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On the Tempo-Spatial Evolution of the Lower Ionospheric Perturbation for the 2016 Kumamoto Earthquakes from Comparisons of VLF Propagation Data Observed at Multiple Stations with Wave-Hop Theoretical Computations

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Open Journal of Earthquake Research 2018年第3期7卷 161-185页

作者： tomokazu asano Masashi Hayakawa Hayakawa Institute of Seismo Electromagnetics Co. Ltd. (Hi-SEM) University of Electro-Communications (UEC) Alliance Center 1-1-1 Kojima-cho Chofu Japan Advanced Wireless & Communications Research Center UEC Chofu Japan

There have been published many papers on VLF (very low frequency) characteristics to study seismo-ionospheric perturbations. Usually VLF records (amplitude and/or phase) are used to investigate mainly the temporal evolution of VLF propagation anomalies with special attention to one particular propagation path. The most important advantage of this paper is the simultaneous use of several propagation paths. A succession of earthquakes (EQs) happened in the Kumamoto area in Kyusyu Island;two strong foreshocks with magnitude of 6.5 and 6.4 on 14 April (UT) and the main shock with magnitude 7.3 on 15 April (UT). Because the EQ epicenters are not far from the VLF transmitter (with the call sign of JJI in Miyazaki prefecture), we can utilize simultaneously 8 observing stations of our network all over Japan. Together with the use of theoretical computations based on wave-hop theory, we try to trace both the temporal and spatial evolutions of the ionospheric perturbation associated with this succession of EQs. It is found that the ionospheric perturbation begins to appear about two weeks before the EQs, and this perturbation becomes most developed 5 - 3 days before the main shock. When the perturbation is most disturbed, the maximum change in vertical direction is depletion in the VLF effective ionospheric height of the order of 10 km, and its horizontal scale (or its radius) is about 1000 km. These spatio-temporal changes of the seismo-ionospheric perturbation will be investigated in details in the discus-sion, a comparison has made with the VLF characteristics of the 1995 Kobe with the same magnitude and of the same fault-type, and a brief discussion on the generation mechanism of seismo-ionospheric perturbation is finally made.

关键词： VLF/LF Propagation Anomaly Ionospheric Perturbations Earthquake Precursor Earthquake Prediction the 2016 Kumamoto Earthquakes Japanese VLF/LF Network Wave-Hop Computation Nighttime Fluctuation Method Atmospheric Oscillation Hypothesis

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A Study on the Correlation of Milk Yield of Cows with Seismicity and ULF Magnetic Field Variations

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Open Journal of Earthquake Research 2016年第4期5卷 206-218页

作者： Masashi Hayakawa tomokazu asano Alexander Schekotov Hiroyuki Yamauchi Hayakawa Institute of Seismo Electromagnetics Co. Ltd. University of Electro-Communications (UEC) Incubation Center Chofu Japan Advanced Wireless & Communications Research Center UEC Chofu Japan Institute of Physics of the Earth Russian Academy of Sciences Moscow Russia Department of Human and Animal-Plant Relationships Azabu University Sagamihara Japan

A statistical study on the basis of one-year data of 2014 has been performed in order to find whether abnormal animal behavior is related with seismic activity and also whether the ULF (Ultra Low Frequency) electromagnetic radiation might be a possible sensory mechanism of abnormal animal behavior. Abnormal animal behavior has been studied with the use of digitally recorded milk yield of cows at Ibaraki Prefecture Livestock Station, and the ULF magnetic field changes have been studied with the data at a magnetic observatory of Kakioka. As the result of correlation analyses, clear responses are observed for both the milk yield of cows and ULF magnetic field changes (both ULF radiation (ULF emissions from the lithosphere) and ULF depression (as an indicator of lower ionospheric perturbations)) for most powerful and not distant earthquakes (EQs) with magnitude > 6, that is, the milk yield of cows is found to exhibit a conspicuous depletion about 17 - 18 days before an EQ, though the correlation coefficient is not so big. Another important objective in this paper is to identify that ULF radiation is the main agent of abnormal behavior so that we have compared the temporal evolutions of milk yield of cows, ULF radiation and ULF depression for three major EQs. As a result, it is found that ULF radiation happens, at least, during the periods of abnormal depletion of milk yield of cows.

