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Whole-genome sequencing to detect mutations associated with resistance to insecticides and Bt proteins in Spodoptera frugiperda

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Insect Science 2021年第3期28卷 627-638页

作者： Fang Guan jianpeng Zhang Huiwen Shen Xingliang Wang Amanda Padovan tom K.Walsh Wee Tek Tay Karl H.j.Gordon William james Cecilia Czepak Michael Hilary Otim Donald Kachigamba Yidong Wu College of Plant Protection Nanjing Agricultural UniversityNanjingChina CSIRO Black Mountain Laboratories Clunies Ross StreetCanberraACTAustralia Escola de Agronomia Universidade Federal de GoiasGoianiaBrazil National Crops Resources Research Institute NamulongeKampalaUganda Department of Agricultural Research Services(DARS) LilongweMalawi

The fall armyworm(FAW),Spodoptera frugiperda,is a major pest native to the Americas that has recently invaded the Old *** mutations in the target-site proteins acetylcholinesterase-1(ace-1),voltage-gated sodium channel(VGSC)and ryanodine receptor(RyR)have been identified in *** as major resistance mechanisms to organophosphate,pyrethroid and diamide insecticides *** in the adenosine triphosphate-binding cassette transporter C2 gene(ABCC2)have also been identified to confer resistance to Cry IF *** this study,we applied a whole-genome sequencing(WGS)approach to identify point mutations in the target-site genes in 150 FAW individuals collected from China,Malawi,Uganda and *** approach revealed three amino acid substitutions(A201S,G227A and F290V)of *** ace-1,which are known to be associated with organophosphate *** Brazilian population had all three ace-1 point mutations and the 227A allele(mean frequency=0.54)was the most *** from China,Malawi and Uganda harbored two of the three ace-1 point mutations(A201S and F290V)with the 290V allele(0.47-0.58)as the dominant *** mutations in VGSC(T929I,L932F and L1014F)and RyR(I4790M and G4946E)were not detected in any of the 150 individuals.A novel 12-bp insertion mutation in exon 15 of the ABCC2 gene was identified in some of the Brazilian individuals but absent in the invasive *** results not only demonstrate robustness of the WGS-based genomic approach for detection of resistance mutations,but also provide insights for improvement of resistance management tactics in ***.

关键词： Bt resistance insecticide resistance mutation detection Spodoptera frugiperda whole-genome sequencing

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SAR of tricyclic sulfones as γ-secretase inhibitors

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Science China Chemistry 2011年第11期54卷 1688-1701页

作者： COLE David ASBEROM Ted BARA tom BENNETT Chad BURNETT Duane A. CLADER john DOMALSKI Martin GREENLEE William j. HYDE Lynn jOSIEN Hubert McBRIAR Mark McKITTRICK Brian PISSARNITSKI Dmitri RAjAGOPALAN Murali SASIKUMAR Thavalakulamgara Merck Research Laboratories 2015 Galloping Hill RoadKenilworth New Jersey 07033 USA

Novel tricyclic sulfones as γ-secretase inhibitors have been reported by this laboratory for the treatment of Alzheimer's disease. Compounds in this series have comparable or better in vitro activities and in vivo efficacies than sulfonamide analogues re- ported previously by this laboratory. Based on the previously reported tricyclic sulfone scaffold, additional SAR studies of C ring were carried out. Various C-ring structures including cyclohexane, pyran, and piperidine were tolerated. Additionally, the 7- and 8- positions of the C-ring were identified as the best sites to introduce substituent for modulating the pharmacokinetic properties of compounds from this series.

关键词： tricyclic sulfones T-secretase Alzheimer's disease inhibitors

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Topical Treatment of Infectious Vaginitis:Effects of Antibiotic,Antifungal and Antiseptic Drugs on the Growth of Normal Vaginal Lactobacillus Strains

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Open journal of Obstetrics and Gynecology 2015年第3期5卷 173-180页

作者： Christel Neut Francois Verrière Hans j.Nelis tom Coenye Laboratoire de Bactériologie Clinique Faculté de Pharmacie Lille France Laboratoire Innotech International Arcueil France Laboratorium voor Farmaceutische Microbiologie Gent Belgium

