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Prospective postsurgical capsule endoscopy in patients with Crohn's disease

World Journal of Gastrointestinal Endoscopy 2014年第3期6卷 88-98页

作者： Tomoaki Kono Nobuyuki Hida Koji Nogami Masaki Iimuro Yoshio Ohda Yoko Yokoyama Koji Kamikozuru Katsuyuki Tozawa Mikio Kawai tomohiro ogawa Kazutoshi Hori Hiroki Ikeuchi Hiroto Miwa Shiro Nakamura Takayuki Matsumoto Department of Lower Gastroenterology Hyogo College of Medicine Department of Surgery Hyogo College of Medicine Department of Upper Gastroenterology Hyogo College of Medicine

AIM: To clarify the usefulness of postsurgical capsule endoscopy(CE) in the diagnosis of recurrent small bowel lesions of Crohn's disease(CD). METHODS: This prospective study included 19 patients who underwent ileocolectomy or partial ileal resection for CD. CE was performed 2-3 wk after surgery to check for the presence/absence and severity of lesions remaining in the small bowel, and for any recurrence at the anastomosed area. CE was repeated 6-8 mo after surgery and the findings were compared with those obtained shortly after surgery. The Lewis score (LS) was used to evaluate any inflammatory changes of the small bowel. RESULTS: One patient was excluded from analysis because of insufficient endoscopy data at the initial CE. The total LS shortly after surgery was 428.3 on average(median, 174; range, 8-4264), and was ≥ 135(active stage) in 78%(14 of 18) of the patients. When the remaining unresected small bowel was divided into 3 equal portions according to the transition time(proximal, middle, and distal tertiles), the mean LS was 286.6, 83.0, and 146.7, respectively, without any significant difference. Ulcerous lesions in the anastomosed area were observed in 83% of all patients. In 38% of the 13 patients who could undergo CE again after 6-8 mo, the total LS was higher by ≥ 100 than that recorded shortly after surgery, thus indicating a diagnosis of endoscopic progressive recurrence. CONCLUSION: Our pilot study suggests that CE can be used to objectively evaluate the postoperative recurrence of small bowel lesions after surgery for CD.

关键词： Crohn’s disease Postoperative recurrence Capsule endoscopy Lewis score Small bowel

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Diagnosis of small intramucosal signet ring cell carcinoma of the stomach by non-magnifying narrow-band imaging: A pilot study

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World Journal of Gastrointestinal Endoscopy 2015年第12期7卷 1070-1077页

作者： Jiro Watari Toshihiko Tomita Hisatomo Ikehara Masato Taki tomohiro ogawa Takahisa Yamasaki Takashi Kondo Fumihiko Toyoshima Jun Sakurai Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Tadayuki Oshima Hirokazu Fukui Seiichi Hirota Hiroto Miwa Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine NishinomiyaHyogo 663-8501 Japan Department of Surgical Pathology Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Division of Gastroenterology Department of Internal Medicine Hyogo College of MedicineNishinomiyaHyogo 663-8501 Japan

AIM: To examine the efficacy of non-magnifying narrow-band imaging(NM-NBI) imaging for small signet ring cell carcinoma(SRC).METHODS: We retrospectively analyzed 14 consecutive small intramucosal SRCs that had been treated with endoscopic submucosal dissection(ESD) and 14 randomly selected whitish gastric ulcer scars(control). The strength and shape of the SRCs and whitish scars by NM-NBI and white-light imaging(WLI) were assessed with Image J(NIH, Bethesda).RESULTS: NM-NBI findings of SRC showed a clearly isolated whitish area amid the brown color of the surrounding normal mucosa. The NBI index, which indicates the potency of NBI for visualizing SRC, was significantly higher than the WLI index(P = 0.001), indicating SRC was more clearly identified by NM-NBI. Although the NBI index was not significantly different between SRCs and controls, the circle(C)-index, as an index of circularity of tumor shape, was significantly higher in SRCs(P = 0.001). According to the receiveroperating characteristic analysis, the resulting cut-off value of the circularity index(C-index) for SRC was 0.60(85.7% sensitivity, 85.7% specificity). Thus a lesion with a C-index ≥ 0.6 was significantly more likely to be an SRC than a gastric ulcer scar(OR = 36.0; 95%CI: 4.33-299.09; P = 0.0009).CONCLUSION: Small isolated whitish round area by NM-NBI endoscopy is a useful finding of SRCs which is the indication for ESD.

