检索结果-南通市图书馆

A prospective cancer chemo-immunotherapy approach mediated by synergistic CD326 targeted porous silicon nanovectors

Nano Research 2015年第5期8卷 1505-1521页

作者： Mohammad-Ali Shahbazi Neha Shrestha Ermei Makila Francisca Araujo Alexandra Correia tomas ramos Bruno Sarmento Jarno Salonen Jouni Hirvonen Helder A. Santos Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University ofHelsinki FI-00014 Helsinki Finland Laboratory of Industrial Physics Departmen t of Physics and Astronomy University of Turku FI-20014 Turku Finland INEB - Instituto de Engenharia Biomedica NewTherapies Group Universidade do Porto Rua do Campo Alegre 823 4150-180 Porto Portuga ICBAS - Instituto Ciencias Biomedicas Abel Salazar University of Porto Rua de Jorge Viterbo Ferreira 4050-313 Porto Portugal Faculty of Pharmacy University of Coimbra 3000-548 Coimbra Portugal IINFACTS - Instituto de Investigacao e Formacao Avancada em Ciencias e Tecnologias da Saude Instituto Superior de Ciencias da Saude-Norte Department of Pharmaceutical Sciences CESPU Rua Central de Gandra 4585-116 Gandra Portugal

Combination therapy via nanoparticulate systems has already been proposed as a synergistic approach for cancer treatment. Herein, undecylenic acid modified thermally hydrocarbonized porous silicon nanoparticles （UnTHCPSi NPs） loaded with sorafenib and surface-biofunctionalized with anti-CD326 antibody （Ab） were developed for cancer chemo-immunotherapy in MCF-7 and MDA-MB-231 breast cancer cells. The cytocompatibility study showed no significant toxicity for the bare and antibody-conjugated UnTHCPSi （Un-Ab） NPs at concentrations lower than 200 μg·mL^-1. Compared to the bare UnTHCPSi, Un-Ab NPs loaded with sorafenib reduced the premature drug release in plasma, increasing the probability of proper drug targeting. In addition, high cellular interaction and subsequent internalization of the Un-Ab NPs into the cells expressing CD326 antigen demonstrated the possibility of improving antigen-mediated endocytosis via CD326 targeting. While an in vitro antitumor study revealed a higher inhibitory effect of the sorafenib-loaded Un-Ab NPs compared to the drug-loaded UnTHCPSi NPs in the CD326 positive MCF-7 cells, there was no difference in the anti-proliferation impact of both the abovementioned NPs in the CD326 negative MDA-MB-231 cells, suggesting CD326 as an appropriate receptor for Ab-mediated drug delivery. It was also shown that the anti-CD326 Ab can act as an immunotherapeutic agent by inducing antibody dependent cellular cytotoxicity and enhancing the interaction of effector immune and cancer cells for subsequent phagocytosis and cytokine secretion. Hence, the developed nanovectors can be applied for simultaneous tumor-selective drug targeting and immunotherapy.

关键词： CD326 antibody porous silicon nanopartides chemo-immunotherapy breast cancer drug targeting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

指标在流域管理规划和战略环境评价过程中的应用(下)

引用

环境影响评价 2019年第5期41卷 I0005-I0013页

作者： Rosa Santos Coelho Pedro S.Coelho tomas B.ramos Paula Antunes 吴成志(译) 张怡悦(译) 卿野(译) Faculdade de Ciencias e Tecnologia Departamento de Ciencias e Engenharia do AmbienteCenter for Environmental and Sustainability Research (CENSE)Universidade NOVA de LisboaCampus da CaparicaCaparicaPortugal Instituto Politecnico de Santarem Escola Superior AgrariaSantaremPortugal Faculdade de Ciencias e Tecnologia Departamento de Ciencias e Engenharia do AmbienteMarine and Environmental Sciences Centre (MARE)Universidade NOVA de LisboaCampus da CaparicaCaparicaPortugal 三捷环境工程咨询(杭州)有限公司

流域管理规划(RBMP)和战略环境影响评价(SEA)过程通常需要使用指标来评估规划方案的可持续性、与利益相关者进行沟通并对决策提供支持。这项研究的目的是为了支持主要过程和调查指标的使用效果,并分析整合后的情况。葡萄牙RBMP的内容分... 详细信息

