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Intraductal papillary neoplasm of the bile duct developing in a patient with primary sclerosing cholangitis: A case report

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World Journal of Gastroenterology 2014年第42期20卷 15925-15930页

作者： Hiroyuki hachiya Junji Kita Takayuki Shiraki Yukihiro Iso Mitsugi Shimoda Keiichi Kubota Second Department of Surgery Dokkyo Medical University

We report a case of intraductal papillary neoplasm of the bile duct(IPNB) that developed in a patient with primary sclerosing cholangitis. A 46-year-old woman was admitted to our hospital with obstructive jaundice. The liver function tests demonstrated increased serum liver enzyme levels. Computed tomography showed dilatation of the intrahepatic bile ducts. Abdominal ultrasonography revealed a highly echoic protruding lesion in the posterior bile duct near the right lobe of the liver. The lesion was suspected to be IPNB, but we were unable to confirm whether it was a carcinoma. A right hepatectomy was performed, and this showed that the dilated bile duct was filled with mucin and contained several yellowish papillary tumors. Histologically, the neoplastic biliary epithelium showed papillary growth in the dilated lumen. The tumor was diagnosed as IPNB, high-grade intraepithelial neoplasia secreting abundant mucin. No recurrence has been detected 3 years after surgery.

关键词： Intraductal papillary neoplasm of the bile duct Primary sclerosing cholangitis Cholangiocarcinoma High-grade intraepithelial neoplasia Premalignant lesion

Primary hepatic leiomyosarcoma:Case report and literature review

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World Journal of Gastrointestinal Oncology 2011年第10期3卷 148-152页

作者： Nairuthya Shivathirthan Junji Kita Yukihiro Iso Hiroyuki hachiya Park KyungHwa Tokihiko Sawada Keiichi Kubota Second Department of Surgery Dokkyo Medical University880 Kita KobayashiMibuTochigi 321-0293Japan

Primary hepatic leiomyosarcoma are rare tumors with less than 30 cases reported in the English *** specific presentations and often diagnosis delayed until they reach a large size,is the norm with therapy leading to an often dismal prognosis.A 67-year-old man presented complaining of abdominal pain and a palpable abdominal mass since Jan *** ultrasonography and abdominal computed tomography revealed a large tumor in the left lobe of the *** exploration was undertaken and an extended left hepatectomy with extension onto the dorsal part of segment 8 preserving the MHV with partial resection of segment 6 was *** weight of the resected specimen was 1300 g of the left lobectomy specimen and 8 g of the segment 6 partial resection *** pathology report confirmed the diagnosis of *** immunohistochemistry,the tumor cells were positive for smooth muscle actin *** patient is on regular follow up and is currently 9 mo post resection with no evidence of *** report the case of a resected primary hepatic leiomyosarcoma and emphasize the need for a global database for these rare tumors to promote a better and broader understanding of this less understood subject.

关键词： Primary hepatic leiomyosarcoma Smooth muscle actin Smooth muscle Hepatectomy

A Comprehensive Mixed Media Model for Boosting Automobile Dealer Visits

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Chinese Business Review 2013年第3期12卷 195-203页

作者： Motoi Ogura Takayuki hachiya Kakuro Amasaka Aoyama Gakuin University Kanagawa-ken Japan

This paper validates the effectiveness of a comprehensive mixed media model for effective advertising designed to bring customers into auto dealerships by use of their AIDA （attention, interest, desire, action） model and statistical science to quantitatively assess the effectiveness of various advertising methods using television, newspapers, flyers, direct mail, public transportation, and the internet. This model is applied to a dealership representing a well-known automaker, where its effectiveness is verified.

关键词： AIDA model Comprehensive Mixed Media Model (CMMM) automobile advertising

Double Nucleophilic Addition of Ketene Silyl (THIO)Acetals and Trimethylsilyl Cyanide to N-Allylideneamine

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复旦学报（自然科学版） 2007年第5期46卷 586-页

作者： Isao Mizoia Iwao hachiya Makoto Shimizu Department of Chemistry for Materials Mie University

1 Results We have already published a double nucleophilic addition reaction of α,β-unsaturated imines with several nucleophiles such as ketene silyl acetals, trimethylsilyl cyanides, trimethylsilyl azides and thiols[1]. However, it was not easy to use N-allylideneamine 2 derived from acrolein for such reactions. Since there is no substituent at the β-position, imine 2 has high reactivity and are prone to be polymerization. We report the first synthesis of N-allylideneamines 2 using the isomerization of ...

