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Simple and Robust Direct Drive Wave Power Generation System Using Dielectric Elastomers

材料科学与工程（中英文B版） 2017年第1期7卷 39-47页

作者： Seiki Chiba Mikio Waki Koji Fujita Koichi Masuda tomoki ikoma Chiba Science Institute Meguro Ward Tokyo 152-0023 Japan Wits Inc. Sakura City Tochigi 329-1334 Japan Institute of Space and Astronautical Science Japan Aerospace Exploration Agency Sagamihara City Kanagawa 252-5210 Japan Department of Oceanic Architecture and Engineering CST Nihon University Funabashi City Chiba 274-8501 Japan

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Involvement of A5/A7 noradrenergic neurons and B2 serotonergic neurons in nociceptive processing:a fiber photometry study

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Neural Regeneration Research 2022年第4期17卷 881-886页

作者： Shunpei Moriya Akira Yamashita Daiki Masukawa Junichi Sakaguchi Yoko ikoma Yoshimune Sameshima Yuki Kambe Akihiro Yamanaka Tomoyuki Kuwaki Department of Physiology Kagoshima University Graduate School of Medical and Dental ScienceKagoshimaJapan Department of Molecular Pharmacologyand Neurobiology Yokohama City University Graduate School of MedicineYokohamaJapan Department of Pharmacology Kagoshima University Graduate School of Medical and Dental ScienceKagoshimaJapan Research Institute of Environmental Medicine Nagoya UniversityNagoyaJapan

In the central nervous system,the A6 noradrenaline(NA)and the B3 serotonin(5-HT)cell groups are well-recognized players in the descending antinociceptive system,while other NA/5-HT cell groups are not well characterized.A5/A7 NA and B25-HT cells project to the spinal horn and form descending *** recorded G-Ca MP6 green fluorescence signal intensities in the A5/A7 NA and the B25-HT cell groups of awake mice in response to acute tail pinch stimuli,acute heat stimuli,and in the context of a non-noxious control test,using fiber photometry with a calcium imaging *** first introduced G-Ca MP6 in the A5/A7 NA or B25-HT neuronal soma,using transgenic mice carrying the tetracycline-controlled transactivator transgene under the control of either a dopamineβ-hydroxylase or a tryptophan hydroxylase-2 promoters and by the site-specific injection of adeno-associated virus(AAV-Tet O(3 G)-G-Ca MP6).After confirming the specific expression patterns of G-Ca MP6,we recorded G-Ca MP6 green fluorescence signals in these sites in awake mice in response to acute nociceptive stimuli.G-Ca MP6 fluorescence intensity in the A5,A7,and B2 cell groups was rapidly increased in response to acute nociceptive stimuli and soon after,it returned to baseline fluorescence *** was not observed in the non-noxious control *** results indicate that acute nociceptive stimuli rapidly increase the activities of A5/A7 NA or B25-HT neurons but the non-noxious stimuli do *** present study suggests that A5/A7 NA or B25-HT neurons play important roles in nociceptive processing in the central nervous *** suggest that A5/A7/B2 neurons may be new therapeutic *** performed procedures were approved by the Institutional Animal Use Committee of Kagoshima University(MD17105)on February 22,2018.

关键词： A5 NA neurons A7 NA neurons B25-HT neurons DBH-tTA mice fiber photometry G-CaMP6 mCherry monoaminergic signaling nociception TPH-t TA mice

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Progression of remnant gastric cancer is associated with duration of follow-up following distal gastrectomy

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World Journal of Gastroenterology 2012年第22期18卷 2832-2836页

作者： Shuhei Komatsu Daisuke Ichikawa Kazuma Okamoto Daito ikoma Masahiro Tsujiura Yukihisa Nishimura Yasutoshi Murayama Atsushi Shiozaki Hisashi ikoma Yoshiaki Kuriu Masayoshi Nakanishi Hitoshi Fujiwara Toshiya Ochiai Yukihito Kokuba Eigo Otsuji Division of Digestive Surgery Department of Surgery Kyoto Prefectural University of Medicine 465 Kajii-cho Kawaramachihirokoji Kamigyo-ku Kyoto 602-8566 Japan

