检索结果-南通市图书馆

Oral tolerance is inducible during active dextran sulfate sodium-induced colitis

World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 242-253页

作者： Satoshi Ino Chikara Kohda Kosuke Takeshima Hiroki Ishikawa tomoko norose Toshiko Yamochi Masafumi Takimoto Hiroshi Takahashi Kazuo Tanaka Department of Microbiology and Immunology School of Medicine Showa University Department of Pathology and Laboratory Medicine School of Medicine Showa University Division of Gastroenterology Department of Internal Medicine Showa University

AIM:To investigate whether oral tolerance is inducible during the active phase of dextran sulfate sodium(DSS)-induced ***:Colitis was induced in 6-to 8-wk-old female BALB/c mice by the administration of 2%*** induce oral tolerance,mice that received water with DSS[DSS(+)]and mice that received autoclaved water[DSS(-)]were intragastrically(i.g.)administered ovalbumin(OVA)as a tolerogen before systemic challenge with *** this,serum levels of OVA-specific Ig E antibodies were *** mice with activecolitis,CD4+CD25+Foxp3+cell and B10 cell frequencies were evaluated using flow *** m RNA expression profiles were evaluated by reverse transcription real-time polymerase chain ***:Regardless of the presence of DSS colitis,OVA-specific immunoglobulin E concentrations were significantly reduced in mice that were *** OVA compared to mice that were *** PBS[DSS(+):4.4(4.2-9.5)ng/m L vs 83.9(66.1-123.2)ng/m L,P<0.01;DSS(-):27.7(0.1-54.5)ng/m L vs116.5(80.6-213.6)ng/m L,P<0.01].These results demonstrated that oral tolerance was induced in both the presence and absence of *** the spleen and mesenteric lymph nodes(MLN),the frequencies of CD4+CD25+Foxp3+cells and B10 cells,both of which are associated with oral tolerance,did not significantly *** the spleen,interferon-γm RNA expression significantly decreased in mice with colitis[DSS(+):0.42(0.31-0.53)vs DSS(-):1.00(0.84-1.39),P<0.01].The expression levels of other cytokines did not significantly ***:Oral tolerance is inducible during active DSS *** stability of regulatory cell populations in the spleen and MLN in colitis might correlate with these results.

关键词： Cytokine Dextran sulfate sodium colitis Oral tolerance Regulatory T cell Regulatory B cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：