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The Group A Streptococcus Interleukin-8 Protease SpyCEP Promotes Bacterial Intracellular Survival by Evasion of Autophagy

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Infectious Microbes & Diseases 2022年第3期4卷 116-123页

作者： RenéBergmann Giuseppe Gulotta Federica Andreoni tomoko sumitomo Shigetada Kawabata Annelies S.Zinkernagel Gursharan S.Chhatwal Victor Nizet Manfred Rohde Satoshi Uchiyama Central Unit for Microscopy(ZEIM) Helmholtz Centre for Infection ResearchBraunschweigGermany Division of Infectious Diseases and Hospital Epidemiology University Hospital ZurichZurichSwitzerland Department of Oral and Molecular Microbiology Osaka University Graduate School of DentistrySuita-OsakaJapan Division of Host-Microbe Systems and Therapeutics Department of PediatricsUniversity of CaliforniaSan DiegoLa JollaCalifornia

Autophagy serves an innate immune function in defending the host against invading bacteria,including group A Streptococcus(GAS).Autophagy is regulated by numerous host proteins,including the endogenous negative regulator calpain,a cytosolic *** disseminated serotypeM1T1 GAS strains associated with high invasive disease potential express numerous virulence factors and resist autophagic *** in vitro infection of human epithelial cell lines with representative wild-type GAS M1T1 strain 5448(M1.5448),we observed increased calpain activation linked to a specific GAS virulence factor,the interleukin-8 protease *** activation inhibited autophagy and decreased capture of cytosolic GAS in *** contrast,the serotype M6 GAS strain JRS4(***4),which is highly susceptible to host autophagy-mediated killing,expresses low levels of SpyCEP and does not activate *** of SpyCEP in ***4 stimulated calpain activation,inhibited autophagy,and significantly decreased bacterial capture in *** paired loss-and gain-of-function studies reveal a novel role for the bacterial protease SpyCEP in enabling GAS M1 evasion of autophagy and host innate immune clearance.

关键词： group A Streptococcus SpyCEP virulence factor epithelial cells intracellular survival autophagy xenophagy calpain

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Genetic Characterization of Streptococcus pyogenes emm89 Strains Isolated in Japan From 2011 to 2019

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Infectious Microbes & Diseases 2020年第4期2卷 160-166页

作者： Yujiro Hirose Masaya Yamaguchi Norihiko Takemoto Tohru Miyoshi-Akiyama tomoko sumitomo Masanobu Nakata Tadayoshi Ikebe Tomoki Hanada Takahiro Yamaguchi Ryuji Kawahara Rumi Okuno Hitoshi Otsuka Yuko Matsumoto Yuji Terashima Yu Kazawa Noriko Nakanishi Kaoru Uchida Yumi Akiyama Kaori Iwabuchi Chikara Nakagawa Kazunari Yamamoto Victor Nizet Shigetada Kawabata Department of Oral and Molecular Microbiology Osaka University Graduate School of DentistrySuitaOsakaJapan Department of Pediatrics University of California at San Diego School of MedicineLa JollaCAUSA Department of Infectious Diseases Research InstituteNational Center for Global Health and MedicineTokyoJapan Department of Oral Microbiology Kagoshima University Graduate School of Medical and Dental SciencesKagoshimaJapan Department of Bacteriology I National Institute of Infectious DiseasesTokyoJapan Division of Microbiology Osaka Institute of Public HealthOsaka CityOsakaJapan Department of Microbiology Tokyo Metropolitan Institute of Public HealthTokyoJapan Department of Public Health Sciences Yamaguchi Prefectural Institute of Public Health and Environment Yamaguchi CityYamaguchiJapan Microbiological Testing and Research Division Yokohama City Institute of Public HealthYokohamaKanagawaJapan Department of Microbiology Fukushima Prefectural Institute of Public HealthFukushima CityFukushimaJapan Department of Infectious Diseases Kobe Institute of HealthKobeHyogoJapan Department of Bacteriology Toyama Institute of HealthImizuToyamaJapan Infectious Disease Research Division Hyogo Prefectural Institute of Public Health ScienceKakogawaHyogoJapan Department of Health Science Iwate Prefectural Research Institute for Environmental Sciences and Public HealthMoriokaIwateJapan Division of Microbiology Kyoto City Institute of Health and Environmental SciencesKyoto CityKyotoJapan Niigata City Institute of Public Health and the Environment Niigata CityNiigataJapan Skaggs School of Pharmaceutical Sciences University of California at San DiegoLa JollaCAUSA.