AIM: To re-evaluate the recent clinicopathological features of remnant gastric cancer (RGC) and to develop desirable surveillance programs. METHODS: Between 1997 and 2008, 1149 patients underwent gastrectomy for gastric cancer at the Department of Digestive Surgery, Kyoto Prefectural University of Medicine, Japan. Of these, 33 patients underwent gastrectomy with lymphadenectomy for RGC. Regarding the initial gastric disease, there were 19 patients with benign disease and 14 patients with gastric cancer. The hospital records of these patients were reviewed retrospectively. RESULTS: Concerning the initial gastric disease, the RGC group following gastric cancer had a shorter interval [P < 0.05; gastric cancer vs benign disease: 12 (2-22) vs 30 (4-51) years] and were more frequently reconstructed by Billroth-Ⅰ procedure than those following benign lesions (P < 0.001). Regarding reconstruction, RGC following Billroth-Ⅱ reconstruction showed a longer interval between surgical procedures [P < 0.001; Billroth-Ⅱ vs Billroth-Ⅰ: 32 (5-51) vs 12 (2-36) years] and tumors were more frequently associated with benign disease (P < 0.001) than those following Billroth-Ⅰ reconstruction. In tumor location of RGC, after Billroth-Ⅰ reconstruction, RGC occurred more frequently near the suture line and remnant gastric wall. After Billroth-Ⅱ reconstruction, RGC occurred more frequently at the anastomotic site. The duration of follow-up was significantly associated with the stage of RGC (P < 0.05). Patients diagnosed with early stage RGC such as stage Ⅰ-Ⅱ tended to have been followed up almost every second year. CONCLUSION: Meticulous follow-up examination and early detection of RGC might lead to a better prognosis. Based on the initial gastric disease and the procedure of reconstruction, an appropriate follow-up interval and programs might enable early detection of RGC.

关键词：时间间隔胃癌随访远端早期阶段有限元分析早期检测切除术

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Laparoscopic cholecystectomy for gangrenous cholecystitis in around nineties: Two case reports

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World Journal of Clinical Cases 2021年第14期9卷 3424-3431页

作者： Hiroyuki Inoue Toshiya Ochiai Hidemasa Kubo Yusuke Yamamoto Ryo Morimura Hisashi ikoma Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectual University of MedicineKyoto 6028566Japan Department of Surgery North Medical Center Kyoto Prefectural University of MedicineKyoto 6292261Japan Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKyoto 6028566Japan

BACKGROUND Gangrenous cholecystitis is a form of acute cholecystitis which involves gangrenous alterations in the gallbladder wall and it often follows an acute and serious *** herein report on two cases of very elderly people diagnosed early with gangrenous cholecystitis,who safely underwent laparoscopic cholecystectomy(LC)and both demonstrated a good *** SUMMARY Case 1:An 89-year-old *** underwent abdominal contrast-enhanced computed tomography(CECT)due to abdominal pain and *** gallbladder wall indicated the absence of contrast enhancement,thus leading to diagnosis of gangrenous cholecystitis and she therefore underwent *** her gallbladder demonstrated diffuse necrosis and it was also partly perforated,she was able to be discharged without any serious *** 2:A 91-year-old *** made an emergency visit with a chief complaint of abdominal *** CECT revealed swelling of the gallbladder and an ambiguous continuity of the gallbladder *** was diagnosed with gangrenous cholecystitis and underwent *** gallbladder had swelling and diffuse *** her preoperative blood culture was positive,she showed a good outcome following *** Although a definite diagnosis of gangrenous cholecystitis is difficult to make prior to surgery,if an early diagnosis can be made and appropriate treatment can be carried out,then even very elderly individuals may be discharged without major complications.