关键词： Gastric cancer Signet ring cell carcinoma Narrow-b

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Histological diagnosis of gastric submucosal tumors: A pilot study of endoscopic ultrasonography-guided fine-needle aspiration biopsy vs mucosal cutting biopsy

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World Journal of Gastrointestinal Endoscopy 2015年第14期7卷 1142-1149页

作者： Hisatomo Ikehara Zhaoliang Li Jiro Watari Masato Taki tomohiro ogawa Takahisa Yamasaki Takashi Kondo Fumihiko Toyoshima Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Toshihiko Tomita Tadayuki Oshima Hirokazu Fukui Ikuo Matsuda Seiichi Hirota Hiroto Miwa Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine Department of Surgical Pathology Hyogo College of Medicine

AIM: To compare the usefulness of endoscopic ultrasonography-guided fine-needle aspiration biopsy(EUS-FNAB) without cytology and mucosal cutting biopsy(MCB) in the histological diagnosis of gastric submucosal tumor(SMT).METHODS: We prospectively compared the diagnostic yield, feasibility, and safety of EUS-FNAB and those of MCB based on endoscopic submucosal dissection. The cases of 20 consecutive patients with gastric SMT ≥1 cm in diameter. who underwent both EUS-FNAB and MCB were ***: The histological diagnoses were gastrointestinal stromal tumors(n = 7), leiomyoma(n =6), schwannoma(n = 2), aberrant pancreas(n = 2), and one case each of glomus tumor, metastatic hepatocellular carcinoma, and no-diagnosis. The tumors' mean size was 23.6 mm. Histological diagnosis was made in 65.0% of the EUS-FNABs and 60.0% of the MCBs, a nonsignificant difference. There were no significant differences in the diagnostic yield concerning the tumor location or tumor size between the two methods. However, diagnostic specimens were significantly more frequently obtained in lesions with intraluminal growth than in those with extraluminal growth by the MCB method(P = 0.01). All four SMTs with extraluminal growth were diagnosed only by EUSFNAB(P = 0.03). No complications were found in either ***: MCB may be chosen as an alternative diagnostic modality in tumors showing the intraluminal growth pattern regardless of tumor size, whereas EUSFNAB should be performed for SMTs with extraluminal growth.

关键词： Submucosal tumor Endoscopic ultrasonography-guided

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Acquisition of hyponymy relations for agricultural terms from a Japanese statutory corpus

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Information Processing in Agriculture 2014年第2期1卷 95-104页

作者： Makoto Nakamura tomohiro Ohno Yasuhiro ogawa Katsuhiko Toyama Japan Legal Information Institute Graduate School of LawNagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Information Technology Center Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan Graduate School of Information Science Nagoya UniversityFuro-choChikusa-kuNagoya 464-8601Japan

This paper,which aims to increment the vocabulary of an existing thesaurus using hyponymy relations,focuses on an agricultural thesaurus called *** main goal is to acquire AGROVOC-qualified candidates from the hyponymy relations of legal texts and *** propose a pattern-based approach to hyponymy relation *** experimental result showed that 222 and 868 candidates are extracted from statutory sentences with 67.1%precision and tables with 37.0%precision,respectively.

