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Journal of Rock Mechanics and Geotechnical Engineering 2019年第5期11卷 979-989页

作者： Tetsuji Okada tomohiro naya Central Research Institute of Electric Power Industry ChibaJapan Dia Consultants Co. Ltd.SaitamaJapan

The dynamic shear strength of rocks is required for the earthquake-resistant design of nuclear power plants in *** research aims to propose a mathematical model for estimating the dynamic strength and to validate the *** different types of specimens were prepared for the model validation,and the monotonic and cyclic loading tests were conducted to obtain the mathematical model ***,multistep cyclic loading tests were performed,followed by simulations using the mathematical *** test results demonstrated that the dynamic shear strength exceeded the static shear strength,which agreed with previous ***,the dynamic shear strength calculated using the mathematical model was generally consistent with that obtained from the experimental data.

关键词： Dynamic shear strength Static shear strength Cyclic loading Strain rate Fatigue Mathematical model

Abnormal expression of Tau in damaged oligodendrocytes of HLD1 mice

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Neural Regeneration Research 2024年第7期19卷 1405-1406页

作者： tomohiro Torii Laboratory of Ion Channel Pathophysiology Graduate School of Brain ScienceDoshisha UniversityKyotanabe-shiKyotoJapan Center for Research in Neurodegenerative Disease Doshisha UniversityKyotanabe-shiKyotoJapan

Patients with hypomyelinating leukodystrophies(H LDs),multiple sclerosis(MS),and leukodystrophies including Aicardi-Goutieres syndrome,adrenoleukodystrophy,Alexander disease,Canavan disease,cerebrotendinous xanthomato... 详细信息

关键词： dystrophy cytes Patients

A gigaparsec-scale local void and the Hubble tension

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Science China(Physics,Mechanics & Astronomy) 2020年第9期63卷 7-15页

作者： QianHang Ding tomohiro Nakama Yi Wang Department of Physics The Hong Kong University of Science and TechnologyHong KongChina Jockey Club Institute for Advanced Study The Hong Kong University of Science and TechnologyHong KongChina

We explore the possibility of using a gigaparsec-scale local void to reconcile the Hubble *** a gigaparsec-scale void can be produced by multi-stream inflation where different parts of the observable universe follow different inflationary *** trajectories become different parts of the observable universe after inflation,when these scales return to the *** these trajectories have different e-folding numbers,these parts of the universe have different energy densities,possibly creating a local large *** impacts of such a void for cosmological observations are studied,especially those involving supernovae,Baryon Acoustic Oscillations(BAO)and the kinetic Sunyaev-Zel’dovich(kSZ)*** show that with the presence of the void,supernovae observations may be more consistent with the *** also estimate the impacts of a local large void on BAO *** addition,we show that a local large void and hence its capabilities to ease the Hubble tension is limited by the kSZ *** a benchmark model,a 1.7 Gpc scale void with boundary width 0.7 Gpc and density contrast-0.14 may ease the Hubble tension,evading the kSZ limit.

关键词： Hubble tension void cosmology inflation

Platelets in liver disease, cancer and regeneration

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World Journal of Gastroenterology 2017年第18期23卷 3228-3239页

作者： tomohiro Kurokawa Nobuhiro Ohkohchi Department of Surgery Division of Gastroenterological and Hepatobiliary Surgery and Organ Transplantation Faculty of Medicine University of Tsukuba

Although viral hepatitis treatments have evolved over the years, the resultant liver cirrhosis still does not completely heal. Platelets contain proteins required for hemostasis, as well as many growth factors required for organ development, tissue regeneration and repair. Thrombocytopenia, which is frequently observed in patients with chronic liver disease(CLD) and cirrhosis, can manifest from decreased thrombopoietin production and accelerated platelet destruction caused by hypersplenism; however, the relationship between thrombocytopenia and hepatic pathogenesis, as well as the role of platelets in CLD, is poorly understood. In this paper, experimental evidence of platelets improving liver fibrosis and accelerating liver regeneration is summarized and addressed based on studies conducted in our laboratory and current progress reports from other investigators. In addition, we describe our current perspective based on the results of these studies. Platelets improve liver fibrosis by inactivating hepatic stellate cells, which decreases collagen production. The regenerative effect of platelets in the liver involves a direct effect on hepatocytes, a cooperative effect with liver sinusoidal endothelial cells, and a collaborative effect with Kupffer cells. Based on these observations, we ascertained the direct effect of platelet transfusion on improving several indicators of liver function in patients with CLD and liver cirrhosis. However, unlike the results of our previous clinical study, the smaller incremental changes in liver function in patients with CLD who received eltrombopag for 6 mo were due to patient selection from a heterogeneous population. We highlight the current knowledge concerning the role of platelets in CLD and cancer and anticipate a novel application of platelet-based clinical therapies to treat liver disease.

