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Discrete Circular Distributions with Applications to Shared Orthologs of Paired Circular Genomes

Computer Modeling in Engineering & Sciences 2020年第6期123卷 1131-1149页

作者： tomoaki imoto Grace S.Shieh Kunio Shimizu School of Management and Information University of ShizuokaShizuokaJapan Institute of Statistical Science Academia SinicaTaipeiTaiwan School of Statistical Thinking The Institute of Statistical MathematicsTokyoJapan

For structural comparisons of paired prokaryotic genomes,an important topic in synthetic and evolutionary biology,the locations of shared orthologous genes(henceforth orthologs)are observed as binned *** and other data,e.g.,wind directions recorded at monitoring sites and intensive care unit arrival times on the 24-hour clock,are counted in binned circular arcs,thus modeling them by discrete circular distributions(DCDs)is *** propose a novel method to construct a DCD from a base continuous circular distribution(CCD).The probability mass function is defined to take the normalized values of the probability density function at some pre-fixed equidistant points on the *** families of constructed DCDs which have normalizing constants in closed form are *** studies show that DCDs outperform the corresponding CCDs in modeling grouped(discrete)circular data,and minimum chi-square estimation outperforms maximum likelihood estimation for *** apply the constructed DCDs,invariant wrapped Poisson and wrapped discrete skew Laplace to compare the structures of paired bacterial ***,discrete four-parameter wrapped Cauchy(nonnegative trigonometric sums)distribution models multi-modal shared orthologs in Clostridium(Sulfolobus)better than the others considered,in terms of AIC and Freedman’s goodness-of-fit *** result that different DCDs fit the shared orthologs is consistent with the fact they belong to two ***,these prokaryotes have a common favored site around 70°on the unit circle;this finding is important for building synthetic prokaryotic genomes in synthetic *** DCDs can also be applied to other binned circular data.

关键词： Bacterial genomes circular distribution goodness-of-fit test modeling synthetic and evolutionary biology.

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Cisplatin-induced activation of TGF-βsignaling contributes to drug resistance

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Oncology Research 2024年第1期32卷 139-150页

作者： SAYAKA IMATSUJI YUKIKO UJIE HIROYUKI ODAKE MASAYA imoto SUSUMU ITOH ETSU TASHIRO Department of Biosciences and Informatics Faculty of Science and TechnologyKeio UniversityYokohama223-8522Japan Department of Neurology Juntendo University Graduate School of MedicineTokyo113-8421Japan Laboratory of Biochemistry Showa Pharmaceutical UniversityTokyo194-8543Japan

Growing evidence suggests an association between epithelial-mesenchymal transition(EMT),a hallmark of tumor malignancy,and chemoresistance to a number of anti-cancer ***,the mechanism of EMT induction in the process of acquiring anti-cancer drug resistance remains *** address this issue,we obtained a number of cisplatin-resistant clones from LoVo cells and found that almost all of them lost cell-cell *** these clones,the epithelial marker E-cadherin was downregulated,whereas the mesenchymal marker N-cadherin was ***,the expression of EMT-related transcription factors,including Slug,was *** the other hand,the upregulation of other mesenchymal marker Vimentin was weak,suggesting that the mesenchymal-like phenotypic changes occurred in these cisplatin-resistant *** mesenchymal-like features of cisplatin-resistant clones were partially reversed to parental epithelial-like features by treatment with transforming growth factor-β(TGF-β)receptor kinase inhibitors,indicating that TGF-βsignaling is involved in cisplatin-induced the mesenchymallike phenotypic ***,cisplatin was observed to enhance the secretion of TGF-βinto the culture media without influencing TGF-βgene *** results suggest that cisplatin may induce the mesenchymal-like phenotypic changes by enhancing TGF-βsecretion,ultimately resulting in drug resistance.