Objectives: The balance of the vaginal ecosystem depends on lactobacilli whose biofilm protectsagainst microorganisms that are not normally present or are subdominant in vaginal flora. Vaginal?infection treatments should eliminate pathogens while preserving the?Lactobacillus?flora to prevent relapse or recurrence. The objective of this study was to determine the sensitivity of lactobacilli to antiseptics, antibiotics and antifungal agents used, alone or in combination, in the topical treatment of infectious vaginitis. Materials and Methods: The minimum inhibitory concentration (MIC) of 15 active ingredients and the minimum inhibitory dilution (MID) of 17 pharmaceuticals products were determined for three main?Lactobacillus?strains (L. crispatus,?L. gasseri?and?L. jensenii). Results: The MICs of the antibiotics and antifungal agents were above their critical concentrations in the three strains, contrary to the antiseptics. According to their MID, some pharmaceutical products, especially combinations, inhibit the growth of one or more strains at concentrations that can be found in the vaginal mucosa after application at the usual dosage. Conclusions: Certain topical anti-infective drugs may interfere with the growth of lactobacilli, worsening the vaginal flora imbalance. Maintaining vaginal flora balance should be a selection criterion when choosing an anti-infective therapy.

关键词： Lactobacillus Infectious Vaginitis Antiseptics Antibiotics Antifungal Agents

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Proposed approach to the challenging management of progressive gastroesophageal reflux disease

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World journal of Gastrointestinal Endoscopy 2018年第9期10卷 175-183页

作者： joachim Labenz Parakrama T Chandrasoma Laura j Knapp tom R DeMeester Diakonie Klinikum Jung-Stilling HospitalSiegen 57074Germany Keck School of Medicine University of Southern CaliforniaLos AngelesCA 91108United States PharmaGenesis London London SW1A 2DDUnited Kingdom

The progression of gastroesophageal reflux disease(GERD) in patients who are taking proton pump inhibitors(PPIs) has been reported by several investigators,leading to concerns that PPI therapy does not address all aspects of the *** who are at risk of progression need to be identified early in the course of their disease in order to receive preventive treatment.A review of the literature on GERD progression to Barrett's esophagus and the associated physiological and pathological changes was performed and risk factors for progression were *** addition,a potential approach to the prevention of progression is *** evidence shows that GERD can progress;however,patients at risk of progression may not be identified early enough for it to be *** of the squamocolumnar junction that show microscopic intestinalization of metaplastic cardiac mucosa in endoscopically normal patients are predictive of future visible Barrett's esophagus,and an indicator of GERD *** changes can be identified only through biopsy,which is not currently recommended for endoscopically normal *** treatment should aim to prevent *** propose that endoscopically normal patients who partially respond or do not respond to PPI therapy undergo routine biopsies at the squamocolumnar junction to identify histological changes that may predict future *** will allow earlier intervention,aimed at preventing Barrett's esophagus.

关键词： Barrett's esophagus Gastroesophageal reflux disease Endoscopy Progression Treatment

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Is physical performance(in mice)increased by Veillonella atypica or decreased by Lactobacillus bulgaricus?

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journal of Sport and Health Science 2020年第3期9卷 197-200页

作者： Manuel Fernández-Sanjurjo javier Fernández Cristina tomás-Zapico Benjamín Fernández-García Claudio j.Villar Felipe Lombó Eduardo Iglesias-Gutiérrez Department of Functional Biology PhysiologyUniversity of OviedoAsturias 33006Spain Health Research Institute of the Principality of Asturias(ISPA) Asturias 33011Spain Department of Functional Biology MicrobiologyUniversity of OviedoOviedo 33006Spain Department of Morphology and Cell Biology AnatomyUniversity of OviedoOviedo 33006Spain

*** Regular exercise induces changes in the overall diversity and in the relative abundance of certain gut microbiota phyla and families in humans1,2 and in animal models.3,4 This relationship has attracted a great deal of interest because it is one of the mechanisms involved in the health benefits of regular exercise3 that could also influence performance.5 A recent publication by Scheiman et al.

