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Esophageal diverticulum: New perspectives in the era of minimally invasive endoscopic treatment

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World Journal of Gastroenterology 2019年第12期25卷 1457-1464页

作者： Hiroki Sato Manabu Takeuchi Satoru Hashimoto Ken-ichi mizuno Koichi Furukawa Akito Sato Junji Yokoyama Shuji Terai Division of Gastroenterology Niigata University Medical and Dental Hospital Division of Gastroenterology Nagaoka Red Cross Hospital Division of Gastroenterology Niigata City General Hospital Division of Gastroenterology Nagaoka Chuo General Hospital

Esophageal diverticula are rare conditions that cause esophageal symptoms, such as dysphagia, regurgitation, and chest pain. They are classified according to their location and characteristic pathophysiology into three types: epiphrenic diverticulum, Zenker's diverticulum, and Rokitansky diverticulum. The former two disorders take the form of protrusions, and symptomatic cases require interventional treatment. However, the esophageal anatomy presents distinct challenges to surgical resection of the diverticulum, particularly when it is located closer to the oral orifice. Since the condition itself is not malignant,minimally invasive endoscopic approaches have been developed with a focus on alleviation of symptoms. Several types of endoscopic devices and techniques are currently employed, including peroral endoscopic myotomy(POEM). However,the use of minimally invasive endoscopic approaches, like POEM, has allowed the development of new disorder called iatrogenic esophageal diverticula. In this paper, we review the pathophysiology of each type of diverticulum and the current state-of-the-art treatment based on our experience.

关键词： Diverticulum Esophagus Epiphrenic diverticulum Zenker's diverticulum Rokitansky diverticulum Iatrogenic disease Esophageal achalasia Peroral endoscopic myotomy Diverticulectomy

A Study on the Correlation of Milk Yield of Cows with Seismicity and ULF Magnetic Field Variations

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Open Journal of Earthquake Research 2016年第4期5卷 206-218页

作者： Masashi Hayakawa tomokazu Asano Alexander Schekotov Hiroyuki Yamauchi Hayakawa Institute of Seismo Electromagnetics Co. Ltd. University of Electro-Communications (UEC) Incubation Center Chofu Japan Advanced Wireless & Communications Research Center UEC Chofu Japan Institute of Physics of the Earth Russian Academy of Sciences Moscow Russia Department of Human and Animal-Plant Relationships Azabu University Sagamihara Japan

A statistical study on the basis of one-year data of 2014 has been performed in order to find whether abnormal animal behavior is related with seismic activity and also whether the ULF (Ultra Low Frequency) electromagnetic radiation might be a possible sensory mechanism of abnormal animal behavior. Abnormal animal behavior has been studied with the use of digitally recorded milk yield of cows at Ibaraki Prefecture Livestock Station, and the ULF magnetic field changes have been studied with the data at a magnetic observatory of Kakioka. As the result of correlation analyses, clear responses are observed for both the milk yield of cows and ULF magnetic field changes (both ULF radiation (ULF emissions from the lithosphere) and ULF depression (as an indicator of lower ionospheric perturbations)) for most powerful and not distant earthquakes (EQs) with magnitude > 6, that is, the milk yield of cows is found to exhibit a conspicuous depletion about 17 - 18 days before an EQ, though the correlation coefficient is not so big. Another important objective in this paper is to identify that ULF radiation is the main agent of abnormal behavior so that we have compared the temporal evolutions of milk yield of cows, ULF radiation and ULF depression for three major EQs. As a result, it is found that ULF radiation happens, at least, during the periods of abnormal depletion of milk yield of cows.

