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ABCDE—agile block chain DApp engineering

Blockchain(Research and Applications) 2020年第1期1卷 18-35页

作者： Lodovica Marchesi Michele Marchesi Roberto tonelli DMI University of CagliariCagliari09124Italy

Blockchain software development is becoming more and more important for any modern software developer and IT ***,blockchain software production still lacks a disciplined,organized and mature development process,as demonstrated by the many and(in)famous failures and frauds occurred in recent *** this paper we present ABCDE,a complete method addressing blockchain software *** method considers the software integration among the blockchain components—smart contracts,libraries,data structures—and the out-of-chain components,such as web or mobile applications,which all together constitute a complete DApp *** advocate for ABCDE the use of agile practices,because these are suited to develop systems whose requirements are not completely understood since the beginning,or tend to change,as it is the case of most blockchain-based *** is based on Scrum,and is therefore iterative and *** Scrum,we kept the requirement gathering with user stories,the iterative-incremental approach,the key roles,and the *** main difference with Scrum is the separation of development activities in two flows—one for smart contracts and the other for out-of-chain software interacting with the blockchain—each performed iteratively,with integration activities every 2–3 *** makes explicit the activities that must be performed to design,develop,test and integrate smart contracts and out-of-chain software,and documents the smart contracts using formal diagrams to help development,security assessment,and maintenance.A diagram derived from UML class diagram helps to effectively model the data structure of smart contracts,whereas the exchange of messages between the entities of the system is modeled using a modified UML sequence *** proposed method has also specific activities for security assessment and gas optimization,through systematic use of patterns and *** focuses on Ethereum blockchain and its

关键词： Blockchain Smart contracts Blockchain-oriented software engineering UML DApp design

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Long-term Regional Dynamic Sea Level Changes from CMIP6 Projections

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Advances in Atmospheric Sciences 2021年第2期38卷 157-167页

作者： Bruno FERRERo Marcos tonelli Fernanda MARCELLo Ilana WAINER University of São Paulo São Paulo 05508120Brazil

Anthropogenic climate forcing will cause the global mean sea level to rise over the 21st ***,regional sea level is expected to vary across ocean basins,superimposed by the influence of natural internal climate ***,we address the detection of dynamic sea level(DSL)changes by combining the perspectives of a single and a multimodel ensemble approach(the 50-member CanESM5 and a 27-model ensemble,respectively,all retrieved from the CMIP6 archive),under three CMIP6 projected scenarios:SSP1-2.6,SSP3-7.0 and *** ensemble analysis takes into account four key metrics:signal(S),noise(N),S/N ratio,and time of emergence(ToE).The results from both sets of ensembles agree in the fact that regions with higher S/N(associated with smaller uncertainties)also reflect earlier *** DSL signal is projected to emerge in the Southern ocean,Southeast Pacific,Northwest Atlantic,and the *** common for both sets of ensemble simulations show that while S progressively increases with increased projected emissions,N,in turn,does not vary substantially among the SSPs,suggesting that uncertainty arising from internal climate variability has little dependence on changes in the magnitude of external *** changes are greater and quite similar for the scenarios SSP3-7.0 and SSP5-8.5 and considerably smaller for the SSP1-2.6,highlighting the importance of public policies towards lower emission scenarios and of keeping emissions below a certain threshold.

关键词： dynamic sea level CMIP6 sea level rise signal-to-noise time of emergence

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Ultrastructural analysis of sperm from the genus Idarnes(Hymenoptera:Chalcidoidea,Sycophaginae)

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BIoCELL 2022年第1期46卷 275-283页

作者： KHESLLER PATRÍCIA oLAZIA JULIANA SoUZA DA SILVA GUILHERME SIRIMARCo DE SoUZA tonelli SÔNIA NAIR BÁo Departamento de Biologia Celular Instituto de Ciências BiológicasUniversidade de BrasíliaBrasíliaBrazil Instituto de Ciências da Saúde Coordenação de Ciências BiológicasUniversidade Paulista UNIPBrasíliaBrazil

