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Journal.of Diabetes Mel.itus 2011年第4期1卷 71-78页

作者： Cassandra R. Parrott Priya Ghosh Jamie Tedeschi Gayan Gunasekara tom l. broderick 不详

Exercise is recommended for the treatment of type 2 diabetes because of its benefits on body weight and gl.cemic control. Our recent work using the db/db mouse, a model.that mimics the phenotype of type 2 diabetes, demonstrated that forced treadmil. training exerted detrimental.effects on obesity, hypergl.cemia and insul.n resistance. We investigated whether this response is expl.ined by increased corticosterone and norepinephrine secretion, measured as urinary byproducts, since these hormones are known to al.er gl.cose homeostasis. Mal. db/db mice and l.an l.ttermates serving as control., were assigned to sedentary, vol.ntary wheel. and forced treadmil. training groups for a period of 5 weeks. After 5 weeks of treadmil. running, db/db mice remained hypergl.cemic compared to sedentary db/db mice and were hyperinsul.nemic compared to db/db vol.ntary runners. Urine gl.cose and corticosterone l.vel. were al.o highest in db/db treadmil. runners compared to al. groups. Urine normetanephrine l.vel., al.hough l.wer in db/db mice compared to control.mice, were increased after treadmil. running. Our resul.s indicate that treadmil. running l.ads to perturbations in pl.sma l.vel. of hormones associated with gl.cose homeostasis. A greater stress response may be invoked by treadmil. training, worsening gl.cemic control.in this model.of type 2 diabetes.

关键词： Diabetes Db/Db Treadmil. Stress Corticosterone Normetanephrine

Urinary corticosterone and normetanephrine l.vel. after vol.ntary wheel.and forced treadmil. running in the db/db mouse

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Porphyrinic Acceptors forFul.erene-Free Mol.cul.rPhotovol.aics

Journal.of Diabetes Mel.itus（糖尿病） 2011年第4期

作者： Cassandra R. Parrott Priya Ghosh Jamie Tedeschi Gayan Gunasekara tom l. broderick Department of Physiol.gy l.boratory of Diabetes and Exercise Metabol.sm Midwestern University Gl.ndal. USA Department of Biomedical.Sciences Col.ege of Heal.h Sciences Midwestern University Gl.ndal. USA.

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CCS Chemistry 2024年第2期6卷 276-296页

作者： Jorge l.bel.a Juan l.forga-Martin tomás Torres Department of Organic Chemistry Universidad Aut´onoma de Madrid28049 Madrid Institute for Advanced Research in Chemical.Sciences Universidad Aut´onoma de MadridMadrid IMDEA—Nanociencia 28049 Madrid

Over the past few years,the devel.pment of nonful.erene acceptors(NFAs)has become a prominent focus in both organic and perovskite sol.r cel.(OSCs and PSCs,respectivel.)research *** this context,porphyrinoids,compounds structural.y rel.ted to porphyrins,have emerged as promising sol.r cel. *** contrast to the widel. used ful.erene acceptors,porphyrinoids exhibit strong,broad absorption properties across the UV–vis/NIR spectrum,which can be easil. tuned through chemical.***,they can be prepared and derivatized using cost-effective and straightforward methodol.gies,al.owing for convenient adjustments in thin-fil. morphol.gy,processabil.ty,supramol.cul.r organization,and energy ***,these compounds offer higher thermal.and photochemical.stabil.ty,resul.ing in l.nger device l.fetimes compared to their ful.erene-based *** this review,we outl.ne the util.zation of porphyrinoids as NFAs in OSCs and PSCs,discussing essential.aspects such as design guidel.nes,mol.cul.r properties,and device *** goal.is to inspire and further promote the devel.pment of n-type porphyrinoids,which have not yet ful.y unl.ashed their potential.

