检索结果-南通市图书馆

Quantification of uric acid in vasculature of patients with gout using dual-energy computed tomography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Radiology 2020年第8期12卷 184-194页

作者： Sharon Hannah Barazani Wei-Wei Chi Renata Pyzik Helena Chang Adam Jacobi tom o’donnell Zahi A Fayad Yousaf Ali Venkatesh Mani Department of Radiology Translational and Molecular Imaging InstituteIcahn School of Medicine at Mount SinaiNew YorkNY 10029United States Division of Rheumatology Department of MedicineIcahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Population Health Science and Policy Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Department of Radiology Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Siemens Healthineers Erlangen 91052Germany

BACKGRoUNDGout, caused by hyperuricemia and subsequent deposition of aggregatedmonosodium urate crystals (MSU) in the joints or extra-articular regions, is themost common inflammatory arthritis. There is increasing evidence that gout is anindependent risk factor for hypertension, cardiovascular disease progression *** evaluate if dual energy computed tomography (DECT) could identify MSUwithin vessel walls of gout patients, and if MSU deposits within the vasculaturediffered between patients with gout and controls. This study may help elucidatewhy individuals with gout have increased risk for cardiovascular ***31 gout patients and 18 controls underwent DECT scans of the chest andabdomen. A material decomposition algorithm was used to distinguish regions ofMSU (coded green), and calcifications (coded purple) from soft tissue (uncoded). Volume of green regions was calculated using a semi-automated volumeassessment program. Between-group differences were analyzed using Mann-Whitney U exact test and nonparametric rank *** patients had significantly higher volume of MSU within the aorta comparedto controls [Median (Min-Max) of 43.9 (0-1113.5) vs 2.9 (0-219.4), P = 0.01].Number of deposits was higher in gout patients compared to controls [Median(Min-Max) of 20 (0-739) vs 1.5 (0-104), P = 0.008]. However, the difference wasinsignificant after adjustment for age, gender, history of cardiovascular diseaseand diabetes. Increased age was positively associated with total urate volume (rs =0.64;95% confidence interval: 0.43-0.78).CoNCLUSIoNThis pilot study showed that DECT can quantify vascular urate deposits withvariation across groups, with gout patients possibly having higher *** relationship disappeared when adjusted for age, and there was a positiverelationship between age and MSU deposition. While this study does not provethat green coded regions are truly MSU deposition, it corroborates recent studiesthat show the pr

关键词： Gout Tophaceous Dual-energy computed tomography Hyperuricemia Monosodium urate Cardiovascular disease

Remaking a connection:molecular players involved in post-injury synapse formation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： Diogo tomé Ramiro D.Almeida iBiMED-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Dehydration Melting and Proterozoic Granite Petrogenesis in a Collisional orogen——A Case from the Svecofennian of Southern Finland

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2021年第6期32卷 1289-1299页

作者： tom Andersen o.Tapani Rämö Department of Geosciences University of OsloN-0316OsloNorway Department of Geosciences and Geography Geology and Geophysics Research ProgramUniversity of Helsinki00014HelsinkiFinland

Dehydration melting of metasupracrustal rocks at mid-to deep-crustal levels can generate water undersaturated granitic *** this study,we evaluate the potential of~1.89–1.88 Ga metasupracrustal rocks of the Precambrian of southern Finland as source rocks for the 1.86–1.79 Ga late-orogenic leucogranites in the region,using the Rhyolite-MELTS *** close in composition to leucogranite is produced over a range of realistic pressures(5 to 8 kbar)and temperatures(800 to 850℃),at 20%–30%of partial melting,allowing separation of melt from unmelted *** solid residue is a dry,enderbitic to charnoenderbitic ganulite depleted in incompatible components,and will only yield further melt above 1000–1050℃,when rapidly increasing fractions of increasingly calcic(granodioritic to tonalitic)melts are *** solid residue after melt extraction is incapable of producing syenogranitic magmas similar to the Mid-Proterozoic,A-type rapakivi granites on further *** granitic fraction of the syenogranitic rapakivi complexes must thus have been formed by a different chain of processes,involving mantle-derived mafic melts and melts from crustal rock types not conditioned by the preceding late-orogenic Svecofennian anatexis.

