检索结果-南通市图书馆

Visible and Near-Infrared Contrast of Faculae in Active Region NOAA 8518

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese journal of Astronomy and Astrophysics 2004年第5期4卷 481-489页

作者： YanXu GuoYang jiongQiu tomj.Spirock jujing CarstenDenker HaiminWang CenterforSolar-TerrestrialResearch NewJerseyInstituteofTechnology323MartinLutherKingBlvdNewarkNJ07102USA

We compare the contrast of faculae, in visible light and in the near infrared (NIR), that were associated with the active region NOAA 8518 which crossed the solar disk from April 19 to 27, 1999. We obtained NIR continuum images at 1.6 μm at the Big Bear Solar Observatory (BBSO) with an Indium Gallium Arsenide (In Ga As) NIR digital camera. We also obtained high-resolution longitudinal magnetograms and visible light filtergrams at 610.3 nm with the newly developed Digital Vector Magnetograph (DVMG). Our data show that the contrast of faculae has the same sign in both the visible and the NIR. We did not find any so-called ``dark faculae', faculae that are bright in the visible and simultaneously dark in the NIR. We determined a threshold magnetic flux density that separates pores from faculae.

关键词： sun: infrared sun: faculae

Survival trends of patients with non-metastatic gastric adenocarcinoma in the US and European countries:the impact of decreasing resection rates

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2022年第7期42卷 648-662页

作者： Lei Huang Lina jansen Rob H.A.Verhoeven jelle P.Ruurda Liesbet Van Eycken Harlinde De Schutter jan johansson Mats Lindblad tom B.johannesen Vesna Zadnik Tina Zagar Sjoerd M.Lagarde Cornelis j.Hvan de Velde Petra Schrotz-King Hermann Brenner Division of Clinical Epidemiology and Aging Research German Cancer Research Center(DKFZ)Heidelberg 69120Germany Medical Faculty Heidelberg of Heidelberg University Heidelberg 69120Germany German Cancer Consortium German Cancer Research CenterHeidelberg 69120Germany Department of Research&Development Netherlands Comprehensive Cancer OrganizationUtrecht 3501 DBThe Netherlands Department of Medical Oncology Amsterdam University Medical CentersAmsterdam 1105 AZThe Netherlands Department of Surgery University Medical Center UtrechtUtrecht 3508 GAThe Netherlands Belgian Cancer Registry Brussels B-1210Belgium Department of Esophageal and Gastric Surgery Lund University HospitalLund 22185Sweden Department of Clinical Science Interventionand TechnologyDivision of SurgeryKarolinska University HospitalStockholm 17176Sweden Registry Department The Cancer Registry of NorwayOslo 0379Norway Epidemiology and Cancer Registry Institute of Oncology LjubljanaLjubljana 1000Slovenia Department of Surgery Erasmus Medical Centre-University Medical Centre RotterdamRotterdam 3015 CEThe Netherlands Department of Surgical Oncology Leiden University Medical CenterLeiden 2300 RCThe Netherlands Division of Preventive Oncology German Cancer Research Center and National Center for Tumor DiseasesHeidelberg 69120Germany

Background:We previously observed decreasing resection rates of nonmetastatic gastric adenocarcinoma(GaC)in the US and some European *** and to what extent these trends affect the trends in overall survival(OS)of patients with non-metastatic GaC at the population level remain *** large international population-based cohort study aimed to assess the impact of the previously observed decreasing resection rates on multivariable-adjusted trends in the long-term OS of patients with non-metastatic ***:Individual-level data of patients with non-metastatic GaC were obtained from the national cancer registries of the Netherlands,Belgium,Sweden,Norway,and Slovenia,and the US Surveillance,Epidemiology,and End Results *** analyzed data for each country *** between year of diagnosis and OS were assessed using Cox proportional hazards regression model with adjustment for multiple prognostic variables,with and without including resection and chemotherapy as potential explanatory ***:A total of 66,398 non-metastatic GaC patients diagnosed in 2003-2016 were analyzed,with an accumulated follow-up of 172,357 *** adjustment for resection,OS was improved only slightly in the US[hazard ratio(HR)_(per year)=0.99;HR_(≥vs.justing for resection,the increasing OS trend became stronger in the US(HR_(per year)=0.98;HR_(≥vs.<2010)=0.88),and the temporal trend became insignificant in *** Slovenia(HR_(per year)=0.99;HR_(≥vs.<2010)=0.92)and Norway(HR_(per year)=0.97;HR_(≥vs.<2010)=0.86),improved OS over time emerged after resection *** OS in patients undergoing resection was observed in the US,the Netherlands,and *** for chemotherapy did not alter the observed *** analyses by tumor location showedm

