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Survival trends of patients with non-metastatic gastric adenocarcinoma in the US and European countries:the impact of decreasing resection rates

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Cancer Communications 2022年第7期42卷 648-662页

作者： Lei huang Lina Jansen Rob h.A.Verhoeven Jelle P.Ruurda Liesbet Van Eycken harlinde De Schutter Jan Johansson Mats Lindblad tom B.Johannesen Vesna Zadnik Tina Zagar Sjoerd M.Lagarde Cornelis J.hvan de Velde Petra Schrotz-King hermann Brenner Division of Clinical Epidemiology and Aging Research German Cancer Research Center(DKFZ)Heidelberg 69120Germany Medical Faculty heidelberg of heidelberg University Heidelberg 69120Germany German Cancer Consortium German Cancer Research CenterHeidelberg 69120Germany Department of Research&Development Netherlands Comprehensive Cancer OrganizationUtrecht 3501 DBThe Netherlands Department of Medical Oncology Amsterdam University Medical CentersAmsterdam 1105 AZThe Netherlands Department of Surgery University Medical Center UtrechtUtrecht 3508 GAThe Netherlands Belgian Cancer Registry Brussels B-1210Belgium Department of Esophageal and Gastric Surgery Lund University HospitalLund 22185Sweden Department of Clinical Science Interventionand TechnologyDivision of SurgeryKarolinska University HospitalStockholm 17176Sweden Registry Department The Cancer Registry of NorwayOslo 0379Norway Epidemiology and Cancer Registry Institute of Oncology LjubljanaLjubljana 1000Slovenia Department of Surgery Erasmus Medical Centre-University Medical Centre RotterdamRotterdam 3015 CEThe Netherlands Department of Surgical Oncology Leiden University Medical CenterLeiden 2300 RCThe Netherlands Division of Preventive Oncology German Cancer Research Center and National Center for Tumor DiseasesHeidelberg 69120Germany

Background:We previously observed decreasing resection rates of nonmetastatic gastric adenocarcinoma(GaC)in the US and some European *** and to what extent these trends affect the trends in overall survival(OS)of patients with non-metastatic GaC at the population level remain *** large international population-based cohort study aimed to assess the impact of the previously observed decreasing resection rates on multivariable-adjusted trends in the long-term OS of patients with non-metastatic ***:Individual-level data of patients with non-metastatic GaC were obtained from the national cancer registries of the Netherlands,Belgium,Sweden,Norway,and Slovenia,and the US Surveillance,Epidemiology,and End Results *** analyzed data for each country *** between year of diagnosis and OS were assessed using Cox proportional hazards regression model with adjustment for multiple prognostic variables,with and without including resection and chemotherapy as potential explanatory ***:A total of 66,398 non-metastatic GaC patients diagnosed in 2003-2016 were analyzed,with an accumulated follow-up of 172,357 *** adjustment for resection,OS was improved only slightly in the US[hazard ratio(hR)_(per year)=0.99;hR_(≥vs.he investigated European countries,with OS even worsening in Sweden(hR_(per year)=1.03;hR_(≥vs.he increasing OS trend became stronger in the US(hR_(per year)=0.98;hR_(≥vs.he temporal trend became insignificant in *** Slovenia(hR_(per year)=0.99;hR_(≥vs.hR_(per year)=0.97;hR_(≥vs.he US,the Netherlands,and *** for chemotherapy did not alter the observed *** analyses by tumor location showedm

关键词： gastric adenocarcinoma resection rate adjusted overall survival temporal trend prognostic factors international population-based cohort study

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Realization of a Nine-Level Cascaded NPC/h-Bridge PWM Inverter Using Phase-Shifted Carrier PWM Technique

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Journal of Energy and Power Engineering 2012年第8期6卷 1335-1342页

作者： tom Wanjekeche Dan Valentin Nicolae Adisa Abdul Jimoh Department of Electrical Engineering Tshwane University of Technology Pretoria Private Bag X680 South Africa

Cascaded h-Bridge inverter has been researched for the past two decades, but there are no explicit guidelines on how one can realize a cascaded NPC （neutral-point-clamped）/h-Bridge inverter. Past research has also concentrated on realizing a five-level NPC/h-Bridge inverter. This fails to address the principle of realizing a general cascaded N-level NPC/h-Bridge PWM inverter. This paper proposes an improved topology for achieving a nine-level cascaded NPC （neutral-point-clamped） h-Bridge inverter with reduced harmonic content. This new proposed topology requires a lesser number of separate dc sources as compared to conventional cascaded h-Bridge inverter. The whole system is considered as having four three level legs having two positive and two negative legs. By properly phase shifting the modulating wave and carriers, a nine-level output is achieved. A theoretical harmonic analysis of the proposed inverter is carried out based on double Fourier principle. The theoretical results are verified through MATLAB simulation.

关键词： harmonic content NPC/h-Bridge PWM inverter phase shifted carrier PWM technique three level inverter.