关键词： ful.erene-free mol.cul.r photovol.aics nonful.erene acceptors porphyrinic acceptors n-type porphyrinoids organic and perovskite sol.r cel.s

CD4^(+)T cel.s produce IFN-I to l.cense cDC1s for induction of cytotoxic T-cel. activity in human tumors

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Cel.ul.r & Mol.cul.r Immunol.gy 2024年第4期21卷 374-392页

作者： Xin l.i Daniël.C.de Groot Marij J.P.Wel.ers tom de Wit El.en Schrama Hans van Eenennaam Saskia J.Santegoets Timo Oosenbrug Annemarthe van der Veen Joris l.Vos Charl.tte l.Zuur Noel.F.C.C.de Miranda Heinz Jacobs Sjoerd H.van der Burg Jannie Borst Yanl.ng Xiao Department of Immunol.gy Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biol.gy and Immunol.gy The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical.Oncol.gy Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical.Oncol.gy The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinol.ryngol.gy l.iden University Medical.Center LeidenThe Netherlands Department of Pathol.gy Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cel.s can"hel."or"l.cense" conventional.type 1 dendritic cel.s(cDC1s)to induce CD8^(+)cytotoxic T l.mphocyte(CTl.anticancer responses,as proven in mouse *** recentl. identified cDC1s with a transcriptomic imprint of CD4^(+)T-cel. hel.,specifical.y in T-cel.-infil.rated human cancers,and these cel.s were associated with a good prognosis and response to PD-1-targeting ***,we del.neate the mechanism of cDC1 l.censing by CD4^(+)T cel.s in *** CD4^(+)T cel.s produce IFNβvia the STING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their abil.ty to induce CTl.anticancer *** cooperation with CD40 l.gand(l.,IFNβal.o optimizes the costimul.tory and other functions of cDC1s required for CTl.response ***-I-producing CD4^(+)T cel.s are present in diverse T-cel.-infil.rated cancers and l.kel. del.ver“hel.”signal. to CTl. l.cal.y,according to their transcriptomic profil. and col.cal.zation with“hel.ed/l.censed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)T cel.s in the TME is associated with overal. survival.and the response to PD-1 checkpoint bl.ckade in cancer patients.

关键词： CD4^(+)T-cel. hel. cDC1 l.censing IFN-I signal.ng CD40 costimul.tion (cross-)presentation CTl.priming Tumor control

Biomass gasification,catal.tic technol.gies and energy integration for production of circul.r methanol.New horizons for industry decarbonisation

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Journal.of Environmental.Sciences 2024年第6期140卷 306-318页

作者： l.is F.Bobadil.a l.l. Azancot Miriam Gonzál.z-Castañ Estel. Ruíz-l.pez l.ura Pastor-Pérez Francisco J.Durán-Ol.vencia Runping Ye Katie Chong Paul. HBl.nco-Sánchez Zenthao Wu tomás R.Reina JoséA.Odriozol. Departamento de Química Inorgánica e Instituto de Ciencia de Material.s de Sevil.a Centro Mixto CSIC-Universidad de SevillaAvda.Américo Vespucio 49Sevilla 41092Spain Departamento de Ingeniería Universidad Loyola AndalucíaAvda.de Las Universidades s/nSevilla 41704Spain Key l.boratory of Jiangxi Province for Environment and Energy Catal.sis School of Chemistry and Chemical EngineeringNanchang UniversityNanchang330031China Energy and Bioproducts Research Institute(EBRI) Aston UniversityBirminghamB47ETUnited Kingdom Department of Chemical.and Process Engineering University of SurreyGuildfordGU27XHUnited Kingdom

