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Inflammation mediates the pathogenesis of cerebral aneurysm and becomes therapeutic target

Neuroimmunology and Neuroinflammation 2015年第1期2卷 86-92页

作者： tomohiro aoki Center for Innovation in Immunoregulation Technology and Therapeutics Graduate School of MedicineKyoto UniversityKyoto 606-8501Japan

The treatment of cerebral aneurysms(CAs)is of social importance,because poor outcomes result in subarachnoid hemorrhages after ***,there is currently no medical treatment available to prevent the progression and rupture of CAs,which results in a large number of patients without receiving *** studies using human samples have revealed the presence of inflammatory responses in lesions and also the possible correlation of inflammation with CA progression or ***,experimental studies using animal models of CAs have supported the notion from human studies and have clarified the crucial contribution of inflammation to the *** this process,a vicious cycle/positive feedback loop includes the nuclear factor-kappa B(NF-kB)activation,which plays a role in amplifying inflammatory responses to the point of *** addition,the infiltration of macrophages via NF-kB-mediated monocyte chemotactic protein 1 induction expands inflammation in whole arterial walls and contributes to the degeneration of media by producing various cytokines and tissue-destructive *** series of studies have provided an important insight-antiinflammatory drugs can be therapeutically significant in the treatment of ***,in animal models,some drugs with an antiinflammatory effect effectively suppressed CA formation and progression,which supports this *** addition,in human cases,some case-control studies have reported the preventive effect of statins and nonsteroidal antiinflammatory drugs on CA ***,the development of novel medical treatment for preventing the progression and rupture of CAs is needed in the near *** this literature review,articles were selected by performing a PubMed search using the key words“cerebral aneurysm”and“inflammation”.

关键词： Cerebral aneurysm inflammation macrophage nuclear factor‑kappa B

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Statins as a Candidate of Drugs for Intracranial Aneurysm Treatment

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Health 2014年第12期6卷 1459-1466页

作者： Keiichi Tsuji tomohiro aoki Miyuki Fukuda Kazuhiko Nozaki Department of Neurosurgery Kyoto University Graduate School of Medicine Kyoto Japan Department of Neurosurgery Shiga University of Medical Science Shiga Japan Innovation Center for Immunoregulation Technologies and Drugs (AK Project) Kyoto University Graduate School of Medicine Kyoto Japan

The treatment for intracranial aneurysm (IA) is socially important because of poor outcome posed by subarachnoid hemorrhage after rupture. Further, the incidence of IAs in general public is high and, indeed, in developed countries many IAs are incidentally found through brain check. However, to date, options for treatment of IAs to prevent rupture are quite limited only to surgical procedures such as microsurgical clipping and endovascular coiling. Taking into account unavoidable risks of complication from surgical interventions and numerous aneurysm careers without treatment, less invasive medical therapies should be established. In human IA lesions, the presence of inflammatory responses, such as expressions of pro-inflammatory mediators and infiltration of inflammatory cells, have been reported, which suggests the involvement of inflammatory responses in the pathogenesis of IA. Recent experimental studies using rodent models have revealed the crucial role of inflammatory responses mediated by NF-κB activation in IA formation and progression and supported the notion that IA is an inflammatory disease affected intracranial arteries. To find out a candidate drug for IA treatments, the effect of several drugs with anti-inflammatory and anti-NF-κB actions on IA progression has been examined using rodent models and revealed the excellent inhibitory effect of statins (HMG-CoA reductase inhibitors) on IA progression. Based on these findings, the case-control study was recently carried out enrolling patients with unruptured or ruptured IAs to examine the effect of statin usage on rupture. This study revealed the significant differences in the ratio of statin usage between two groups and notably the remarkable reduction of risk of rupture of pre-existing IAs under statin usage at the adjusted odds ratio of 0.30. Recent laboratory and clinical studies make considerable achievement toward the future development of drugs for IA treatment and especially suggest the potential o