关键词： Cisplatin EMT Chemo-resistance TGF-β

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抓斗式疏浚作业区域流场及悬沙运动规律的模拟分析

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长江科学院院报 2024年

作者：龙瑞金中武 tomoaki NAKAMURA Yonghwan CHO Norimi MIZUTANI 长江科学院河流研究所长江科学院水利部长江中下游河湖治理与防洪重点实验室 Nagoya University

疏浚作业时，以底泥释放为代表的内源污染治理问题变得日益突出，减少疏浚带来的水体二次污染是河湖治理中的重点和难点。本文通过使用数学模型FS3M进行全尺寸数值模拟，从流场、悬沙运动及体积变化的角度研究了能减少水体浑浊产生的抓... 详细信息

疏浚作业时，以底泥释放为代表的内源污染治理问题变得日益突出，减少疏浚带来的水体二次污染是河湖治理中的重点和难点。本文通过使用数学模型FS3M进行全尺寸数值模拟，从流场、悬沙运动及体积变化的角度研究了能减少水体浑浊产生的抓斗最佳下落操作。数值结果表明，抓斗在自重和机械力的控制下，下降过程中会对周围水体产生较大的扰动，卷起较多的床沙，对周边水体环境造成影响。在作业过程中适当的减缓自身下降速度可以有效的抑制床面附近产生的水流速度，随之也会减少悬沙的产生并抑制其随水流运动而向外部扩散。随着计算模型的不断优化升级，今后还需对抓斗铲沙这一动态行为进行模拟分析，深入研究这一行为对泥沙运动规律的影响。该研究的成果可为环保式疏浚工艺提供一定参考。

关键词：疏浚抓斗流场悬沙运动数值模拟

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Development and Evaluation of 3D Delivery Animation Software Designed to Improve the Mother’s and Spouse’s Satisfaction with Delivery

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Health 2024年第5期16卷 439-458页

作者： Ayako Sasaki Sachi Chikazawa Nojima Kumiko Tomita Takako Hatakeyama Keiko imoto Yasufumi imoto Nobutane Faculty of Nursing Osaka Medical and Pharmaceutical University Takatsuki Japan imoto Ladies Clinic Echizen Japan

Purpose: To clarify the effectiveness of 3-D delivery animation software for the mother’s and husband’s satisfaction with delivery. Subjects and Method: We independently developed a software application used to display the pelvic region and explain the labor process. The study involved a collaboration with hospital staff who recruited 18 primiparous and 18 multiparous mothers who were hospitalized for delivery at Facility A. The midwife explained the process of delivery using the “Delivery Animation Software”. A self-administered, anonymous questionnaire was distributed and analyzed separately for primiparous and multiparous mothers and their husbands. Results: 1) For both primiparous and multiparous couples, both mothers and their husbands gained a significantly higher level of understanding after delivery than during pregnancy. 2) The Self-Evaluation Scale for Experience of Delivery results were as follows: “I did my best for the baby even if it was painful” was selected more often for “birth coping skills”;“reliable medical staff” was selected more often for “physiological birth process”;“the birth progressed as I expected” was selected frequently by primiparous mothers;and “the birth progressed smoothly” was selected often by multiparous mothers. 3) In terms of husbands’ satisfaction with the delivery, “I was satisfied with the delivery”, “I was given an easy-to-understand explanation”, and “They explained the process to me” was selected of primiparous and multiparous fathers. 4) All primiparous and multiparous mothers positively evaluated whether the delivery animation was helpful in understanding the process of delivery. Conclusion: The delivery animation was effective in improving the understanding and satisfaction of both the mothers and their husbands.

关键词： Mother Spouse Satisfaction 3D Delivery Animation Software

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PM_(2.5)粉末样品中不同组分的氧化潜势及影响因素

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中国环境科学 2024年第4期44卷 1957-1965页

作者：彭勤李丹罗玉彭泽志孙健 tomoaki Okuda 沈振兴西安交通大学环境科学与工程系陕西西安710049 庆应义塾大学科学技术学院日本神奈川县横滨市223-8522

基于大流量旋风式冲击采样器在西安市采集了四季大气PM_(2.5)粉末样品,分别测定其水溶和非水溶相的氧化潜势(OP)､无机元素､水溶性离子､金属组分､碳组分和有机官能团,揭示水溶相/非水溶相的化学组分对OP的影响.结果显示,西安市PM_(2.5)... 详细信息