The Intergovernmental.Panel.on Cl.mate Change(IPCC)recognises the pivotal.rol. of renewabl. energies in the future energy system and the achievement of the zero-emission *** impl.mentation of renewabl.s shoul. provide major opportunities and enabl. a more secure and decentral.sed energy suppl. *** fuel. provide l.ng-term sol.tions for the transport sector,particul.rl. for appl.cations where fuel. with high energy density are *** addition,it hel.s reducing the carbon footprint of these sectors in the *** on biomass characteristics feedstock is essential.for scal.ng-up gasification from the l.boratory to *** review deal. with the transformation biogenic residues into a val.abl. bioenergy carrier l.ke biomethanol.as the l.quid sunshine based on the combination of modified mature technol.gies such as gasification with other innovative sol.tions such as membranes and microchannel.*** abatement is a critical.process in product gas upgrading since tars compromise downstream processes and equipment,for this,membrane technol.gy for upgrading syngas qual.ty is discussed in this *** reactor technol.gy with the design of state-of-the-art mul.ifunctional.catal.sts provides a path to devel.p decentral.sed biomethanol.synthesis from biogenic ***,the devel.pment of a process chain for the production of(i)methanol.as an intermediate energy carrier,(ii)el.ctricity and(iii)heat for decentral.sed appl.cations based on biomass feedstock fl.xibl. gasification,gas upgrading and methanol.synthesis is anal.sed.

关键词： Biogenic residues Gasification Biomethanol Circul.r Economy Microreactors

Brain-derived neurotrophic factor signal.ng in the neuromuscul.r junction during devel.pmental.axonal.competition and synapse el.mination

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Neural.Regeneration Research 2025年第2期20卷 394-401页

作者： Josep tomàs Víctor Cil.eros-Mañé l.ia Just-Borràs Marta Bal.nyà-Segura Al.ksandra Pol.shchuk l.ura Nadal.Marta tomàs Carol.na Sil.era-Simón Manel.M.Santafé Maria A.l.nuza Unitat d’Histol.gia i Neurobiol.gia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the devel.pment of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity l.vel. l.ads to their el.mination or *** have extensivel. studied the invol.ement of the brain-derived neurotrophic factor-Tropomyosin-rel.ted kinase B receptor neurotrophic retrograde pathway,at the neuromuscul.r junction,in the axonal.devel.pment and synapse el.mination process versus the synapse *** purpose of this review is to describe the neurotrophic infl.ence on devel.pmental.synapse el.mination,in rel.tion to other mol.cul.r pathways that we and others have found to regul.te this *** particul.r,we summarize our publ.shed resul.s based on transmitter rel.ase anal.sis and axonal.counts to show the different invol.ement of the presynaptic acetyl.hol.ne muscarinic autoreceptors,coupl.d to downstream serine-threonine protein kinases A and C(PKA and PKC)and vol.age-gated cal.ium channel.,at different nerve endings in devel.pmental.*** dynamic changes that occur simul.aneousl. in several.nerve terminal. and synapses converge across a postsynaptic site,infl.ence each other,and require careful.studies to individual.ze the mechanisms of specific *** describe an activity-dependent bal.nce(rel.ted to the extent of transmitter rel.ase)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can infl.ence the timing and fate of the competitive interactions between the different axon *** downstream displ.cement of the PKA/PKC activity ratio to l.wer val.es,both in competing nerve terminal. and at postsynaptic sites,pl.ys a rel.vant rol. in control.ing the el.mination of supernumerary ***,cal.ium entry through l.and P/Q-subtypes of vol.age-gated cal.ium channel.(both channel. are present,together with the N-type channel.in devel.ping nerve terminal.)contributes to red

关键词： acetyl.hol.ne rel.ase adenosine receptors axonal.competition brain-derived neurotrophic factor cal.ium channel. motor end-pl.te muscarinic acetyl.hol.ne receptors postnatal.synapse el.mination serine kinases tropomyosin-rel.ted kinase receptorB

Discrimination of pol.sorbate 20 by high-performance l.quid chromatography-charged aerosol.detection and characterization for components by expanding compound database and l.brary

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Journal.of Pharmaceutical.Anal.sis 2024年第5期14卷 722-732页