关键词： leucogranite rapakivi granite anatexis restite depleted granulite Finland

同方期刊数据库

JES Special issue in Mercury Biogeochemistry and Fate

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2018年第6期30卷 1-4页

作者： tom Sizmur Nelson o'Driscoll Yong Cai

The global and regional redistribution of mercury within the environment is of primary importance to both natural ecosystems and human *** ratification of the Minamata Convention on Mercury by 91 parties represents a ... 详细信息

关键词： JES Special issue in Mercury Biogeochemistry and Fate Hg

Antibiotic use in early childhood and risk of obesity: longitudinal analysis of a national cohort

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2019年第4期15卷 390-397页

作者： Dervla Kelly Alan Kelly tom o'Dowd Catherine B.Hayes Department of Public Health and Primary Care Trinity College DublinRussell CenterTallaght CrossDublin 24Ireland

Background Taking oral antibiotics during childhood has been linked with an increased risk of childhood *** study assessed any potential association in number of courses of antibiotics taken between 2-3 and 4-5 years of age and body mass trajectory up to age *** The study was a secondary analysis of 8186 children and their parents from the infant cohort of the Irish National Longitudinal Study of *** use was measured by parental recall between ages 2-3 and *** models described the relationship between antibiotic exposure and body mass index (BMI) standard deviation scores andbinary outcomes,and examined interactions between covariates,which included socioeconomic status,diet assessed by food frequency questionnaires and maternal *** Any antibiotic usage between 2 and 3 years did not predict risk of overweight or obesity at age *** or more courses of antibiotics between 2 and 3 years were independently associated with obesity at age 5 (odds ratio 1.6,95% confidence interval 1.11-2.31).Effect size was modest (coefficient + 0.09 body mass SD units,standard error 0.04,P =0.037).Maternal BMI modified the relationship:≥ 4 courses of antibiotics between 2 and 3 years were associated with a + 0.12 body mass SD units increase in weight at age 5 among children of normal-weight mothers (P=0.035),but not in children of overweight *** Number of antibiotic courses,rather than antibiotic use,may be an important factor in any link between early antibiotic exposure and subsequent childhood *** is needed to confirm differential effects on babies of normal versus overweight/obese mothers independent of socioeconomic factors.

关键词： Antibiotics Body mass index Early childhood Infants obesity

Rock joint coefficients and their computerized classification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2019年第5期29卷 701-709页

作者： tomás Ficker Faculty of Civil Engineering Brno University of Technology60200 BrnoCzech Republic

A computerized method for determining rock joint coefficients is *** relative similarity indicators are introduced to classify surface morphology of rock *** classification enables to compare investigated and database rock *** a comparison aims at finding the couple of surfaces that are distinguished by the highest dynamical *** first absolute indicator results from the Fourier matrix and evaluates wavy shapes of *** second absolute indicator quantifies the heights of surface reliefs and is defined as the root mean square height of the surface *** reliability of these indicators is tested within the surface analysis of a series of limestone *** the computerized assessment,25 people have performed visual assessment of these limestone *** results of visual assessments have been statistically processed and compared to the results received from the computerized *** newly introduced absolute indicators have proved to be prospective numerical tools for evaluating joint rock coefficients.

关键词： Rock joints Shear strength Joint rock coefficients Numerical indicators Computerized assessment

Impact of the spindle number on the material transport and mixing during planetary roller melt granulation Author links open overlay panel

在线全文

学校读者我要写书评

暂无评论

Particuology 2024年第8期91卷 260-267页

作者： tom Lang Jens Bartsch Laboratory of Solids Process Engineering Department of Biochemical and Chemical EngineeringTU Dortmund University44227DortmundGermany

In comparison to the established twin-screw machines,the application of a planetary roller granulator for continuous operation of melt granulation is a promising alternative based on the unique process *** initial study focused on the material transport during processing as a key driver for the overall ***,the impact of direct process parameters on the residence time distribution was the main *** investigations are complemented in this study by considering the free processing volume,which is defined by the number of planetary spindles applied within a *** impact on the processing conditions is evaluated with respect to the process setting in terms of feed rate and rotation *** results highlight the potential of altering the underlying transport function in planetary roller melt granulation(PRMG)via the investigated direct process and equipment *** impact of the feed rate is lower in comparison,while a higher rotation speed as well as a higher free processing volume promote material ***,a normalization of the determined residence time distribution(RTD)model data was feasible with respect to the process settings and the number of applied planetary spindles in the processing *** demonstrates the key role of the free processing volume in the fundamental mechanisms of material transport and mixing during PRMG.

关键词： Continuous manufacturing Melt granulation Planetaryroller granulator Quality-by-Design Residence time Material mixing

Application of electrical capacitance tomography for imaging industrial processes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2005年第12期6卷 1374-1378页

作者： DYAKoWSKI tom School of Chemical Engineering and Analytical Science The University of Manchester Manchester M60 1QD UK

Electrical tomography is, in certain cases, the most attractive method for real imaging of industrial processes, because of its inherent simplicity, rugged construction of the tomographer and high-speed capability. This paper presents examples illus- trating applications of electrical tomography for imaging fluidized beds, bubble columns and pneumatic conveyors. Electrical tomography opens up new ways for processing, imaging and modelling multi-phase flows as shown by 2D and 3D images illus- trating the various types of flow morphology.

关键词： Process imaging Fluid mixing Stired vessel