurrence and prognosis are currently clinically available. In this review, we provide an overview of recently published articles addressing HCC-related genes and microRNAs to update what is currently known regarding genetic and epigenetic aspects of the pathogenesis of HCC and propose novel promising candidates for use as diagnostic and therapeutic targets in HCC.

关键词： Hepatocellular carcinoma Oncogene Tumor suppressor

Solid-Phase Formation in Nanospace -Phase Diagram of Confined Lennard-Jones Fluids

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Solid-Phase Formation in Nanospace -Phase Diagram of Confine...

INTERACTION FORCES BETWEEN HYDROPHILIC SURFACES IN ELECTROLYTE DMSO SOLUTION MEASURED BY AFM

第四届中美化学工程会议和第三届中日化工研讨会合并的三边化学工程大会

作者： Minoru Miyahara Hideki kanda Kyoto University Japan

Understanding for phase transitions of confined fluids in nanospace has progressed a great deal in this decade. However, solidification phenomena still remain largely unresolved. Employing molecular simulation techniques, the present authors had found liquid-solid phase boundaries, or freezing points, for Lennard-Jones (LJ) fluids confined in nanopores, which differ significantly from those for bulk phase because of important factors peculiar to nanospace. In this presentation, sublimation or gas-solid transition of LJ-methane confined in carbon nanopore is examined employing a unique Molecular Dynamics method developed by the authors. The obtained sublimation temperature is significantly elevated, because of the compressing effect by strongly attractive walls. A simple model on the sublimation is presented, which successfully predicts the simulation results with no adjustable parameter. With this success a whole Lennard-Jones phase diagram in slit-shaped nanopore can now be predictable.

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INTERACTION FORCES BETWEEN HYDROPHILIC SURFACES IN ELECTROLY...

深部俯冲板片三维构造重建及其几何学、运动学研究——以汤加—克马德克地区俯冲板片为例

第二届中日化工学术研讨会

作者： Yoichi kanda Ko HIGASHITANI Department of Chemical Engineering Kyoto University Kyoto 606-8501 Japan

The experimental measurements of the forces acting on silica-mica surfaces immersed in lithium chloride DMSO solutions were performed using an atom force microscopy (AFM) . Various force curves were obtained by changing the ionic concentration, the radius of curvature of surfaces and approaching velocity of two surfaces. It is found that there exist two kinds of structured layers on the surface;the thin but firm primary layer composed of DMSO molecules, ions and solvated ions adsorbed on the surface, and the thick but fragile secondary layer outside the primary layer.

关键词： AFM DMSO Adhesive force Structured layer

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地球物理学报 2013年第11期56卷 3837-3845页

作者：鲁人齐 John Suppe 何登发 Jonny Wu Ravi V S kanda 刘波陈于高北京大学地球与空间科学学院北京100871 台湾大学地质科学系台北10617 中国地质大学(北京)能源学院北京100083

西南太平洋板块与澳大利亚板块之间的汤加-克马德克俯冲带，是研究地球动力学最重要的区域之一．本文研究根据MIT～P08地震数据，结合板块构造边界、地震活动分布、海岸地形数据等，基于GOCAD软件平台建立三维地震层析成像，对西南太平... 详细信息

西南太平洋板块与澳大利亚板块之间的汤加-克马德克俯冲带，是研究地球动力学最重要的区域之一．本文研究根据MIT～P08地震数据，结合板块构造边界、地震活动分布、海岸地形数据等，基于GOCAD软件平台建立三维地震层析成像，对西南太平洋板块的汤加-克马德克俯冲板片进行三维解释．地震层析成像显示汤加-斐济地区地幔至少存在三个“高速”异常体．早期汤加-克马德克俯冲板片穿过地幔转换带，并进入下地幔，最大深度达1600km．三维构造模型揭示了汤加克马德克板片在深度600～800km处存在断折形变，该俯冲板片去褶皱恢复后，测量其俯冲的最大位移达2600km．汤加-克马德克板片开始快速俯冲的时间至少在30Ma之前，平均移动速率约为68～104mrn／a．俯冲板片三维构造重建和恢复，可以有效揭示俯冲板片几何学、运动学，为研究深源地震成因、地球深部变化过程和动力学机制提供约束．

