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Length of hospital stay and mortality associated with burns from assault:a retrospective study with inverse probability weighting analysis

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Burns & Trauma 2020年第1期8卷 351-358页

作者： Ryo Yamamoto Mitsunobu Toyosaki tomohiro Kurihara Junichi Sasaki Department of Emergency and Critical Care Medicine Keio University School of Medicine35 ShinanomachiShinjukuTokyo160-8582Japan

Background:Burns resulting from assaults account for considerable morbidity and mortality among patients with burn injuries around the ***,it is still unclear whether unfavorable clinical outcomes are associated primarily with the severity of the *** elucidate the direct relationship between burns resulting from assaults and mortality and/or length of hospital stays,we performed this study with the hypothesis that burns from assault would be independently associated with fewer hospital-free days than would burns from other causes,regardless of the severity of burn ***:We conducted a retrospective cohort study,using a city-wide burn registry(1996–2017)accounting for 14 burn centers in Tokyo,*** who arrived within 24 hours after injury were included,and those with self-inflicted burn injuries were *** were divided into two groups according to mechanism of burns(assault ***),and the number of hospitalfree days until day 30 after injury(a composite of in-hospital death and hospital length of stay)was compared between the *** estimate the probability that an injury would be classified as an assault,we calculated propensity scores,using multivariate logistic regression analyses adjusted for known outcome *** also performed an inverse probability weighting(IPW)analysis to compare adjusted numbers of hospital-free ***:Of 7419 patients in the registry with burn injuries during the study period,5119 patients were included in this *** these,113(2.2%)were injured as a result of assault;they had significantly fewer hospital-free days than did those with burns caused by accident(18[27]vs.24[20]days;coefficient=−3.4[−5.5 to−1.3]days;p=0.001).IPW analyses similarly revealed the independent association between assault burn injury and fewer hospital-free days(adjusted coefficient=−0.6[−1.0 to−0.1]days;p=0.009).Conclusions:Burn from assault was independently associated with fewer hospital-fre

关键词： Assault Burn Mortality Length of hospital stay Inverse probability weighting

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Differences in spatial understanding between physical and virtual models

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Frontiers of Architectural Research 2014年第1期3卷 28-35页

作者： Lei Sun tomohiro Fukuda Toshiki Tokuhara Nobuyoshi Yabuki Graduate School of Engineering Osaka University Osaka 565-0871 Japan

In the digital age, physical models are still used as major tools in architectural and urban design processes. The reason why designers still use physical models remains unclear. In addition, physical and 3D virtual models have yet to be differentiated. The answers to these questions are too complex to account for in all aspects. Thus, this study only focuses on the differences in spatial understanding between physical and virtual models. In particular, it emphasizes on the perception of scale. For our experiment, respondents were shown a physical model and a virtual model consecutively. A questionnaire was then used to ask the respondents to evaluate these models objectively and to establish which model was more accurate in conveying object size. Compared with the virtual model, the physical model tended to enable cluicker and more accurate comDarisons of building heights.

关键词： Spatialunderstanding Scale perception Physical model Virtual model Virtual reality

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Combustion synthesis of YAG:Ce phosphors via the thermite reaction of aluminum

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Journal of Rare Earths 2018年第3期36卷 248-256页

作者： Junpei Ohyama Chunyu Zhu Genki Saito Miki Haga Takahiro Nomura Norihito Sakaguchi tomohiro Akiyama Center for Advanced Research of Energy and Materials Hokkaido UniversityKita 13 Nishi 8KitakuSapporo 060-8628Japan Division of Applied Chemistry&Frontier Chemistry Center Faculty of EngineeringHokkaido University5apporoHokkaido 060-8628Japan Graduate School of Chemical Sciences and Engineering Hokkaido University SapporoHokkaido 060-8628Japan

Cerium-doped yttrium aluminum garnet（YAG：Ce） as a yellow phosphor for white light-emitting diodes（LEDs） was synthesized via a facile combustion method using Y2 O3, CeO2, Al2 O3, Al,and NaClO4 as raw materials. The combustion synthesis approach utilizes the strong exothermic oxidation of aluminum to realize a self-sustaining reaction. In this study, we investigated the effects of the ratios of Al2 O3 to AI,fluxes, and coprecipitated materials as raw materials on the luminescence properties of the synthesized YAG：Ce phosphors. When the amount of Al2 O3 x is varied, the combustion reaction proceeds at x ≤ 1.8,with x = 1.725 being the optimum condition for producing a high-performance product. When 5 wt%BaF2 is added, the luminescence intensity is significantly improved owing to a decrease of YAP（YAlO3）formation with improved uniformity. However, the addition of CaF2 and NaF does not improve the luminescence properties. To suppress the segregation of CeO2, we used the coprecipitated material Y2 O3-CeO2 as a raw material. Unlike with separate addition of Y2 O3 and CeO2, Ce ions are uniformly distributed in the coprecipitated material, resulting in improved luminescence properties. The combination of BaF2 and coprecipitated material significantly improves the internal quantum efficiency to83.0%, which is close to that of commercial phosphors.