In this study,the sperm ultrastructure of three species of Idarnes genus was investigated using light and transmission electron *** morphology of the three species was similar to that of most Chalcidoidea,with helicoidally twisted nucleus and *** head region consists of an acrosome and a nucleus;the nucleus-flagellum transition region characterized by the presence of mitochondrial derivatives and the centriolar adjunct;a flagellum region,which includes the axoneme with microtubular arrangement 9+9+2 and two mitochondrial ***,the sperm of these three species exhibit features that discriminate one species from each other:(1)only one species,Idarnes sp.2(carme group)exhibited an extracellular sheath surrounding the anterior portion of the nucleus,which extends to the anterior region of the flagellum,but it did not present filaments;(2)the acrosome in the three species was quite different,Idarnes sp.1 and Idarnes sp.2(carme group)has two compartments(acrosomal and subacrosomal vesicles)while Idarnes sp.3(flavicollis group)has a third compartment(perforatorium);(3)the centriolar adjunct elongated and its location among the mitochondrial derivatives is similar for the three species analyzed;(4)mitochondrial derivatives differ between the species,with triangular(Idarnes sp.1 and sp.3)and elongated or flat shaped(Idarnes sp.2)*** data shows that sperm structure may differ within the same genus and confirms the potential of these cells in phylogenetic and taxonomic analyses in the Chalcidoidea superfamily,as well as in Hymenoptera in general.

关键词： Chalcidoidea Idarnes genus Insect sperm Sperm ultrastructure Fig wasps

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A blockchain architecture for industrial applications

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Blockchain(Research and Applications) 2022年第4期3卷 1-13页

作者： Lodovica Marchesi Michele Marchesi Roberto tonelli Maria Ilaria Lunesu Department of Mathematics and Computer Science University of CagliariCagliari09124Italy

Blockchain and the programs running on it,called smart contracts,are increasingly applied in all fields where trust and strong certifications are *** work focuses on industrial applications of blockchains and not on cryptocurrencies or *** use frameworks to compare public and permissioned blockchains specifically suited for industrial *** also propose a complete solution based on Ethereum to implement a decentralized application,putting together in an original way,components and patterns already used and *** solution is characterized by a set of validator nodes running the blockchain using Proof-of-Authority or similar efficient consensus algorithms,by the use of an explorer enabling users to check the blockchain state,and the source code of the smart contracts running on *** time to time,the hash digest of the last mined block is written into a public blockchain to guarantee *** right to send transactions is granted by validator nodes to users by endowing them with the Ethers mined ***,the proposed approach has the same transparency and immutability as a public blockchain,largely reducing its drawbacks.

关键词： Permissioned blockchain Industrial application Information system Software application Ethereum

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Spectral properties of Tm,Ho:LiYF_4 laser crystal

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Journal of Rare Earths 2011年第6期29卷 592-595页

作者：李春张莹张学建曾繁明 Mauro tonelli 刘景和 School of Materials Science and Engineering Changchun University of Science and Technology office of Foreign Affairs Jilin Architectural and Civil Engineering Institute NEST-CNR and Dipartimento di Fisica Universita` di Pisa Largo B. Pontecorvo 3 56127 Pisa Italy

The LiYF4 single crystal codoped with thulium and holmium ions was successfully grown by the Cz method. The optimal technical parameters obtained were as follows： the pulling rate was 0.16 mm/h; the rotation speed was 3 rpm; the cooling rate was 15 °C/h. The result of XRD curve showed that as-grown Tm,Ho：LiYF4 laser crystal belonged to the monoclinic system with scheelite-type structure and space group I41/a. The cell parameters calculated were： a=0.52160 nm, c=1.09841 nm and Z=4. Absorption and fluorescence spectra of Tm,Ho：LiYF4 laser crystal at room temperature were measured and analysed. The absorption cross section, FWHM and absorption coefficient at 779.3 nm calculated were 7.44×10–21 cm2, 8.7 nm and 2.23 cm–1, respectively. An intensive fluorescence emission peak appeared near 2045 nm. The emission cross section and fluorescence lifetime were 0.87×10–20 cm2 and 10.8 ms, respectively. The ratio of Tm–Ho transfer to its back-transfer process was 10.6.

