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The Effect of Umami Stimulation on Salivary Secretion Rate and Duration

Health 2024年第1期16卷 52-59页

作者： Eri Sambuichi Rumi Nishimura Shiho morishita Shigeru Watanabe Department of Oral Health Sciences School of Health Sciences Meikai University Urayasu Japan Department of Oral Epidemiology Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan

Purpose: Umami reportedly promotes salivation. We aimed to investigate the effects of taste stimuli on slow and fast salivary secretion in humans using umami, sweet, and sour stimuli. Methods: Eight healthy women participated between 14:00 and 15:00, taking the circadian rhythm of salivary secretion into account. The types and concentrations of the taste solutions were glutamic acid (1.7 × 10−3 M), inosinic acid (9.8 × 10−3 M), and guanylic acid (9.8 × 10−3 M) for umami stimulation, citric acid (6.5 × 10−3 M) for acidity stimulation, and sucrose (1.6 × 10−2 M) for sweetness stimulation. First, the unstimulated salivary flow rate was measured. Then, 3 ml of a flavor solution was dropped under the tongue using a syringe. The saliva was expelled into an aluminum cup every minute and weighed. The first minute’s value minus 3 ml flavor solution was the stimulated salivary secretion rate produced by each flavor. The time-to-return to the initial unstimulated salivary flow rate was the duration of the stimulated saliva secretion rate. Results: The mean unstimulated salivary flow rate across participants was 0.64 ± 0.25 ml/min (range: 0.23 - 1.03 ml/min). The highest amount of saliva was induced by citric acid. There were significant differences between citric acid and the other flavor solutions (p < 0.05 for glutamic acid, inosinic acid, and sucrose;p < 0.01 for guanylic acid). There were no significant differences in duration of salivation between the flavor solutions. When the participants were divided into slow (0.45 ± 0.16 ml/min) and fast groups (0.83 ± 0.15 ml/min) based on their median resting salivary secretion rate, there were no significant differences between the two groups in the amount of saliva secreted at 1 minute after stimulation and the duration of the salivary secretion rate. Conclusion: Umami stimulation was effective in slowing salivary secretion and sustaining salivary secretion after stimulation.

关键词： Salivary Secretion Umami Flavor Oral Health Stimulated Salivary Secretion

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Seismic response reduction of a three-story building by an MR grease damper

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Frontiers of Mechanical Engineering 2017年第2期12卷 224-233页

作者： Tomoki SAKURAI Shin morishita Graduate School of Environment and Information Sciences YokohamaNational University Yokohama 240-8501 Japan Environment and Information Sciences Yokohama National UniversityYokohama 240-8501 Japan

This paper describes an application of mag- neto-rheological （MR） grease dampers as seismic dampers for a three-story steel structure. MR fluid is widely known as a smart material with rheological properties that can be varied by magnetic field strength. This material has been applied to various types of devices, such as dampers, clutches, and engine mounts. However, the ferromagnetic particles dispersed in MR fluid settle out of the suspension after a certain interval because of the density difference between the particles and their carrier fluid. To overcome this defect, we developed a new type of controllable working fluid using grease as the carrier of magnetic particles. MR grease was introduced into a cylindrical damper, and the seismic performance of the damper was subsequently studied via numerical analysis. The analysis results of the MR grease damper were compared with those of other seismic dampers. We confirmed that the MR grease damper is an effective seismic damper.

关键词： MR grease damper seismic damper vibration control structural response FEM analysis

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Potential role of biofeedback therapy for Parkinson’s disease

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Neural Regeneration Research 2021年第10期16卷 2021-2022页

作者： Naoya Kotani Takashi morishita Tooru Inoue Department of Neurosurgery Fukuoka University Faculty of MedicineFukuokaJapan Department of Rehabilitation Medicine Fukuoka University HospitalFukuokaJapan

Parkinson’s disease(PD)is a neurological disorder characterized by rigidity,tremor,bradykinesia,and postural *** disturbance is one of cardinal symptoms of PD and affects the activities of daily living and quality of *** symptom in advanced PD patients is usually refractory to medication and surgical intervention such as deep brain stimulation(morishita et al.,2016).

关键词： stimulation instability. al.