关键词： Phosphor Yttrium aluminum garnet Combustion synthesis Flux Coprecipitated material Rare earths

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Hypoxia and fatty liver

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World Journal of Gastroenterology 2014年第41期20卷 15087-15097页

作者： tomohiro Suzuki Satoko Shinjo Takatomo Arai Mai Kanai Nobuhito Goda Department of Life Science and Medical BioScience Waseda University School of Advanced Science and Engineering

The liver is a central organ that metabolizes excessive nutrients for storage in the form of glycogen and lipids and supplies energy-producing substrates to the peripheral tissues to maintain their function,even under starved *** processes require a considerable amount of oxygen,which causes a steep oxygen gradient throughout the hepatic *** consumption and/or excessive food intake can alter the hepatic metabolic balance drastically,which can precipitate fatty liver disease,a major cause of chronic liver diseases worldwide,ranging from simple steatosis,through steatohepatitis and hepatic fibrosis,to liver *** hepatic metabolism and tissue remodeling in fatty liver disease further disrupt hepatic oxygen homeostasis,resulting in severe liver *** master regulators of adaptive responses to hypoxic stress,hypoxia-inducible factors(HIFs) modulate various cellular and organ functions,including erythropoiesis,angiogenesis,metabolic demand,and cell survival,by activating their target genes during fetal development and also in many disease conditions such as cancer,heart failure,and *** the past decade,it has become clear that HIFs serve as key factors in the regulation of lipid metabolism and fatty liver *** review discusses the molecular mechanisms by which hypoxia and HIFs regulate lipid metabolism in the development and progression of fatty liver disease.

关键词： Hypoxia Fatty liver disease Hypoxia-inducible factor Lipid metabolism Obstructive sleep apnea

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Nucleotide-binding oligomerization domain 1 and Helicobacter pylori infection: A review

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World Journal of Gastroenterology 2018年第16期24卷 1725-1733页

作者： Kosuke Minaga tomohiro Watanabe Ken Kamata Naoki Asano Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of Medicine Division of Gastroenterology Tohoku University Graduate School of Medicine

Nucleotide-binding oligomerization domain 1(NOD1) is an intracellular innate immune sensor for small molecules derived from bacterial cell components. NOD1 activation by its ligands leads to robust production of pro-inflammatory cytokines and chemokines by innate immune cells, thereby mediating mucosal host defense systems against microbes. Chronic gastric infection due to Helicobacter pylori(H. pylori) causes various upper gastrointestinal diseases, including atrophic gastritis, peptic ulcers, and gastric cancer. It is now generally accepted that detection of H. pylori by NOD1 expressed in gastric epithelial cells plays an indispensable role in mucosal host defense systems against this organism. Recent studies have revealed the molecular mechanism by which NOD1 activation caused by H. pylori infection is involved in the development of chronic gastritis and gastric cancer. In this review, we have discussed and summarized how sensing of H. pylori by NOD1 mediates the prevention of chronic gastritis and gastric cancer.

关键词： Nucleotide-binding oligomerization domain 1 Helicobacter pylori,gastritis gastric cancer

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Ruptured gastric artery aneurysm:An uncommon manifestation of microscopic polyangiitis

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World Journal of Gastroenterology 2014年第35期20卷 12668-12672页

作者： Yoshihiro Ikura tomohiro Kadota Shuhei Watanabe Akira Arimoto Eiko Nishioka Department of Pathology Takatsuki General Hospital Department of Gastroenterology Takatsuki General Hospital Department of Nephrology Takatsuki General Hospital Department of Surgery Takatsuki General Hospital Department of Radiology Takatsuki General Hospital

Gastric artery aneurysm is a rare and lethal condition,and is caused by inflammatory or degenerative *** describe herein the clinical course of a patient with a ruptured gastric artery aneurysm associated with microscopic *** of vasculitic changes in the aneurysm resected and negative results of autoantibodies interfered with our diagnostic *** should have adopted an interventional radiology and initiated steroid therapy promptly to rescue the patient.

关键词： Aneurysm Stomach Microscopic polyangiitis Segmental arterial mediolysis Interventional radiology Steroids Therapy

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Low-grade myofibroblastic sarcoma of the palate

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International Journal of Oral Science 2012年第3期4卷 170-173页

作者： tomohiro Yamada Tomohide Yoshimura Naoya Kitamura Eri Sasabe Seiji Ohno Tetsuya Yamamoto Department of Oral and Maxillofacial Surgery Kochi Medical SchoolKochi University

Low-grade myofibroblastic sarcoma （LGMS） is a rare, malignant tumor with myofibroblastic differentiation. Despite it being classified as a distinct entity by the World Health Organization, a few cases were reported in the oral and maxillofacial region. Here, a LGMS developed on the palate of a 73-year-old man who presented with a 1-cm tumor on the posterior border of the palate. Based on the histological and immunohistochemical features, a diagnosis of LGMS was established. The tumor was resected, and no recurrence was observed over 2 years. Although the tongue is the most preferred site for LGMS, it may occur in any region of the oral cavity.