基于大流量旋风式冲击采样器在西安市采集了四季大气PM_(2.5)粉末样品,分别测定其水溶和非水溶相的氧化潜势(OP)､无机元素､水溶性离子､金属组分､碳组分和有机官能团,揭示水溶相/非水溶相的化学组分对OP的影响.结果显示,西安市PM_(2.5)粉末样品总OP的趋势为秋冬(秋7.24μmol/(min·mg),冬5.19μmol/(min·mg))显著高于春夏季(春2.06μmol/(min·mg),夏3.15μmol/(min·mg));春夏季PM_(2.5)粉末样品的OP以水溶相OP为主(70.0%),秋冬季以非水溶相为主(73.9%).水溶性金属Ni､Pb､Ba､Mn､Cu､Ti(0.60

关键词： PM_(2.5) 粉末样品 ROS 氧化潜势氧化应激化学组分

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Inverse relationship between platelet Akt activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhiko Tokuda Takamitsu Hori Daisuke Mizutani Tomoyuki Hioki Kumi Kojima Takashi Onuma Yukiko Enomoto tomoaki Doi Rie Matsushima-Nishiwaki Shinji Ogura Hiroki Iida Toru Iwama Takashi Sakurai Osamu Kozawa Department of Metabolic Research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACKGROUND Akt plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(T2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without *** To investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in T2DM *** Platelet-rich plasma(PRP)was prepared from the venous blood of patients with T2DM or age-matched *** pellet lysate of the centrifuged PRP was subjected to western blotting to analyse the phosphorylation of Akt,p38 mitogen-activated protein(MAP)kinase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** The levels of phosphorylated Akt corrected with phosphorylated p38 MAP kinase were inversely correlated with the Z-scores in the T2DM subjects,whereas the levels of phosphorylated Akt corrected with GAPDH were ***,this relationship was not observed in the control *** These results suggest that an inverse relationship may exist between platelet Akt activation and hippocampal atrophy in T2DM *** findings provide insight into the molecular mechanisms underlying T2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

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Carbon Nanobelts:Brief History and Perspective

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Precision Chemistry 2023年第9期1卷 516-523页

作者： Daiki imoto Akiko Yagi Kenichiro Itami Department of Chemistry Graduate School of ScienceNagoya UniversityNagoya 464-8602Japan Institute of Transformative Bio-Molecules(WPI-ITbM) Nagoya UniversityNagoya 464-8602Japan

Carbon nanotubes(CNTs)are an emerging nanomaterial because of their outstanding performance in various *** recent years,the segment molecules of CNTs,referred to as carbon nanorings(CNRs)or carbon nanobelts(CNBs),have gained attention for their unique structures and properties,as well as their potential as seed molecules for the precise synthesis of *** are rigid and thick segments of CNTs whose synthesis has been addressed by scientists fascinated by the uniqueness of CNBs long before the discovery of *** 60 years of efforts by synthetic chemists all over the world,the synthesis of the first CNB,(6,6)CNB,was achieved by our group in *** this milestone,diverse types of nanobelts have been synthesized through various synthetic routes,thereby demonstrating their photophysical,magnetic,and redox properties derived from rigid belt *** applications of CNBs have also been introduced *** formation of the host−guest complex,transformation to three-dimensional molecules,and measurement of conductivity have been reported for *** paper summarizes the brief history and perspective of *** synthetic campaigns and aggressive application of CNBs would create novel and groundbreaking scenes in materials science.

关键词： carbon nanobelt carbon nanoring carbon nanotube cycloparaphenylene aromatic compounds organic synthesis

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High piezoelectricity after field cooling AC poling in temperature stable ternary single crystals manufactured by continuous-feeding Bridgman method

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Journal of Advanced Ceramics 2022年第1期11卷 57-65页

作者： Cong LUO tomoaki KARAKI Zhuangkai WANG Yiqin SUN Yohachi(John)YAMASHITA Jiayue XU School of Materials Science and Engineering Shanghai Institute of TechnologyShanghai 201418China Department of Electrical and Computer Engineering Faculty of EngineeringToyama Prefectural UniversityToyama 939-0398Japan Department of Mechanical&Aerospace Engineering North Carolina State UniversityNC 27695-7910USA

