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Involvement of miR-214 and miR-375 in Malignant Features of Non-Small-Cell Lung Cancer by Down-Regulating CADM1

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Journal of Cancer Therapy 2012年第4期3卷 379-387页

作者： Megumi Ishimura Mika Sakurai-Yageta tomoko Maruyama tomoko Ando Masashi Fukayama Akiteru Goto Yoshinori Murakami Department of Pathology Graduate School of Medicine The University of Tokyo Tokyo Japan Division of Molecular Pathology The University of Tokyo Tokyo Japan Laboratory of Pathology Institute of Medical Science The University of Tokyo Tokyo Japan

A tumor suppressor gene, CADM1, encoding an immunoglobulin superfamily cell adhesion molecule, is inactivated in various cancers, including non-small-cell lung cancer (NSCLC). Although promoter methylation is one of the mechanisms to suppress CADM1 expression, about half of tumors lacking CADM1 expression do not show methylation of the gene promoter. We herein investigated the possible involvement of microRNA (miRNA) in the down-regulation of CADM1. Using computational algorithms, miR-214 and miR-375 were identified as candidate miRNAs targeting CADM1. A luciferase reporter assay demonstrated that miR-214 and miR-375 repressed the promoter activity through 3’-UTR of CADM1. Quantitative RT-PCR analysis demonstrated that miR-214 and miR-375 was highly expressed in 21 (62%) and 17 cases (50%) of 34 primary NSCLCs. Notably, increased expression of miR-214 was preferentially observed in tumors with advanced pathological stages and in those lacking CADM1 expression but were not associated with the promoter methylation, suggesting that miR-214-mediated silencing would be another mechanism to suppress CADM1 expression. On the other hand, introduction of miR-214 or miR-375 into NSCLC cells decreased CADM1 protein expression. Furthermore, overexpression of miR-214 enhanced anchorage-independent growth of NSCLC cells, A549, whereas transfection of miRNA inhibitor, miR-214 or miR-375, significantly suppressed the in vitro wound healing activity of HCC827 cells. These findings suggest that overexpression of miR-214 and miR-375 could participate in the malignant features of NSCLC through down-regulating CADM1 and would provide a potential target for the treatment of a subset of NSCLC.

关键词： CADM1 miR-214 miR-375 Non-Small-Cell Lung Cancer

Risk factors for the recurrence of hepatocellular carcinoma after radiofrequency ablation of hepatocellular carcinoma in patients with hepatitis C

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World Journal of Gastroenterology 2005年第14期11卷 2174-2178页

作者： Yutaka Yamanaka Katsuya Shiraki Kazumi Miyashita tomoko Inoue Tomoyuki Kawakita Yumi Yamaguchi Yukiko Saitou Norihiko Yamamoto Takeshi Nakano Atsuhiro Nakatsuka Koichiro Yamakado Kan Takeda First Department of Internal Medicine Mie University School of Medicine 2-174 EdobashiTsuMie 514-8507Japan Department of Radiology Mie University School of Medicine 2-174 EdobashiTsuMie 514-8507Japan

AIM: To analyze the risk factors of hepatocellular carcinoma (HCC) recurrence after radiofrequency ablation (RFA) treatment with HCV-associated hepatitis. METHODS: Twenty-six patients with HCV-associated HCC who were followed-up for more than 12 mo were selected for this study. Risk factors for distant intrahepatic recurrences of HCC were evaluated for patients in whom complete coagulation was achieved without recurrence in the same subsegment as the primary nodule. Twelve clinical and tumoral factors were examined: Age, gender, nodule diameter, number of primary HCC nodule, Child-Pugh classification, serum platelet, serum albumin, serum AST, post RFA AST, serum ALT, post RFA ALT, post RFA ***: Distant recurrences of HCC in remnant liver after RFA were observed in 14 cases and in the number of primary HCC nodules (P = 0.047), and the serum platelets (P = 0.030), the clear difference came out by the recurrence group and the non-recurrence group. The cumulative recurrence rates after 1 and 2 years were30.8% and 86.8%, respectively for primary multinodular HCC, and 15.4% and 29.5% respectively, for primary uninodular HCC. In addition the 1-year recurrence rates for patients with serum albumin more than 3.4 g/dL and less than 3.4 g/dL were 23.1% for both, but the 2-years recurrence rates were 89.0% and 23.1%, respectively. The number of primary HCC nodules (relative risk, 6.970; P = 0.016) were found to be a statistically significant predictor for poor distant intrahepatic recurrence by univariate ***: Patients who have multiple HCC nodules, low serum platelets and low serum albumin accompanied by HCV infection, should be carefully followed because of the high incidence of new HCC lesions in the remnant liver, even if coagulation RFA is complete.