Invasive infection caused by Streptococcus pyogenes emm89 strains has been increasing in several countries linked to a recently emergent clade of emm89 strains,designated clade *** Japan,the features of emm89 *** strains,such as clade classification,remains *** this study,we collected emm89 strains isolated from both streptococcal toxic shock syndrome(STSS)(89 STSS isolates)and noninvasive infections(72 non-STSS isolates)in Japan from 2011 to 2019,and conducted wholegenome sequencing and comparative analysis,which resulted in classification of a large majority into clade 3 regardless of disease *** addition,invasive disease-associated factors were found among emm89 strains,including mutations of control of virulence sensor,and absence of the hylP1 gene encoding *** findings provide new insights into genetic features of emm89 strains.

关键词： clade 3 emm89 streptococcal toxic shock syndrome Streptococcus pyogenes

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AGENT MODEL ANALYSIS TO EXPLORE EFFECTS OF INTERACTION AND ENVIRONMENT ON INDIVIDUAL PERFORMANCE

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Journal of Systems Science & Complexity 2007年第1期20卷 1-17页

作者： tomoko KIKUCHI Yoshiteru NAKAMORI School of Knowledge Science Japan Advanced Institute of Science and Technology 1-1 Asahidai Nomi Ishikawa 923-1292 Japan

This paper tries to find interaction rules between members and self-reform rules of members in some scientific research laboratories at a graduate school. The candidate of rules are extracted from the personality description sentences about factors： extroversion, agreeableness, conscientiousness, neuroticism and openness in the big five theory of personality psychology. In this paper, interaction and self-reform rules are not described by personalities themselves; instead, they are described by corresponding phenomena： activity, empathy, persistence, autonomy, and analytical ability which appear in the behavior side. Each member＇s initial value is determined from the main 5-factor personality investigation to the member, and the target value is given by the member＇s self-declaration. The rule selection is carried out by the genetic algorithm, where a sigmoid function is introduced in the renewal algorithm of the value, whereby a difficulty of setting the renewal parameters is avoided. An analysis is added about the obtained rules, and the validity of this approach and the subjects for future study are discussed. Finally, consideration is extended to the effect of environment on the behavior of members to reinforce the set of rules.

关键词： Agent model environment interaction performance personality psychology self-reform

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Methane emissions from wetlands on the Qinghai-Tibet Plateau

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Chinese Science Bulletin 1999年第24期44卷 2282-2286页

作者： Nakano tomoko Department of Geography Tokyo Metropolitan University 192-03 Japan

The areal extent of cold freshwater wetlands on the Qinghai-Tibet Plateau (QTP) is estimated at 0.133 × 106 km2, suggesting a significant methane potential. Methane fluxes from wet alpine meadows, peatlands, Hippuris vulgaris mires and secondary marshes were 43.18, 12.96, -0.28 and 45.90 mgf33m-2f33d-1, respectively based on the transect flux studies at the Huashixia Permafrost Station (HPS) from July to August 1996. Average CH4 fluxes in the

关键词： QTP wetland ecosystems CH4 emission spatiality and seasonality fluxes.