关键词： Inflammation Intracranial Aneurysm NF-κB Statin Subarachnoid Hemorrhage

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Abnormal expression of Tau in damaged oligodendrocytes of HLD1 mice

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Neural Regeneration Research 2024年第7期19卷 1405-1406页

作者： tomohiro Torii Laboratory of Ion Channel Pathophysiology Graduate School of Brain ScienceDoshisha UniversityKyotanabe-shiKyotoJapan Center for Research in Neurodegenerative Disease Doshisha UniversityKyotanabe-shiKyotoJapan

Patients with hypomyelinating leukodystrophies(H LDs),multiple sclerosis(MS),and leukodystrophies including Aicardi-Goutieres syndrome,adrenoleukodystrophy,Alexander disease,Canavan disease,cerebrotendinous xanthomato... 详细信息

关键词： dystrophy cytes Patients

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Assessing efficacy of standard impregnation techniques on die-cast aluminum alloys using X-ray micro-CT

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China Foundry 2024年第3期21卷 276-286页

作者： Ajith Bandara Koichi Kan Katanaga Yusuke Natsuto Soga Akifumi Koike Toru aoki Hamamatsu TSC Chuo Hatsumei Institute322 lida-choMinami-kuHamamatsu435-0028Japan Graduate School of Medical Photonics ShizuokaUniversityJohoku 3-5-1HamamatsuShizuoka432-8561Japan ANSeeN Inc Johoku 3-5-1HamamatsuShizuoka432-8561Japan Research Institute of Electronics ShizuokaUniversityJohoku 3-5-1HamamatsuShizuoka432-8561Japan

Utilizing lightweight Al alloys in various industrial applications requires achieving precise pressure tightness and leak *** pressure impregnation(VPI)with thermosetting polymers is commonly used to address leakage defects in die-cast Al *** this study,the efficacy of the VPI technique in sealing alloy parts was investigated using a combination of nondestructive micro X-ray computed tomography(micro XCT)and a standard leak *** results demonstrate that the commonly used water leak test is insufficient for determining the sealing ***,micro XCT shows distinct advantages by enabling more comprehensive *** reveals the presence of a low atomic number impregnates sealant within casting defects,which has low grey contrast and allows for visualizing primary leakage paths in *** effective atomic number of impregnated resin is 6.75 and that of Al alloy is 13.69 by dual-energy X-ray *** research findings will contribute to enhancing the standard VPI process parameters and the properties of impregnating sealants to improve quality assurance for impregnation in industrial metals.

关键词： nondestructive testing Al alloy die-casting vacuum pressure impregnation micro X-ray computed tomography duel-energy X-ray CT

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Population of inflammatory cells in intracranial aneurysm with the special insight to the development of novel diagnostic and therapeutic approaches

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Neuroimmunology and Neuroinflammation 2016年第1期3卷 173-179页

作者： Hirokazu Koseki tomohiro aoki Center for Innovation in Immunoregulation Technologies and Therapeutics(AK project) Kyoto University Graduate School of MedicineKyoto 606-8501Japan Department of Neurosurgery Tokyo Women’s Medical University Medical Center EastTokyo 116-8567Japan Core Research for Evolutional Science and Technology(CREST)from Japan Agency for Medical Research and Development(AMED) Kyoto University Graduate School of MedicineKyoto 606-8501Japan

Intracranial aneurysms(IAs)can cause a lethal subarachnoid hemorrhage after *** prevalence of IA is high in the general public;however,the annual risk for the rupture of an incidentally found lesion is relatively ***,it is crucial to selectively diagnose rupture-prone IAs among many diagnosed IAs,and properly treat such IAs before *** studies using human IA specimens or experimentally-induced IAs in animals have revealed some important findings regarding the role of inflammatory cells infiltrating IA ***,IA is considered an inflammatory disease of the intracranial arterial *** are presumably a major type of inflammatory cells regulating the pathogenesis of IAs through the production of a wide range of pro-inflammatory *** on a series of studies,macrophages could be a diagnostic target for rupture-prone ***,the potential diagnostic method to detect iron-engulfing macrophages in IA lesions by magnetic resonance imaging is *** this review,the authors will summarize the findings regarding the inflammatory cell types present in IA lesions and discuss future prospects for the development of a novel diagnostic method identifying rupture-prone IAs.