关键词： Gangrenous cholecystitis Laparoscopic cholecystectomy Elderly people Critical view of safety Tokyo guidelines 2018 Case report

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The naked planet Earth:Most essential pre-requisite for the origin and evolution of life

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Geoscience Frontiers 2013年第2期4卷 141-165页

作者： S.Maruyama M.ikoma H.Genda K.Hirose T.Yokoyama M.Santosh Department of Earth and Planetary Sciences Tokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo 152-8551Japan Department of Earth and Planetary Science.The University of Tokyo 7-3-1 HongoBunkyo-kuTokyo 113-0033.Japan Department of Earth and Planetary Sciences.Tokyo Institute of Technology 2-12-1 OokayamaMeguro-ku.Tokyo 152-8551Japan School of Earth Sciences and Resources China University of Geosciences(Beijing) Faculty of Science Kochi UniversityKochi 780-8520Japan

Our blue planet Earth has long been regarded to carry full of nutrients for hosting life since the birth of the *** we speculate the processes that led to the birth of early life on Earth and its aftermath, finally leading to the evolution of *** evaluate：（1） the source of nutrients,（2） the chemistry of primordial ocean,（3） the initial mass of ocean,and（4） the size of *** the life-building nutrients,phosphorus and potassium play a key *** three types of rocks can serve as an adequate source of nutrients：（a） continent-forming TTG（granite）,enabling the evolution of primitive life to metazoans;（b） primordial continents carrying anorthosite with KREEP（Potassium,Rare Earth Elements, and Phosphorus） basalts,which is a key to bear life;（c） carbonatite magma,enriched in radiogenic elements such as U and Th,which can cause mutation to speed up evolution and promote the birth of new species in continental rift *** second important factor is ocean *** primordial ocean was extremely acidic（pH = 1-2） and enriched in halogens（CI,F and others）,S,N and metallic elements（Cd,Cu,Zn,and others）,inhibiting the birth of *** tectonics cleaned up these elements which interfered with *** ocean finally appeared in the Phanerozoic with pH = 7 through extensive interaction with surface continental crust by weathering,erosion and transportation into *** initial ocean mass was also *** birth of life and aftermath of evolution was possible in the habitable zone with 3-5 km deep ocean which was able to supply sufficient nutrients. Without a huge landmass,nutrients cannot be supplied into the ocean only by ridge-hydrothermal circulation in the ***,the size of the planet plays a crucial *** of massive planets is less efficient than smaller ones,so that return-flow of seawater into mantle does not occur until central stars finish their main *** to the suitable size of Earth,the dawn of Phaneroz

关键词： Earth Life Habitable planet Initial ocean mass Metazoan Nutrients

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Successful endovascular treatment of endoscopically unmanageable hemorrhage from a duodenal ulcer fed by a renal artery: A case report

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World Journal of Clinical Cases 2018年第15期6卷 1012-1017页

作者： Shimpei Anami Hiroki Minamiguchi Naoaki Shibata Takao Koyama Hirotatsu Sato Akira ikoma Motoki Nakai Takuji Yamagami Tetsuo Sonomura Department of Radiology Wakayama Medical University Department of Radiology Kochi Medical School Kochi University Department of Emergency and Critical Care Medicine Wakayama Medical University

A 52-year-old woman was admitted with hypovolemic shock. Emergency endoscopy revealed three hemorrhagic duodenal ulcers(all stage A1) with exposed vessels. Two ulcers were successfully treated by endoscopic clipping; however, the remaining ulcer on the posterior wall of the horizontal portion of the duodenum could not be clipped. Because her vital signs were rapidly worsening, we performed transcatheter arterial embolization(TAE) as it is less invasive than surgery. Computed tomography aortography showed that the duodenal hemorrhage was sourced from the lower branch of the right renal artery. In general, the duodenum is fed by branches from the gastroduodenal artery or superior mesenteric artery. However, this patient had three right renal arteries. The lower branch of the right renal artery at the L3 vertebral level was at the same level as the horizontal portion of the duodenum. Complete hemostasis was achieved by TAE using metallic coils and n-butyl-2-cyanoacrylate. After TAE, she recovered from the hypovolemic shock and was discharged from hospital. She has had no recurrence of the hemorrhagic duodenal ulcer for over 1 yr, and followup endoscopy showed no necrosis or stricture of the duodenum. Although she developed a small infarct of her right kidney, her renal function was satisfactory. In summary, the present case is the first reported case of hemorrhagic duodenal ulcer in which the culprit vessel was a renal artery that was successfully treated by TAE. Computed tomography aortography before TAE provides valuable information regarding the source of a duodenal hemorrhage.

