检索结果-南通市图书馆

Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C

World Journal of Gastroenterology 2016年第27期22卷 6224-6234页

作者： Takafumi Saito Masahiro Sugimoto Kazuo Okumoto Hiroaki Haga tomohiro katsumi Kei Mizuno Taketo Nishina Sonoko Sato Kaori Igarashi Hiroko Maki Masaru Tomita Yoshiyuki Ueno Tomoyoshi Soga Department of Gastroenterology Yamagata University School of Medicine Institute for Advanced Biosciences Keio University

AIM: To clarify the characteristics of metabolite profiles in virus-related hepatocellular carcinoma (HCC) patients using serum metabolome ***: The serum levels of low-molecular-weight metabolites in 68 patients with HCC were quantified using capillary electrophoresis chromatography and mass spectrometry. Thirty and 38 of the patients suffered from hepatitis B virus-related HCC (HCC-B) and hepatitis C virus-related HCC (HCC-C), ***: The main metabolites characteristic of HCC were those associated with glutathione metabolism, notably 13 γ-glutamyl peptides, which are by-products of glutathione induction. Two major profiles, i.e., concentration patterns, of metabolites were identified in HCC patients, and these were classified into two groups: an HCC-B group and an HCC-C group including some of the HCC-B cases. The receiver operating characteristic curve for the multiple logistic regression model discriminating HCC-B from HCC-C incorporating the concentrations of glutamic acid, methionine and γ-glutamyl-glycine-glycine showed a highly significant area under the curve value of 0.94 (95%CI: 0.89-1.0, P < 0.0001).CONCLUSION: The serum levels of γ-glutamyl peptides, as well as their concentration patterns, contribute to the development of potential biomarkers for virus-related HCC. The difference in metabolite profiles between HCC-B and HCC-C may reflect the respective metabolic reactions that underlie the different pathogeneses of these two types of HCC.

关键词： Metabolome Hepatocellular carcinoma γ -glutamyl peptides Glutathione Oxidative stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Opening a new route to multiport coherent XUV sources via intracavity high-order harmonic generation

引用

Light(Science & Applications) 2020年第1期9卷 398-406页

作者： Natsuki Kanda tomohiro Imahoko Koji Yoshida Akihiro Tanabashi AAmani Eilanlou Yasuo Nabekawa Tetsumi Sumiyoshi Makoto Kuwata-Gonokami katsumi Midorikawa RIKEN Center for Advanced Photonics RIKENWakoSaitama 351-0198Japan Photon Science Center The University of TokyoTokyo 113-8656Japan Intstitute for Solid State Physics The University of TokyoKashiwaChiba 277-8581Japan Cyber Laser Inc. WakoSaitama 351-0104Japan Institute for Photon Science and Technology The University of TokyoTokyo 113-0033Japan Department of Physics The University of TokyoTokyo 113-0033Japan

High-order harmonic generation(HHG)is currently utilized for developing compact table-top radiation sources to provide highly coherent extreme ultraviolet(XUV)and soft X-ray pulses;however,the low repetition rate of fundamental lasers,which is typically in the multi-kHz range,restricts the area of application for such HHG-based radiation ***,we demonstrate a novel method for realizing a MHz-repetition-rate coherent XUV light source by utilizing intracavity HHG in a mode-locked oscillator with an Yb:YAG thin disk laser medium and a 100-m-long ring *** have successfully implemented HHG by introducing two different rare gases into two separate foci and picking up each HH *** to the two different HH beams generated from one cavity,this XUV light source will open a new route to performing a time-resolved measurement with an XUV-pump and XUV-probe scheme at a MHzrepetition rate with a femtosecond resolution.

关键词： intracavity coherent repetition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Abnormal expression of Tau in damaged oligodendrocytes of HLD1 mice

引用

Neural Regeneration Research 2024年第7期19卷 1405-1406页

作者： tomohiro Torii Laboratory of Ion Channel Pathophysiology Graduate School of Brain ScienceDoshisha UniversityKyotanabe-shiKyotoJapan Center for Research in Neurodegenerative Disease Doshisha UniversityKyotanabe-shiKyotoJapan

Patients with hypomyelinating leukodystrophies(H LDs),multiple sclerosis(MS),and leukodystrophies including Aicardi-Goutieres syndrome,adrenoleukodystrophy,Alexander disease,Canavan disease,cerebrotendinous xanthomato... 详细信息

关键词： dystrophy cytes Patients

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A gigaparsec-scale local void and the Hubble tension

引用

Science China(Physics,Mechanics & Astronomy) 2020年第9期63卷 7-15页

作者： QianHang Ding tomohiro Nakama Yi Wang Department of Physics The Hong Kong University of Science and TechnologyHong KongChina Jockey Club Institute for Advanced Study The Hong Kong University of Science and TechnologyHong KongChina

