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Identification of potential biomarkers of Peyronie's disease

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Asian Journal of Andrology 2005年第3期7卷 237-243,页

作者： Gui-Ting Lin Zhong Wang Ben-Chun Liu tom F. Lu Ching-Shwun Lin Knuppe Molecular Urology Laboratory Department of Urology School of Medicine University of California San Francisco California 94143-1695 USA Department of Urology 9th Hospital Shanghai Second Medical University Shanghai 200011 China Department of Urology Huashan Hospital Fudan University Shanghai 200040 China

Aim： To identity proteins that are differentially expressed in cells derived from normal and diseased tunica albuginea （TA） as related to Peyronie＇s disease （PD）. Methods： Cells with characteristics of fibroblasts were isolated from two tissue sources. Those from the plaque of patients with PD were designated as PT cells, and those from the normally- appearing TA of the same patients were designated as NT cells. Messenger RNAs of these cells were analyzed by real-time polymerase chain reaction （RT-PCR） for the expression of monocyte chemoattractant protein 1 （MCP-1）. Crude protein lysates were analyzed by surface-enhanced laser desorption/ionization mass spectrometry （SELDI-MS） with IMAC30-Cu, CM10, and h50 chips. Each lysate was then separated into six fractions, which were further analyzed by SELDI-MS. Results： RT- PCR analysis showed that PT cells expressed higher levels of MCP-1 than their counterpart NT cells. SELDI-MS analysis showed that the crude protein lysates of all four cell strains produced similar and reproducible protein profiles on IMAC30-Cu and CM 10 chips. Additional SELDI-MS analyses with the fractionated lysates detected three proteins of 11.6 kDa, 14.5 kDa, 22.6 kDa that were upregulated in PT cells and two proteins of 6.3 kDa and 46,9 kDa that were downregulated in PT cells. Conclusion： MCP-1, which is often involved in tissue fibrosis, was expressed at higher levels in PT than that in NT cells. Five potential biomarkers for PD were identified by SELDI-MS analysis. （Asian J Androl 2005 Sep; 7： 237-243）

关键词： Peyronie's disease MCP-I tunica albuginea penis mass spectrometry SELDI

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C#技术内幕 1

三维不可压Navier-Stokes方程组轨道统计解的退化正则性

丛书名：微软Visual Studio.NET程序开发系列丛书

2002年

作者：（美）tom Archer 侯晓霞柴洪辉译

本书分为基础篇、C＃类基础、编写代码和高级C＃4个部分，分别描述了关于C＃和.NET开发环境的一个特定方面的内容，其中包括：C＃编程原则、类型系统、特性、多线程编程等。

ISBN: (数字)7900637591

ISBN: (纸本)7900637591

关键词： C语言程序设计

来源：畅想之星图书光盘版（南... 评论

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数学物理学报（A辑） 2021年第2期41卷 336-344页

作者：徐明月赵才地 tomás Caraballo 温州大学数理学院浙江温州325035 塞维利亚大学数学系西班牙塞维利亚41012

该文研究三维自治不可压Navier-Stokes方程组轨道统计解的退化正则性.作者证明了当该方程组的外力项具有h^(-1)正则性且Grashof数小于2.057时它的弱轨道统计解退化成具有部分正则性的统计解.同时也证明了当外力项具有L^(2)正则性且Gras... 详细信息

该文研究三维自治不可压Navier-Stokes方程组轨道统计解的退化正则性.作者证明了当该方程组的外力项具有h^(-1)正则性且Grashof数小于2.057时它的弱轨道统计解退化成具有部分正则性的统计解.同时也证明了当外力项具有L^(2)正则性且Grashof数小于2.057时它的轨道统计解退化成强轨道统计解.

关键词：轨道统计解退化正则性三维不可压Navier-Stokes方程组轨道吸引子 Grashof数

玉米秸秆液化制备生物高聚物材料的研究(英文)

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农业工程学报 2005年第12期21卷 116-120页

作者：刘玉环阮榕生林向阳虞飞陈灵邓少波李宇红 Vance Morey tom Yang 美国明尼苏达大学生物系统与农业工程系和食品营养系

该研究旨在探讨低温生物质液化技术及液化产物应用的可能性。以玉米秸秆为原料在酸性、常压条件下快速液化成多羟基化合物,再以多羟基化合物为原料合成一系列的聚合材料。采用不同的有机溶剂,在稀硫酸的催化作用下,对不同的温度下生物... 详细信息