关键词： Milk Yield of Cows Correlation Analyses Earthquake Prediction ULF Radiation ULF Depression

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Characteristic Variations of VLF/LF Signals during a High Seismic Activity in Japan in November 2016

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Open Journal of Earthquake Research 2017年第4期6卷 204-215页

作者： tomokazu asano Alexander Rozhnoi Maria Solovieva Masashi Hayakawa Hayakawa Institute of Seismo Electromagnetics Co.Ltd.(Hi-SEM) UEC(University of Electro-Communications)Alliance Center#521TokyoJapan Institute of Physics of the Earth Russian Academy of SciencesMoscowRussia UEC Advanced Wireless&Communications Research Center TokyoJapan

The measurements of very low frequency/low frequency (VLF/LF) signals at the Petropavlovsk-Kamchatsky (PTK) and Yuzhno-Sakhalinsk (YSH) stations in Russia and several observing stations in Japan were used for the analysis of lower ionospheric perturbations in possible association with two earthquakes (EQs) which occurred offshore the Pacific Ocean of Japan in November 2016. The first EQ with M (magnitude) = 6.1 (depth 42 km) happened close to the coast line on 11 November (UT). The second EQ was recorded in the sea on 21 November (UT) with M = 6.9 (depth 11 km) and they had a series of aftershocks with M up to 5.6. As for the long-range monitoring, the significant negative nighttime amplitude decreases as propagation anomalies were found for two subionospheric paths: NWC (Australia)-PTK and JJY (Fukushima, Japan)-YSH during about a week, mainly before the first EQ. The anomalies of signal in the path JJY-PTK were observed 4 - 5 days before the second EQ and 3 days after it. Extensive analyses have been performed as well for these two EQs by using the short-range monitoring of VLF data observed at all of the seven VLF/LF stations in Japan in relation to the JJY signal. As related with the 1st EQ, there were observed anomalies on the two paths of JJY-STU (Suttsu) and JJY-NSB (Nakashibetsu) (both stations in Hokkaido) on 2 and 3 November. While, for the 2nd EQ clear anomalies have been observed on 14 and 15, and on 21 November at Ito station in Izu peninsula, Kamakura, Togane and Katsuura in Chiba. Taking into account the possible influence of other factors which can produce perturbations in VLF/LF signals and also using control paths, we may conclude that observed anomalies were very likely to be signatures of lower ionospheric perturbations caused by impending EQs. Finally, we try to estimate the possible perturbation scale for both EQs.

关键词： VLF/LF Propagation Anomalies lonospheric Perturbations Earthquake Precursor Short-and Long-Range Monitoring

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On the Anomalies in ULF Magnetic Field Variations Prior to the 2008 Sichuan Earthquake

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Open Journal of Earthquake Research 2015年第2期4卷 55-64页

作者： Qi Li Alexander Schekotov tomokazu asano Masashi Hayakawa Institute of Geophysics China Earthquake Administration Beijing China Institute of Physics of the Earth Russian Academy of Sciences Moscow Russia Earthquake Analysis Laboratory Information Systems Inc. Minato-ku Japan Hayakawa Institute of Seismo Electromagnetics Co. Ltd. University of Electro-Communications (UEC) Chofu Japan UEC Advanced Wireless Communications Research Center Chofu Japan