关键词： Tm Ho:LiYF4 laser crystal Cz method absorption spectrum fluorescence spectrum rare earths

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Biliary tree gastrinomas in multiple endocrine neoplasia type 1 syndrome

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World Journal of Gastroenterology 2013年第45期19卷 8312-8320页

作者： Francesco tonelli Francesco Giudici Gabriella Nesi Giacomo Batignani Maria Luisa Brandi Department of Surgery and Translational Medicine University of Florence50014 Florence Italy

AIM:To describe our patients affected with ectopic biliary tree gastrinoma and review the literature on this ***:Between January 1992 and June 2012,28 patients affected by duodenopancreatic endocrine tumors in multiple endocrine neoplasia type 1(MEN1)syndrome underwent surgery at our *** retrospective review article analyzes our experience regarding seventeen of these patients subjected to duodenopancreatic surgery for Zollinger-Ellison syndrome(ZES).Surgical treatment consisted of duodenopancreatectomy(DP)or total pancreatectomy(TP).Regional lymphadenectomy was always *** hepatic tumoral lesions found were removed during *** MEN1 patients,removal of duodenal lesions can sometimes lead to persistence or recurrence of *** possible explanation for this unfavorable outcome could be unrecognized ectopic localization of gastrin-secreting *** study described three cases among the seventeen patients who were found to have an ectopic gastrinoma located in the biliary ***:Seventeen MEN1 patients affected with ZES were *** mean age was 40 *** patients underwent DP and two *** histopathological examination,duodeno pancreatic endocrine tumors were found in all 17 ***-one gastrinomas were detected in the first three portions of the *** one gastrinoma was found in the *** mean number of gastrinomas per patient was 5(range 1-16).Malignancy was established in 12 patients(70.5%)after lymph node,liver and omental metastases were *** patients exhibited biliary tree gastrinomas as well as duodenal gastrinoma(s).In two cases,the ectopic gastrinoma was removed at the same time as pancreatic surgery,while in the third case,the biliary tree gastrinoma was resected one year after DP because of recurrence of ***:These findings suggest the importance of checking for the presence of ectopic gastrinomas in the biliary tree in MEN1 patients undergoing Z

关键词： Gastrinoma Multiple endocrine neoplasia type 1 Zollinger-Ellison Syndrome Ectopic gastrinoma Biliary tree Duodenopancreatectomy

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Chronic kidney disease and the aging population

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肾脏病与透析肾移植杂志 2014年第1期23卷 1-5页

作者： Marcello tonelli Miguel Riella University of Alberta.Alberta Canada Catholic University of Parana CuritibaBrazil

"Youth,which is forgiven everything,forgives itself nothing:age,which forgives itself everything,is forgiven nothing."George Bernard ShawThe proportion of older people in the general population is steadily increasing worldwide,with the most rapid growth in low-and middle-income countries[1].This demographic change is to be celebrated,because it is the consequence of socioeconomic development and better life ***,population aging also

关键词：摘要编辑部编辑工作读者

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Growth and spectral properties of Nd3+-doped potassium ytterbium tungstate laser crystal

Growth and spectral properties of Nd3+-doped potassium ytter...

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第六届国际稀土开发与应用研讨会

作者： MAURo tonelli Department of physics The University of Pisa

The 5at.%Nd -doped potassium ytterbium tungstate(KNdYb(Wo)) laser crystal with the dimension up to 28mm×l5mm×12mm was grown by the Kyropoulos method for the first *** unpolarization absorption spectrum of the crystal sample with the dimension of 3×3×1mm cut perpendicularly to the b axis was *** absorption cross sections is 16.03×l0cm at 808nm with an FWHM of *** strongest absorption peak observed at 890—1000nm is due to the I-F transition in Nd overlapping with the F—F transition in *** is indicated that effective energy transfer between Nd and Yb ions can be *** on the Judd-ofelt theory,the intensity parametersΩ(λ=2,4,6) calculated were:Ω=9.39×l0cm,Ω=3.18×l0cm,Ω=3.35×*** fluorescence spectrum was measured in the 950-1150 nm range at room *** fluorescence life of F energy level is 196.33us,and the fluorescence branching ratio for the F—I transition at 1067nm is 55.74%.The energy transfer between Nd and Yb ions was observed from the fluorescence spectra pumped by 808nm and 980nm LD sources,and the Stark levels of Yb in Nd:KYbW crystal were determined.