关键词： Milk Yield of Cows Correlation Analyses Earthquake Prediction ULF Radiation ULF Depression

Preparation of Iron Ferrocyanide-Supported Nanofiber Membrane for Purification of Cesium-Contaminated Water

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Journal of Water Resource and Protection 2014年第4期6卷 249-255页

作者： Yasuhito Mukai Ayana mizuno Department of Chemical Engineering Nagoya University Nagoya Japan

The earthquake in northeastern Japan that occurred on March 11, 2011 brought about the nuclear accident, resulting in the detection of radioactive cesium in soil and water over a wide region around Fukusihma. In this study, with the aim of the establishment of an effective method for removing cesium from water contaminated with cesium, the functionalized membrane with large cesium adsorption capacity per unit mass was prepared by combining nanofibers having a large specific surface area with iron ferrocyanide having a high selectivity for cesium adsorption. The nanofiber membrane made of polyacrylonitrile (PAN) was used as a base material of the functionalized membrane. Nanofiber membranes were immersed in the dispersions of iron ferrocyanide with various concentrations and pH values. After taking it out, it was dried at various temperatures and then non-immobilized iron ferrocyanide was completely removed through cleaning. As a result of the evaluation of completed affinity membranes, the amount of iron ferrocyanide immobilized by the nanofiber membrane increased significantly with the increase in the iron ferrocyanide concentration but subsequently showed a tendency to decrease rapidly, resulting in a distinct maximum at the iron ferrocyanide concentration of 3 wt%. And, the supported amount of iron ferrocyanide to the nanofiber membrane increased as pH became lower. Moreover, it was found that as high temperature as possible without exceeding the glass transition temperature of PAN was optimal as a drying temperature of prepared affinity membrane.

关键词： Nanofiber Membrane Iron Ferrocyanide Cesium Adsorption

An Analysis of Three Inflection on Four Economic Phases in the Thetical Economics and the Antithetical Economics

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通讯和计算机（中英文版） 2016年第5期13卷 217-224页

作者： Eizo Kinoshita Takafumi mizuno School of Urban Science Meijo University Gifu Japan

Diagnosis and management of fibromuscular dysplasia and segmental arterial mediolysis in gastroenterology field: A mini-review

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World Journal of Gastroenterology 2018年第32期24卷 3637-3649页

作者： Masayoshi Ko Kenya Kamimura Kohei Ogawa Kentaro Tominaga Akira Sakamaki Hiroteru Kamimura Satoshi Abe Kenichi mizuno Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

The vascular diseases including aneurysm, occlusion, and thromboses in the mesenteric lesions could cause severe symptoms and appropriate diagnosis and treatment are essential for managing patients. With the development and improvement of imaging modalities, diagnostic frequency of these vascular diseases in abdominal lesions is increasing even with the small changes in the vasculatures. Among various vascular diseases, fibromuscular dysplasia(FMD) and segmental arterial mediolysis(SAM) are noninflammatory, nonatherosclerotic arterial diseases which need to be diagnosed urgently because these diseases could affect various organs and be lethal if the appropriate management is not provided. However, because FMD and SAM are rare, the cause, prevalence, clinical characteristics including the symptoms, findings in the imaging studies, pathological findings, management, and prognoses have not been systematically summarized. Therefore, there have been neither standard diagnostic criteria nor therapeutic methodologies established, to date. To systematically summarize the information and to compare these disease entities, we have summarized the characteristics of FMD and SAM in the gastroenterological regions by reviewing the cases reported thus far. The information summarized will be helpful for physicians treating these patients in an emergency care unit and for the differential diagnosis of other diseases showing severe abdominal pain.

关键词： Fibromuscular dysplasia Segmental arterial mediolysis Mesenteric lesion diagnosis Humans

SREBP2 restricts osteoclast differentiation and activity by regulating IRF7 and limits inflammatory bone erosion

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Bone Research 2024年第3期12卷 689-703页