关键词： Intracranial aneurysm macrophage neutrophil mast cell imaging

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Green hydrogen production by intermediate-temperature protonic solid oxide electrolysis cells:Advances,challenges,and perspectives

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InfoMat 2024年第3期6卷 22-65页

作者： Chunmei Tang Yao Yao Ning Wang Xiaohan Zhang Fangyuan Zheng Lei Du Dongxiang Luo Yoshitaka aoki Siyu Ye Huangpu Hydrogen Energy Innovation Center School of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhouthe People's Republic of China Beijing Institute of Metrology Beijingthe People's republic of China Faculty of Engineering Hokkaido UniversitySapporoJapan

Protonic solid oxide electrolysis cells(P-SOECs)operating at intermediate temperatures,which have low costs,low environmental impact,and high theoretical electrolysis efficiency,are considered promising next-generation energy conversion devices for green hydrogen ***,the developments and applications of P-SOECs are restricted by numerous material-and interface-related issues,including carrier mismatch between the anode and electrolyte,current leakage in the electrolyte,poor interfacial contact,and chemical *** the past few decades,considerable attempts have been made to address these issues by improving the properties of *** review comprehensively explores the recent advances in the mechanisms governing steam electrolysis in P-SOECs,optimization strategies,specially designed components,electrochemical performance,and *** particular,given that the lack of suitable anode materials has significantly impeded P-SOEC development,the relationships between the transferred carriers and the cell performance,reaction models,and surface decoration approaches are meticulously ***,the challenges hindering P-SOEC development are discussed and recommendations for future research directions,including theoretical calculations and simulations,structural modification approaches,and large-scale single-cell fabrication,are proposed to stimulate research on P-SOECs and thereby realize efficient electricity-to-hydrogen conversion.

关键词： designed components electrochemical performance hydrogen production key materials protonic solid oxide electrolysis cells

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Changes over time in treatment for obstructive jaundice

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3074-3077页

作者： Hideki aoki Department of Surgery National Hospital Organization Iwakuni Clinical CenterIwakuni 740-8510YamaguchiJapan

This editorial discusses an article by Peng et *** study reviewed the efficacy and safety of a new approach for treating obstructive *** the pathophysiology of obstructive jaundice has not yet been fully elucidated,pro-gress has been made in its *** are two aspects of obstructive jaundice:Cholestatic status and absence of bile in the intestinal *** biliary drainage resolved both the ***,endoscopic retrograde biliary drainage(ERBD)has replaced percutaneous transhepatic biliary drainage,and ERBD is transitioning to endoscopic ultrasound guided biliary *** editorial briefly explains the mechanism and treatment of obstructive jaundice and the prospects of this new internal biliary drainage technique.

关键词： Obstructive jaundice Intestinal permeability Biliary drainage Endoscopic retrograde biliary drainage Endoscopic ultrasound guided biliary drainage

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Clinical practice guidelines for acute pancreatitis in the United States and Japan:similarities and differences

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 869-872页

作者： Yasuo Otsuka Ikue Sekai Yasuhiro Masuta Kosuke Minaga tomohiro Watanabe Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsakaJapan

Acute pancreatitis(AP)is defined as sudden inflammation that occurs in the pancreas(1-4).Although most cases of AP are mild,approximately 20%of patients develop severe acute pancreatitis(SAP),which is potentially lethal(3,4).Because of the rapid expansion of knowledge regarding the pathogenesis,diagnosis,and treatment of AP,remaining apprised of the latest information regarding clinical practice can be *** practice guidelines are published statements proposed by a panel of experts and include recommendations regarding the optimal diagnosis and treatment of disease(5).Therefore,many clinicians rely on clinical practice guidelines for patient ***,the American College of Gastroenterology(ACG)published clinical practice guidelines for AP management(1).However,in Japan,clinicians often rely on the 2021 Japanese clinical practice guidelines when managing AP(2).The ACG and Japanese clinical practice guidelines for AP share various recommendations regarding diagnosis,severity assessment,and management of this condition;however,these guidelines also have significant ***,this editorial article discusses these similarities and differences.