该研究旨在探讨低温生物质液化技术及液化产物应用的可能性。以玉米秸秆为原料在酸性、常压条件下快速液化成多羟基化合物,再以多羟基化合物为原料合成一系列的聚合材料。采用不同的有机溶剂,在稀硫酸的催化作用下,对不同的温度下生物质的液化效果进行研究。同时探讨了液化有机溶剂同生物质物料的混合比率对液化过程的影响。试验表明,碳酸乙烯酯比乙烯醇具有较高的液化率。优化试验结果表明,在较佳的液化效果下,有机溶剂同玉米秆的混合比率为3∶1,反应温度160℃,稀硫酸浓度3%,反应时间2.5 h。液化产物经稀释、调节ph值、过滤、臭氧氧化一系列过程的处理后得到具有高活性多羟基聚合物。阐述了以多羟基聚合物制备各种生物聚合物材料如聚酯薄膜、聚胺酯泡沫和颗粒板的方法。聚酯薄膜是多羟基化合物上的羟基和多元酸上的羧基通过酯化反应形成的;聚胺酯泡沫通过多羟基化合物上的羟基和二异氰酸酯反应形成。研究表明以多羟基化合物和多元酸(酐)形成的聚酯型胶粘剂适合于制造颗粒板。

关键词：生物质玉米秸秆液化生物多羟基化合物生物高聚物

Fecal microbiota transplantation for the treatment of irritable bowel syndrome:A systematic review and meta-analysis

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World Journal of Gastroenterology 2023年第20期29卷 3185-3202页

作者： Sofie Ingdam halkjaer Bobby Lo Frederik Cold Alice hojer Christensen Savanne holster Julia Konig Robert Jan Brummer Olga C Aroniadis Perttu Lahtinen tom holvoet Lise Lotte Gluud Andreas Munk Petersen Gastro Unit Medical DivisionCopenhagen University Hospital HvidovreHvidovre 2650Denmark Copenhagen IBD Center Copenhagen University Hospital HvidovreHvidovre 2650Denmark Department of Gastroenterology Aleris-Hamlet Hospitals CopenhagenSøborg 2860Denmark Nutrition-Gut-Brain Interactions Research Centre Faculty of Medicine and HealthSchool of Medical SciencesÖrebro UniversityÖrebro 70362Sweden Department of Internal Medicine Division of GastroenterologyRenaissance School of MedicineStony Brook University HospitalNew YorkNY 11794-8434United States Department of Internal Medicine Päijät-Häme Central HospitalLahti 15850Finland Department of Medicine University of HelsinkiHelsinki 00014Finland Department of Gastroenterology University Hospital GhentGhent 9000Belgium Department of Clinical Medicine University of CopenhagenCopenhagen 2200Denmark Department of Clinical Microbiology Copenhagen University Hospital HvidovreHvidovre 2650Denmark

BACKGROUND Irritable bowel syndrome(IBS)is the most prevalent gastrointestinal disorder in developed countries and reduces patients’quality of life,hinders their ability to work,and increases health care costs.A growing number of trials have demonstrated an aberrant gut microbiota composition in IBS,also known as‘gut dysbiosis’.Fecal microbiota transplantation(FMT)has been suggested as a treatment for *** To assess the efficacy and safety of FMT for the treatment of *** We searched Cochrane Central,MEDLINE,EMBASE and Web of Science up to 24 October 2022 for randomised controlled trials(RCTs)investigating the effectiveness of FMT compared to placebo(including autologous FMT)in treating *** primary outcome was the number of patients with improvements of symptoms measured using a validated,global IBS symptoms *** outcomes were changes in quality-of-life scores,non-serious and serious adverse *** ratios(RR)and corresponding 95%CI were calculated for dichotomous outcomes,as were the mean differences(MD)and 95%CI for continuous *** Cochrane risk of bias tool was used to assess the quality of the *** criteria were used to assess the overall quality of the *** Eight RCTs(484 participants)were included in the *** resulted in no significant benefit in IBS symptoms three months after treatment compared to placebo(RR 1.19,95%CI:0.68-2.10).Adverse events were reported in 97 participants in the FMT group and in 45 participants in the placebo group(RR 1.17,95%CI:0.63-2.15).One serious adverse event occurred in the FMT group and two in the placebo group(RR 0.42,95%CI:0.07-2.60).Endoscopic FMT delivery resulted in a significant improvement in symptoms,while capsules did *** did not improve the quality of life of IBS patients but,instead,appeared to reduce it,albeit non significantly(MD-6.30,95%CI:-13.39-0.79).The overall quality of the evidence was low due to moderate-high inconsistency,the small number of

关键词： Fecal microbiota transplantation Irritable bowel syndrome Meta-analysis Systematic review

Mangrove forests as a nature-based solution for coastal flood protection:Biophysical and ecological considerations

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Water Science and Engineering 2023年第1期16卷 1-13页

