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Transformed gastric mucosa-associated lymphoid tissue lymphoma originating in the colon and developing metachronously after Helicobacter pylori eradication:A case report

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4281-4288页

作者： Makoto Saito Zen-Ichi Tanei Masumi Tsuda toma.Suzuki Emi Yokoyama Minoru Kanaya Koh Izumiyama Akio Mori Masanobu Morioka Takeshi Kondo Blood Disorders Center Aiiku HospitalSapporo 064-0804HokkaidoJapan Department of Cancer Pathology Faculty of MedicineHokkaido UniversitySapporo 060-8638HokkaidoJapan

BACKGROUND Helicobacter pylori(***)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been ***,t(11;18)(q21;q21)/API2-MALT1 translocation-positive lesions are a type of primary gastric MALT lymphoma in which a response to eradication treatment is difficult to *** addition,trisomy 18 may be associated with diffuse large B-cell lymphoma(DLBCL)transformation of gastric MALT *** SUMMARY A 66-year-old man was diagnosed with MALT lymphoma in the ascending colon by colonoscopy and *** years later,esophagogastroduodenoscopy revealed chronic atrophic gastritis that was positive for ***,and eradication treatment was *** years and nine months later(at the age of 70),a new ulcerative lesion suggestive of MALT lymphoma appeared in the gastric body,and six months later,a similar lesion was also found in the *** year later(4 years and 3 months after *** eradication),at the age of 72,the lesion in the gastric body had become deeper and had propagated.A biopsy revealed a pathological diagnosis of *** MALT lymphoma lesions in the ascending colon and DLBCL lesions in the stoma.h were positive for the t(11;18)(q21;q21)/API2-MALT1 translocation,and trisomy 18q21 was also *** 6 courses of R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine and prednisone)chemotherapy,all of the above lesions disappeared[complete remission(CR)],and CR has been maintained for more than 3 *** addition,both the colonic and gastric lesions were proven to have the same *** Because the patient had a MALT1 translocation with trisomy 18q21,it was thought that this gastric MALT lymphoma developed independently of *** infection and progressed.

关键词： Gastric mucosa-associated lymphoid tissue lymphoma Transform Diffuse large B-cell lymphoma Colonic mucosa-associated lymphoid tissue lymphoma Helicobacter pylori eradication MALT1 translocation Case report

转录因子HNF1A、HNF4A和FOXA2调节肝细胞蛋白质N-糖基化

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Engineering 2024年第1期32卷 57-68页

作者： Vedrana Vicic Bockor Nika Foglar Goran Josipovic Marija Klasic Ana Vujic Branimir Plavsa toma.Keser Samira Smajlovic Aleksandar Vojta Vlatka Zoldos Laboratory for Epigenetics Department of BiologyFaculty of ScienceUniversity of ZagrebZagreb 10000Croatia Genos Glycoscience Research Laboratory Zagreb 10000Croatia Faculty of Pharmacy and Biochemistry University of ZagrebZagreb 10000Croatia

Hepatocyte nuclear factor 1 alpha(HNF1A),hepatocyte nuclear factor 4 alpha(HNF4A),and forkhead box protein A2(FOXA2)are key transcription factors that regulate a complex gene network in the liver,cre-ating a regulatory transcriptional *** Encode and ChIP-Atlas databases identify the recognition sites of these transcription factors in many glycosyltransferase *** in silico analysis of HNF1A,*** FOXA2 binding to the ten candidate glyco-genes studied in this work confirms a significant enrich-ment of these transcription factors specifically in the *** previous studies identified HNF1A as a master regulator of fucosylation,glycan branching,and galactosylation of plasma ***,we aimed to functionally validate the role of the three transcription factors on downstream glyco-gene transcriptional expression and the possible effect on glycan *** used the state-of-the-art clus-tered regularly interspaced short palindromic repeats/dead Cas9(CRISPR/dCas9)molecular tool for the downregulation of the HNF1A,HNF4A,and FOXA2 genes in HepG2 cells-a human liver cancer cell *** results show that the downregulation of all three genes individually and in pairs affects the transcrip-tional activity of many glyco-genes,although downregulation of glyco-genes was not always followed by an unambiguous change in the corresponding glycan *** effect is better seen as an overall change in the total HepG2 N-glycome,primarily due to the extension of biantennary *** propose an alternative way to evaluate the N-glycome composition via estimating the overall complexity of the glycome by quantifying the number of monomers in each glycan *** also propose a model showing feedback loops with the mutual activation of HNF1A-FOXA2 and HNF4A-FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.

