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汇流博物馆法国里昂(2001-2014)

世界建筑导报 2016年第2期31卷 38-45页

作者：沃尔夫.狄.普瑞克斯 tom wiscombe sergio pirrone 无不详蓝天组建筑设计事务所

法国里昂汇流博物馆方案从2001年在里昂举办的自然历史馆国际大赛中脱颖而出,它被看作是＂传递知识的媒介＂,而不仅仅是一个产品展示厅。博物馆建造在一个百年前人工扩建的半岛上,位于罗纳河与索恩河的汇流处。显而易见,在这个场址上施... 详细信息

法国里昂汇流博物馆方案从2001年在里昂举办的自然历史馆国际大赛中脱颖而出,它被看作是＂传递知识的媒介＂,而不仅仅是一个产品展示厅。博物馆建造在一个百年前人工扩建的半岛上,位于罗纳河与索恩河的汇流处。显而易见,在这个场址上施工比较困难（要将536根桩牢牢打入地面30米深）,显然,这个地方对于城市设计工程来说至关重要。建筑物应能成为迎接南方访客的入口,为他们指明方向,并同时作为城市开发的起点工程。

关键词：博物馆汇流里昂法国设计工程城市开发展示厅罗纳河

阿克伦艺术博物馆美国俄亥俄州(2001-2007)

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世界建筑导报 2016年第2期31卷 78-81页

作者：沃尔夫.狄.普瑞克斯 tom wiscombe mona marbach roland halbe 无不详蓝天组建筑设计事务所

蓝天组通过阿克伦艺术博物馆展现了一种新的博物馆设计理念,即＂未来博物馆＂。博物馆的传统功能和城市空间共同形成了一座新型的文化中心,向参观者提供数字,模拟信息和体验。博物馆由三个部分组成：水晶体、美术馆和云顶。水晶体作为... 详细信息

蓝天组通过阿克伦艺术博物馆展现了一种新的博物馆设计理念,即＂未来博物馆＂。博物馆的传统功能和城市空间共同形成了一座新型的文化中心,向参观者提供数字,模拟信息和体验。博物馆由三个部分组成：水晶体、美术馆和云顶。水晶体作为博物馆的主入口,可作为一个指示方位的场所,并与新旧建筑物的公共功能区相连。它是一个大型、灵活的空间,可用于举办宴会、艺术节,或供外部机构和企业举办各种活动。美术馆内部是一个广阔的空间,柱体较少.

关键词：艺术博物馆阿克伦城市空间文化中心云顶主入口美国俄亥俄州模拟信息 heating 人造光源

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台北表演艺术中心数字创作

城市建筑 2010年第6期7卷 77-80页

作者：涌现组 EMERGENT/tom wiscombe LLC

台北表演艺术中心设计力图营造一种充满未来感的都市体验,它以多元混合的城市环境为创作依据,又不拘泥于传统表演艺术剧院固有的设计模式,使建筑整体在城市中获得地标性的构筑意义。艺术中心由三座剧院构成,通过一个高架的统一连接体将... 详细信息

台北表演艺术中心设计力图营造一种充满未来感的都市体验,它以多元混合的城市环境为创作依据,又不拘泥于传统表演艺术剧院固有的设计模式,使建筑整体在城市中获得地标性的构筑意义。艺术中心由三座剧院构成,通过一个高架的统一连接体将其紧密地整台起来,令三座剧院在空间上相互串连,流通,形成整体绵亘迂回之势。

关键词：表演艺术创作台北市台湾省中心数艺术剧院城市环境艺术中心中心设计

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云9号·瑞士日内瓦联合国总部

城市环境设计 2020年第4期126卷 32-35页

作者： Hannes Aichholzer Urs Bette Stefan Niese Régis Péan Markus Pillhofer Adam Swiczinsky Iwan Tochew Sergej Serr tom wiscombe d?gl & cherkoori Markus Pillhofer

日内瓦联合国总部"万国广场"竞赛项目1968年成立之初,蓝天组的理念源于"建筑可以像云一样变幻莫测"的想法。云9号的理念即始于回到蓝天组的本源,从那里待发并前行。20世纪末,尤其是在联合国主办的竞赛背景下,"云"的概念重新变得至关重...