关键词： AGROVOC Japanese statutory corpus Legal text processing

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Synchronous pancreatic solid pseudopapillary neoplasm and intraductal papillary mucinous neoplasm

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World Journal of Gastroenterology 2013年第21期19卷 3358-3363页

作者： Kenichi Hirabayashi Giuseppe Zamboni Hiroyuki Ito Masami ogawa Yoshiaki Kawaguchi tomohiro Yamashita Toshio Nakagohri Naoya Nakamura Department of Pathology Tokai University School of MedicineIsehara 259-1193Japan Department of Pathology Ospedale Sacro Cuore Don Calabria37024 Negrar VeronaItaly Department of Pathology University of Verona37134 Negrar VeronaItaly Department of Gastroenterology Tokai University School of MedicineIsehara 259-1193Japan Department of Radiology Tokai University School of MedicineIsehara 259-1193Japan Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259-1193Japan

Solid pseudopapillary neoplasm (SPN) is a rare and low-grade malignant pancreatic neoplasm composed of poorly cohesive monomorphic neoplastic cells forming solid and pseudopapillary structures with frequent hemorrhagic-cystic degeneration. Intraductal papillary mucinous neoplasm (IPMN) is a pancreatic exocrine tumor composed of intraductal papillary growth of mucin containing neoplastic cells in the main pancreatic duct or its major branches. In the case presented here, a 53-year-old, Japanese man was found to have multiple cystic lesions and dilatation of the main pancreatic duct in the neck of the pancreas. Histological examination revealed a main-duct and branch-duct type IPMN, of the gastric-type, involving the neck of the pancreas, associated with a 0.5 cm SPN in the caudal side of the IPMN. We diagnosed this case as synchronous SPN and IPMN. As far as we know, only one other case of synchronous SPN and IPMN has been reported. Both the present case and the previously reported case showed abnormal nuclear expression of β-catenin in SPN, whereas IPMN showed no abnormal nuclear expression. These results suggest that β-catenin abnormality is not a common pathogenetic factor of synchronous SPN and IPMN.

关键词： Intraductal papillary mucinous neoplasms Solid pseudopapillary neoplasms Pancreatic neoplasms Synchronous neoplasms Pancreas Beta-catenin

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Abnormal expression of Tau in damaged oligodendrocytes of HLD1 mice

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Neural Regeneration Research 2024年第7期19卷 1405-1406页

作者： tomohiro Torii Laboratory of Ion Channel Pathophysiology Graduate School of Brain ScienceDoshisha UniversityKyotanabe-shiKyotoJapan Center for Research in Neurodegenerative Disease Doshisha UniversityKyotanabe-shiKyotoJapan

Patients with hypomyelinating leukodystrophies(H LDs),multiple sclerosis(MS),and leukodystrophies including Aicardi-Goutieres syndrome,adrenoleukodystrophy,Alexander disease,Canavan disease,cerebrotendinous xanthomato... 详细信息

关键词： dystrophy cytes Patients

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A gigaparsec-scale local void and the Hubble tension

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Science China(Physics,Mechanics & Astronomy) 2020年第9期63卷 7-15页

作者： QianHang Ding tomohiro Nakama Yi Wang Department of Physics The Hong Kong University of Science and TechnologyHong KongChina Jockey Club Institute for Advanced Study The Hong Kong University of Science and TechnologyHong KongChina

We explore the possibility of using a gigaparsec-scale local void to reconcile the Hubble *** a gigaparsec-scale void can be produced by multi-stream inflation where different parts of the observable universe follow different inflationary *** trajectories become different parts of the observable universe after inflation,when these scales return to the *** these trajectories have different e-folding numbers,these parts of the universe have different energy densities,possibly creating a local large *** impacts of such a void for cosmological observations are studied,especially those involving supernovae,Baryon Acoustic Oscillations(BAO)and the kinetic Sunyaev-Zel’dovich(kSZ)*** show that with the presence of the void,supernovae observations may be more consistent with the *** also estimate the impacts of a local large void on BAO *** addition,we show that a local large void and hence its capabilities to ease the Hubble tension is limited by the kSZ *** a benchmark model,a 1.7 Gpc scale void with boundary width 0.7 Gpc and density contrast-0.14 may ease the Hubble tension,evading the kSZ limit.