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Need for multiple biomarkers to adjust parameters of closed-loop deep brain stimulation for Parkinson's disease

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Neural Regeneration Research 2017年第5期12卷 747-748页

作者： Takashi morishita Tooru Inoue Department of Neurosurgery Fukuoka University Faculty of Medicine Fukuoka Japan

Closed-loop deep brain stimulation（DBS）：DBS has been established as a surgical therapy for movement disorders and select neuropsychiatric *** efforts to improve the clinical outcomes of the procedure have been prev... 详细信息

关键词： DBS Need for multiple biomarkers to adjust parameters of closed-loop deep brain stimulation for Parkinson’s disease deep

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Pharmacokinetics of paclitaxel in a hemodialysis patient with advanced gastric cancer: A case report

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World Journal of Gastroenterology 2006年第32期12卷 5237-5239页

作者： Susumu Kawate Izumi Takeyoshi Yasuo morishita Department of Thoracic and Visceral Organ Surgery Gunma University Graduate School of Medicine MaebashiGunma 371-8511Japan

We report for the first time the possibility of weekly paclitaxel chemotherapy for a patient with advanced, nonresectable gastric cancer undergoing hemodialysis. A 50-year-old man with chronic renal failure due to bilateral polycystic kidneys, who had undergone hemodialysis three times a week for 5 years, presented with hematemesis in December 2004. Based on the diagnosis of gastric cancer with lymph node metastases, surgery was performed. On the 15th postoperative day, the patient was treated with chemotherapy using paclitaxel. Paclitaxel was administered at a dose of 60 mg/m^2 as a 1 h iv infusion in 250 mL of saline. Hemodialysis was started 1 h after the completion of the paclitaxel infusion and was performed for 3 h. Paclitaxel was administered weekly on d 1, 8, and 15 on a 28-d cycle. The maximum plasma concentration of paclitaxel was 1390 μg/L. The area under the curve of paclitaxel was 4398.6 μg·h/L. Grade 2 leukopenia was encountered during the first cycle. The plasma concentrations of paclitaxel from 6 to over 24 h after the infusion were 0.01 to 0.1 μmol/L in our patient, and these concentrations have been shown to be effective on inhibiting the growth of gastric cancer cells without producing adverse side effects in the patient. The plasma concentration of paclitaxel was not influenced by hemodialysis. We conclude that the pharmacokinetics of paclitaxel is not altered in a patient with renal failure, and that weekly paclitaxel is a suitable treatment regimen for hemodialysis patients with advanced gastric cancer.

关键词： Paclitaxel Gastric cancer Hemodialysis

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Targeting receptor tyrosine kinases in gastric cancer

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World Journal of Gastroenterology 2014年第16期20卷 4536-4545页

作者： Asahiro morishita Jian Gong Tsutomu Masaki Department of Gastroenterology and Neurology Kagawa University School of MedicineKagawa 761-0793Japan

Molecularly targeted therapeutic agents are constantly being developed and have been shown to be effective in various clinical trials. One group of representative targeted oncogenic kinases, the receptor tyrosine kinases (RTKs), has been associated with gastric cancer development. Trastuzumab, an inhibitor of ERBB2, has been approved for the treatment of gastric cancer, although other receptor tyrosine kinases, such as epidermal growth factor receptor, vascular endothelial growth factor, platelet-derived growth factor receptor, c-Met, IGF-1R and fibroblast growth factor receptor 2, are also activated in gastric cancer. The promising results of the trastuzumab clinical trial for gastric cancer resulted in the approval of trastuzumab-based therapy as a first-line treatment for human epidermal growth factor receptor 2-positive patients. On the other hand, the trial examining bevacizumab in combination with conventional chemotherapy did not meet its primary goal of increasing the overall survival time of gastric cancer patients; however, a significantly higher response rate and a longer progression-free survival were observed in the bevacizumab arm of the trial. Other clinical trials, especially phase III trials that have tested drugs targeting RTKs, such as cetuximab, panitumumab, gefitinib, erlotinib, figitumumab, sorafenib, sunitinib and lapatinib, have shown that these drugs have modest effects against gastric cancer. This review summarizes the recent results from the clinical trials of molecularly targeted drugs and suggests that further improvements in the treatment of advanced gastric cancer can be achieved through the combination of conventional drugs with the new molecularly targeted therapies.