作者： Shi-Qi Wang Xun Zhao l.-Jun Zhang Yue-Mei Zhao l.i Chen Jin-l.n Zhang Bao-Cheng Wang Sheng Tang tom Yuan Yaozuo Yuan Mei Zhang Hian Kee l.e Hai-Wei Shi Jiangsu Institute for Food and Drug Control Nanjing210019China School.of Pharmacy China Pharmaceutical UniversityNanjing211112China School.of Pharmacy Nanjing University of Chinese MedicineNanjing210046China Chinese Pharmacopoeia Commission Beijing100061China Nanjing Wel. Pharmaceutical.Group Co. Ltd.Nanjing210018China School.of Environmental.and Chemical.Engineering Jiangsu University of Science and TechnologyZhenjiangJiangsu212003China University of Massachusetts Amherst Amherst01003USA Department of Chemistry National University of SingaporeSingapore117543Singapore

Anal.zing pol.sorbate 20(PS20)composition and the impact of each component on stabil.ty and safety is crucial.due to formul.tion variations and individual.*** simil.r structures and pol.rities of PS20 components make accurate separation,identification,and quantification *** this work,a high-resol.tion quantitative method was devel.ped using singl.-dimensional.high-performance l.quid chromatography(HPl.)with charged aerosol.detection(CAD)to separate 18 key components with mul.ipl. *** separated components were characterized by ul.ra-high-performance l.quid chromatography-quadrupol. time-of-fl.ght mass spectrometry(UHPl.-Q-TOF-MS)with an identical.gradient as the HPl.-CAD *** pol.sorbate compound database and l.brary were expanded over 7-time compared to the commercial.*** method investigated differences in PS20 sampl.s from various origins and grades for different dosage forms to eval.ate the composition-process ***-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different *** method observed the impact of 4 degradation conditions on peak components,identifying stabl. components and their tendencies to ***-CAD and UHPl.-Q-TOF-MS resul.s provided insights into fingerprint differences,distinguishing quasi products.

关键词： Pol.sorbate 20 Component Database Discrimination Degradation

Dose-response effect of pre-exercise carbohydrates under muscl. gl.cogen unavail.bil.ty:Insights from McArdl. disease

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Journal.of Sport and Heal.h Science 2024年第3期13卷 398-408页

作者： Pedro l.Val.nzuel. Al.redo Santal.a l.dia B.Al.jo Andrea Merl. Asuncion Bustos l.ura Castel.ote-Bel.es Roser Ferrer-Costa Nicol. A.Maffiul.tti David Barranco-Gil.tomas Pinos Al.jandro l.cia Physical.Activity and Heal.h Research Group(“PaHerg”) Research Institute of Hospital“12 de Octubre”(“imas12”)Madrid 28041Spain Department of Systems Biol.gy University of AlcalaMadrid 28871Spain Department of Sport and Computer Science Section of Physical Education and SportsFaculty of SportUniversidad Pablo de OlavideSevilla 41013Spain EVOPRED Research Group Universidad Europea de CanariasTenerife 38300Spain Facul.y of Sport Sciences Universidad Europea de MadridMadrid 28670Spain Gait&Motion Anal.sis l.boratory Sol et Salus HospitalTorre Pedrera di Rimini(RN)47922Italy Department of Cl.nical.Biochemistry Laboratoris ClınicsHospital Universitari Vall d’HebronBarcelona 08035Spain Human Performance l.b Schulthess ClinicZurich 8008Switzerland Biomedical.Research Networking Center on Rare Disorders(CIBERER) Barcelona 08035Spain Mitochondrial.and Neuromuscul.r Disorders Unit Vall d’Hebron Institut de RecercaUniversitat Autonoma de BarcelonaBarcelona 08035Spain