关键词： Hubble tension void cosmology inflation

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A new model for evaluating the dynamic shear strength of rocks based on laboratory test data for earthquake-resistant design

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第5期11卷 979-989页

作者： Tetsuji Okada tomohiro Naya Central Research Institute of Electric Power Industry ChibaJapan Dia Consultants Co. Ltd.SaitamaJapan

The dynamic shear strength of rocks is required for the earthquake-resistant design of nuclear power plants in *** research aims to propose a mathematical model for estimating the dynamic strength and to validate the *** different types of specimens were prepared for the model validation,and the monotonic and cyclic loading tests were conducted to obtain the mathematical model ***,multistep cyclic loading tests were performed,followed by simulations using the mathematical *** test results demonstrated that the dynamic shear strength exceeded the static shear strength,which agreed with previous ***,the dynamic shear strength calculated using the mathematical model was generally consistent with that obtained from the experimental data.

关键词： Dynamic shear strength Static shear strength Cyclic loading Strain rate Fatigue Mathematical model

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Platelets in liver disease, cancer and regeneration

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World Journal of Gastroenterology 2017年第18期23卷 3228-3239页

作者： tomohiro Kurokawa Nobuhiro Ohkohchi Department of Surgery Division of Gastroenterological and Hepatobiliary Surgery and Organ Transplantation Faculty of Medicine University of Tsukuba

Although viral hepatitis treatments have evolved over the years, the resultant liver cirrhosis still does not completely heal. Platelets contain proteins required for hemostasis, as well as many growth factors required for organ development, tissue regeneration and repair. Thrombocytopenia, which is frequently observed in patients with chronic liver disease(CLD) and cirrhosis, can manifest from decreased thrombopoietin production and accelerated platelet destruction caused by hypersplenism; however, the relationship between thrombocytopenia and hepatic pathogenesis, as well as the role of platelets in CLD, is poorly understood. In this paper, experimental evidence of platelets improving liver fibrosis and accelerating liver regeneration is summarized and addressed based on studies conducted in our laboratory and current progress reports from other investigators. In addition, we describe our current perspective based on the results of these studies. Platelets improve liver fibrosis by inactivating hepatic stellate cells, which decreases collagen production. The regenerative effect of platelets in the liver involves a direct effect on hepatocytes, a cooperative effect with liver sinusoidal endothelial cells, and a collaborative effect with Kupffer cells. Based on these observations, we ascertained the direct effect of platelet transfusion on improving several indicators of liver function in patients with CLD and liver cirrhosis. However, unlike the results of our previous clinical study, the smaller incremental changes in liver function in patients with CLD who received eltrombopag for 6 mo were due to patient selection from a heterogeneous population. We highlight the current knowledge concerning the role of platelets in CLD and cancer and anticipate a novel application of platelet-based clinical therapies to treat liver disease.

关键词： Platelet Liver cirrhosis Liver regeneration Cancer Thrombopoietin Thrombopoietin agonist Eltrombopag

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Effects of reduction on the catalytic performance of limonite ore

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Journal of Energy Chemistry 2018年第5期27卷 1489-1495页

作者： Keisuke Abe Ade Kurniawan Takahiro Nomura tomohiro Akiyama Graduate school of Engineering Hokkaido University Sapporo 060-8628 Japan Center for Advanced Research of Energy and Materials Hokkaido University Sapporo 060-8628 Japan

The catalytic performance of Ni-containing limonite ore in the dry reforming reaction of methane （CH_4＋CO_2→2H_2＋2CO） was determined before and after hydrogen reduction, and under a flow of hydrogen. After hydrogen reduction, the limonite ore exhibited higher catalytic performance, because of the formation of Fe-Ni. However, the Fe in Fe-Ni was readily oxidized by the input CO_2 gas. resulting in a rapid decrease in the catalytic performance of limonite ore. The performance de- crease was due to a decrease in the Ni surface area; Ni could not dissolve in iron oxides and this caused segregation in the iron oxides. When the reaction was conducted under a hydrogen flow, the Fe-Ni was formed and maintained. Ni was highly dispersed in the Fe-Ni phase, resulting in greater surface area of Ni and higher conversion rate of CH_4 and CO_2. The catalytic performance of the limonite ore was inferior to the Ni/Al_2O_3 catalyst because the effect of catalyst support was small, however, the limonite ore was more stable during catalytic use and much cheaper than the Ni/Al_2O_3.

关键词： Limonite Dry reforming Fe-Ni Catalyst

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