关键词： Receptor tyrosine kinases Gastric cancer Epidermal growth factor receptor Trastuzumab Cetuximab Lapatinib Panitumumab Erlotinib Bevacizumab

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Effect of collagen-induced residual stress on the frictional property of articular cartilage

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Biosurface and Biotribology 2018年第2期4卷 68-71页

作者： Hiromichi Fujie Sou morishita Seido Yarimitsu Graduate School of System Design Tokyo Metropolitan UniversityHachiojiTokyoJapan

Previous findings,such as split-line of the articular cartilage surface and curving of sliced cartilage specimen,would suggest that residual stress is contained in articular *** study was performed to determine the effect of collagen fibre-induced residual stress on the biphasic lubrication property of articular cartilage.A fibre-reinforced poroelastic model of articular cartilage was developed in *** the model,residual stress was contained in the collagen fibre in the surface layer by applying 1-5%of tensile *** friction analysis was performed between the model and a sphere at a friction speed of 1.0-10.0 mm/*** revealed that the coefficients of start-up and dynamic friction at second friction cycle were lower in residual stress model than in no-residual stress model,with the largest decreases observed at a friction speed of 1 mm/*** was obse rved that re hydration was promoted in the bearing area in residual stress *** results suggest that collagen-induced residual stress plays an important role in enhancing the biphasic lubrication property of articular cartilage.

关键词： friction stress residual

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A ROBUST FLOW CALCULATION TECHNIQUE WITH MULTIPLE FINITE CONTROL VOLUMES

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Chinese Journal of Aeronautics 1991年第2期6卷 121-125页

作者： E.morishita Department of Aeronautics Faculty of Engineering Universtty of Tokyo 7-3-1 Bunkyo-ku Tokyo 113 JAPAN

The control volume method gives the forces which act on the system, but not necessarily the wall pressure of the system. The author has made an attempt to develop a control volume method which makes it possible to obtain the wall pressure of the control volume. The 2-D inviscid incompressible steady duct flow is considered. The conservation equations in integral form are discretized for a control volume. The circulation along the control surface is expressed as a nonlinear function of the vertical velocity component at the inlet and is set equal to zero for the inviscid flow. The equation is solved by the Newton method, and the other aerodynamic properties can be obtained. The calculated results have been compared to the experiment and the agreement has been found fairly satisfactory.

关键词： A ROBUST FLOW CALCULATION TECHNIQUE WITH MULTIPLE FINITE CONTROL VOLUMES

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Vibration control of a structure using Magneto-Rheological grease damper

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Frontiers of Mechanical Engineering 2013年第3期8卷 261-267页

作者： Shinya SUGIYAMA Tomoki SAKURAI Shin morishita Graduate School of Environment and Information Sciences Yokohama National University

This paper describes an application study of Magneto-Rheological(MR)grease damper to a structure with three *** fuid is known as one of successful smart materials whose rheological properties can be varied by magnetic feld strength,and has been applied to various kinds of device such as dampers,clutches,engine mounts,***,ferromagnetic particles dispersed in MR fuid settle out of the suspension after a certain interval due to the density difference between the particles and their career *** overcome this defect,we have developed a new type of controllable working fuid using grease as the career of magnetic *** of thickener in grease is expected to hold the magnetic particles and prevent them from settled *** or little sedimentation was observed in MR grease whose characteristics could be controlled by the magnetic feld *** grease was introduced into a cylindrical damper and its performance was *** a result,it was confrmed that the damping force of MR grease damper could be controlled by the applied electric current to the coil in the cylinder of ***,vibration response of a three-story model structure equipped with MR grease damper was investigated experimentally,and it was shown that MR grease damper worked effectively as a semi-active damper.

关键词： vibration control damper smart material Magneto-Rheological (MR) grease MR fluid

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Xanthogranulomatous cholangitis causing obstructive jaundice:A case report

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World Journal of Gastroenterology 2006年第27期12卷 4428-4430页

作者： Susumu Kawate Susumu Ohwada Hayato Ikota Kunihiro Hamada Kenji Kashiwabara Yasuo morishita Department of Surgery Gunma University Graduate School of MedicineGunma 371-8511Japan Clinical Department of Pathology Gunma University HospitalMaebashiGunma 371-8511Japan

This article reports the case of a 34-year-old woman with xanthogranulomatous cholangitis who developed obstructive jaundice. Microscopically, the bile duct was surrounded and narrowed by a xanthogranulomatous lesion, but no xanthogranulomatous cholecystitis was seen. Although percutaneous cholangiograms done via the transhepatic biliary drainage showed smooth narrowing of the upper to middle bile duct, the cytology of bile was diagnosed as class V adenocarcinoma. Therefore, right extended hepatectomy and extrahepatic bile duct resection were performed. The differentiation of benign and malignant strictures at the hepatic hilum is often difficult. Xanthogranulomatous cholangitis is one possible diagnosis of a bile duct stricture. Precise review of all the preoperative information is required to make a correct diagnosis.

关键词： Xanthogranulomatous cholangitis Obstructive jaundice Bile cytology Bile duct stricture

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