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World Journal of Gastroenterology 2014年第43期20卷 16318-16322页

作者： Makoto Arai tomoaki matsumura Kenichiro Okimoto Arata Oyamada Keiko Saito Shoko Minemura Daisuke Maruoka Takeshi Tanaka Tomoo Nakagawa Tatsuro Katsuno Osamu Yokosuka Department of Gastroenterology and Nephrology (K1) Graduate School of MedicineChiba UniversityChiba 260-8670Japan

AIM: To investigate the optimum period of treatment for post endoscopic submucosal dissection (ESD) ulcers.

关键词： Proton pump inhibitor Endoscopic submucosal dissection Esomeprazole Rebamipide Randomized control trial

Polysomnographic assessment of respiratory disturbance during deep propofol sedation for endoscopic submucosal dissection of gastric tumors

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World Journal of Gastrointestinal Endoscopy 2018年第11期10卷 340-347页

作者： Ryuma Urahama Masaya Uesato Mizuho Aikawa Yukiko Yamaguchi Koichi Hayano tomoaki matsumura Makoto Arai Reiko Kunii Shiroh Isono Hisahiro Matsubara Department of Frontier Surgery Chiba University Graduate School of Medicine Department of Gastroenterology Chiba University Graduate School of Medicine Department of Medical Oncology Chiba University Graduate School of Medicine Staff of Clinical Laboratory Chiba University Hospital Department of Anesthesiology Chiba University Graduate School of Medicine

AIM To investigate that polysomnographic monitoring can accurately evaluate respiratory disturbance incidence during sedation for gastrointestinal endoscopy compare to pulse oximetry *** This prospective observational study included 10 elderly patients with early gastric cancer undergoing endoscopic submucosal dissection(ESD) under propofol sedation. Apart from routine cardiorespiratory monitoring, polysomnography measurements were acquired. The primary hypothesis was tested by comparing the apnea hypopnea index(AHI), defined as the number of apnea and hypopnea instances per hour during sedation, with and without hypoxemia; hypoxemia was defined as the reduction in oxygen saturation by ≥ 3% from *** Polysomnography(PSG) detected 207 respiratory disturbances in the 10 patients. PSG yielded a significantly greater AHI(10.44 ± 5.68/h) compared with pulse oximetry(1.54 ± 1.81/h, P < 0.001), thus supporting our hypothesis. Obstructive AHI(9.26 ± 5.44/h) was significantly greater than central AHI(1.19 ± 0.90/h, P < 0.001). Compared with pulse oximetry, PSG detected the 25 instances of respiratory disturbances with hypoxemia 107.4 s earlier on *** Compared with pulse oximetry, PSG can better detect respiratory irregularities and thus provide superior AHI values, leading to avoidance of fatal respiratory complications during ESD under propofol-induced sedation.

关键词： Polysomnography Hypoxemia Propofol Endoscopic submucosal dissection Pulse oximetry Sedation

Efficacy of computed image modification of capsule endoscopy in patients with obscure gastrointestinal bleeding

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World Journal of Gastrointestinal Endoscopy 2012年第9期4卷 421-428页

作者： tomoaki matsumura Makoto Arai Toru Sato Tomoo Nakagawa Daisuke Maruoka Masaru Tsuboi Sachio Hata Eiji Arai Tatsuro Katsuno Fumio Imazeki Osamu Yokosuka Department of Medicine and Clinical Oncology Graduate School of MedicineChiba UniversityChiba 2608670Japan

AIM:To investigate whether flexible spectral color enhancement(FICE) improves diagnostic yields of capsule endoscopy(CE) for obscure gastro-intestinal bleeding(OGIB).METHODS:The study subjects consisted of 81 *** FICE,there were three different sets with different *** randomly selected sets of FICE,images of CE were evaluated again by two individuals who were not shown the conventional CE reports and *** difference between FICE and conventional imaging was ***:The overall diagnostic yields in FICE sets 1,2,3 and conventional imaging(48.1%) were 51.9%,40.7%,51.9% and 48.1%,respectively,which showed no statistical difference compared to conventional *** total numbers of detected lesions per examination in FICE imaging and conventional imaging were 2.5 ± 2.1 and 1.8 ± 1.7,respectively,which showed a significant difference(P = 0.01).CONCLUSION:The diagnostic yield for OGIB is not improved by ***,FICE can detect significantly more small bowel lesions compared to conventional imaging.