流域管理规划(RBMP)和战略环境影响评价(SEA)过程通常需要使用指标来评估规划方案的可持续性、与利益相关者进行沟通并对决策提供支持。这项研究的目的是为了支持主要过程和调查指标的使用效果,并分析整合后的情况。葡萄牙RBMP的内容分析及相应的SEA报告采用了概念框架来支持其内容的定性分析。主要的发现是指标通常被用于SEA和规划报告中。被分析的文件中使用了大量的指标,其中大多数指标是定量的,并在组织、选择和验证时使用了差别很大的方法。通常这些过程都不需要公众参与。此研究给出了需要改进的方面,例如还需研究是否有需要增加利益相关者在指标发展过程中的参与度、标准化和交叉性指标使用时的相关性以及两个过程中都使用的关键性指标的确定。

关键词：河流流域管理规划环境影响评价指标概念框架内容分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

引用

Neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier ramos Laboratorio de Neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRNAs or lncRNA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

引用

Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita O.Teodoro Mafalda Ribeiro ramos Lara Carvalho iNOVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

指标在流域管理规划和战略环境评价过程中的应用(上)

引用

环境影响评价 2019年第4期41卷 I0005-I0010页

作者：吴成志(译) 张怡悦(译) 卿野(译) Rosa Santos Coelho Pedro S. Coelho tomas B. ramos Paula Antunes 三捷环境工程咨询(杭州)有限公司 Faculdade de Ciencias e Tecnologia Departamento de Ciencias e E)ngenliaria do Ambiente Center for Environmental and Sustainability Research (CENSE) Universidade NOVA de Lisboa Campus da Caparica Caparica Portugal Instituto Politecnico de Santarem Escola Superior Agraria Santarem Portugal Faculdade de Ciencias e Tecnologia Departamento de Ciencias e Eugenharia do Ambiente Marine and Environmental Sciences Centre (MARE) Universidade NOVA de Lisboa Campus da Caparica Caparica Portugal

流域管理规划(RBMP)和战略环境影响评价(SEA)过程通常需要使用指标来评估规划方案的可持续性,与利益相关者进行沟通并对决策提供支持。这项研究的目的是支持主要过程和调查指标的使用效果,并分析整合后的情况。葡萄牙RBMP的内容分析及... 详细信息

流域管理规划(RBMP)和战略环境影响评价(SEA)过程通常需要使用指标来评估规划方案的可持续性,与利益相关者进行沟通并对决策提供支持。这项研究的目的是支持主要过程和调查指标的使用效果,并分析整合后的情况。葡萄牙RBMP的内容分析及相应的SEA报告采用了概念框架来支持其内容的定性分析。主要的发现是指标通常被用于SEA和规划报告中。被分析的文件中使用了大量的指标,其中大多数指标是定量的,并在组织、选择和验证时使用了差别很大的方法。通常这些过程都不需要公众参与。此研究给出了需要改进的方面,例如还需研究是否有需要增加利益相关者在指标发展过程中的参与度、标准化和交叉性指标使用时的相关性以及两个过程中都使用的关键性指标的确定。

关键词：水影河流流域管理规划略环境影响评价指标概念框架内容分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Brachioradialis tendon transfer and palmaris longus tendon graft for thumb avulsion:A case report and review of literature

引用

World Journal of Clinical Cases 2025年第4期13卷 48-55页

作者： Pierre Curings Sonia ramos-Pascual Kinga Michalewska Nicolas Gibert Lionel Erhard Mo Saffarini AlexisNogier Department of Hand Surgery Clinique TrenelSainte-Colombe 69560France Medical Research ReSurg SANyon 1260VaudSwitzerland Department of Hand Surgery Hand and Upper Limb Surgical InstituteVilleurbanne 69100France Department of Orthopaedics Clinique TrenelSainte-Colombe 69560France

BACKGROUND Thumb replantation following complete traumatic avulsion requires complex techniques to restore function,especially in cases of avulsion at the level of the metacarpophalangeal joint(MCP I)and avulsion of the flexor pollicis longus(FPL)at the musculotendinous *** treatments include direct tendon suture or tendon transfer,most commonly from the ring *** optimize function and avoid donor finger complications,we performed thumb replantation with flexion restoration using brachioradialis(BR)tendon transfer with palmaris longus(PL)tendon *** SUMMARY A 20-year-old left-handed male was admitted for a complete traumatic left thumb amputation following an accident while sliding from the top of a *** patient presented with skin and bone avulsion at the MCP I,avulsion of the FPL tendon at the musculotendinous junction(zone 5),avulsion of the extensor pollicis longus tendon(zone T3),and avulsion of the thumb’s collateral arteries and *** patient was treated with two stage thumb *** first intervention consisted of thumb replantation with MCP I arthrodesis,resection of avulsed FPL tendon and implantation of a silicone tendon *** second intervention consisted of PL tendon graft and BR tendon ***-up at 10 months showed good outcomes with active interphalangeal flexion of 70°,grip strength of 45 kg,key pinch strength of 15 kg and two-point discrimination threshold of 4 *** Flexion restoration after complete thumb amputation with FPL avulsion at the musculotendinous junction can be achieved using BR tendon transfer with PL tendon graft.