关键词： Clustered regularly interspaced short palindromic repeats/dead Cas9(CRISPR/dCas9) Epigenetics Hepatocyte nuclear factor 1 alpha(HNF1A) Hepatocyte nuclear factor 4 alpha(HNF4A) Forkhead box protein A2(FOXA2) N-glycosylation HepG2 cells

Optimizing laser coupling,matter heating,and particle acceleration from solids using multiplexed ultraintense lasers

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Matter and Radiation at Extremes 2024年第4期9卷 16-28页

作者： Weipeng Yao Motoaki Nakatsutsumi Sébastien Buffechoux Patrizio Antici Marco Borghesi Andrea Ciardi Sophia N.Chen Emmanuel d’Humières Laurent Gremillet Robert Heathcote Vojtech Horny Paul McKenna Mark N.Quinn Lorenzo Romagnani Ryan Royle Gianluca Sarri Yasuhiko Sentoku Hans-Peter Schlenvoigt toma.Toncian Olivier Tresca Laura Vassura Oswald Willi Julien Fuchs LULI-CNRS CEASorbonne UniversitéEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbonne Université Observatoire de ParisUniversité PSLCNRSLERMAF-75005 ParisFrance INRS-EMT 1650 BoulLionel-BouletVarennesQuebec J3X 1S2Canada Center for Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUnited Kingdom “Horia Hulubei”National Institute for Physics and Nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania University of Bordeaux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance CEA DAMDIFF-91297 ArpajonFrance Université Paris-Saclay CEALMCE91680 Bruyères-le-ChatelFrance Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUnited Kingdom SUPA Department of PhysicsUniversity of StrathclydeGlasgow G40NGUnited Kingdom Department of Physics University of NevadaRenoNevada 89557USA Institute of Laser Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan Institut fur Laser und Plasmaphysik Heinrich Heine Universitat DusseldorfDusseldorfGermany

Realizing the full potential of ultrahigh-intensity lasers for particle and radiation generation will require multi-beam arrangements due to technology ***,we investigate how to optimize their coupling with solid ***,we show that overlapping two intense lasers in a mirror-like configuration onto a solid with a large preplasma can greatly improve the generation of hot electrons at the target front and ion acceleration at the target *** underlying mechanisms are analyzed through multidimensional particle-in-cell simulations,revealing that the self-induced magnetic fields driven by the two laser beams at the target front are susceptible to reconnection,which is one possible mechanism to boost electron *** addition,the resistive magnetic field generated during the transport of the hot electrons in the target bulk tends to improve their *** simulations also indicate that such effects can be further enhanced by overlapping more than two laser beams.

关键词： laser acceleration particle

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希腊铁路牵引动力的复兴

国外铁道机车与动车 2024年第4期 45-48页

作者： [希腊]toma.Bacié 石开文(译) 孟娜(校) 不详

尽管宏观经济复苏,欧盟也为基础设施建设注入资金,但希腊铁路复苏仍然面临着阻力文章介绍了希腊铁路复兴项目,包括机车车辆的运用、欧洲列控系统ETCS的应用、既有铁路电气化和新线建设。

关键词：希腊铁路 Pendolino摆式列车信号系统铁路扩建

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创新引领未来--Allegris开启汉莎航空中欧航线新篇章专访汉莎航空公司执行董事会成员兼首席执行官延斯·里特先生

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旅行者 2024年第S1期 6-11页

作者：延斯·里特 sky&汉莎航空公司(图) 冯俊奇汉莎航空公司不详

近年来,航空业经历了前所未有的挑战。如今,随着洲际旅行的恢复,市场需求和行业格局已经发生了巨大变化。在这样的背景下,汉莎航空公司作为全球领先的航空公司之一,凭借其卓越的服务和稳健的战略,始终引领市场,逆流而上。此次,我们非常... 详细信息

近年来,航空业经历了前所未有的挑战。如今,随着洲际旅行的恢复,市场需求和行业格局已经发生了巨大变化。在这样的背景下,汉莎航空公司作为全球领先的航空公司之一,凭借其卓越的服务和稳健的战略,始终引领市场,逆流而上。此次,我们非常荣幸能在德国慕尼黑机场的汉莎航空头等舱休息室与执行董事会成员兼首席执行官延斯·里特(Jens Riter)先生进行深度交流。

关键词：汉莎航空公司行业格局首席执行官深度交流头等舱里特中欧航线董事会成员

转录因子HNF1A、HNF4A和FOXA2调节肝细胞蛋白质N-糖基化（英文）

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Engineering 2024年第1期 57-68页

作者： Vedrana Vi?i? Bo?kor Nika Foglar Goran Josipovi? Marija Klasi? Ana Vuji? Branimir Plav?a toma.Keser Samira Smajlovi? Aleksandar Vojta Vlatka Zoldo? Laboratory for Epigenetics Department of Biology Faculty of Science University of Zagreb Genos Glycoscience Research Laboratory Faculty of Pharmacy and Biochemistry University of Zagreb