There have been reported several papers on the ionospheric F region perturbations prior to the 2008 Sichuan earthquake (EQ) (magnitude 8.0), but it seems that very few reports have been published on the characteristics of ground-based ULF (ultra low frequency) magnetic field variations for this EQ. This paper deals with two different aspects of ground-based ULF magnetic field variations: 1) ULF radiation from the lithosphere, and 2) depression of ULF horizontal magnetic field as a signature of lower ionospheric perturbations. ULF data from two Chinese stations [Chengdu (epicentral distance, 80 km) and Xichang (about 300 km away from the EQ epicenter)] are analyzed, with paying attention to the local nighttime period (LT = 22 h to 02 h, UTC = 14 h to 18 h) in order to avoid man-made noise. We have analyzed powers of the horizontal component (H2), vertical component (Z2), polarization as their ratio (Z2/H2), depression of the horizontal component (as an inverse of horizontal magnetic field component power, 1/H2) and δDep as a variation of depression at a particular frequency of 0.01 - 0.02 Hz (10 - 20 mHz). It is then found that there seems no clear signature of lithospheric ULF radiation. Whilst, the most evident fact is the finding of depression of ULF horizontal magnetic field at Chengdu a few days before the Sichuan EQ, which suggests that the lower ionosphere was perturbed before the EQ. The characteristics of the lower ionospheric perturbations are compared with those of upper ionospheric perturbations reported before.

关键词： Earthquake Earthquake Prediction ULF Magnetic Variation Lithospheric ULF Radiation ULF Depression

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Electromagnetic Precursors to the 2016 Kumamoto Earthquakes

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Open Journal of Earthquake Research 2017年第4期6卷 168-179页

作者： Alexander Schekotov Jun Izutsu tomokazu asano Stelios Marcos Potirakis Masashi Hayakawa Institute of Physics of the Earth Russian Academy of Sciences Moscow Russia International Digital Earth Applied Science Research Center Chubu University Kasugai Japan Hayakawa Institute of Seismo Electromagnetics Co. Ltd. (Hi-SEM) UEC (University of Electro-Communications) Alliance Center #521 Chofu Japan Piraeus University of Applied Science (TEI of Piraeus) Athens Greece UEC Advanced Wireless & Communications Research Center Chofu Japan

The Kumamoto area of Kyusyu Island was attacked by a series of large earthquakes (EQs) in April, 2016. The first two foreshocks had the magnitudes of 6.5 and 6.4, and about 1 day later there was the main shock on 15 April (UT) with magnitude 7.3. These are fault-type EQs, and so we would expect a variety of electromagnetic precursors to these EQs because we had detected different phenomena for the 1995 Kobe EQ, same fault-type EQ. As for the lithospheric effect, the ULF data at Kanoya observatory (about 150 km from the EQ epicenters) are used, but the simple statistical analysis could not provide us with any clear evidence of ULF radiation from the lithosphere. However, our conventional analyses indicated clear signatures in the atmosphere as ULF/ELF impulsive emissions and also in the ionosphere as observed by means of VLF propagation anomalies and ULF depression. ULF/ELF radiation appeared on 8-11 April (in UT) (maximum on 10 and 11 April (UT)), while ULF depression took place on 8 and 10 April (in UT), so that both atmospheric radiation and ionospheric perturbation took place nearly during the same time period.

关键词： Electromagnetic Precursors The 2016 Kumamoto Earthquakes ULF/ELF Radiation VLF Propagation Anomaly ULF Depression

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An Integrated Study of ULF Magnetic Field Variations in Association with the 2008 Sichuan Earthquake, on the Basis of Statistical and Critical Analyses

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Open Journal of Earthquake Research 2015年第3期4卷 85-93页

作者： Masashi Hayakawa Alexander Schekotov Stelios M. Potirakis Konstantinos Eftaxias Qi Li tomokazu asano Hayakawa Institute of Seismo Electromagnetics Co. Ltd. University of Electro-Communications (UEC) Incubation Center Tokyo Japan Advanced Wireless & Communications Research Center UEC Tokyo Japan Earthquake Analysis Laboratory Information Systems Inc. Tokyo Japan Institute of Physics of the Earth Russian Academy of Sciences Moscow Russia Department of Electronics Engineering Piraeus University of Applied Sciences (TEI of Piraeus) Athens Greece Department of Physics University of Athens Athens Greece Institute of Geophysics China Earthquake Administration Beijing China Fuji Security Systems Co. Ltd. Tokyo Japan