关键词： Hepatocellular carcinoma Radiofrequency ablation

Long-term follow-up of ulcerative colitis patients treated on the basis of their cytomegalovirus antigen status

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World Journal of Gastroenterology 2014年第2期20卷 509-517页

作者： Toshihiro Inokuchi Jun Kato Sakiko Hiraoka Hideyuki Suzuki Asuka Nakarai tomoko Hirakawa Mitsuhiro Akita Sakuma Takahashi Keita Harada Hiroyuki Okada Kazuhide Yamamoto Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Second Department of Internal Medicine Wakayama Medical UniversityWakayama 641-0012Japan

AIM:To clarify the impact of cytomegalovirus(CMV)activation and antiviral therapy based on CMV antigen status on the long-term clinical course of ulcerative colitis(UC)***:UC patients with flare-up were divided into CMV-positive and-negative groups according to the CMV antigenemia *** main treatment strategy provided for the patients in the CMV-positive group comprised a dose reduction of corticosteroids and administration of ***:The median number of days to initial remission was significantly greater for the patients in the CMV-positive group(21 d vs 16 d,P=0.009).However,the relapse rate after remission and colectomy rate during more than 30 mo of observation did not differ between the two *** analysis revealed that administration of ganciclovir was the only independent factor for avoiding colectomy in patients of the CMV-positive ***:CMV antigen status did not significantly affect the long-term prognosis in UC patients under treatment with appropriate antiviral therapy.

关键词： Ulcerative colitis Cytomegalovirus Cytomegalovirus antigenemia assay

Implementation and Evaluation of a Postpartum Care Program for Mothers Raising Infants: A Pilot Study

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Open Journal of Nursing 2020年第8期10卷 758-769页

作者： Kyoko Asazawa Natsuko Kojima tomoko Kato Mieko Hirade Division of Nursing Faculty of Nursing Tokyo Healthcare University Tokyo Japan

Background: The aims of this pilot study were to implement and evaluate a postpartum care program for mothers raising children younger than one year to provide physical relaxation, and to reduce mothers’ parenting problems. Methods: A day-service and group-type postpartum care program was implemented with the aim of interacting with peers, promoting local communication, and relaxing mothers. Results: Forty-five pairs of mothers and infants participated in the study. Most of the mothers experienced relaxation, communicated with each other, resolved physical problems, reduced childcare concerns, and developed parenting friends. Conclusions: In addition, feasibility was assured as they were very satisfied with the content of programs such as baby massage and aroma treatment.

关键词： Postnatal Care Mothers Midwifery Program Evaluation Feasibility Studies

How Do Weekly Magazines Provide Information on Urogenital Cancer to the Public in Aged Societies?

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Open Journal of Urology 2013年第6期3卷 246-247页

作者： Masayoshi Nagata tomoko Matsumura Masahiro Kami Department of Urology National Center of Global Health and Medicine Tokyo Japan Division of Social Communication System for Advanced Clinical Research The Institute of Medical Science The University of Tokyo Tokyo Japan

Little information on cancer coverage rather than newspaper and television is available. Japanese weekly magazines have a circulation of over 2,700,000 per week. To examine how they delivered urogenital cancer information to the public, cancer-related articles and advertisements in six major Japanese weekly magazines from 2009 to 2010 was analyzed. 1.8% of total articles and advertisements were cancer-related. Prostate cancer (n = 119) was the second-most common topic, following lung cancer (n = 145), whereas only three articles were published on kidney or bladder cancer. The 53 articles on therapies for prostate cancer comprised radiotherapy (n = 29), surgery (n = 16), chemotherapy (n = 4), and others (n = 4). All 42 comments or interviews were cited in the article on prostate cancer, while 26 of them were attributed to only two famous doctors. Although cancer coverage in weekly magazines could be useful to spread information on prostate cancer, we should recognize their considerable bias based on a disproportionate emphasis.