We explore the possibility of using a gigaparsec-scale local void to reconcile the Hubble *** a gigaparsec-scale void can be produced by multi-stream inflation where different parts of the observable universe follow different inflationary *** trajectories become different parts of the observable universe after inflation,when these scales return to the *** these trajectories have different e-folding numbers,these parts of the universe have different energy densities,possibly creating a local large *** impacts of such a void for cosmological observations are studied,especially those involving supernovae,Baryon Acoustic Oscillations(BAO)and the kinetic Sunyaev-Zel’dovich(kSZ)*** show that with the presence of the void,supernovae observations may be more consistent with the *** also estimate the impacts of a local large void on BAO *** addition,we show that a local large void and hence its capabilities to ease the Hubble tension is limited by the kSZ *** a benchmark model,a 1.7 Gpc scale void with boundary width 0.7 Gpc and density contrast-0.14 may ease the Hubble tension,evading the kSZ limit.

关键词： Hubble tension void cosmology inflation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sex differences in estrogen receptor promoter expression in the area postrema

引用

Neural Regeneration Research 2013年第2期8卷 149-155页

作者： Chunxiao Zhang tomohiro Hamada Department of Physiology Norman Bethune College of Medicine Jilin University Department of Physiology Nippon Medical School

Estrogen receptor a is widely distributed in the rat brain, but the tissue- or target-specificity of the estrogen receptor a gene promoters remains unknown. In the present study, we used transgenic rats expressing enhanced green fluorescent protein under the control of the estrogen receptor a 0/B promoter to examine expression driven by this promoter in two significant nuclei that regulate cardiovascular activity, the area postrema and the nucleus tractus solitarius. Immunohistochemistry showed that enhanced green fluorescent protein-labeled cells were distributed in the area postrema and the nucleus tractus solitarius of both female and male transgenic rats, and a neural network of enhanced green fluorescent protein-positive fibers was seen between the area postrema and the nucleus tractus solitarius. The number of enhanced green fluorescent protein-labeled cells in the area postrema of female rats was significantly higher than in the males, but no significant difference was found in the number of enhanced green fluorescent protein-labeled cells in the nucleus tractus solitarius. The sex differences in the number of enhanced green fluorescent protein-labeled cells in the area postrema was not affected after ovariectomy or 1713-estradiol benzoate treatment in adult rats. Our results suggest that the effects of estrogen in the area postrema are related to the expression of estrogen receptor a under the control of the 0/B promoter, and changes in the sex hormone environment in the adult period do not affect estrogen receptor a expression in the area postrema or the nucleus tractus solitarius.

关键词： neural regeneration basic research estrogen receptor a promoter green fluorescent protein sexdifferences area postrema nucleus tractus solitarius medulla estrogen rats grant-supportedpaper photographs-containing paper neuroregeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new model for evaluating the dynamic shear strength of rocks based on laboratory test data for earthquake-resistant design

引用

Journal of Rock Mechanics and Geotechnical Engineering 2019年第5期11卷 979-989页

作者： Tetsuji Okada tomohiro Naya Central Research Institute of Electric Power Industry ChibaJapan Dia Consultants Co. Ltd.SaitamaJapan

The dynamic shear strength of rocks is required for the earthquake-resistant design of nuclear power plants in *** research aims to propose a mathematical model for estimating the dynamic strength and to validate the *** different types of specimens were prepared for the model validation,and the monotonic and cyclic loading tests were conducted to obtain the mathematical model ***,multistep cyclic loading tests were performed,followed by simulations using the mathematical *** test results demonstrated that the dynamic shear strength exceeded the static shear strength,which agreed with previous ***,the dynamic shear strength calculated using the mathematical model was generally consistent with that obtained from the experimental data.

关键词： Dynamic shear strength Static shear strength Cyclic loading Strain rate Fatigue Mathematical model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Platelets in liver disease, cancer and regeneration

引用

World Journal of Gastroenterology 2017年第18期23卷 3228-3239页

作者： tomohiro Kurokawa Nobuhiro Ohkohchi Department of Surgery Division of Gastroenterological and Hepatobiliary Surgery and Organ Transplantation Faculty of Medicine University of Tsukuba