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真菌Drechslera catenaria聚酮类代谢产物及聚酮合成酶基因的初步研究

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中国抗生素杂志 2011年第12期36卷 905-911页

作者：史彦斌宋中枢 tom J Simpson 支德娟兰州大学药学院兰州730000 School of Chemistry University of Bristol

目的分离分析内脐蠕孢真菌(Drechslera catenaria)的次级聚酮类代谢产物,初步分析其非还原型I型聚酮合成酶基因组成,为该菌株中大黄酚生物合成机制的阐明奠定理论基础。方法应用Czapek Dox培养基发酵培养,酸化乙酸乙酯提取,硅胶柱层析... 详细信息

目的分离分析内脐蠕孢真菌(Drechslera catenaria)的次级聚酮类代谢产物,初步分析其非还原型I型聚酮合成酶基因组成,为该菌株中大黄酚生物合成机制的阐明奠定理论基础。方法应用Czapek Dox培养基发酵培养,酸化乙酸乙酯提取,硅胶柱层析及薄层制备等方法,对该菌株产生的聚酮类代谢产物进行分离纯化;利用紫外(UV),液相-质谱联用(LC-MS)和核磁共振谱(1h-NMR)鉴定化学结构;基于真菌聚酮合成酶保守序列设计引物,克隆与代谢产物合成相关的聚酮合成酶基因。结果与结论从试验菌株菌丝体及发酵液中分离获得4个芳香聚酮类化合物,其结构分别为大黄酚(chrysophanol),长蠕孢素(helminthosporin),冰岛青霉素(islandicin),链蠕孢素(catenarin),其中后3个为首次从该真菌中得到。从基因组DNA中得到一段非还原性聚酮合成酶(PKS)基因序列(约5.3kb),与Pyrenophora tritici-repentis Pt-1C-BFP中黄色色素合成相关的基因片段有较高类似度,很有可能与内脐蠕孢真菌中大黄酚的生物合成有关;在距离该基因2.5kb处克隆到一段基因序列(0.79kb),与***-repentis Pt-1C-BFP中β-酮酯酰基-ACP-还原酶(KR)基因完全相似,其很可能负责大黄素的6位羰基经还原形成大黄酚。

关键词：内脐蠕孢真菌聚酮类代谢产物聚酮合成酶基因

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The Identification and Treatment of Gait Problems in Cerebral Palsy 2

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2009年

作者： Gage, James R./ Schwartz, Michael h./ Koop, Steven E./ Novacheck, tom F.

ISBN: (纸本)9781898683650

The only book to deal specifically with the treatment of gait problems in cerebral palsy, this comprehensive, multi-disciplinary volume will be invaluable for all those working in the field of cerebral palsy and gait (neurologists, therapists, physiatrists, orthopaedic and neurosurgeons, and bioengineers). The book is divided into two parts. The first is designed to help the reader evaluate and understand a child with cerebral palsy. It deals with neurological control, musculoskeletal growth, and normal gait, as well as cerebral injury, growth deformities and gait pathology in children with cerebral palsy. The second section is a comprehensive overview of management. It emphasizes the most fundamental concept of treatment: manage the child's neurologic dysfunction first and then address the skeletal and muscular consequences of that dysfunction. The book has been thoroughly updated since the previous edition, with a greater focus on treatment and several entirely new topics covered, including chapters on the operative treatment of orthopaedic deformities. The book is accompanied by a DVD containing a teaching video on normal gait and a CD-ROM containing the videos and motion analysis data of all case examples used in the book, as well as teaching videos demonstrating the specifics of many of the procedures used in the correction of gait deformities and gait modelling examples from the Department of Bioengineering at Stanford University.

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解析约翰·斯图亚特·穆勒《功利主义》

解析约翰·斯图亚特·穆勒《功利主义》

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2019年

作者： Patrick tom，Sander Werkhoven

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sTREM-1 is a specific biomarker of TREM-1 pathway activation

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Cellular & Molecular Immunology 2021年第8期18卷 2054-2056页

作者： Lucie Jolly Kévin Carrasco Margarita Salcedo-Magguilli Jean-Jacques Garaud Simon Lambden tom van der Poll Alexandre Mebazaa Pierre-François Laterre Sebastien Gibot Amir Boufenzer Marc Derive Inotrem Vandœuvre-lès-NancyFrance Division of Infectious Diseases Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands Intensive Care Unit Saint Louis-Lariboisière-Fernand Widal University HospitalAssistance Publique Hôpitaux de Parisand Universitéde ParisInserm MASCOTParisFrance Intensive Care Unit UniversitéCatholique de LouvainLouvain-la-NeuveBelgium Intensive Care Unit CHRU de Nancyand Universitéde LorraineNancyFrance

TREM-1(triggering receptor expressed on myeloid cells-1)is a transmembrane receptor expressed by innate immune cells,including endothelial cells and ***-1 is a crucial mediator of septic shock that acts by synergizing with Toll-like receptors(TLRs)to amplify the inflammatory responses to pathogens,thus promoting sepsis-induced immune dysregulation and organ dysfunction[1,2,3].