关键词： Transcatheter arterial embolization Metallic coils N-butyl-2-cyanoacrylate Renal artery Emergency radiology Case report Duodenal ulcer

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Preoperative microcoil embolization of the common hepatic artery for pancreatic body cancer

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World Journal of Gastroenterology 2012年第16期18卷 1940-1945页

作者： Isao Takasaka Nobuyuki Kawai Morio Sato Hirohiko Tanihata Tetsuo Sonomura Hiroki Minamiguchi Motoki Nakai Akira ikoma Kouhei Nakata Hiroki Sanda Department of Radiology Wakayama Medical University811-1 KimiideraWakayama-shiWakayama 641-8510Japan

AIM:To evaluate safety and feasibility of microcoil embolization of the common hepatic artery under proper or distal balloon inflation in preoperative preparation for en bloc celiac axis resection for pancreatic body ***:Fifteen patients(11 males,4 females;median age,67 years) with pancreatic body cancer involving the nerve plexus surrounding the celiac artery underwent microcoil *** alter the total hepatic blood flow from superior mesenteric artery(SMA),microcoil embolization of the common hepatic artery(CHA) was conducted in 2 cases under balloon inflation at the proximal end of the CHA and in 13 cases under distal microballoon inflation at the distal end of the ***:Of the first two cases of microcoil embolization with proximal balloon inflation,the first was successful,but there was microcoil migration to the proper hepatic artery in the *** migrated microcoil was withdrawn to the CHA by an inflated microballoon *** embolization was successful in the other 13 cases with distal microballoon inflation,with no microcoil *** microcoil embolization under distal microballoon inflation created sufficient resistance against the vascular wall to prevent *** balloon inflation achieved the requisite 1 cm patency at the CHA end for vascular *** patients underwent en bloc celiac axis resection without arterial reconstruction or liver ***:To impede microcoil migration to the proper hepatic artery during CHA microcoil embolization,distal microballoon inflation is preferable to proximal balloon inflation.

关键词：肝动脉栓塞癌术前准备周围神经通货膨胀肝脏缺血 CHA

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Surgical treatment of hepatocellular carcinoma with severe intratumoral arterioportal shunt

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World Journal of Gastroenterology 2010年第25期16卷 3211-3214页

作者： Hiromichi Ishii Teruhisa Sonoyama Shingo Nakashima Hiroyuki Nagata Atsushi Shiozaki Yoshiaki Kuriu Hisashi ikoma Masayoshi Nakanishi Daisuke Ichikawa Hitoshi Fujiwara Kazuma Okamoto Toshiya Ochiai Yukihito Kokuba Chohei Sakakura Eigo Otsuji Division of Digestive Surgery Department of Surgery Kyoto Prefectural University of Medicine Kyoto 602-8566 Japan

We report a case of hepatocellular carcinoma (HCC) that caused a severe arterioportal shunt (APS). A 49-year-old man was admitted to hospital due to esophagogastric variceal hemorrhage and HCC, and underwent endoscopic variceal ligation (EVL) and endoscopic injection sclerotherapy (EIS). He was then referred to our hospital. Abdominal computed tomography revealed a lowdensity lesion in the posterior segment of the liver and an intratumoral APS, which caused portal hypertension. Although the patient underwent EVL, EIS, Hassab’s operation, and transcatheter arterial embolization for APS, he vomited blood due to rupture of esophagogastric varices. Right hepatectomy was performed for the treatment of HCC and APS, although the indocyanine green retention value at 15 min after intravenous injection was poor (30%). The patient’s postoperative course was uneventful. Eventually, APS disappeared and the esophagogastric varices improved.

