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Secondary rectal linitis plastica caused by prostatic adenocarcinoma-magnetic resonance imaging findings and dissemination pathways:A case report

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world Journal of Radiology 2024年第9期16卷 473-481页

作者： Andres Antonio Labra Giancarlo Schiappacasse Rolando Alfonso Cocio Jorge tomás torres Fernando Omar González Joaquin Alberto Cristi Marcela Schultz department of Radiology Facultad de Medicina Clínica Alemana-Universidad del DesarrolloSantiago 7650568Región MetropolitanaChile department of Pathology Clínica Alemana de SantiagoSantiago 7650568Región MetropolitanaChile

BACKGROUND Secondary rectal linitis plastica(RLP)from prostatic adenocarcinoma is a rare and poorly understood form of metastatic spread,characterized by a desmoplastic response and concentric rectal wall infiltration w.th mucosal *** complicates endoscopic diagnosis and can mimic gastrointestinal *** case series underscores the critical role of magnetic resonance imaging(MRI)in identifying the distinct imaging features of RLP and highlights the importance of considering this condition in the differential diagnosis of patients w.th a history of prostate *** SUMMARY three patients w.th secondary RLP due to prostatic adenocarcinoma presented w.th varied clinical *** first patient,a 76-year-old man w.th advanced prostate cancer,had rectal pain and *** showed diffuse prostatic invasion and significant rectal wall thickening w.th a characteristic"target sign"*** second,a 57-year-old asymptomatic man w.th elevated prostatespecific antigen levels and a history of prostate cancer exhibited rectoprostatic angle involvement and rectal wall thickening on MRI,w.th positron emission tomography/computed tomography PSMA confirming the prostatic origin of the metastatic *** third patient,an 80-year-old post-radical prostatectomy,presented w.th refractory *** revealed a neoplastic mass infiltrating the rectal *** all cases,MRI consistently showed stratified thickening,concentric signal changes,restricted diffusion,and contrast enhancement,which were essential for diagnosing secondary *** confirmed the prostatic origin of the neoplastic involvement in the *** Recognizing MRI findings of secondary RLP is essential for accurate diagnosis and management in prostate cancer patients.

关键词： Rectal linitis plastica Prostatic adenocarcinoma Signet ring cell carcinoma Metastatic spread Magnetic resonance imaging Concentric wall infiltration Case report

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Influence of bed elevation discordance on flow patterns and head losses in an open-channel confluence

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w.ter Science and Engineering 2019年第3期12卷 235-243页

作者： Pedro Xavier Ramos Laurent Schindfessel Joao Pedro Pego tom de Mulder department of Civil Engineering Ghent University Ghent 9000 Belgium Faculty of Engineering University of Porto Porto 4200-465 Portugal

Confluences play a major role in the dynamics of networks of natural and man-made open channels, and field measurements on river confluences reveal that discordance in bed elevation is *** of schematized confluences w.th a step at the interface between the tributary and the main channel bed reveal that bed elevation discordance is an important additional control for the confluence *** study aimed to improve understanding of the influence of bed elevation discordance on the flow patterns and head losses in a right-angled confluence of an open channel w.th rectangular cross-sections.A large eddy simulation (LES)-based numerical model was set up and validated w.th experiments by *** configurations w.th different bed discordance ratios were *** results confirm that, w.th increasing bed elevation discordance, the tributary streamlines at the confluence interface deviate less from the geometrical confluence angle, the extent of the recirculation zone (RZ) gets smaller, the ratio of the w.ter depth upstream to that downstream of the confluence decreases, and the w.ter level depression *** bed elevation discordance also leads to the development of a large-scale structure in the lee of the *** the appearance of the large-scale structure, the reduced extent of the RZ and associated changes in flow deflection/contraction reduce total head losses experienced by the main channel w.th an increase of the bed discordance *** turns out that bed elevation discordance converts the lateral momentum from the tributary to streamwise momentum in the main channel more efficiently.

关键词： Open channel confluence Bed elevation discordance three-dimensional numerical modelling Large eddy simulation Recirculation zone

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“the response of stromatolites to seismic shocks: tomboliths from the Palaeoproterozoic Chaibasa Formation,E India”: Reply

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Journal of Palaeogeography 2017年第3期6卷 235-241页

作者： A.J. (tom) van Loon Rajat Mazumder Shuvabrata de College of Earth Science and Engineering Shandong University of Science and Technology Geocom Consultants department of Applied Geology Faculty of Science and EngineeringCurtin University Sarawak Geological Studies Division CSIR-National Geophysical Research Institute

Our contribution about a newly recognized sedimentological feature, which we called tombolith,has raised some comments on the etymology of the term, the assumed lack of field data, the usage of a term that has a special meaning in stratigraphy, the origin of the seismic shocks that played a role, so-called basic tenets, the origin of soft-sediment deformation structures, and the role of liquefaction. we argue that most comments result from an insufficiently thorough reading of our text, whereas some other remarks concern aspects that we did not deal w.th. Finally, several remarks are based on outdated literature and from insufficient knowledge of the regional geology.