关键词： immune myeloid activation

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Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice

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World Journal of Gastroenterology 2010年第6期16卷 703-712页

作者： Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans tom G Moreels Laboratory of Experimental Medicine and Pediatrics Division of GastroenterologyUniversity of Antwerp Division of Infectious Diseases and Immunology Queensland Institute of Medical Research 4006 Brisbane Division of Gastroenterology-hepatology Tufts New England Medical Center

AIM:To investigate the therapeutic effect of Schistosoma mansoni(***) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METhODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with *** *** were performed 5 d after TNBS *** quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal *** activity of distal colonic segments was studied in vitro using a modified Trendelenburg *** profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe *** with *** proteins significantly ameliorated colonic inflammation after 5 *** did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of *** with *** proteins ameliorated these in vivo and in vitro motility *** addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a *** protein effect was no longer observed at this time point. CONCLUSION:Treatment with *** proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis.

关键词： Schistosoma mansoni helminth proteins Colitis Peristalsis Crohn’s disease Gastrointestinal motility Trinitrobenzene sulphate

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Enhanced cell transfection using subwavelength focused optical eigenmode beams[Invited]

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Photonics Research 2013年第1期1卷 42-46页

作者： Xanthi Tsampoula Michael Mazilu tom Vettenburg Frank Gunn-Moore Kishan Dholakia SUPA School of Physics and AstronomyUniversity of St.AndrewsSt.Andrews KY169SSUK School of Biology Medical and Biological Science BuildingUniversity of St.AndrewsSt.AndrewsNorth HaughFife KY169TFUK

We show that superoscillating light fields,created using the method of optical eigenmodes,enable more efficient multiphoton-mediated cell *** hamster ovary cells are transfected with a plasmid and exhibit expression of DsRed-Mito in the *** demonstrate an efficiency improvement of 35%compared to the diffraction-limited *** opens up new vistas for nanoscale localized cell transfection.

关键词： enable oscillating eigen

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大比尺切削模型试验条件下砂岩破坏特征研究

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岩土力学 2020年第4期41卷 1211-1218页

作者：刘功勋李威洪国军张坤勇 ChEN Xiu-han 施绍刚 RUTTEN tom 中交疏浚技术装备国家工程研究中心有限公司上海201208 南京水利科学研究院岩土工程研究所江苏南京210024 河海大学岩土工程科学研究所江苏南京210098 代尔夫特理工大学海洋及疏浚工程系荷兰代尔夫特

为探究单刀齿线性切削作用下岩石的破坏规律,利用大比尺模型试验平台对砂岩开展了线性切削试验,结合分形几何学方法,对砂岩在不同切削角度及不同切削深度下的切削产物,包括切削沟槽的尺寸及切削碎块的几何特征进行了分析。试验结果表明... 详细信息

为探究单刀齿线性切削作用下岩石的破坏规律,利用大比尺模型试验平台对砂岩开展了线性切削试验,结合分形几何学方法,对砂岩在不同切削角度及不同切削深度下的切削产物,包括切削沟槽的尺寸及切削碎块的几何特征进行了分析。试验结果表明,切削影响宽度与切削深度呈良好的线性关系,且随切削深度的增加而增加,切削角度为45°时相同切削深度对应的切削影响宽度最小。砂岩的切削碎块块度分布具有分形特征,分形维数集中在1.88~2.66。分形维数与切削深度呈良好的线性关系,随切削深度的增加而减小。分形维数与切削角度间的关系可统一用二次函数进行拟合,但随着切削深度的增加,函数二次项系数由正值变为负值。

关键词：大比尺模型试验线性切削砂岩分形维数切削参数切削沟槽

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Targeting Divalent Metal Ions at the Active Site of the hIV-1 RNase h Domain: NMR Studies on the Interactions of Divalent Metal Ions with RNase h and Its Inhibitors

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American Journal of Analytical Chemistry 2011年第6期2卷 639-649页

作者： Jiangli Yan haihong Wu Tiffany tom Oleg Brodsky Karen Maegley 不详

hIV-1 reverse transcriptase (RT) RNase h (hIV-Rh) is a key target of anti-AIDS drugs. Metal-chelating compounds are an important class of chemicals in pharmacological drug discovery, especially in relation to hIV-RT and the highly-related hIV-integrase. The correlation between the metal-chelating properties and enzyme activities of the metal chelators is always of high scientific interest, as an understanding of this may accelerate the rational optimization of this class of inhibitors. Our NMR data show that Mg2+ and Ca2+ bind specifically to the active site of the RNase h domain and two Mg2+ ions sequentially bind one molecule of RNase h. We also demonstrate here, using saturated and unsaturated tricyclic N-hydroxypyridones designed to block the active site, that the primary binding sites and affinities of divalent metal ions are correlated with the structures of the chelating motifs. Chemical shift perturbation studies of protein/metal-ion/compound ternary complexes also indicate that divalent metal ions play important roles for the specific interaction of the compounds with the RNase h active site.

关键词： Metal Chelation hIV-1 Reverse Transcriptase RNase h NMR Spectroscopy

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