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Retinal ganglion cell protection by hop-flower extract as a novel neuroprotective strategy for glaucoma

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Neural Regeneration Research 2022年第6期17卷 1267-1268页

作者： tomoko Hasegawa Hanako Ohashi Ikeda Department of Ophthalmology and Visual Sciences Kyoto University Graduate School of MedicineKyotoJapan Research Fellow of Japan Society for the Promotion of Science TokyoJapan

In glaucoma,a leading cause of blindness,retinal ganglion cells are progressively *** pressure reduction is the only established treatment for glaucoma(Collaborative Normal-Tension Glaucoma Study Group,1998;Vass et al.,2007).However,in some cases,visual field loss progresses despite sufficiently reduced intraocular pressure(Collaborative Normal-Tension Glaucoma Study Group,1998;Killer and Pircher,2018).While intraocular pressure and age are known risk factors for glaucoma(Ernest et al.,2013),the underlying mechanisms of glaucoma progression are not fully understood.

关键词： glaucoma al. protective

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Adenosine triphosphate maintenance by branched chain amino acids as a novel neuroprotective strategy for retinal neurodegenerative diseases

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Neural Regeneration Research 2019年第1期14卷 82-84页

作者： tomoko Hasegawa Hanako Ohashi Ikeda Department of Ophthalmology and Visual Sciences Kyoto University Graduate School of Medicine Department of Experimental Therapeutics Institute for Advancement of Clinical and Translational Science Kyoto University Hospital

Retinal neuronal cell death is caused in many incurable eye diseases such as retinitis pigmentosa(RP)and glaucoma,which are leading causes of adult *** RP,progressive loss of photoreceptor cells leads to visual *** established treatments are available to date for this condition,although potential treatments,including regenerative medicine,gene therapy,and neurotropic factor therapy are being *** glaucoma。

关键词：眼睛疾病视网膜氨基酸基因治疗腺苷分叉维护光敏电阻器

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A Rice Phytochrome A in Arabidopsis： The Role of the N-terminus under red and far-red light

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Molecular Plant 2008年第1期1卷 84-102页

作者： Julia Kneissl tomoko Shinomura Masaki Furuya Cordelia Bolle Ludwig-Maximilians-Universitat Munchen Bereich Botanik Menzinger Str. 67 80638 Munchen Germany Hitachi Advanced Research Laboratory Hatoyama Saitama 350-0395 Japan

The phytochrome （phy）A and phyB photoreceptors mediate three photobiological response modes in plants; whereas phyA can mediate the very-low-fluence response （VLFR）, the high-irradiance response （HIR） and, to some extent, the low fluence response （LFR）, phyB and other type U phytochromes only mediate the LFR. To investigate to what level a rice phyA can complement for Arabidopsis phyA or phyB function and to evaluate the role of the serine residues in the first 20 amino acids of the N-terminus of phyA, we examined VLFR, LFR, and HIR responses in phyB and phyAphyB mutant plants transformed with rice PHYA cDNA or a mutant rice PHYA cDNA in which the first 10 serine residues were mutated to alanines （phyA SA）. Utilizing mutants without endogenous phyB allowed the evaluation of red-light-derived responses sensed by the rice phyA. In summary, the WT rice phyA could complement VLFR and LFR responses such as inhibition of hypocotyl elongation under pulses of FR or continuous R light, induction of flowering and leaf expansion, whereas the phyA SA was more specific for HIR responses （e.g. inhibition of hypocotyl elongation and anthocyanin accumulation under continuous far-red light）. As the N-terminal serines can no longer be phosphorylated in the phyA SA mutant, this suggests a role for phosphorylation discriminating between the different phyA-dependent responses. The efficacy of the rice phyA expressed in Arabidopsis was dependent upon the developmental age of the plants analyzed and on the physiological response, suggesting a stage-dependent downstream modulation of phytochrome signaling.