关键词： Computed virtual chromoendoscopy Flexible spectral color enhancement Capsule endoscopy Obscure gastro-intestinal bleeding Diagnostic yield

A comparative study on demineralization of coals by acid-washing and solvent-extraction methods for low temperature catalytic coal gasification application

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Carbon Resources Conversion 2019年第3期2卷 175-181页

作者： Atul Sharma Akimitsu matsumura Research Institute of Energy Frontier Non-conventional Carbon Resources GroupNational Institute of Advanced Industrial Science&Technology16-1OnogawaTsukubaJapan

Catalytic coal gasification is an efficient way to achieve high conversion rates at low *** loss due to the reaction between the inherent mineral matter in the coal and the catalyst is a major hurdle for its practical *** problem may be overcome by removing the mineral matter from the coal before *** demineralizing approaches,acid-washing and solvent-extraction methods are investigated for demineralizing the *** analysis,XRD analysis,NMR analysis,and N_(2)adsorption analysis were made to compare the demineralization efficiency,crystallographic carbon microstructure,chemical structure,and micro-porosity,***-extraction method was found be more efficient for *** was observed in the chemical structure and micro-porosity while crystallographic carbon-microstructure was found to be ***-catalytic and catalytic gasification reactivity of the chars obtained by the two methods was *** composition and gas evolution profiles were also obtained and found to be influenced by the degree of demineralization.

关键词： Coal Demineralization Acid washing Solvent extraction Catalytic gasification

A general extension theorem for cohomology classes on non reduced analytic subspaces

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Science China Mathematics 2017年第6期60卷 949-962页

作者： CAO JunYan DEMAILLY Jean-Pierre matsumura Shin-ichi Institut de Mathématiques de Jussieu UniversitéPierre et Marie CurieParis 75252France Institut Fourier UniversitéGrenoble AlpesGlares 38610France Mathematical Institute Tohoku UniversitySendal 980-8578Japan

The main purpose of this paper is to generalize the celebrated L^2 extension theorem of Ohsawa and Takegoshi in several directions: The holomorphic sections to extend are taken in a possibly singular hermitian line bundle, the subvariety from which the extension is performed may be non reduced, the ambient manifold is K¨ahler and holomorphically convex, but not necessarily compact.

关键词： compact Kahler manifold singular hermitian metric coherent sheaf cohomology Dolbeault coho- mology plurisubharmonic function L2 estimates Ohsawa-Takegoshi extension theorem multiplier ideal sheaf

Development of a GIS-based Decision Support System for Assessing Land Use Status

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Geo-Spatial Information Science 2004年第1期7卷 72-78页

作者： Ryosuke Shibasaki Kanichiro matsumura Center for Spatial Information Science The University of Tokyo 4-6-1 Tokyo Japan

The objectives of this study are to assess land s ui tability and to predict the spatial and temporal changes in land use types (LUTs ) by using GIS-based land use management decision support system. A GIS databas e with data on climate, topography, soil characteristic, irrigation condition, f ertilizer application, and special socioeconomic activities has been developed a nd used for the evaluation of land productivity for different crops by integrati ng with a crop growth model-the erosion productivity impact calculator (EPIC). International food policy simulation model (IFPSIM) is also embedded into GIS fo r the predictions of how crop demands and crop market prices will change under a lternative policy scenarios. An inference engine (IE) including land use choice model is developed to illustrate land use choice behavior based on logit models , which allows to analyze how diversified factors ranging from climate changes, crop price changes to land management changes can affect the distribution of agr icultural land use. A test for integrated simulation is taken in each 0.1° by 0.1° grid cell to predict the change of agricultural land use types at globa l level. Global land use changes are simulated from 1992 to 2050.

关键词： EPIC land use decision support system international trade model logitmodel

Interaction Dynamics in AEC Global Teamwork

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Tsinghua Science and Technology 2008年第S1期13卷 145-150页

作者： Renate Fruchter Shubashri Swaminathan Naohiro matsumura Yukio Ohsawa Department of Civil and Environmental Engineering Stanford University Graduate School of Economics Osaka University Faculty of Engineering The University of Tokyo

Architecture, engineering, and construction (AEC) global project teamwork is communication intensive and relies heavily on synchronous and asynchronous information and collaboration technologies (ICT). We explore in this paper how an asynchronous ICT, called ThinkTank, reshaped the work practice of design-construction global teams, and how the interaction with this ICT reshaped the purpose and benefits of its use. ThinkTank is a web-based asynchronous collaboration and discussion forum. We introduce the influence diffusion model (IDM) that formalizes the process of identifying the influence of people, messages, and terms mathematically. Discovering who the influence leaders in project teams are can be beneficial and critical from a corporate management perspective, since they can guide or motivate the team towards successful actions and outcomes. We present the ThinkTank-IDM integrated system and its validation with a testbed of 53 AEC global team project archived in ThinkTank over 8 years.