关键词：地震层析成像俯冲板片三维构造模型几何学运动学汤加-克马德克地区

Atypical lipomatous tumor in the ligamentum teres of liver:A case report and review of the literature

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World Journal of Clinical Cases 2018年第12期6卷 548-553页

作者： Daisuke Usuda Kento Takeshima Ryusho Sangen Kisuke Nakamura Kei Hayashi Hideyuki Okamura Yasuhiro Kawai Yuji Kasamaki Yoshitsugu Iinuma Hitoshi Saito Tsugiyasu kanda Sachio Urashima Department of Community Medicine Kanazawa Medical University Himi Municipal Hospital Department of Infectious Diseases Kanazawa Medical University Department of General and Digestive Surgery Kanazawa Medical University Himi Municipal Hospital Department of Gastroenterology Kanazawa Medical University Himi Municipal Hospital

A 61-year-old male was referred to our hospital with a three-month history of persistent epigastralgia and right hypochondralgia. Initial examination revealed a fist-size mass at the epigastric fossa. Ultrasonography showed a hemangioma and a mosaic echoic lesion in the ventromedian with poor blood-flow signal and linear hyperechoic part inside, and a clear border to the surroundings. Dynamic computed tomography revealed a highly enhanced effect from the portal-venous phase continuing to the equilibrium phase. T1-weighted gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced image revealed a high intensity effect at the early phase that continued to the next phase. On the other hand, it contained a low intensity area by a fat suppression of that image. In addition, a T2-weighted image did not show a high intensity effect. Laparotomy was performed on the second day of hospitalization. The tumor had arisen from the ligamentum teres of the liver, and no metastasis or invasion of other organs was noted. It consisted of a lipid component of mature adipocytes and a fibrous component of deep dyeing pleomorphic or multinuclear atypical stromal cells. Immunohistochemical study of the atypical stromal cells demonstrated that they were positive for MDM2 and CDK4. A pathological diagnosis of atypical lipomatous tumor(ALT) was made, and the patient was discharged on the eighth day following the procedure. At the 6-mo follow-up dynamic CT, the patient was free of recurrence or metastasis. We experienced a patient with ALT in the ligamentum teres of the liver. This case suggests the need for a careful and detailed examination when encountering patients presenting with a mass; when neoplastic lesion is confirmed by image inspection, we should thoroughly investigate, including further image investigations and pathologic examination. The latter is the most important.

关键词： Liposarcoma Atypical lipomatous tumor Malignant adipose mesenchymal tumor Ligamentum teres of liver Operation

Artificial intelligence and machine learning could support drug development for hepatitis A virus internal ribosomal entry sites

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Artificial Intelligence in Gastroenterology 2021年第1期2卷 1-9页

作者： Tatsuo kanda Reina Sasaki Ryota Masuzaki Mitsuhiko Moriyama Division of Gastroenterology and Hepatology Department of MedicineNihon University School of MedicineItabashi-ku 173-8610TokyoJapan

Hepatitis A virus(HAV)infection is still an important health issue *** several effective HAV vaccines are available,it is difficult to perform universal vaccination in certain ***,it may be better to develop antivirals against HAV for the prevention of severe hepatitis *** found that several drugs potentially inhibit HAV internal ribosomal entry site-dependent translation and HAV *** intelligence and machine learning could also support screening of anti-HAV drugs,using drug repositioning and drug rescue approaches.

关键词： Artificial intelligence Hepatitis A virus internal ribosomal entry sites Capindependent translation Antivirals Severe hepatitis A Glucose-regulated protein 78