After field cooling(FC)alternating current poling(ACP),we investigated the dielectric and piezoelectric properties of[001]_(pc)-oriented 0.24Pb(In_(1/2)Nb_(1/2))O_(3)(PIN)-0.46Pb(Mg_(1/3)Nb_(2/3))O_(3)(PMN)-0.30PbTiO3(PT)(PIMN-0.30PT)single crystals(SCs),which were manufactured by continuous-feeding Bridgman(CF BM)within morphotropic phase boundary(MPB)*** ACP with 4 kVrms/cm from 100 to 70℃,the PIMN-0.30PT SC attained high dielectric permittivity of 8330,piezoelectric coefficient(d_(33))of 2750 pC/N,bar mode electromechanical coupling factorκ_(33)of 0.96 with higher phase change temperature(T_(pc))of 103℃,and high Curie temperature(7c)of 180℃.These values are the highest ever reported as PIMN-xPT SC system with Tpc>100℃.The enhancement of these properties is attributed to the induced low symmetry multi-phase supported by phase *** work indicates that FC ACP is a smart and promising method to enhance piezoelectric properties of relaxor-PT ferroelectric SCs including PIMN-xPT,and provides a route to a wide range of piezoelectric device applications.

关键词： field cooling(FC)alternating current poling(ACP) PIMN-0.30PT high piezoelectricity

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Spurious-mode vibrations caused by alternating current poling and their solution process for Pb(Mg_(1/3)Nb_(2/3))O_(3)-PbTiO_(3) single crystals

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Journal of Materiomics 2022年第1期8卷 96-103页

作者： Yiqin Sun tomoaki Karaki Tadashi Fujii Yohachi John Yamashita Department of Intelligent Robotics Toyama Prefectural UniversityImizu9390398ToyamaJapan Mechanical&Aerospace Engineering North Carolina State UniversityRaleighNC27695-7910USA

The effects of alternating current poling(ACP)at 80℃on electrical properties of[001]-oriented 0.72 Pb(Mg_(1/3)Nb_(2/3))O_(3)-0.28PbTiO_(3)(PMN-28PT)single crystals(SCs)have been *** square-wave ACP SCs poled at high voltage(HV,5 kV_(rms)/cm)occasionally showed large fluctuations and low opposite values of piezoelectric coefficient(d_(33)=±1370 pC/N)in one *** revealed spuriousmode vibrations(SMV)of impedance ***,after depolarizing and repolarizing the sample with a sine-wave ACP at low voltage(LV,3.5 kV_(rms)/cm),the d_(33) enhanced to be 1720 pC/N(+26%)and did not exhibit large fluctuation or opposite values in one plate any *** impedance spectrum became clean and the abnormal SMV *** proposed four possible mechanisms of the SMV,and speculate that the main cause maybe by macro-scale sub-domain structure and/or phase change in the main domain structure and/or phase in the SC plate due to the specific poling conditions not eternal mechanical damage of PMN-PT *** study will be useful to realize a high d_(33) and improve other properties of PMN-PT ACP SC ultrasonic transducers without any SMV for high-frequency medical imaging equipment.

关键词： Alternating current poling Ferroelectric single crystal Ultrasonic transducer Spurious mode vibration Piezoelectric property

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Recent Research Progress in λ-Tunable WDM/TDM-PON

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光子学报 2014年第3期43卷 1-8页

作者： tomoaki YOSHIDA NTT Access Network Service Systems Laboratories NTT Corporation

This paper describes the current research status of theλ-tunable Wavelength-Division Multiplexing/Time-Division-Multiplexing-Passive Optical Network(WDM/TDM-PON). This optical access system realizes new cost-effective operations from the network operator′s point of *** main feature of the proposed system is that it aggressively exploits wavelength *** classify the system configurations and ***,we describe key technologies,namely newly developedλ-tuning burst-mode transceivers and a widely applicable Dynamic Wavelength and Bandwith Allocation(DWBA)***,we summarize our research and discuss several issues related to the λ-tunable Wavelength-Division Multiplexing/Time-Division-MultiplexingPassive Optical Network(WDM/TDM-PON).

关键词：摘要编辑部编辑工作读者

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