关键词： Acute pancreatitis(AP) clinical practice guideline severe acute pancreatitis(SAP)

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Influences of Horticultural Therapy and Functional Recovery Training at a Day-Care Center for the Elderly and Text Mining of Care Records by AI

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Open Journal of Therapy and Rehabilitation 2024年第2期12卷 117-131页

作者： Seigo Koura Shinya Matsutani Kazuho Nagao Yu Fukushima Akiko Ikeda Takeshi Oshikawa tomohiro Inagaki Kentaro Higashi Faculty of Graduate School Postdoctoral Course in Health Care Medicine Nishikyusyu University Kanzaki Japan Social Welfare Corporation Kanjikai Miyakonojyo Japan Sophia Phyto-Therapy College Tokyo Japan

Background: In Japan, due to the COVID-19 pandemic, various behavioral restrictions were implemented from March 2020, resulting in an increased number of elderly people with reduced participation in care and rehabilitation. As a result, the decline in motor and cognitive functions became more pronounced. Purpose: The study examined how activities combining passive horticultural therapy, which is always introduced, with active functional recovery training, which is used in the functional recovery training of patients with hemiplegia, influence the behavior of elder people using the facility. Methods: 36 elder people with care need 1 or 2 who regularly used the day-care facilities after the pandemic ended and who agreed to participate in the study was included. The assessment data were every three months from December 2021 to December 2023 after the COVID-19 pandemic, the MMSE and Moca-J, TMIG-Index, and GDS15. AI-based text mining was used to compare changes in visit reports before and after the introduction of the Posture Chart and Red Code, and the relationship between the language used. Results: The results of MMSE and Moca-J were both significantly higher in Group B and C than in Group A. TIMG assessment, was significantly higher in Group B and C than in Group A, and Group C was significantly higher than Group B. The GDS, an assessment of depression in old age, tended to be significantly higher in Group A than in Groups B and C. In the “Co-Occurrence Network Analysis” shown after the introduction of the latest functional recovery training equipment such as the Red Cord, its results showed a high association between the words Bathing and CARE and words such as POSTURE, Red-Code, and AI, App, which are used in functional training and rehabilitation, and their analysis. Conclusion: At day-care facilities specializing in functional recovery training and rehabilitation, a combination of horticultural therapy and the latest functional training equipment found to help m

关键词： Horticultural Therapy Hand Care Treatment Senior Day-Care Center Functional Recovery Training KH-Corder

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MnO/N—C anode materials for lithium-ion batteries prepared by cotton-templated combustion synthesis

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Green Energy & Environment 2017年第4期2卷 377-386页

作者： Cheng-Gong Han Chunyu Zhu Yoshitaka aoki Hiroki Habazaki tomohiro Akiyama Faculty of Engineering Hokkaido University

We herein report a facile one-pot synthesis of MnO/N-doped carbon(N—C) composites via a sustainable cotton-template glycineenitrate combustion synthesis to yield superior anode materials for Li ion batteries. MnO nanoparticles with several nanometers were well-embedded in a porous N-doped carbon matrix. It displays the unique characteristics, including the shortened Li^+-ion transport path, increased contact areas with the electrolyte solution, inhibited volume changes and agglomeration of nanoparticles, as well as good conductivity and structural stability during the cycling process, thereby benefiting the superior cycling performance and rate capability. This favorable electrochemical performance of obtained MnO/N—C composites via a one-pot biomass-templated glycine/nitrate combustion synthesis renders the suitability as anode materials for Li-ion batteries.

关键词： Biomass Cotton Manganese oxide Lithium ion battery Porous carbon

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