关键词： gastric adenocarcinoma resection rate adjusted overall survival temporal trend prognostic factors international population-based cohort study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

斑翅肩花蝽生物学特性、生境及食性选择

昆虫学报 2011年第7期54卷 800-808页

作者：李立虞国跃 tom j.MCAVOY Richard C.REARDON 吴云 Scott M.SALOM 和景福中国林业科学研究院资源昆虫研究所昆明650224 北京市农林科学院植物保护环境保护研究所北京100097 Department of Entomology Virginia Polytechnic Institute and State University Blacksburg VA 24061 USA USDA Forest Service Forest Health Technology Enterprise Team Morgantown WV 26505 USA 云南省怒江州林业局云南泸水673100

斑翅肩花蝽Tetraphleps galchanoides Ghauri是铁杉球蚜Adelges tsugae Annand(hemlock woolly adelgid)的重要天敌昆虫。在云南省兰坪县天生桥林区通过实验室和林间的饲养观察与测定、林间线路调查等方法,研究了斑翅肩花蝽的生物学特... 详细信息

斑翅肩花蝽Tetraphleps galchanoides Ghauri是铁杉球蚜Adelges tsugae Annand(hemlock woolly adelgid)的重要天敌昆虫。在云南省兰坪县天生桥林区通过实验室和林间的饲养观察与测定、林间线路调查等方法,研究了斑翅肩花蝽的生物学特性、生境及食性选择,并描述各虫态形态特征。斑翅肩花蝽在该林区一年发生2代,无世代重叠,寿命长。第1代(5月下旬至10月下旬)卵期13.8±1.6d,若虫期97.6±7.4d,成虫期55.2±4.7d;第2代(11月中旬至翌年4月下旬)卵期11.3±1.1d,若虫期105.7±8.5d,成虫期60.4±5.3d。若虫共5龄,以5龄若虫在云南铁杉Tsuga dumosa枝条树皮裂缝下或枯枝落叶层内越冬。雌雄成虫性比8.5∶1,雌雄成虫飞行缓慢,其飞行活动主要受到交尾、产卵、捕食铁杉球蚜补充营养的影响,多在树冠下层活动。该林区的斑翅肩花蝽最适生境选择:海拔为2851～2980m,云南铁杉密度为13.3～15.5株/100m、郁闭度为0.61～0.70。以寄主铁杉球蚜及附近常见的冷杉球蚜Aphrastasia pectinatae(Cholodkovsky)、华山松球蚜Pineus armandicola Zhang和落叶松球蚜Adelges laricis Vall为食物进行选择性试验,结果表明,斑翅肩花蝽对这4种球蚜的选择性存在显著差异,最喜好捕食铁杉球蚜,可成为生物防治铁杉球蚜的主要天敌之一。

关键词：斑翅肩花蝽铁杉球蚜生物学捕食生境食性选择生物防治

A DL-4- and TNFα-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第7期18卷 1662-1676页