作者： Rosanna van hespen Zhan hu Bas Borsje Michela De Dominicis Daniel AFriess Svetlana Jevrejeva Maarten GKleinhans Maria Maza Celine EJvan Bijsterveldt tom Van der Stocken Bregje van Wesenbeeck Danghan Xie Tjeerd JBouma NIOZ Royal Netherlands Institute for Sea Research Department of Estuarine and Delta SystemsP.O.Box 1404400 AC Yersekethe Netherlands Faculty of Geosciences Department of Physical GeographyUtrecht UniversityP.O.Box 80.1153508 TC Utrechtthe Netherlands School of Marine Science Sun Yat-Sen University Zhuhai Campus2 University RoadZhuhai 519000China Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering Guangzhou 510275China Pearl River Estuary Marine Ecosystem Research Station Ministry of EducationZhuhai 519082China Water Engineering&Management University of TwenteP.O.Box 2177500 AE Enschedethe Netherlands National Oceanography Centre Joseph Proudman Building6 Brownlow StreetLiverpool L35DAUK Department of Geography National University of Singapore1 Arts LinkSingapore 117570Singapore Centre for Nature-based Climate Solutions National University of Singapore16 Science Drive 4Singapore 117558Singapore Instituto de hidraulica Ambiental de La Universidad de Cantabria(IhCantabria) Isabel Torres 1539011 SantanderSpain Wetlands International P.O.Box 4716700 AL Wageningenthe Netherlands Ecology and Biodiversity Group Department of BiologyVrije Universiteit BrusselPleinlaan 2B-1050 BrusselsBelgium Earth Science Section Jet Propulsion LaboratoryCalifornia Institute of Technology4800 Oak Grove DrivePasadenaCA 91109USA Unit for Marine and Coastal Systems Deltares2600 MH Delftthe Netherlands Department of hydraulic Engineering Delft University of Technology2600 GA Delftthe Netherlands

Nature-based coastal protection is increasingly recognised as a potentially sustainable and cost-effective solution to reduce coastal flood *** uses coastal ecosystems such as mangrove forests to create resilient designs for coastal flood ***,to use mangroves effectively as a nature-based measure for flood risk reduction,we must understand the biophysical processes that govern risk reduction capacity through mangrove ecosystem size and *** this perspective,we evaluate the current state of knowledge on local physical drivers and ecological processes that determine mangrove functioning as part of a nature-based flood *** show that the forest properties that comprise coastal flood protection are well-known,but models cannot yet pinpoint how spatial heterogeneity of the forest structure affects the capacity for wave or surge ***,there is relatively good understanding of the ecological processes that drive forest structure and size,but there is a lack of knowledge on how daily bed-level dynamics link to long-term biogeomorphic forest dynamics,and on the role of combined stressors influencing forest *** simulation models of forest structure under changing physical(*** to sea-level change)and ecological drivers with hydrodynamic attenuation models will allow for better projections of long-term natural coastal protection.

关键词： Forest dynamics Seedling establishment hydrodynamic energy attenuation Bed-level dynamics Forest structure Mangrove tree mortality

Increased branching independent of strigolactone in cytokinin oxidase 2-overexpressing tomato is mediated by reduced auxin transport

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Molecular horticulture 2022年第1期2卷 153-171页

作者： Lilian Ellen Pino Joni E.Lima Mateus h.Vicente Ariadne F.L.de Sá Francisco Pérez-Alfocea Alfonso Albacete Juliana L.Costa tomášWerner Thomas Schmülling Luciano Freschi Antonio Figueira Agustin Zsögön Lázaro E.P.Peres Laboratory of Plant Breeding Centro de Energia Nuclear na AgriculturaUniversity of Sao PauloSão PauloBrazil Laboratory of hormonal Control of Plant Development Department of Biological SciencesEscola Superior de Agricultura‘Luiz de Queiroz’University of Sao PauloPiracicabaBrazil Botany Department ICBFederal University of Minas GeraisBelo HorizonteBrazil Department of Plant Nutrition CEBAS-CSICCampus Univ.EspinardoMurciaSpain Institute of Biology/Applied Genetics Freie Universität BerlinBerlinGermany Institute of Biology University of GrazSchubertstraße 518010 GrazAustria Biosciences Institute University of Sao PauloSão PauloBrazil Plant Sciences Department Federal University of ViçosaViçosaBrazil