关键词： Cancer Coverage Weekly Magazine Prostate Cancer

Inhibitory Activity of Paenibacillussp. Isolated from Soil in Gotsu City, Shimane Prefecture, Against Xanthomas oryzaepv. oryzae, the Causal Agent of Rice Bacterial Leaf Blight

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Advances in Microbiology 2018年第3期8卷 197-210页

作者： Mohammad Naser Haidary tomoko Tamura Makoto Ueno Laboratory of Plant Pathology Faculty of Life and Environmental ScienceShimane UniversityMatsueJapan

Microorganism isolates (n = 49) were obtained from the soil samples collected from field in Gotsu city (Kawahira), Shimane. Isolate GT2-E culture inhibited the growth of Xanthomonas oryzae pv. oryzae in disk diffusion method. Rice bacterial leaf blight was suppressed by GT2-E culture in the pre- and post-treated rice leaves. Sequence analysis of 16S rDNA region of the GT2-E isolate indicated that it shared 99% similarity with Paenibacillus polymyxa. The growth of GT2-E on LB medium was observed at 15°C, 28°C, 37°C, and 45°C, but not at 4°C. GT2-E isolate could be grown even in the presence of agrochemicals (Amister, Blasin and Kasumin). Furthermore, the growth of X. oryzae pv. oryzae was inhibited by the culture filtrate of GT2-E isolate in disk diffusion method. However, the inhibitory activity of the culture filtrate was heat-unstable. This result suggested that GT2-E isolate can produce heat-unstable inhibitory compound(s). In conclusion, GT2-E isolate might contribute to the development of a new bactericide and biological agent against rice bacterial leaf blight.

关键词： Rice Bacterial Leaf Blight Xanthomonas oryzae pv. oryzae Microorganisms Paenibacillus polymyxa

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tomoko的时尚日记

中国服装（北京） 2005年第16期 82-84,86-88页

作者： tomoko Oka[日] 李代（编译）孔繁勃（编译）

很多人说，把握时尚是很难的事情，看起来它会瞬息变幻嘏没有任何理由。但其实，是有理由的，只要我们不知道它是什么，以及它是怎么发生的。每年云游世界时尚城市的日本著名资深时尚摄影记者，评论家tomoko Oka女士在参加了近期于欧洲... 详细信息

很多人说，把握时尚是很难的事情，看起来它会瞬息变幻嘏没有任何理由。但其实，是有理由的，只要我们不知道它是什么，以及它是怎么发生的。每年云游世界时尚城市的日本著名资深时尚摄影记者，评论家tomoko Oka女士在参加了近期于欧洲举行的一系列男装展之后，为我们独家奉献了精彩的时尚日记，虽然简短，却字字珠玑。但愿时尚界的有心人，能从中找到你们所需要的，一切理由。

关键词：日记摄影记者理由世界时

Oxone-Mediated Oxidative Esterification of Heterocyclic Aldehydes Using Indium(III) Triflate

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Green and Sustainable Chemistry 2014年第1期4卷 20-23页

作者： tomoko Mineno Saki Yoshino Akira Ubukata aboratory of Medicinal Chemistry Faculty of Pharmacy Takasaki University of Health and Welfare Takasaki Japan Laboratory of Medicinal Chemistry Faculty of Pharmacy Takasaki University of Health and Welfare Takasaki Japan

Recent investigations have shown the oxone-mediated oxidative methyl esterification of benzaldehyde derivatives using methanol. The reactions were accelerated in the presence of indium(III) triflate, a trivalent indium reagent, in many cases. Based on this method of methyl esterification of benzaldehyde derivatives, we further explored an application to heterocyclic aldehydes. The reactions were examined using methanol as well as other alcohols in order to establish a suitable range.

关键词： Oxidative Esterification Heterocyclic Aldehydes Indium(III) Triflate

Chemistry and Mineralogy of Inhalable Particulate Matter in Kumamoto, Southwestern Japan

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Chemistry and Mineralogy of Inhalable Particulate Matter in ...