关键词： Platelet Liver cirrhosis Liver regeneration Cancer Thrombopoietin Thrombopoietin agonist Eltrombopag

Effects of reduction on the catalytic performance of limonite ore

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Journal of Energy Chemistry 2018年第5期27卷 1489-1495页

作者： Keisuke Abe Ade Kurniawan Takahiro Nomura tomohiro Akiyama Graduate school of Engineering Hokkaido University Sapporo 060-8628 Japan Center for Advanced Research of Energy and Materials Hokkaido University Sapporo 060-8628 Japan

The catalytic performance of Ni-containing limonite ore in the dry reforming reaction of methane （CH_4＋CO_2→2H_2＋2CO） was determined before and after hydrogen reduction, and under a flow of hydrogen. After hydrogen reduction, the limonite ore exhibited higher catalytic performance, because of the formation of Fe-Ni. However, the Fe in Fe-Ni was readily oxidized by the input CO_2 gas. resulting in a rapid decrease in the catalytic performance of limonite ore. The performance de- crease was due to a decrease in the Ni surface area; Ni could not dissolve in iron oxides and this caused segregation in the iron oxides. When the reaction was conducted under a hydrogen flow, the Fe-Ni was formed and maintained. Ni was highly dispersed in the Fe-Ni phase, resulting in greater surface area of Ni and higher conversion rate of CH_4 and CO_2. The catalytic performance of the limonite ore was inferior to the Ni/Al_2O_3 catalyst because the effect of catalyst support was small, however, the limonite ore was more stable during catalytic use and much cheaper than the Ni/Al_2O_3.

关键词： Limonite Dry reforming Fe-Ni Catalyst

Time-dependent Calculations for Two-proton Decay Width with Schematic Density-dependent Contact Pairing Interaction

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原子核物理评论 2016年第2期33卷 203-206页

作者： Oishi tomohiro Helsinki Institute of Physics University of Helsinki Department of Physics University of Jyvskyl

We calculate the two-proton decay width of the6 Be nucleus employing the schematic densitydependent contact potential for the proton-proton pairing interaction. The decay width is calculated with a time-dependent method, in which the two-proton emission is described as a time-evolution of a threebody meta-stable state. Model-dependence of the two-proton decay width has been shown by comparing the results obtained with the two different pairing models, schematic density-dependent contact and Minnesota interactions, which have zero and finite ranges, respectively.

关键词： two-proton radioactivity nuclear pairing interaction time-dependent method

Influence of normal to high stroke volume on congestive heart failure development after transcatheter aortic valve implantation:case series

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Journal of Geriatric Cardiology 2021年第1期18卷 83-88页

作者： Tomoko Tomioka tomohiro Ito Ryokichi Takahasi Shuhei Tanaka Department of Cardiology South Miyagi Medical CenterShibataJapan

Aortic stenosis(AS)is the most common valvular disease in the older adults'population,and its prevalence will likely continue to increase with the aging society.[1]Surgical aortic valve replacement(SAVR)for elderly patients is known as a high-risk procedure.[2-4]Transcatheter aortic valve implantation(TAVI)is a reasonable alternative to SAVR for older and inoperable patients with AS,and TAVI significantly improves outcomes in elderly patients with severe AS and serious comorbidities,[5,6]TAVI achieves a 20%relative reduction in mortality compared with SAVR.