关键词： Nd3+ -doped potassium ytterbium tungstate Kyropoulos method laser crystal growth spectral properties rare earths

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Temperature-Dependent Fluorescence Properties and Diode-Pumped Deep Red Laser Performance of Pr:LiGdF4 Crystal

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Chinese Physics Letters 2015年第5期32卷 86-90页

作者：张玉霞王树贤 Alberto Di Lieto 于果蕾于浩海张怀金 Mauro tonelli 徐现刚王继扬 State Key Laboratory of Crystal Materials and Institute of Crystal Materials Shandong University Jinan 250100 NEST Istituto Nanoscienze-CNR and Dipartimento di Fisica dell'UniversitA di Pisa Largo B. Pontecorvo 3 Pisa 56127 Italy 3 Inspur Hizaguang optoelectronics Co. Ltd Jinan 250101

We demonstrate the temperature-dependent fluorescence properties of Pr：LiGdF4 crystal tor the first time, to the best of our knowledge, and its blue diode pumped cw red laser at 720 nm at room temperature. The fluorescence lifetime and polarized emission cross sections in the visible range are measured and calculated in a temperature range from 77K to 300 K, and the variations of the fluorescence lifetime and spectra are discovered. The reasons for these changes are explained accordingly. The output wavelength of the 720nm laser is first reported on the laser performance by using a fiber-coupled laser diode at the wavelength of 442nm as the pump source, and the maximum cw output power is about 303roW.

关键词： Pr Temperature-Dependent Fluorescence Properties and Diode-Pumped Deep Red Laser Performance of Pr:LiGdF4 Crystal

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Small diameter H-graft porta-caval shunt performed at different stages of liver disease

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Hepatobiliary & Pancreatic Diseases International 2004年第4期3卷 516-521页

作者： Giacomo Batignani Francesco Vizzutti Luigi Rega Michele Zuckermann Geri Fratini Massimo Pinzani Francesco tonelli Dipartimento di Fisiopatologia Clinica-Unità di Chirurgia Firenze Italy Diparti- mento di Medicina Interna Sezione Clinica Medica ed Epatologia Laboratono di Emodinamica Epatica Firenze Italy Dipartimento di Fisiopatologia Clinica Unità di Radiodiagnostica Firenze Italy

BACKGRoUND: Partial porto-systemic shunts have been popularized because of reported low rate of mortality and morbidity (especially encephalopathy, liver failure and oc- clusion). To further investigate these assumptions, we ret- rospectively reviewed the results of partial porta-caval shunts performed at different stages of liver disease. METHoDS: Twenty-nine cirrhotic patients underwent a partial porta-caval shunt with a ringed polytetrafluoroethy- lene interposition prosthesis of 8-mm ( 20 patients) or 10- mm (9 patients) in diameter. Pre- and post-shunt porta- caval pressure was measured in all patients. Twelve patients (41.4%) belonged to Child A, 11 Child B (37.9%), and 6 Child C (20.7%). Eleven patients (37.9%) suffered from hepatic encephalopathy preoperatively. Twelve patients (41%) were operated on in emergency/urgency. RESULTS: Porta-caval pressure gradient, reduced signifi- cantly using either 8- or 10-mm prosthesis. The overall ear- ly mortality and morbidity were 13. 8% and 48% respec- tively. The early mortality and morbidity were different be- tween patients of Child A and B when compared to those of Child C (0 vs 66.6% and 34.8% vs 66.6% respectively). No patient re-bled early from varices. The overall late mor- tality and morbidity were 40% and 64% respectively. Shunt thrombosis and stenosis took place in 16% and 8% of the two groups of patients respectively; variceal re-bleeding oc- curred in 4 patients (16%). Encephalopathy occurred post- operatively in 5 patients (20%), acute in 3 patients (12%), and chronic in 2 (8%). The actuarial survival rate at 3 and 5 years was 92% and 75% for patients of Child A, 70% and 60% for patients of Child B, and 0% for patients of Child C. CoNCLUSIoNS: our results indicate that partial porta-ca- val shunt with a small diameter interposition H-graft is an effective procedure for the treatment of variceal bleeding, as well as for the prevention of re-bleeding in patients of Child A and those of Child B, as an electi

关键词： partial porto-systemic shunts portal hypertension cirrhosis variceal bleeding encephalopathy.

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