作者： Haemin Kim In Ah Choi Akio Umemoto Seyeon Bae Kaichi Kaneko Masataka mizuno Eugenia Giannopoulou Tania Pannellini Liang Deng Kyung-Hyun Park-Min Arthritis and Tissue Degeneration Program David Z.Rosensweig Genomics Research CenterHospital for Special SurgeryNew YorkNY 11366USA Department of Medicine Weill Cornell Medical CollegeNew YorkNY 10021USA CHA Biomedical Research Institute CHA Bundang Medical CenterCHA University School of MedicineSeongnam 13496Republic of Korea Department of Internal Medicine College of MedicineChungbuk National UniversityCheongjuChungbuk 28644Republic of Korea Biological Sciences Department New York City College of TechnologyCity University of New YorkBrooklynNY 11201USA Dermatology Service Department of MedicineMemorial Sloan Kettering Cancer CenterNew YorkNY 10065USA Department of Dermatology Weill Cornell Medical CollegeNew YorkNY 10021USA BCMB Allied Program Weill Cornell Graduate School of Medical SciencesNew YorkNY 10065USA

Osteoclasts are multinucleated bone-resorbing cells,and their formation is tightly regulated to prevent excessive bone ***,the mechanisms by which osteoclast formation is restricted remain incompletely ***,we found that sterol regulatory element binding protein 2(SREBP2)functions as a negative regulator of osteoclast formation and inflammatory bone *** and SREBP2,a key transcription factor for cholesterol biosynthesis,increased in the late phase of osteoclastogenesis.

关键词： SREBP2 incomplete restrict

Characteristic Variations of VLF/LF Signals during a High Seismic Activity in Japan in November 2016

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Open Journal of Earthquake Research 2017年第4期6卷 204-215页

作者： tomokazu Asano Alexander Rozhnoi Maria Solovieva Masashi Hayakawa Hayakawa Institute of Seismo Electromagnetics Co.Ltd.(Hi-SEM) UEC(University of Electro-Communications)Alliance Center#521TokyoJapan Institute of Physics of the Earth Russian Academy of SciencesMoscowRussia UEC Advanced Wireless&Communications Research Center TokyoJapan

The measurements of very low frequency/low frequency (VLF/LF) signals at the Petropavlovsk-Kamchatsky (PTK) and Yuzhno-Sakhalinsk (YSH) stations in Russia and several observing stations in Japan were used for the analysis of lower ionospheric perturbations in possible association with two earthquakes (EQs) which occurred offshore the Pacific Ocean of Japan in November 2016. The first EQ with M (magnitude) = 6.1 (depth 42 km) happened close to the coast line on 11 November (UT). The second EQ was recorded in the sea on 21 November (UT) with M = 6.9 (depth 11 km) and they had a series of aftershocks with M up to 5.6. As for the long-range monitoring, the significant negative nighttime amplitude decreases as propagation anomalies were found for two subionospheric paths: NWC (Australia)-PTK and JJY (Fukushima, Japan)-YSH during about a week, mainly before the first EQ. The anomalies of signal in the path JJY-PTK were observed 4 - 5 days before the second EQ and 3 days after it. Extensive analyses have been performed as well for these two EQs by using the short-range monitoring of VLF data observed at all of the seven VLF/LF stations in Japan in relation to the JJY signal. As related with the 1st EQ, there were observed anomalies on the two paths of JJY-STU (Suttsu) and JJY-NSB (Nakashibetsu) (both stations in Hokkaido) on 2 and 3 November. While, for the 2nd EQ clear anomalies have been observed on 14 and 15, and on 21 November at Ito station in Izu peninsula, Kamakura, Togane and Katsuura in Chiba. Taking into account the possible influence of other factors which can produce perturbations in VLF/LF signals and also using control paths, we may conclude that observed anomalies were very likely to be signatures of lower ionospheric perturbations caused by impending EQs. Finally, we try to estimate the possible perturbation scale for both EQs.