关键词： Stromatolites Seismic shocks Palaeoproterozoic Singhbhum Craton tomboliths India

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the mechanism of auxin transport in lateral root spacing

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Molecular Plant 2021年第5期14卷 708-710页

作者： Jian Chen Hugues de Gernier Alaeddine Safi tom Beeckman Steffen Vanneste department of Plant Biotechnology and Bioinformatics Ghent University9052 GhentBelgium Centerfor Plant Systems Biology VIB9052 GhentBelgium Lab of Plant Growth Analysis Ghent University Global CampusIncheon 21985Republic of Korea department of Plants and Crops Ghent University9000 GhentBelgium

transport of the plant hormone auxin(lndole-3-acetic acid;IAA)is crucial to ensure proper growth *** particular,the regular spacing of lateral roots(LRs)is governed by intricate auxin movements and an internal oscillator,called the“root clock”(Xuan et al.,2020).Multiple auxin influx and efflux carriers have been characterized in the broad context of root development.

关键词： development. spacing

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FURtHER OPENING- UP IS KEY FOR CHINA’S HIGH-QUALItY deVELOPMENt

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China Report ASEAN 2024年第1期9卷 64-64页

作者： tom Fowdy international relations analyst and a graduate of Durham and Oxford universities

the Central Economic work Conference was held in Beijing from december 11 to *** conference discussed the plans,prospects and challenges for China’s economy heading into 2024,as well as evaluating the events of this *** goes w.thout saying that 2023 has been a challenging year for countries around the world as the global context has been *** geopolitical tensions have created a rise in uncertainties which have led to reduced growth worldwide and sent many economies into *** light of the critical factors affecting the stability of the global economy,China’s primary economic goal corresponds w.th the promotion and sustaining of free trade.

关键词： promotion heading OPEN

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CHINA’S PUSH FOR UNIFIED NAtIONAL MARKEt BRINGS NEw OPPORtUNItIES

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China Report ASEAN 2024年第2期9卷 79-79页

作者： tom Fowdy Durham and Oxford universities

In recent years,China has implemented measures to advance the building of a unified national market,aiming to boost domestic demand and consolidate the foundations of its economic *** March 2022,the Chinese government issued a guideline on accelerating the construction of a unified national *** issue was also a focus at the annual Central Economic work Conference held in december 2023.

关键词： unified PUSH measures

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Histologically proven hepatic steatosis associates w.th lower testosterone levels in men w.th obesity

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Asian Journal of Andrology 2020年第3期22卷 252-257页

作者： Frederique Van de Velde Marlies Bekaert Anne Hoorens Anja Geerts Guy t'Sjoen tom Fiers Jean-Marc Kaufman Yves Van Nieuwenhove Bruno Lapauw department of Endocrinology Ghent University Hospital9000 GhentBelgium department of Pathology Ghent University Hospital9000 GhentBelgium department of Hepathology Ghent University Hospital9000 GhentBelgium department of Clinical Biology Ghent University Hospital9000 GhentBelgium department of Gastro-Intestinal Surgery Ghent University Hospital9000 GhentBelgium.

Men w.th obesity often present w.th low.testosterone(t)and sex hormone-binding globulin(SHBG)*** mechanisms for this have been proposed,but as SHBG is secreted by hepatocytes and sex steroids undergo hepatic metabolization,this study investigates whether severity and histological components of nonalcoholic fatty liver disease(NAFLD)are associated w.th sex steroid levels in obese *** cross-sectional study included 80 obese men(age:46±11 years;body mass index:42.2±5.5 kg m^-2).Serum levels of total t and estradiol(E.)were measured using liquid chromatography coupled w.th tandem mass spectroscopy(LC/MS-MS)and SHBG and gonadotropins by *** biopsies were evaluated using ***,and Fibrosis *** w.th steatohepatitis had similar median(1st quartile-3rd quartile)total t levels(7.6[5.0-11.0]nmol l^-1 vs 8.2[7.2-10.9]nmol l^-1;P=0.147),lower calculated free t(cFt)levels(148.9[122.9-188.8]pmol 1-1 s 199.5[157.3-237.6] pmol l^-1;P=0.006),and higher free E.t ratios(10.0[6.4-13.9]×10^-3 vs 7.1[5.7-10.7]×10^-3;P=0.026)compared to men w.th only nonalcoholic fatty *** the histological components of *** steatosis was independently associated w.th total t(r=-0.331.P=0.003)and cFt levels(r=-0.255.P=0.025).Obese men *** have even lower cFt levels compared to those w.thout,an association mainly driven by grade of *** this reflects a subgroup of men w.th a more severe obesity-related phenotype or results from direct relations between hepatic steatosis and sex steroid metabolism needs further investigation.