The ultra-low frequency (ULF) magnetic field data at a station very close to the 2008 Sichuan earthquake (EQ) (on 12 May, 2008;M = 8.0) are extensively studied on the basis of combined statistical and natural time analyses. Two effects in ULF are treated: one is the well-known ULF radiation from the lithosphere, and the other is the non-conventional depression of ULF horizontal magnetic field. The simple statistical analysis has yielded: 1) no clear evidence of the presence of precursory ULF radiation, and 2) a significant effect of depression of ULF horizontal field a few days before the EQ (as a signature of ionospheric perturbations). The recently introduced natural time analysis has also been performed in order to study the critical features of the lithosphere and essentially new information has been brought about. The parameter “polarization”, as the ratio of vertical to horizontal components, showed critical features in the time period of 17 - 27 April, about one month to two weeks before the EQ as a signature of lithospheric radiation. Then, the natural time analysis has reconfirmed the presence of ionospheric perturbations a few days before the EQ, together with an additional time window found on 19 - 23 April, about one month before the EQ, exhibiting critical features in the ULF depression.

关键词： 2008 Sichuan EQ ULF Magnetic Field Variations Statistical Analysis Critical Analysis EQ Precursor

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Unveiling the anticancer effect of traditional Chinese herbal medicine

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World Journal of Gastroenterology 2024年第30期30卷 3625-3627页

作者： Naoki asano Division of Carcinogenesis and Senescence Biology Tohoku University Graduate School of MedicineNatori 981-1293MiyagiJapan Division of Cancer Stem Cell Miyagi Cancer Center Research InstituteNatori 981-1293MiyagiJapan

In this issue of World Journal of Gastroenterology,Huang et al reported that Calculus bovis(CB),a traditional Chinese herbal medicine,impedes the growth of liver cancers in *** further in vitro studies,they showed that CB suppressed the M2 polarization of tumor-associated macrophages by suppressing the Wnt signaling pathway,which consequently inhibited the growth of liver *** the effects of traditional Chinese herbal medicine are often not scientifically proven,Huang et al successfully identified the molecular mechanism involved in the anticancer effect of CB,and it is anticipated that the molecular mechanisms involved in the effects of other traditional Chinese herbal medicines will be scientifically elucidated,as demonstrated in this article.

关键词： Calculus bovis Chinese herbal medicine Wnt Hepatocellular carcinoma Liver cancer Tumor-associated macrophages M2 polarization

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On the Precursory Abnormal Animal Behavior and Electromagnetic Effects for the Kobe Earthquake (M~6) on April 12, 2013

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Open Journal of Earthquake Research 2016年第3期5卷 165-171页

作者： Masashi Hayakawa Hiroyuki Yamauchi Nobuyo Ohtani Mitsuaki Ohta Susumu Tosa tomokazu asano Alexander Schekotov Jun Izutsu Stelios M. Potirakis Konstantinos Eftaxias Hayakawa Institute of Seismo Electromagnetics Co. Ltd. UEC (University of Electro-Communications) Incubation Center Chofu Japan UEC Advanced Wireless & Communications Research Center Chofu Japan Department of Animal Science and Biotechnology Azabu University Sagamihara Japan Department of Human and Animal-Plant Relationships Tokyo University of Agriculture Atsugi Japan Kagawa Prefecture Livestock Experiment Station Kida Japan Institute of Physics of the Earth Russian Academy of Sciences Moscow Russia Department of Electronic Engineering Chubu University Kasugai Japan Department of Electronics Engineering Piraeus University of Applied Sciences (TEI of Piraeus) Athens Greece Department of Physics University of Athens Athens Greece

After the 2011 Tohoku earthquake (EQ), there have been numerous aftershocks in the eastern and Pacific Ocean of Japan, but EQs are still rare in the western part of Japan. In this situation a relatively large (magnitude (M) ~6) EQ happened on April 12 (UT), 2013 at a place close to the former 1995 Kobe EQ (M~7), so we have tried to find whether there existed any precursors to this EQ, especially abnormal animal behavior (milk yield of cows), observed at Kagawa, Shikoku, near the EQ epicenter. The milk yield of cows has been continuously monitored at Kagawa, and it is found that the milk yield exhibited an abnormal depletion about 10 days before the EQ. This behavior has been extensively compared with the former electromagnetic precursors (ULF radiation, ionos-pheric perturbation). This leads to the discussion on the sensory mechanism of unusual behavior of mild yield of cows, and it may be suggested that ULF radiation among different electromagnetic precursors is a mostly likely driver, at least, for this EQ.