关键词： VLF/LF Propagation Anomalies lonospheric Perturbations Earthquake Precursor Short-and Long-Range Monitoring

On the Anomalies in ULF Magnetic Field Variations Prior to the 2008 Sichuan Earthquake

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Open Journal of Earthquake Research 2015年第2期4卷 55-64页

作者： Qi Li Alexander Schekotov tomokazu Asano Masashi Hayakawa Institute of Geophysics China Earthquake Administration Beijing China Institute of Physics of the Earth Russian Academy of Sciences Moscow Russia Earthquake Analysis Laboratory Information Systems Inc. Minato-ku Japan Hayakawa Institute of Seismo Electromagnetics Co. Ltd. University of Electro-Communications (UEC) Chofu Japan UEC Advanced Wireless Communications Research Center Chofu Japan

There have been reported several papers on the ionospheric F region perturbations prior to the 2008 Sichuan earthquake (EQ) (magnitude 8.0), but it seems that very few reports have been published on the characteristics of ground-based ULF (ultra low frequency) magnetic field variations for this EQ. This paper deals with two different aspects of ground-based ULF magnetic field variations: 1) ULF radiation from the lithosphere, and 2) depression of ULF horizontal magnetic field as a signature of lower ionospheric perturbations. ULF data from two Chinese stations [Chengdu (epicentral distance, 80 km) and Xichang (about 300 km away from the EQ epicenter)] are analyzed, with paying attention to the local nighttime period (LT = 22 h to 02 h, UTC = 14 h to 18 h) in order to avoid man-made noise. We have analyzed powers of the horizontal component (H2), vertical component (Z2), polarization as their ratio (Z2/H2), depression of the horizontal component (as an inverse of horizontal magnetic field component power, 1/H2) and δDep as a variation of depression at a particular frequency of 0.01 - 0.02 Hz (10 - 20 mHz). It is then found that there seems no clear signature of lithospheric ULF radiation. Whilst, the most evident fact is the finding of depression of ULF horizontal magnetic field at Chengdu a few days before the Sichuan EQ, which suggests that the lower ionosphere was perturbed before the EQ. The characteristics of the lower ionospheric perturbations are compared with those of upper ionospheric perturbations reported before.

关键词： Earthquake Earthquake Prediction ULF Magnetic Variation Lithospheric ULF Radiation ULF Depression

Efficacy of tolvaptan in an infant with syndrome of inappropriate antidiuretic hormone secretion associated with holoprosencephaly:A case report

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World Journal of Clinical Cases 2023年第26期11卷 6262-6267页

作者： Mari Mori Satoru Takeshita Nami Nakamura Yuki mizuno Akiko Tomita Mineyoshi Aoyama Hiroki Kakita Yasumasa Yamada Department of Perinatal and Neonatal Medicine Aichi Medical UniversityNagakute 480-1195Japan Department of Pathobiology Nagoya City University Graduate School of Pharmaceutical SciencesNagoya 467-8603Japan Department of Pediatrics Aichi Medical UniversityNagakute 480-1195Japan Department of Pharmacy Aichi Medical UniversityNagakute 480-1195Japan

BACKGROUND Holoprosencephaly(HPE)is a congenital malformation with various degrees of incomplete separation of the cerebral hemispheres due to differentiation disorders of the *** HPE with diabetes insipidus due to associated pituitary dysfunction has been reported,HPE with the syndrome of inappropriate antidiuretic hormone secretion(SIADH)is very ***,a vasopressin V2 receptor antagonist,is effective in adults with ***,there is no report of its efficacy in infants with *** purpose of this report is to demonstrate that tolvaptan is effective for SIADH in infants and that administration of tolvaptan eliminates the need for restriction of water intake and sodium *** SUMMARY A 2414-g female infant was born at 38 wk by normal vaginal *** anomalies and head magnetic resonance imaging indicated semilobar *** birth,she had hyponatremia due to SIADH and was treated using water and sodium ***,she developed an exaggerated response to the fluid restrictions,resulting in large fluctuations in serum sodium *** administration of tolvaptan improved the fluctuations in serum sodium levels without the need for adjustment of water or sodium *** sodium was maintained within the normal range after discontinuation of tolvaptan at 80 d of *** were no side effects,such as hypernatremia or liver dysfunction,during the administration of *** This is the first report on the safety and efficacy of tolvaptan in an infant with SIADH associated with HPE.

关键词： Tolvaptan Holoprosencephaly Antidiuretic hormone Syndrome of inappropriate secretion of antidiuretic hormone Hyponatremia Case report