关键词： low-grade myofibroblastic sarcoma oral palate

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Gastrojejunostomy followed by induction chemotherapy for incurable gastric cancer with outlet obstruction

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World Journal of Gastroenterology 2010年第34期16卷 4367-4370页

作者： Yasuhiro Okumura Manabu Ohashi Souya Nunobe tomohiro Iwanaga Tatsuo Kanda Yoshiaki Iwasaki Department of Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital Department of Gastrointestinal Surgery Tokyo University Hospital Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences

A 72-year-old male gastric cancer patient with outlet obstruction underwent laparoscopic exploration. The examination disclosed intraperitoneal free cancer cells with no overt peritoneal, lymphatic, or hepatic metastasis. The patient underwent laparoscopy-assisted gastroje-junostomy (LAGJ) and started chemotherapy with S-1 plus cisplatin on postoperative day 13. Three course of the chemotherapy shrank the tumor markedly. Then, the patient underwent gastrectomy with a curative intent. Laparotomy revealed no intraperitoneal free cancer cells, and microscopically complete resection was achieved. The patient received S-1 chemotherapy as postoperative adjuvant treatment for 1 year, and is still alive with no evidence of peritoneal recurrence. LAGJ followed by S-1 plus cisplatin is one of the optional treatments that should be considered for patients with outlet obstruction as it may widen opportunities for potentially curative resection.

关键词： Gastric cancer Outlet obstruction CY1 Laparoscopy-assisted gastrojejunostomy S-1 plus cisplatin

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Metallic Contaminant Detection using a High-Temperature Superconducting Quantum Interference Devices Gradiometer

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Chinese Physics Letters 2010年第8期27卷 253-255页

作者： Saburo Tanaka tomohiro Akai Makoto Takemoto Yoshimi Hatsukade Takeyoshi Ohtani Yoshio Ikeda Shuichi Suzuki Toyohashi University of Technology 1-1 Hibarigaoka Tempaku-cho Toyohashi Aichi 441-8580 Japan Advance Food Technology Co. Ltd. Toyohashi Aichi 441-8113 Japan

We develop magnetic metallic contaminant detectors using high-temperature superconducting quantum interference devices （HTS-SQUIDs） for industrial products. Finding ultra-small metallic contaminants is an important issue for manufacturers producing commercial products such as lithium ion batteries. If such contaminants cause damages, the manufacturer of the product suffers a big financial loss due to having to recall the faulty products. Previously, we described a system for finding such ultra-smafi particles in food. In this study, we describe further developments of the system, for the reduction of the effect of the remnant field of the products, and we test the parallel magnetization of the products to generate the remnant field only at both ends of the products. In addition, we use an SQUID gradiometer in place of the magnetometer to reduce the edge effect by measuring the magnetic field gradient. We test the performances of the system and find that tiny iron particles as small as 50 × 50 μm^2 on the electrode of a lithium ion battery could be clearly detected. This detection level is difficult to achieve when using other methods.

关键词： Uses Metals Squids Production Productivity Products Ions Lithium Contamination Pollutants

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Time-dependent effects of castration on the bladder function and histological changes in the bladder and blood vessels

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Asian Journal of Andrology 2014年第3期16卷 457-460页

作者： tomohiro Magari Yasuhiro Shibata Seiji Arai Bunzo Kashiwagi Keiji Suzuki Kazuhiro Suzuki Department of Urology Gunma University Graduate School of Medicine Maebashi Department of Urology Kurosawa Hospital Takasaki Department of Pathology Gunma University Graduate School of Health Sciences Maebashi Japan

We examined the effect of androgens on bladder blood flow （BBF）, bladder function and histological changes in castrated male rats. Male Wistar rats were classified into unoperated group （control group）, groups castrated at the age of 8weeks （group 8wPC） and groups castrated at the age of 4weeks （group 4wPC）. Each rat was used at the age of 20weeks. BBF was measured using fluorescent microspheres. Bladder cystometry was performed without anesthesia or restraint; the bladder was first irrigated with saline and then with 0.25% acetic acid （AA） solution. Maximum voiding pressure and voiding interval were measured. The bladder and lilac artery were histologically examined for differences in smooth muscle and quantity of collagen fiber to analyze the effect of castration on the smooth muscle content. No differences were noted in BBF following castration. The voiding intervals for all groups were shortened （P 〈 0.001） following AA irrigation. No significant difference was noted in the maximum voiding pressure. Histological changes were observed in bladder and lilac artery. Smooth muscle/collagen ratio at the bladder was lower in groups 8wPC and 4wPC compared to the control group （P 〈 0.01）, while that at the lilac artery was decreased in group 4wPC compared to the control group （P〈 0.001）. In conclusion, our findings indicate that castration does not alter BBF, but leads to histological changes in the bladder as well as its associated blood vessels.

关键词： bladder blood flow bladder function castration fluorescent microsphere method histological changes smooth muscle/collagen ratio

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