关键词： double nucleophilic addition reaction regioselectivity N-allylideneamine silica gel ketene silyl acetal

妊娠小鼠及其胎鼠对辐射诱发嗜多染性红细胞微核的敏感性比较

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中华放射医学与防护杂志 1989年第1期9卷 1-4页

作者：陈德清卫生部工业卫生实验所，北京秋田大学医学部公众卫生学教研室，日本国秋田市

本实验以1OMeVX线照射小鼠，发现胎肝嗜多染性红细胞（PCE）微核率在照射后12小时出现峰值，母鼠的骨髓是在24小吋。而出生第一天的小鼠肝脏中PCE微核率至照射后30小时尚未见峰值。结果表明：胎儿的敏感性高于成年母鼠，似乎胎龄越小敏... 详细信息

本实验以1OMeVX线照射小鼠，发现胎肝嗜多染性红细胞（PCE）微核率在照射后12小时出现峰值，母鼠的骨髓是在24小吋。而出生第一天的小鼠肝脏中PCE微核率至照射后30小时尚未见峰值。结果表明：胎儿的敏感性高于成年母鼠，似乎胎龄越小敏感性越高。小鼠在妊娠期间的敏感性也似乎随着孕期的延长而降低，妊娠前与分娩后第一天的敏感性相同。

关键词：辐射敏感性妊娠红细胞微核小鼠

东京羽田机场道面FWD实测弯沉的温度特性分析

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土木工程学报 1995年第1期28卷 40-45页

作者：唐伯明八谷好高同济大学日本运输省港湾技术研究所

本文依据东京羽田机场道面近4年来的FWD实测弯沉数据,统计分析了道面温度状况对弯沉盆的影响性质,给出了沥青道面弯沉值的温度修正关系.同时,对该机场停机坪试验段水泥混凝土道面板边、板角弯沉及接缝传荷能力的若干温度特性亦进行了分析.

关键词：沥青路面机场弯沉温度落锤式弯沉仪

水泥混凝土路面板模量反算的一种新方法──惰性弯沉法

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土木工程学报 2000年第1期33卷 83-87,99页

作者：孙立军八谷好高姚祖康同济大学日本运输省港湾技术研究所

路面结构层模量反算方法有多种，但都因反算解的唯一性问题而使反算结果误差太大。为了提高反算精度，本文提出了“惰性点”的概念。发现在混凝土路面的弯沉盆上，存在一个其弯沉值几乎不随面层模量变化而改变的点，该点即被定义为惰性... 详细信息

路面结构层模量反算方法有多种，但都因反算解的唯一性问题而使反算结果误差太大。为了提高反算精度，本文提出了“惰性点”的概念。发现在混凝土路面的弯沉盆上，存在一个其弯沉值几乎不随面层模量变化而改变的点，该点即被定义为惰性点。该点的发现，为唯一确定路面结构层模量提供了理论基础。

关键词：惰性弯沉法惰性点模量反算水泥混凝土路面

雷公藤提取物TY16治疗银屑病作用机制的解析

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雷公藤提取物TY16治疗银屑病作用机制的解析

第四次全国雷公藤学术会议

作者： Takashi Kitahara Atushi Ohuchi hachiya Akira Takema Yoshinori Kao Biological Science Lab. Japan

雷公藤(Tripterygium wilfordii Hook f)的根提取物中含有Wilfordine(雷公藤定碱)Celacinnine(苯乙烯南蛇碱)Celafurine(呋喃南蛇碱)等生物碱以及Triptolide(雷公藤甲素)Triptonide(雷公藤内酯)Tripdiolide(雷公藤乙素)Celastrol(雷公藤红素)等的抗癌活性物质(antitumor activity)成分,其祛风除湿,活血通络,消肿止痛的作用已为人所知。另外,其提取物还被用于银屑病(psoriasis)、风湿性关节炎(rightatrium)、慢性关节风湿性病(chronic articular rheumatism)、肾炎(nephritis)红斑

关键词：雷公藤银屑病 TY16 人体角蛋白细胞

来源： cnki会议评论

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基于飞行员主观评价的机场道面优化设计

重庆交通大学学报（自然科学版） 2010年第6期29卷 885-887,933页

作者：姬杨蓓蓓苏凯八谷好高上海应用技术学院上海200235 上海市城市建设投资开发总公司上海200235 日本港湾空港建设技术中心

日本东京羽田国际机场第4跑道规划建于东京湾东侧,2/3位于填海造地的人工岛上,其余1/3位于多摩川河口上,为了疏散河水,该部分采用桥梁结构。对于桥梁部分机场跑道,荷载作用下桥面的变形和桥路基过渡段的不均匀沉降是影响飞机乘坐舒适性... 详细信息

日本东京羽田国际机场第4跑道规划建于东京湾东侧,2/3位于填海造地的人工岛上,其余1/3位于多摩川河口上,为了疏散河水,该部分采用桥梁结构。对于桥梁部分机场跑道,荷载作用下桥面的变形和桥路基过渡段的不均匀沉降是影响飞机乘坐舒适性和飞行操作安全性的2个主要因素。借助飞行模拟试验,根据飞行员主观评价的调查结果对桥面混凝土板厚度和过渡段沉降标准进行优化。结果表明,桥面板弯沉和过渡段不均匀沉降的增大会降低飞行操作安全性和乘坐舒适性,尤其对舒适性的影响更为明显。依据50%以上的飞行员对道面性能的评价为不舒服或更差这一标准,最终对羽田机场第4跑道桥面板厚度和过渡段不均匀沉降标准进行了优化。

关键词：机场道面桥梁结构飞行模拟器操作安全性乘坐舒适性