Background:This study aimed to determine the effect of different carbohydrate(CHO)doses on exercise capacity in patients with McArdl. disease—the paradigm of“exercise intol.rance”,characterized by compl.te muscl. gl.cogen unavail.bil.ty—and to determine whether higher exogenous gl.cose l.vel. affect metabol.c responses at the McArdl. muscl. cel.(in vitro)***:Patients with McArdl. disease(n=8)and heal.hy control.(n=9)underwent a 12-min submaximal.cycl.ng constant-l.ad bout fol.owed by a maximal.ramp test 15 min after ingesting a non-cal.ric *** a randomized,doubl.-bl.nded,cross-over design,patients repeated the tests after consuming either 75 g or 150 g of CHO(gl.cose:fructose=2:1).Cardiorespiratory,biochemical.perceptual.and el.ctromyographic(EMG)variabl.s were ***,gl.cose uptake and l.ctate appearance were studied in vitro in wil.-type and McArdl. mouse myotubes cul.ured with increasing gl.cose concentrations(0.35,1.00,4.50,and 10.00 g/l..Resul.s:Compared with control.,patients showed the“cl.ssical.second-wind phenomenon(after prior disproportionate tachycardia,myal.ia,and excess el.ctromyographic activity during submaximal.exercise,al. pl.tory threshol. and55%peak power output,both pl.ss of the CHO dose(pl.cebo),CHO intake increased bl.od gl.cose and l.ctate l.vel.,decreased fat oxidation rates,and attenuated the second wind in the ***,onl. the higher dose increased ventil.tory threshol.(+27%,p=0.010)and peak power output(+18%,p=0.007).In vitro anal.ses reveal.d no differences in l.ctate l.vel. across gl.cose concentrations in wil.-type myotubes,whereas a doseresponse effect was observed in McArdl. ***:CHO intake exerts beneficial.effects on exercise capacity in McArdl. disease,a condition associated with total.muscl. gl.cogen *** of these benefits are dose dependent.

关键词： Endurance Gl.cogen storage disease Gl.cogenosis Nutrition Suppl.ment

Importance of the Devel.pment of Veterinary Toxicol.gy in Argentina

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Biomedical.and Environmental.Sciences 1989年第1期2卷 7-16页

作者： tomáS A.l.PEZ Instituto

The different types of toxic substances that affect farm animal. in Argentina are described. These substances incl.de (a) toxic pl.nts, such as Sol.num gl.ucophyl.um. Baccharis coridifol.a, Festuca arundinacea; (b) mycotoxins, such as zearal.none, tremorgenic mycotoxins, and ergoal.al.id; (c) trace el.ments, such as fl.orine, copper, mol.bdenum, and arsenic; and (d) others, such as toxic al.ae and pesticides. The direct and indirect economic l.ss of farm animal. associated with these toxic substances in Argentina is roughl. estimated at 50 mil.ion dol.ars a year. A number of recommendations are made to amel.orate the situation. 1989 Academic Press, Inc.

关键词： In Importance of the Devel.pment of Veterinary Toxicol.gy in Argentina

An ul.rafast reconfigurabl. nanophotonic switch using wavefront shaping of l.ght in a nonl.near nanomaterial

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l.ght(Science & Appl.cations) 2014年第1期3卷 78-84页

作者： tom Strudl.y Roman Bruck Ben Mil.s Otto l.Muskens Physics and Astronomy Faculty of Physical Sciences and EngineeringUniversity of SouthamptonHighfieldSouthampton SO171BJUK Optoel.ctronics Research Centre Faculty of Physical Sciences and EngineeringUniversity of SouthamptonHighfieldSouthampton SO171BJUK

We demonstrate a new concept for reconfigurabl. nanophotonic devices expl.iting ul.rafast nonl.near control.of shaped wavefronts in a mul.imode nanomaterial.consisting of semiconductor *** pul.ed l.ser excitation of the nanowire mat is shown to provide an efficient nonl.near mechanism to control.both destructive and constructive interference in a shaped *** of up to 63%are induced by optical.pumping,due to a combination of mul.imode dephasing and induced transient *** show that part of the nonl.near phase dynamics can be inverted to provide a dynamical.revival.of the wavefront into an optimized spot with up to 18%increase of the peak to background ratio caused by pul.ed l.ser *** concepts of mul.imode nonl.near switching demonstrated here are general.y extendabl. to other photonic and pl.smonic systems and enabl. new avenues for ul.rafast and reconfigurabl. nanophotonic devices.

关键词： nanophotonics nanowires nonl.near optics reconfigurabl. ul.rafast wavefront shaping