关键词： al. performance Regular

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Unfolding the complexity of phonon quasi-particle physics in disordered materials

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npj Computational Materials 2020年第1期6卷 1620-1627页

作者： Sai Mu Raina j.Olsen Biswanath Dutta Lucas Lindsay German D.Samolyuk tom Berlijn Eliot D.Specht Ke jin Hongbin Bei Tilmann Hickel Bennet C.Larson George M.Stocks Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTN 37831USA Max-Planck-Institut für Eisenforschung GmbH D-40237 DüsseldorfGermany Center of Nanophase and Material Science Oak Ridge National LaboratoryOak RidgeTN 37831USA Computational Science and Engineering Division Oak Ridge National LaboratoryOak RidgeTN 37831USA Materials Department University of CaliforniaSanta BarbaraCA 93106USA

The concept of quasi-particles forms the theoretical basis of our microscopic understanding of emergent phenomena associated with quantum-mechanical many-body ***,the quasi-particle theory in disordered materials has proven difficult,resulting in the predominance of mean-field ***,we report first-principles phonon calculations and inelastic X-ray and neutron-scattering measurements on equiatomic alloys(NiCo,NiFe,AgPd,and NiFeCo)with force-constant dominant disorder—confronting a key 50-year-old assumption in the Hamiltonian of all mean-field quasi-particle solutions for off-diagonal *** results have revealed the presence of a large,and heretofore unrecognized,impact of local chemical environments on the distribution of the species-pair-resolved force-constant disorder that can dominate phonon *** discovery not only identifies a critical analysis issue that has broad implications for other elementary excitations,such as magnons and skyrmions in magnetic alloys,but also provides an important tool for the design of materials with ultralow thermal conductivities.

关键词： alloys particle phonon

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Long-term follow-up of quality of life in high-risk patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis

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journal of Geriatric Cardiology 2018年第4期15卷 261-267页

作者： Marjo jAG De Ronde-Tillmans tom Aj de jager jeannette A Goudzwaard Nahid El Faquir Nicolas M van Mieghem Felix Zijlstra Elisabeth MWj. Utens Francesco US Mattace-Raso MaRie j Lenzen Peter PT de jaegere Erasmus Medical Center Department of Cardiology Thorax Center Rotterdam the Netherlands Erasmus Medical Center Section of Geriatrics Department of Internal Medicine Rotterdam the Netherlands Erasmus Medical Center Department of Child and Adolescent Psychiatry/Psychology Sophia Children 's Hospital Rotterdam the Netherlands The Netherlands Research Institute of Child Development and Education University of Amsterdam the Netherlands

Background Transcatheter aortic valve implantation （TAVI） has become the standard treatment for patients with severe symptomatic aortic stenosis （AS） considered at very high risk for surgical aortic valve replacement. The purpose of this sub-study was to evaluate long-term （〉 4 years） health-related quality of life （QoL） in octogenarians who underwent TAVI. Methods A single center observational registry in twenty patients who underwent frame analysis assessment ≥ 4 years after TAVI. Health-related QoL was evaluated, using the Short Form-36 （SF-36）, the EuroQoL-5D （EQ-5D） and the visual analogue score （EQ-VAS） questionnaires. Results The mean SF-36 subscale scores at follow-up were physical functioning 40.8 ± 26.3, role physical functioning 67.7 ± 34.9, vitality 54.6 ± 21.6, general health 52.1 ± 20.4, social functioning 63.8 ± 37.7, role emotional functioning 70.2 ± 36.0, mental health 73.2 ± 23.3 and bodily pain 80.9 ± 22.9. The mean EQ-VAS score 〉 4 years after TAVI was 64.7 ± 15.1. With respect to functional class, 80% of the patients were in NYHA class I/II at follow-up compared to 15% prior to TAVI. Conclusions This sub-study reports a significant improvement in functional class （NYHA） in a selected group of very elderly patients 〉 4 years after TAVI. Furthermore, all patients showed a satisfactory QoL despite their age and multiple comorbidities. In addition, our study reveals a lower QoL when compared with the general age matched Dutch population.

关键词： Octogenarians Quality of life Transcatheter aortic valve implantation

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Different types of spin currents in the comprehensive materials database of nonmagnetic spin Hall effect

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npj Computational Materials 2021年第1期7卷 1522-1528页

作者： Yang Zhang Qiunan Xu Klaus Koepernik Roman Rezaev Oleg janson jakub Železný tomáš jungwirth Claudia Felser jeroen van den Brink Yan Sun Max Planck Institute for Chemical Physics of Solids 01187 DresdenGermany Leibniz Institute for Solid State and Materials Research 01069 DresdenGermany Department of Physics Massachusetts Institute of TechnologyCambridgeMA 02139USA Institute of Physics Czech Academy of SciencesCukrovarnicka 1016200 Praha 6Czech Republic School of Physics and Astronomy University of NottinghamNG72RD NottinghamUnited Kingdom Center for Nanoscale Systems Faculty of Arts and SciencesHarvard University11 Oxford StreetLISE 308CambridgeMA 02138USA Institut fur Theoretische Physik and Wurzburg-Dresden Cluster of Excellence ct.qmat Dresden University of Technology01062 DresdenGermany