关键词： aortic mortality implantation

Proposal of Walking to Prevent a Fall of a Planetary Exploration Legged Rover Using Effect of Loose Soil Caused by a Propagation of Vibration

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Journal of Artificial Intelligence and Technology 2021年第3期1卷 153-165页

作者： tomohiro Watanabe Kojiro Iizuka Graduate School of Engineering and Science Shibaura Institute of TechnologySaitama City 337-8570Japan Department of Systems and Engineering and Science Shibaura Institute of TechnologySaitama City 337-8570Japan

In this study,a walking method that prevents a fall of the planetary exploration-legged rover is *** the proposed walking method,the leg is sunk by giving vibration to the *** posture of the rover is changed to prevent a fall of the rover by sinking the ***,the relationship between the kind of vibration and the subsidence of the leg is *** this experimental result,the leg is shown to be easy to sink to the ground by giving ***,the larger the vibratory force is,the easier the leg sinks to the ***,the legged testbed walks on the loose ground with a slope using the proposed walking *** this experimental result,the testbed is difficult to fall down when it uses the proposed ***,the angle of a slope that the testbed can walk becomes large by using the proposed walking.

关键词： planetary exploration legged rover fall prevention loose ground vibration

Preparation of Fe-Al Binary System Intermetallic Compounds by Multi-Layered Roll-Bonding

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材料热处理学报 2004年第5期25卷 53-55页

作者： Akio Nishimoto Katsuya Akamatsu Kazuyoshi Nakao Kazuo Ichii tomohiro Hiraki Department of Materials Science and Engineering Kansai University Osaka JapanDepartment of Materials Science and Engineering Kansai University Osaka JapanDepartment of Materials Science and Engineering Kansai University Osaka JapanDepartment of Materials Science and Engineering Kansai University Osaka JapanToho Zinc Co. Ltd. Gunma Japan

Iron aluminides exhibit good resistance to high-temperature sulfidizing and oxidizing environments and potential for structural applications at high temperatures under corrosive environments. In this study, Fe-Al intermetallic compound was prepared by multi-layered roll-bonding of elemental Fe and Al foils. The process consisted of the accumulative roll-bonding (ARE) for making a laminated Fe/Al sheet and the subsequent heat treatment promoting a solid phase reaction in the laminated Fe/Al sheet. The microstructures produced at each processing stage were characterized by optical microscopy and scanning electron microscopy (SEM) equipped with energy dispersive X-ray spectroscopy (EDS). Vickers microhardness testing was used for hardness determination. A homogeneous intermetallic compound of Fe3Al or FeAl could be obtained after the subsequent heat treatment for 1.8 ks at 973 K and for 10.8 ks at 1123 or 1173 K.

关键词：铁铝合金金属互化物辊压接合分界面反应反应扩散

An effective method for laboratory acoustic emission detection and location using template matching

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第5期14卷 1642-1651页

作者： Xinglin Lei tomohiro Ohuchi Manami Kitamura Xiaying Li Qi Li National Institute of Advanced Industrial Science and Technology(AIST) Tsukuba305-8567Japan Geodynamics Research Center Ehime UniversityMatsuyama790-8577Japan State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

In this paper, a template matching and location method, which has been rapidly adopted in microseismic research in recent years, is applied to laboratory acoustic emission(AE) monitoring. First, we used traditional methods to detect P-wave first motions and locate AE hypocenters in three dimensions. In addition, we selected events located with sufficient accuracy(normally corresponding AE events of relatively larger energy, showing clear P-wave first motion and a higher signal-to-noise ratio in most channels) as template events. Then, the template events were used to scan and match other poorly located events in triggered event records or weak events in continuous records. Through crosscorrelation of the multi-channel waveforms between the template and the event to be detected, the weak signal was detected and located using a grid-searching algorithm(with the grid centered at the template hypocenter). In order to examine the performance of the approach, we calibrated the proposed method using experimental data of different rocks and different types of experiments. The results show that the proposed method can significantly improve the detection capability and location accuracy, and can be applied to various laboratory and in situ experiments, which use multi-channel AE monitoring with waveforms recorded in either triggering or continuous mode.

关键词： Acoustic emission Template matching and location Waveform cross-correlation Grid search