关键词： male hypog on adism non alcoholic fatty liver disease obesity sex steroids steatosis testoster one

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the biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction

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Molecular Plant 2024年第7期17卷 1129-1150页

作者： Paula Berman Luis Alejandro de Haro Ana-Rita Cavaco Sayantan Panda Younghui Dong Nikolay Kuzmich Gabriel Lichtenstein Yoav Peleg Hila Harat Adam Jozwiaki Jianghua Cai Uwe Heinig Sagit Meir Ilana Rogachev Asaph Aharoni department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovot 7610001Israel Life Sciences Core Facilities Weizmann Institute of ScienceRehovot 7610001Israel the Maurice and Vivienne wohl Institute for Drug Discovery Weizmann Institute of ScienceRehovot 7610001Israel Present address:department of Cell and Metabolic Biology Leibniz Institute of Plant BiochemistryWeinberg 306120 Halle(Saale)Germany department of Molecular&Cellular Pharmacology University of Miami Miler School of MedicineMiamiFL 33136USA department of Botany and Plant Sciences University of California RiversideRiversideCA 92521USA Laboratory of Plant Hormones and development Regulation of Chongqing School of Life SciencesChongqing UniversityChongqing 401331China

Mescaline,among the earliest identified natural hallucinogens,holds great potential in psychotherapy ***,despite the existence of a postulated biosynthetic pathway for more than half a century,the specific enzymes involved in this process are yet to be *** this study,we investigated the cactus Lophophora williamsii(Peyote),the largest known natural producer of the phenethylamine *** employed a multi-faceted approach,combining de novo whole-genome and transcriptome sequencing w.th comprehensive chemical profiling,enzymatic assays,molecular modeling,and pathway engineering for pathway *** identified four groups of enzymes responsible for the six catalytic steps in the mescaline biosynthetic pathway,and an N-methyltransferase enzyme that N-methylates all phenethylamine intermediates,likely modulating mescaline levels in ***,we reconstructed the mescaline biosynthetic pathway in both Nicotiana benthamiana plants and yeast cells,providing novel insights into several challenges hindering complete heterologous mescaline *** together,our study opens up avenues for exploration of sustainable production approaches and responsible utilization of mescaline,safeguarding this valuable natural resource for future generations.

关键词： mescaline Lophophora williamsi Peyote biosynthetic pathway de novo genome sequencing mo-lecular modeling

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Recruiting endogenous stem cells： a novel therapeutic approach for erectile dysfunction

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Asian Journal of Andrology 2016年第1期18卷 10-15页

作者： Zhong-Cheng Xin Yong-de Xu Guiting Lin tom FLue Ying-Lu Guo Andrology Center Peking University First Hospital Peking University Beijing 100034 China Knuppe Molecular Urology Laboratory Department of Urology School of Medicine University of California San Francisco CA USA.

transplanted stem cells （SCs）, owing to their regenerative capacity, represent one of the most promising methods to restore erectile dysfunction （ED）. However, insufficient source, invasive procedures, ethical and regulatory issues hamper their use in clinical applications. the endogenous SCs/progenitor cells resident in organ and tissues play critical roles for organogenesis during development and for tissue homeostasis in adulthood. Even w.thout any therapeutic intervention, human body has a robust self-healing capability to repair the damaged tissues or organs. therefore, SCs-for-ED therapy should not be limited to a supply-side approach. the resident endogenous SCs existing in patients could also be a potential target for ED therapy. the aim of this review was to summarize contemporary evidence regarding：（1） SC niche and SC biological features in vitro; （2） localization and mobilization of endogenous SCs; （3） existing evidence of penile endogenous SCs and their possible mode of mobilization. we performed a search on PubMed for articles related to these aspects in a wide range of basic studies. together, numerous evidences hold the promise that endogenous SCs would be a novel therapeutic approach for the therapy of ED.

关键词： endogenous stem cell erectile dysfunction homing niche

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Rock joint coefficients and their computerized classification

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International Journal of Mining Science and technology 2019年第5期29卷 701-709页

作者： tomás Ficker Faculty of Civil Engineering Brno University of Technology60200 BrnoCzech Republic

A computerized method for determining rock joint coefficients is *** relative similarity indicators are introduced to classify surface morphology of rock *** classification enables to compare investigated and database rock *** a comparison aims at finding the couple of surfaces that are distinguished by the highest dynamical *** first absolute indicator results from the Fourier matrix and evaluates wavy shapes of *** second absolute indicator quantifies the heights of surface reliefs and is defined as the root mean square height of the surface *** reliability of these indicators is tested w.thin the surface analysis of a series of limestone *** the computerized assessment,25 people have performed visual assessment of these limestone *** results of visual assessments have been statistically processed and compared to the results received from the computerized *** newly introduced absolute indicators have proved to be prospective numerical tools for evaluating joint rock coefficients.

关键词： Rock joints Shear strength Joint rock coefficients Numerical indicators Computerized assessment

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