Although viral hepatitis treatments have evolved over the years, the resultant liver cirrhosis still does not completely heal. Platelets contain proteins required for hemostasis, as well as many growth factors required for organ development, tissue regeneration and repair. Thrombocytopenia, which is frequently observed in patients with chronic liver disease(CLD) and cirrhosis, can manifest from decreased thrombopoietin production and accelerated platelet destruction caused by hypersplenism; however, the relationship between thrombocytopenia and hepatic pathogenesis, as well as the role of platelets in CLD, is poorly understood. In this paper, experimental evidence of platelets improving liver fibrosis and accelerating liver regeneration is summarized and addressed based on studies conducted in our laboratory and current progress reports from other investigators. In addition, we describe our current perspective based on the results of these studies. Platelets improve liver fibrosis by inactivating hepatic stellate cells, which decreases collagen production. The regenerative effect of platelets in the liver involves a direct effect on hepatocytes, a cooperative effect with liver sinusoidal endothelial cells, and a collaborative effect with Kupffer cells. Based on these observations, we ascertained the direct effect of platelet transfusion on improving several indicators of liver function in patients with CLD and liver cirrhosis. However, unlike the results of our previous clinical study, the smaller incremental changes in liver function in patients with CLD who received eltrombopag for 6 mo were due to patient selection from a heterogeneous population. We highlight the current knowledge concerning the role of platelets in CLD and cancer and anticipate a novel application of platelet-based clinical therapies to treat liver disease.

关键词： Platelet Liver cirrhosis Liver regeneration Cancer Thrombopoietin Thrombopoietin agonist Eltrombopag

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Feeding behavior and gene expression of appetite-related neuropeptides in mice lacking for neuropeptide Y Y5 receptor subclass

引用

World Journal of Gastroenterology 2008年第41期14卷 6312-6317页

作者： Hiroshi Higuchi Takeshi Niki tomohiro Shiiya Division of Pharmacology Niigata University Graduate School of Medical and Dental Sciences

Neuropeptide Y (NPY) is a potent neurotransmitter for feeding. Besides NPY, orexigenic neuropeptides such as agouti-related protein (AgRP), and anorexi- genic neuropeptides such as α-melatonin stimulating hormone (MSH) and cocaine-amphetamine-regulated transcript (CART) are also involved in central feeding regulation. During fasting, NPY and AgRP gene expressions are up-regulated and POMC and CART gene ex- pressions are down-regulated in hypothalamus. Based on the network of peptidergic neurons, the former are involved in positive feeding regulation, and the latter are involved in negative feeding, which exert these feeding-regulated peptides especially in paraventricular nucleus (PVN). To clarify the compensatory mecha- nism of knock-out of NPY system on feeding, change in gene expressions of appetite-related neuropeptides and the feeding behavior was studied in NPY Y5-KO mice. Food intake was increased in Y5-KO mice. Fasting increased the amounts of food and water intake in the KO mice more profoundly. These data indicated the compensatory phenomenon of feeding behavior in Y5-KO mice. RT-PCR and ISH suggested that the compensation of feeding is due to change in gene expressions of AgRP, CART and POMC in hypothalamus. Thus, these fi ndings indicated that the compensatory mechanism involves change in POMC/CART gene expression in arcuate nucleus (ARC). The POMC/CART gene expression is important for central compensatory regulation in feeding behavior.

关键词： Neuropeptide Y Y5 receptor Feeding Arcuate nucleus Knockout mice

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of reduction on the catalytic performance of limonite ore

引用

Journal of Energy Chemistry 2018年第5期27卷 1489-1495页

作者： Keisuke Abe Ade Kurniawan Takahiro Nomura tomohiro Akiyama Graduate school of Engineering Hokkaido University Sapporo 060-8628 Japan Center for Advanced Research of Energy and Materials Hokkaido University Sapporo 060-8628 Japan

The catalytic performance of Ni-containing limonite ore in the dry reforming reaction of methane （CH_4＋CO_2→2H_2＋2CO） was determined before and after hydrogen reduction, and under a flow of hydrogen. After hydrogen reduction, the limonite ore exhibited higher catalytic performance, because of the formation of Fe-Ni. However, the Fe in Fe-Ni was readily oxidized by the input CO_2 gas. resulting in a rapid decrease in the catalytic performance of limonite ore. The performance de- crease was due to a decrease in the Ni surface area; Ni could not dissolve in iron oxides and this caused segregation in the iron oxides. When the reaction was conducted under a hydrogen flow, the Fe-Ni was formed and maintained. Ni was highly dispersed in the Fe-Ni phase, resulting in greater surface area of Ni and higher conversion rate of CH_4 and CO_2. The catalytic performance of the limonite ore was inferior to the Ni/Al_2O_3 catalyst because the effect of catalyst support was small, however, the limonite ore was more stable during catalytic use and much cheaper than the Ni/Al_2O_3.

关键词： Limonite Dry reforming Fe-Ni Catalyst

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gas6-Tyro3 signaling is required for Schwann cell myelination and possible remyelination

引用

Neural Regeneration Research 2016年第2期11卷 215-216页

作者： tomohiro Torii Junji Yamauchi apan Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Bunkyo Tokyo lapan

Myelin plays important roles in vertebrates,ensuring the rapid propagation of action potentials and the long-term integrity of axons,but the molecular mechanisms of myelin formation remain poorly *** studies have demo... 详细信息

关键词： cell Gas6-Tyro3 signaling is required for Schwann cell myelination and possible remyelination LINGO

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：