关键词： Arterioportal shunt Hepatocellular carcinoma Esophagogastric varices

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Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids

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World Journal of Gastroenterology 2017年第31期23卷 5650-5668页

作者： wataru okajima shuhei komatsu daisuke ichikawa mahito miyamae takuma ohashi taisuke imamura jun kiuchi keiji nishibeppu tomohiro arita hirotaka konishi atsushi shiozaki ryo morimura hisashi ikoma kazuma okamoto eigo otsuji division of digestive surgery department of surgery kyoto prefectural university of medicine

Hepatocellular carcinoma(HCC), with its high incidence and mortality rate, is one of the most common malignant tumors. Despite recent development of a diagnostic and treatment method, the prognosis of HCC remains poor. Therefore, to provide optimal treatment for each patient with HCC, more precise and effective biomarkers are urgently needed which could facilitate a more detailed individualized decision-making during HCC treatment, including the following; risk assessment, early cancer detection, prediction of treatment or prognostic outcome. In the blood of cancer patients, accumulating evidence about circulating tumor cells and cell-free nucleic acids has suggested their potent clinical utilities as novel biomarker. This concept, so-called "liquid biopsy" is widely known as an alternative approach to cancer tissue biopsy. This method might facilitate a more sensitive diagnosis and better decision-making by obtaining genetic and epigenetic aberrations that are closely associated with cancer initiation and progression. In this article, we review recent developments based on the available literature on both circulating tumor cells and cell-free nucleic acids in cancer patients, especially focusing on Hepatocellular carcinoma.

关键词： Hepatocellular 癌 Biomarker 液体活体检视传播肿瘤房间没有房间的 nucleic 酸

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Early thrombomodulin-α administration outcome for acute disseminated intravascular coagulopathy in gastrointestinal surgery

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World Journal of Gastroenterology 2017年第5期23卷 891-898页

作者： Hirotaka Konishi Kazuma Okamoto Katsutoshi Shoda Tomohiro Arita Toshiyuki Kosuga Ryo Morimura Shuhei Komatsu Yasutoshi Murayama Atsushi Shiozaki Yoshiaki Kuriu Hisashi ikoma Masayoshi Nakanishi Daisuke Ichikawa Hitoshi Fujiwara Eigo Otsuji Division of Digestive Surgery Department of SurgeryKyoto Prefectural University of MedicineKajii-choKyoto city 6028566Japan

AIM To investigate the efficacy of thrombomodulin(TM)-α for treatment of disseminated intravascular coagulopathy(DIC) in the field of gastrointestinal surgery. METHODS Thirty-six peri-operative DIC patients in the field of gastrointestinal surgery who were treated with TM-α were retrospectively investigated. The relationships between patient demographics and the efficacy of TM-α were examined. Analysis of survival at 28 d was also performed on some parameters by means of the Kaplan-Meier method. Relationships between the ini-tiation of TM-α and patient demographics were also evaluated. RESULTS Abscess formation or bacteremia was the most frequent cause of DIC(33%), followed by digestive tract perforation(31%). Twenty-six patients developed DIC after surgery, frequently within 1 wk(81%). TM-α was most often administered within 1 d of the DIC diagnosis(72%) and was continued for more than 3 d(64%). Although bleeding tendency was observed in 7 patients(19%), a hemostatic procedure was not needed. DIC scores, systemic inflammatory response syndrome(SIRS) scores, quick-sequential organ failure assessment(qS OFA) scores, platelet counts, and prothrombin time ratios significantly improved after 1 wk(P < 0.05, for all). The overall survival rate at 28 d was 71%. The duration of TM-α administration(≥ 4, ≤ 6) and improvements in DIC-associated scores(DIC, SIRS and q SOFA) at 1 wk were significantly better prognostic factors for 28-d survival(P < 0.05, for all). TM-α was administered significantly earlier to patients with severe clinical symptoms, such as high qS OFA scores, sepsis, shock or high lactate values(P < 0.05, for all). CONCLUSION Early administration of TM-α and improvements in each parameter were essential for treatment of DIC. The diagnosis of patients with mild symptoms requires further study.

关键词：快顺序的机关失败评价 Thrombomodulin-α 胃肠的外科全身的煽动性的反应症候群尖锐传播 intravascular coagulopathy

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