关键词： Abnormal Animal Behavior Earthquakes Milk Yield of Cows ULF Radiation Sensory Mechanism of Animals

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Assessing mixing uniformity in microreactors via in-line spectroscopy

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Chinese Journal of Chemical Engineering 2024年第2期66卷 119-124页

作者： Shusaku asano Shinji Kudo Taisuke Maki Yosuke Muranaka Kazuhiro Mae Jun-ichiro Hayashi Institute for Materials Chemistry and Engineering Kyushu UniversityKasuga 816-8580Japan Department of Chemical Engineering Graduate School of EngineeringKyoto UniversityJapan

Mixing behavior is critical for enhancing the selectivity of fast chemical reactions in microreactors.A high Reynolds number(Re)improves the mixing rate and selectivity of the reactions,but some exceptions of increasing side product yield with the higher Re have been *** study investigated the mixing uniformity in microreactors with in-line UV-vis spectroscopy to clarify the relationship between reaction selectivity and chaotic mixing with the higher Re.A colorization experiment of thymolphthalein in an acidic solution was conducted with an excess acid amount to the base to indicate a non-uniformly mixed ***-uniformity significantly increased with *** the same time,the degree of mixing,which was measured by a usual decolorization experiment,showed that the mixing rate increased with *** in-line analysis of the Villermaux-Dushman reaction during the mixing clarified that side product yield significantly increased with Re at around 300 and then decreased at around *** results suggest the compensation effect between the mixing uniformity and mixing rate on the selectivity of the mixing-sensitive *** mixing,characterized by a larger Re,can disturb mixing uniformity and,in some cases,decrease reaction selectivity.

关键词： Microreactor Villermaux-Dushman reaction In-line analysis Mixing Mass transfer Uniformity

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Adjuvant chemotherapy for early-stage cervical cancer

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Chinese Journal of Cancer Research 2016年第2期28卷 228-234页

作者： Hiroshi asano Yukiharu Todo Hidemichi Watari Department of Obstetrics and Gynecology Hokkaido University School of Medicine Division of Gynecologic Oncology National Hospital OrganizationHokkaido Cancer Center

The aim of this review is to address the current status of adjuvant chemotherapy alone in early-stage cervical cancer treatments in the literature. At present, the therapeutic effect of adjuvant chemotherapy alone after radical surgery （RS） has not yet been established, and radiation therapy （RT） or concurrent chemoradiotherapy （CCRT） is recommended as the standard adjuvant therapy after RS for early-stage cervical cancer in various guidelines. The main purpose of adjuvant therapy after RS, however, should be to reduce extrapelvic recurrence rather than local recurrence, although adjuvant RT or CCRT has survival benefits for patients with intermediate- or high-risk factors for recurrence. Moreover, several studies reported that adjuvant therapies including RT were associated with a higher incidence of complications, such as lymphedema, bowel obstruction and urinary disturbance, and a lower grade of long-term quality of life （QOL） or sexual functioning than adjuvant chemotherapy alone. The effect of adjuvant chemotherapy alone for early-stage cervical cancer with intermediate- or high-risk factors for recurrence were not fully investigated in prospective studies, but several retrospective studies suggest that the adjuvant effects of chemotherapy alone are at least similar to that of RT or CCRT in terms of recurrence rate, disease-free survival, or overall survival （OS） with lower incidence of complications. Whereas cisplatin based combination regimens were used in these studies, paclitaxel/cisplatin （TP） regimen, which is currently recognized as a standard chemotherapy regimen for patients with metastatic, recurrent or persistent cervical cancer by Gynecologic Oncology Group （GOG）, had also survival benefit as an adjuvant therapy. Therefore, it may be worth considering a prospective randomized controlled trial （RCT） of adjuvant chemotherapy alone using TP regimen versus adjuvant RT as an alternative adjuvant therapy. Because early-stage cervical cancer is a curable c

关键词： Adjuvant chemotherapy cervical cancer quality of life (QOL) survival intermediate-risk disease

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