关键词： Brachioradialis tendon transfer Flexor pollicis longus Palmaris longus tendon graft Replantation Thumb amputation Thumb avulsion Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel heterozygous SF1/NR5A1 gene variant causes 46,XY DSD-gonadal dysgenesis with hypergonadotropic hypogonadism without adrenal insufficiency

引用

Genes & Diseases 2024年第4期11卷 128-130页

作者： Luis ramos Department of Reproductive Biology Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubirdnTlalpanMexico City 14080Mexico

Steroidogenic factor 1(SF1/NR5A1;nuclear receptor subfamily 5 group A member 1)is an essential orphan protein involved in gonadal embryogenesis,sex determination,and reproductive endocrinology.

关键词： insufficiency determination gonadal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Principles of surgical resection in hilar cholangiocarcinoma

引用

World Journal of Gastrointestinal Oncology 2013年第7期5卷 139-146页

作者： Emilio ramos Department of General Surgery Hospital Universitario de BellvitgeUniversidad de Barcelona08907 BarcelonaSpain

The aim of this article is to describe the surgical techniques for the treatment of hilar cholangiocarcinoma(HC).Resection with microscopically negative margin(R0) is the only way to cure patients with ***,resection of the caudate lobe and part of segment Ⅳ,combined with a right or left hepatectomy,bile duct resection,lymphadenectomy of the hepatic hilum and sometimes vascular resection,is the standard surgical procedure for *** frozen-section examination of proximal and distal biliary margins is necessary to confirm the suitability of *** lymphadenectomy probably has little direct effect on survival,inaccurate staging information may influence post resection treatment *** venous and arterial resections should be undertaken in selected cases to achieve a R0 *** concept of 'no-touch proposed' in 1999 by Neuhaus et al combine an extended right hepatectomy with systematic portal vein resection and caudate lobectomy avoiding hilar dissection and possible intraoperative microscopic dissemination of cancer *** recently minor liver resections have been proposed for treatment of *** the hilar bifurcation of the bile ducts is near to liver segments Ⅳ,Ⅴ and Ⅰ,adequate liver resection of these segments together with the bile ducts can result in cure.

关键词： Cholangiocarcinoma Surgery Technique

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Parabolic Trough Collector and Central Receiver Coupled with Fresnel Lens:Experimental Tests

引用

International Journal of Automation and computing 2020年第4期17卷 572-587页

作者： Angelica Palacios Dario Amaya Olga ramos Universidad Militar Nueva Granada Bogota 110121Colombia

Renewable energies have a high impact on power energy production and reduction of environmental pollution worldwide,so high efforts have been made to improve renewable technologies and research about *** paper presents the thermal performance results obtained by simulation and experimental tests of a parabolic trough collector with central receiver coupled to Fresnel lens,under different configurations on the *** simulation method was computational fluid dynamics(CFD)analysis in SolidWorks(R)soft-ware tool,which works with Naiver-Stokes equations to converge on a *** tests were formed with all configurations proposed and three observations for each one,a total of 12 observations were performed in all *** a result,the best thermal performance in simulation was achieved with the Fresnel lens and black pipe collector,with a maximum temperature of 116℃under 1000 W/m^2 radiation,the same system achieved in experimental tests a maximum temperature of 96℃with a radiation of 983 W/m^2.

关键词： Solar collector parabolic trough collector Fresnel lens thermal conductivity solar power

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nanomechanical hydrodynamic force sensing using suspended microfluidic channels

引用

Microsystems & Nanoengineering 2023年第3期9卷 95-102页

作者： Alberto Martín-Pérez Daniel ramos Optomechanics Lab Instituto de Ciencia de Materiales de Madrid(ICMMCSIC)3 Sor Juana Inés de la Cruz(Madrid)E-28049 MadridSpain

Microfluidics has demonstrated high versatility in the analysis of in-flow particles and can even achieve mechanical properties measurements of biological cells by applying hydrodynamic ***,there is currently no available technique that enables the direct measurement and tracking of these hydrodynamic forces acting on a flowing *** this work,we introduce a novel method for the direct measurement of the hydrodynamic force actuating on an in-flow particle based on the analysis of the induced resonance changes of suspended microchannel resonators(SMRs).This hydrodynamic force sensitivity depends on the device used;therefore,we considered the geometry and materials to advance this dependency on the SMR resonance frequency.

关键词： hydrodynamic applying flow

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：