tomato production is influenced by shoot branching,which is controlled by different *** we produced tomato plants overexpressing the cytokinin-deactivating gene CYTOKININ OXYDASE 2(CKX2).CKX2-overexpressing(CKX2-OE)plants showed an excessive growth of axillary shoots,the opposite phenotype expected for plants with reduced cytokinin content,as evidenced by LC-MS analysis and ARR5-GUS *** TCP transcription factor SlBRC1b was downregulated in the axillary buds of CKX2-OE and its excessive branching was dependent on a functional version of the GRAS-family gene LATERAL SUPPRESSOR(LS).Grafting experiments indicated that increased branching in CKX2-OE plants is unlikely to be mediated by root-derived *** CKX2-OE plants with transgenic antisense plants for the strigolactone biosynthesis gene CAROTENOID CLEAVAGE DIOXYGENASE(CCD7-AS)produced an additive phenotype,indicating independent effects of cytokinin and strigolactones on increased *** the other hand,CKX2-OE plants showed reduced polar auxin transport and their bud outgrowth was reduced when combined with auxin ***,CKX2-OE basal buds did not respond to auxin applied in the decapitated *** results suggest that tomato shoot branching depends on a fine-tuning of different hormonal balances and that perturbations in the auxin status could compensate for the reduced cytokinin levels in CKX2-OE plants.

关键词： CKX2 hormones Plant development Solanum

Individualized Isonatremic and hyponatremic Dialysate Improves Blood Pressure in Patients with Intradialytic hypertension: A Prospective Cross-Over Study with 24-h Ambulatory Blood Pressure Monitoring

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Open Journal of Nephrology 2020年第2期10卷 144-157页

作者： tom Robberechts Mandelina Allamani Xavier Galloo Karl Martin Wissing Patricia Van Der Niepen Department of Nephrology and hypertension Universitair Ziekenhuis Brussel VUB Brussels Belgium

Background. Intradialytic hypertension, a paradoxical rise in systolic blood pressure from pre- to postdialysis, is a poorly understood and difficult-to-treat phenomenon. We examined the effects of individually adjusted isonatremic and hyponatremic dialysate on intradialytic and interdialytic blood pressure in patients with intradialytic hypertension. Methods. We enrolled 11 patients with intradialytic hypertension in a prospective randomized cross-over study, with 4 treatment periods of different dialysate sodium concentrations. Period 1 (run-in) and 3 (wash-out) were standardized at 140 mEq/L;period 2 and 4 with iso- or hyponatremic sodium dialysate. Blood pressure was recorded each dialysis session, and 24-hour ambulatory blood pressure monitoring was performed at the end of each treatment period. Results. Isonatremic and hyponatremic dialysate were associated with significantly lower pre- and post-dialysis blood pressure as compared to baseline 140 mEq/L dialysate (predialysis 148.3 ± 24.7/67.7 ± 12.0 and 144.4 ± 16.5/68.8 ± 13.3 vs. 158.0 ± 18.3/75.6 ± 11.4 mmhg, resp p = 0.04 and 0.007 for systolic and p = 0.004 and 0.04 for diastolic blood pressure;postdialysis 154.2 ± 25.5/76.6 ± 14.1 and 142.5 ± 20.7/73.0 ± 12.9 vs. 159.1 ± 21.6/80.3 ± 12.1 mmhg, resp NS and p = 0.01 for systolic and NS and p = 0.04 for diastolic blood pressure). Postdialysis and 24 h systolic blood pressure tended to be lower with hyponatremic compared to isonatremic dialysate. Conclusion. Individually tailoring dialysate sodium concentration, based on the sodium set-point of each patient, resulted in a lower pre- and post-dialysis blood pressure in patients with intradialytic hypertension. 24 h blood pressure values tended to be lower as well with hyponatremic dialysate.

关键词： Intradialytic hypertension Ambulatory Blood Pressure Monitoring Dialysate Sodium Concentration

Patents on antivirulence therapies

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World Journal of Pharmacology 2014年第4期3卷 97-109页

作者： María López Beathriz Barbosa Eva Gato Germán Bou María tomás Servicio de Microbiología Complejo Hospitalario Universitario A Coru?a-INIBIC 15006 La Coru?a Spain Departamento de Microbiologia Imunologia e Parasitologia-FCM/UERJ 20551-030 Rio de Janeiro Brazil

Antivirulence therapy inhibits bacterial virulence factors, thus preventing the development of infection without affecting bacterial growth. The development of new antibiotics is complicated by the increasing incidence of antibiotic resistance in pathogenic bacteria. Antiviru-lence therapy is a promising alternative to traditional an-tibiotic therapy for the treatment of infectious disease, either alone or in combination with antibiotic treatment. In this review, we consider patents concerning inhibition of several bacterial virulence factors： adhesion/colonization, secretion systems, cellular signalling systems and antimicrobial resistance mechanisms. Finally, we emphasize the importance of analyzing new targets and/or molecules in this feld and of considering possible resistance mechanisms.

关键词： Patents Quorum sensing Adhesion Bacterial secretory systems Resistance