日内瓦联合国总部"万国广场"竞赛项目1968年成立之初,蓝天组的理念源于"建筑可以像云一样变幻莫测"的想法。云9号的理念即始于回到蓝天组的本源,从那里待发并前行。20世纪末,尤其是在联合国主办的竞赛背景下,"云"的概念重新变得至关重要。世界日渐多变和模糊的社会政治结构明示了范式的变化,而这种变化同时又反映在从遗传学到量子力学的诸多层面上。可以说,这种变化是世界观的转变,由从物体的角度看世界转变为从关系的角度看世界,米歇尔·福柯的言论也呼应了这种观点:"每一种形式实际上都是各种力综合而来的。"

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Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： Diogo tomé Ramiro D.Almeida iBiMED-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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格罗宁格博物馆东馆，荷兰，格罗宁根

城市环境设计 2020年第4期 78-87页

作者：沃尔夫·狄·普瑞克斯海默特·斯维茨斯基 Faneé Aaron Gantcho Batchkarov Sam Blower Eric Geddes Spencer Hunt Sandrine Klot Miro Krawczinsky Regis Péan Markus Pfisterer Markus Pillhofer Sandep Raki Jennifer Rakow Stephanie Reich Michael Volk Andreas Wohofsky tom wiscombe Margherita Spiluttini COOP HIMMELB(L)AU

项目大事记/CHRONOLOGY设计/Design:1993规划设计起始时间/Start of Planning:1994竣工/Completion:1994项目参数/PROJECT DATA建筑面积/Floor Area:900m2总体积/Cubage:4 300m3格罗宁格博物馆建筑群堪称形式、色彩和材料的奇妙组合。整体设计由米兰建筑师亚历山德罗·门迪尼负责,为此,他邀请了设计师菲利普·斯塔克和米歇尔·德·卢奇,以及设计博物馆东馆的蓝天组团队共同进行设计。

关键词：

Rock joint coefficients and their computerized classification

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International Journal of Mining Science and Technology 2019年第5期29卷 701-709页

作者： tomás Ficker Faculty of Civil Engineering Brno University of Technology60200 BrnoCzech Republic

A computerized method for determining rock joint coefficients is *** relative similarity indicators are introduced to classify surface morphology of rock *** classification enables to compare investigated and database rock *** a comparison aims at finding the couple of surfaces that are distinguished by the highest dynamical *** first absolute indicator results from the Fourier matrix and evaluates wavy shapes of *** second absolute indicator quantifies the heights of surface reliefs and is defined as the root mean square height of the surface *** reliability of these indicators is tested within the surface analysis of a series of limestone *** the computerized assessment,25 people have performed visual assessment of these limestone *** results of visual assessments have been statistically processed and compared to the results received from the computerized *** newly introduced absolute indicators have proved to be prospective numerical tools for evaluating joint rock coefficients.

关键词： Rock joints Shear strength Joint rock coefficients Numerical indicators Computerized assessment

Impact of the spindle number on the material transport and mixing during planetary roller melt granulation Author links open overlay panel

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Particuology 2024年第8期91卷 260-267页

作者： tom Lang Jens Bartsch Laboratory of Solids Process Engineering Department of Biochemical and Chemical EngineeringTU Dortmund University44227DortmundGermany

In comparison to the established twin-screw machines,the application of a planetary roller granulator for continuous operation of melt granulation is a promising alternative based on the unique process *** initial study focused on the material transport during processing as a key driver for the overall ***,the impact of direct process parameters on the residence time distribution was the main *** investigations are complemented in this study by considering the free processing volume,which is defined by the number of planetary spindles applied within a *** impact on the processing conditions is evaluated with respect to the process setting in terms of feed rate and rotation *** results highlight the potential of altering the underlying transport function in planetary roller melt granulation(PRMG)via the investigated direct process and equipment *** impact of the feed rate is lower in comparison,while a higher rotation speed as well as a higher free processing volume promote material ***,a normalization of the determined residence time distribution(RTD)model data was feasible with respect to the process settings and the number of applied planetary spindles in the processing *** demonstrates the key role of the free processing volume in the fundamental mechanisms of material transport and mixing during PRMG.

关键词： Continuous manufacturing Melt granulation Planetaryroller granulator Quality-by-Design Residence time Material mixing