Hepatocyte nuclear factor 1 alpha(HNF1A),hepatocyte nuclear factor 4 alpha(HNF4A),and forkhead box protein A2(FOXA2) are key transcription factors that regulate a complex gene network in the liver,creating a regulatory transcriptional *** Encode and ChIP-Atlas databases identify the recognition sites of these transcription factors in many glycosyltransferase *** in silico analysis of HNF1A,HNF4A,and FOXA2 binding to the ten candidate glyco-genes studied in this work confirms a significant enrichment of these transcription factors specifically in the *** previous studies identified HNF1A as a master regulator of fucosylation,glycan branching,and galactosylation of plasma ***,we aimed to functionally validate the role of the three transcription factors on downstream glyco-gene transcriptional expression and the possible effect on glycan *** used the state-of-the-art clustered regularly interspaced short palindromic repeats/dead Cas9(CRISPR/dCas9) molecular tool for the downregulation of the HNF1A,HNF4A,and FOXA2 genes in HepG2 cells-a human liver cancer cell *** results show that the downregulation of all three genes individually and in pairs affects the transcriptional activity of many gly co-genes,although downregulation of glyco-genes was not always followed by an unambiguous change in the corresponding glycan *** effect is better seen as an overall change in the total HepG2 N-glycome,primarily due to the extension of biantenna ry *** propose an alternative way to evaluate the N-glycome composition via estimating the overall complexity of the glycome by quantifying the number of monomers in each glycan *** also propose a model showing feedback loops with the mutual activation of HNF1A-FOXA2 and HNF4A-FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.

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Description of alpha-clustering of 8Be nucleus states in high-precision theoretical approach

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Chinese Physics C 2020年第12期44卷 146-157页

作者： D.M.Rodkin Yu.M.Tchuvil’sky Dukhov Research Institute for Automa.ics 127055MoscowRussia Skobeltsyn Institute of Nuclear Physics Lomonosov Moscow State University119991 MoscowRussia

Scrupulous theoretical study of 8Be nucleus states,both clustered and non-clustered,is performed over a wide range of excitation *** quantities that characterize the degree of the alpha-clustering of these states,i.e.,spectroscopic factors,cluster form factors,and alpha-decay widths,are computed in the framework of the developed accurate ab initio *** basic properties of the 8Be spectrum,including the binding and excitation energies and the mean values of the isospin,are calculated *** the majority of instances,the results of the computation turn out to be in good agreement with the spectroscopic data.A number of predictions are made,and corresponding verification experiments are *** of the developed approach for nuclear spectroscopy are demonstrated.

关键词： nuclear clustering nuclear structure light nuclei alpha-spectroscopy ab initio computations

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New results on Cll and C12 lattices with applications to Grothendieck categories and torsion theories

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Frontiers of Mathematics in China 2016年第4期11卷 815-828页

作者： toma.ALBU Mihai IOSIF Simion Stoilow Institute of Mathematics of the Romanian Academy Research Unit 5 P.O. Box 1-764 RO-010145 Bucharest 1 Romania Bucharest University Department of Mathematics Academiei Str. 14RO-010014 Bucharest 1 Romania

In this paper, which is a continuation of our previous paper [T. Albu, M. Iosif, A. Tercan, The conditions （Ci） in modular lattices, and applications, J. Algebra Appl. 15 （2016）, http： ***/10.1142/S0219498816500018], we investigate the latticial counterparts of some results about modules satisfying the conditions （Cll） or （C12）. Applications are given to Grothendieck categories and module categories equipped with hereditary torsion theories.

关键词： Modular complement lattice C12 theory element lattice upper closed element lattice Goldie dimension continuous lattice essential element uniform lattice condition (Ci) Cll socle Grothendieck category torsion

A Variational Finite Element Model for Large-Eddy Simulations of Turbulent Flows

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Chinese Annals of Mathematics,Series B 2013年第5期34卷 667-682页

作者： toma.s Chac'on REBOLLO Roger LEWANDOWSKI Dpto. EDAN & IMUS Universidad de SevillaC/Tarfias/n. 41012 SevillaSpain BCAM-Basque Center for Applied Mathematics AvdaMazarredo14. 48009 BilbaoSpain. Mathematical Research Institute of Rennes UMR CNRS 6625University of Rennes 1 & Fluminance teamINRIABat 22Campus Beaulieu35042 Rennes cedexFrance.

The authors introduce a new Large Eddy Simulation model in a channel, based on the projection on finite element spaces as filtering operation in its variationM form, for a given triangulation （Th）h〉0. The eddy viscosity is expressed in terms of the friction velocity in the boundary layer due to the wall, and is of a standard sub grid-model form outside the boundary layer. The mixing length scale is locally equal to the grid size. The computational domain is the channel without the linear sub-layer of the boundary layer. The no-slip boundary condition （or BC for short） is replaced by a Navier （BC） at the computational wall. Considering the steady state case, the authors show that the variational finite element model they have introduced, has a solution （Vh,Ph）h〉O that converges to a solution of the steady state Navier-Stokes equation with Navier BC.

关键词： Navier-Stokes equations Turbulence modeling Finite elements

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