关键词： global teamwork asynchronous collaboration technology interaction dynamics influence leader influence topic

Load Sharing Behavior of Star Gearing Reducer for Geared Turbofan Engine

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Chinese Journal of Mechanical Engineering 2017年第4期30卷 796-803页

作者： Shuai MO Yidu ZHANG Qiong WU Feiming WANG Shigeki matsumura Haruo HOUJOH State Key Laboratory of Virtual Reality Technology and Systems Beihang University Beijing 100191 China School of Mechanical Engineering & Automation Beihang University Beijing 100191 China AVIC Shenyang Engine Design & Research Institute Shenyang 100015 China Precision and Intelligence Laboratory Tokyo Institute of Technology Yokohama 226-8503 Japan

Load sharing behavior is very important for power-split gearing system, star gearing reducer as a new type and special transmission system can be used in many industry fields. However, there is few literature regarding the key multiple-split load sharing issue in main gearbox used in new type geared turbofan engine. Further mechanism anal- ysis are made on load sharing behavior among star gears of star gearing reducer for geared turbofan engine. Compre- hensive meshing error analysis are conducted on eccentricity error, gear thickness error, base pitch error, assembly error, and bearing error of star gearing reducer respectively. Floating meshing error resulting from meshing clearance variation caused by the simultaneous floating of sun gear and annular gear are taken into account. A refined mathematical model for load sharing coefficient calculation is established in consideration of different meshing stiffness and support- ing stiffness for components. The regular curves of load sharing coefficient under the influence of interactions, single action and single variation of various component errors are obtained. The accurate sensitivity of load sharing coefficienttoward different errors is mastered. The load sharing coef- ficient of star gearing reducer is 1.033 and the maximum meshing force in gear tooth is about 3010 N. This paper provides scientific theory evidences for optimal parameter design and proper tolerance distribution in advanced devel- opment and manufacturing process, so as to achieve optimal effects in economy and technology.

关键词： Geared turbofan engine GTF engineAero-turbofan engine Star gearing reducer Load sharing behavior

Diabetic neuropathy research: from mouse models to targets for treatment

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Neural Regeneration Research 2019年第11期14卷 1870-1879页

作者： Vuong M. Pham Shinji matsumura Tayo Katano Nobuo Funatsu Seiji Ito Department of Medical Chemistry Kansai Medical UniversityHirakataOsakaJapan Singapore Institute for Neurotechnology (SINAPSE) National University of SingaporeSingapore Department of Anesthesiology Osaka Medical CollegeTakatsukiOsakaJapan

Diabetic neuropathy is one of the most serious complications of diabetes, and its increase shows no sign of stopping. Furthermore, current clinical treatments do not yet approach the best effectiveness. Thus, the development of better strategies for treating diabetic neuropathy is an urgent matter. In this review, we first discuss the advantages and disadvantages of some major mouse models of diabetic neuropathy and then address the targets for mechanism-based treatment that have been studied. We also introduce our studies on each part. Using stem cells as a source of neurotrophic factors to target extrinsic factors of diabetic neuropathy, we found that they present a promising treatment.

关键词： brain derived neurotrophic factor diabetes extrinsic factors nerve growth factor nerve regeneration neurotrophic factors non-obese type 2 diabetes phosphatase and tensin homolog stem cell streptozotocin

Treatment of gastric remnant cancer post distal gastrectomy by endoscopic submucosal dissection using an insulation-tipped diathermic knife

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World Journal of Gastroenterology 2008年第16期14卷 2550-2555页

作者： Shoji Hirasaki Hiromitsu Kanzaki Minoru Matsubara Kohei Fujitav Shuji matsumura Seiyuu Suzuki Second Department of Internal Medicine Sumitomo Besshi Hospital

AIM: To evaluate the effectiveness of endoscopic submucosal dissection using an insulation-tipped diathermic knife (IT-ESD) for the treatment of patients with gastric remnant cancer. METHODS: Thirty-two patients with early gastric cancer in the remnant stomach, who underwent distal gastrectomy due to gastric carcinoma, were treated with endoscopic mucosal resection (EMR) or ESD at Sumitomo Besshi Hospital and Shikoku Cancer Center in the 10-year period from January 1998 to December 2007, including 17 patients treated with IT-ESD. Retrospectively, patient backgrounds, the one-piece resection rate, complete resection (CR) rate, operation time, bleeding rate, and perforation rate were compared between patients treated with conventional EMR and those treated with IT-ESD. RESULTS: The CR rate (40% in the EMR group vs 82% in the IT-ESD group) was significantly higher in the IT-ESD group than in the EMR group; however, the operation time was significantly longer for the IT- ESD group (57.6 ± 31.9 min vs 21.1 ± 12.2 min). No significant differences were found in the rate of underlying cardiopulmonary disease (IT-ESD group, 12% vs EMR group, 13%), one-piece resection rate (100% vs 73%), bleeding rate (18% vs 6.7%), and perforation rate (0% vs 0%) between the two groups. CONCLUSION: IT-ESD appears to be an effective treatment for gastric remnant cancer post distal gastrectomy because of its high CR rate. It is useful for histological confirmation of successful treatment. Thelong-term outcome needs to be evaluated in the future.

关键词： Remnant stomach Distal gastrectomy Gastric cancer Endoscopic mucosal resection Insulationtipped diathermic knife