关键词： phytochrome (phy) high-irradiance response (HIR) very-low-fluence response (VLFR)

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Lateral olfactory tract usher substance(LOTUS) protein,an endogenous Nogo receptor antagonist,converts a non-permissive to permissive brain environment for axonal regrowth

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Neural Regeneration Research 2018年第7期13卷 1193-1194页

作者： tomoko Hirokawa Kohtaro Takei Molecular Medical Bioscience Laboratory Yokohama City University Graduate School of Medical Life Science

It is well known that primates,including humans,hardly recover motor function after spinal cord injury（SCI）when compared with non-primate mammals such as *** limited functional recovery is in part due to a non-permi... 详细信息

关键词： MAG Lateral olfactory tract usher substance protein,an endogenous Nogo receptor antagonist,converts a non-permissive to permissive brain environment for axonal regrowth LOTUS SCI CNS

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Improvement of Glacial Lakes Detection under Shadow Environment Using ASTER Data in Himalayas, Nepal

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Chinese Geographical Science 2013年第2期23卷 216-226页

作者： CHEN Wenbo FUKUI Hiromichi DOKO tomoko GU Xingfa Graduate School of Media and Governance Keio University Chubu Institute for Advanced Studies Chubu University Research Institute of Environment and Information Sciences Yokohama National University JSPS Research Fellow Institute of Remote Sensing Applications Chinese Academy of Sciences

The detection of glacial lake change in the Himalayas, Nepal is extremely significant since the glacial lake change is one of the crucial indicators of global climate change in this area, where is the most sensitive area of the global climate changes. In the Hima- layas, some of glacial lakes are covered by the dark mountains＇ shadow because of their location. Therefore, these lakes can not be de- tected by conventional method such as Normalized Difference Water Index （NDWI）, because the reflectance feature of shadowed glacial lake is different comparing to the ones which are located in the open flat area. The shadow causes two major problems： 1） glacial lakes which are covered by shadow completely result in underestimation of the number of glacial lakes; 2） glacial lakes which are partly iden- tified are considered to undervalue the area of glacial lakes. The aim of this study is to develop a new model, named Detection of Shadowed Glacial Lakes （DSGL） model, to identify glacial lakes under the shadow environment by using Advanced Space-borne Ther- mal Emission and Reflection Radiometer （ASTER） data in the Himalayas, Nepal. The DSGL model is based on integration of two dif- ferent modifications of NDWI, namely NDWls model and NDWIshe model. NDWI~ is defined as integration of the NDWI and slope analysis and used for detecting non-shadowed lake in the mountain area. The NDWIshe is proposed as a new methodology to overcome the weakness of NDWI~ on identifying shadowed lakes in highly elevated mountainous area such as the Himalayas. The first step of the NDWIshe is to enhance the data from ASTER 1B using the histogram equalization （HE） method, and its outcome product is named AS- TERho. We used the ASTERhe for calculating the NDWIhc and the NDWIshe. Integrated with terrain analysis using Digital Elevation Model （DEM） data, the NDWIshe can be used to identify the shadowed glacial lakes in the Himalayas. NDWIs value of 0.41 is used to identify the glacier lake （NDWI~ 〉 0.

关键词： glacial lake shadow environment DSGL model ASTER remote sensing Himalayas Nepal

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Influence of normal to high stroke volume on congestive heart failure development after transcatheter aortic valve implantation:case series

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Journal of Geriatric Cardiology 2021年第1期18卷 83-88页

作者： tomoko Tomioka Tomohiro Ito Ryokichi Takahasi Shuhei Tanaka Department of Cardiology South Miyagi Medical CenterShibataJapan

Aortic stenosis(AS)is the most common valvular disease in the older adults'population,and its prevalence will likely continue to increase with the aging society.[1]Surgical aortic valve replacement(SAVR)for elderly patients is known as a high-risk procedure.[2-4]Transcatheter aortic valve implantation(TAVI)is a reasonable alternative to SAVR for older and inoperable patients with AS,and TAVI significantly improves outcomes in elderly patients with severe AS and serious comorbidities,[5,6]TAVI achieves a 20%relative reduction in mortality compared with SAVR.

关键词： aortic mortality implantation

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