Spin Hall effect(SHE)has its special position in *** gain new insight into SHE and to identify materials with substantial spin Hall conductivity(SHC),we performed high-precision high-throughput ab initio calculations of the intrinsic SHC for over 20,000 nonmagnetic *** calculations revealed a strong relationship between the magnitude of the SHC and the crystalline symmetry,where a large SHC is typically associated with mirror symmetry-protected nodal line band *** database includes 11 materials with an SHC comparable to or even larger than that of *** with different types of spin currents were additionally ***,we found that different types of spin current can be obtained by rotating applied electrical *** improves our understanding and is expected to facilitate the design of new types of spin-orbitronic devices.

关键词： symmetry magnetic effect

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Liver bioengineering:Current status and future perspectives

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World journal of Gastroenterology 2012年第47期18卷 6926-6934页

作者： Christopher Booth tom Soker Pedro Baptista Christina L Ross Shay Soker Umar Farooq Robert j Stratta Giuseppe Orlando Wake Forest Institute for Regenerative Medicine Wake Forest University School of MedicineWinston-SalemNC 27101United States Department of General Surgery Section of TransplantationWake Forest University School of MedicineWinston-SalemNC 27101United States

The present review aims to illustrate the strategies that are being implemented to regenerate or bioengineer livers for clinical *** are two general pathways to liver bioengineering and *** first consists of creating a supporting scaffold,either synthetically or by decellularization of human or animal organs,and seeding cells on the scaffold,where they will mature either in bioreactors or in *** strategy seems to offer the quickest route to clinical translation,as demonstrated by the development of liver organoids from rodent livers which were repopulated with organ specific cells of animal and/or human *** bioengineering has potential for transplantation and for toxicity testing during preclinical drug *** second possibility is to induce liver regeneration of dead or resected tissue by manipulating cell *** fact,it is well known that the liver has peculiar regenerative potential which allows hepatocyte hyperplasia after amputation of liver *** of autologous bone marrow cells,which aids in liver regeneration,into patients was shown to be safe and to improve their clinical condition,but the specific cells responsible for liver regeneration have not yet been determined and the underlying mechanisms remain largely unknown.A complete understanding of the cell pathways and dynamics and of the functioning of liver stem cell niche is necessary for the clinical translation of regenerative medicine *** well,it will be crucial to elucidate the mechanisms through which cells interact with the extracellular matrix,and how this latter supports and drives cell fate.

关键词： Liver Regenerative medicine Tissue engineering Extracellular matrix Scaffold Stem cells

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Assessment of the Effects of Poultry Litter on Surface Runoff Water Quality from Agricultural Lands

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journal of Water Resource and Protection 2010年第5期2卷 413-423页

作者： Sudarshan K. Dutta Shreeram P. Inamdar j. tom Sims Alyssa Collins 不详

The use of pelletized poultry litter (PPL) as a substitute for inorganic fertilizers is increasingly being en-couraged in states like Delaware which have a considerable surplus of poultry litter. However, we know very little about the impacts of PPL on runoff water quality and whether it is an environmentally-sound and sus-tainable alternative to inorganic fertilizer. To address these questions we compared the exports of nutrients (NH4-N, NO3-N and PO4-P) and trace elements (As, Cu, and Zn) in surface runoff from agricultural plots receiving PPL, raw poultry litter (RPL), urea and no-fertilizer (control) treatments. The study was conducted on agricultural land located in Middletown, Delaware with corn as the cover crop. The experimental plots were 5 m wide and 12 m long with reduced tillage and no-tillage management practices. Sampling was con-ducted for six natural rainfall events from April through August 2008. Nutrient (NH4-N, NO3-N and PO4-P) exports from plots receiving PPL were less than those with urea or raw litter applications. While exports of trace elements from the PPL treatment exceeded those from urea, they were much lower than the corre-sponding exports from the RPL treatments. Mass exports of nutrients and trace elements were correlated with event size (rainfall amount) but were not correlated with timing of event (days since litter application). Results from this study suggest that the use of PPL in combination with no-tillage may provide an environ-mentally safe alternative to synthetic fertilizers.

关键词： Poultry Litter Surface Runoff Water Quality Tillage Best Management Practices Nutrients Trace Elements

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