作者： Ranjita Devi Moirangthem Kuiying Ma Sabrina Lizot Anne Cordesse juliette Olivré Corinne de Chappedelaine Akshay joshi Agata Cieslak john Tchen Nicolas Cagnard Vahid Asnafi Antonio Rausell Laura Simons julien Zuber tom Taghon Frank j.T.Staal Françoise Pflumio Emmanuelle Six Marina Cavazzana Chantal Lagresle-Peyrou Tayebeh Soheili Isabelle André Universitéde Paris Imagine InstituteLaboratory of Human LymphohematopoiesisINSERM UMR 1163ParisFrance Laboratory of Onco-Hematology AP-HPHôpital Necker-Enfants Malades.ParisFrance Universitéde Paris Institut Necker-Enfants Malades(INEM)INSERM UMR 1151ParisFrance Plateforme Bio-informatique UniversitéParis DescartesStructure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Universitéde Paris Imagine InstituteLaboratory of Clinical BioinformaticsINSERM UMR 1163ParisFrance Department of Biotherapy Clinical Investigation Center AP-HPHôpital Necker-Enfants MaladesParisFrance Department of Adult Kidney Transplantation AP-HPHôpital NeckerParisFrance Cancer Research Institute Ghent(CRIG) GhentBelgium Department of Diagnostic Sciences Faculty of Medicine and Health SciencesGhent UniversityGhentBelgium Department of Immunohematology&Blood Transfusion Leiden University Medical CenterLeidenthe Netherlands Team Niche and Cancer in Hematopoiesis Universitéde Paris and UniversitéParis-SaclayINSERMiRCM/IBFJ CEAUMR StabilitéGénétique Cellules Souches et RadiationsFontenay-aux-RosesFrance

Several obstacles to the production,expansion and genetic modification of immunotherapeutic T cells in vitro have restricted the widespread use of T-cell *** the context of HSCT,delayed naïve T-cell recovery contributes to poor outcomes.A novel approach to overcome the major limitations of both T-cell immunotherapy and HSCT would be to transplant human T-lymphoid progenitors(HTLPs),allowing reconstitution of a fully functional naïve T-cell pool in the patient ***,it is challenging to produce HTLPs in the high numbers required to meet clinical ***,we found that adding tumor necrosis factor alpha(TNFα)to a DL-4-based culture system led to the generation of a large number of nonmodified or genetically modified HTLPs possessing highly efficient in vitro and in vivo T-cell potential from either CB HSPCs or mPB HSPCs through accelerated T-cell differentiation and enhanced HTLP cell cycling and *** study provides a clinically suitable cell culture platform to generate high numbers of clinically potent nonmodified or genetically modified HTLPs for accelerating immune recovery after HSCT and for T-cell-based immunotherapy(including CAR T-cell therapy).

关键词： Human T-lymphoid progenitor Tumor necrosis factor alpha Delta-like ligand 4 Hematopoietic stem and progenitor cells Mobilized peripheral blood

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

上演星际版“泰囧” 疯狂外星人

读写算(科技知识动漫) 2015年第6期 42-43页

作者：本刊编辑部 tom j.Astle

导演:蒂姆·约翰逊编剧:tom ***影片类型:动画/冒险/奇幻制片:麦瑞尔·索瑞亚制作公司:梦工厂动画公司推荐指数:☆☆☆☆☆本片根据亚当·雷克斯的儿童小说《斯麦克节的真正意义》改编,原著故事喜感十足,角色新奇又充满活力。改编为动画... 详细信息

导演:蒂姆·约翰逊编剧:tom ***影片类型:动画/冒险/奇幻制片:麦瑞尔·索瑞亚制作公司:梦工厂动画公司推荐指数:☆☆☆☆☆本片根据亚当·雷克斯的儿童小说《斯麦克节的真正意义》改编,原著故事喜感十足,角色新奇又充满活力。改编为动画后,增加了主题和场景,使得影片更加天马行空、更有想象力。但又保持了原著中的核心精神:理解与爱。

关键词：外星人配音演员

Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2015年第35期21卷 10080-10090页

作者： john j Miklavcic Glen K Shoemaker Vera C Mazurak M tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M tom Clandinin Alberta Institute for Human Nutrition University of Alberta Edmonton AB T6G 2R1 Canada Department of Laboratory Medicine and Pathology University of Alberta Edmonton AB T6G 2B7 Canada Division of General Surgery University of Alberta Edmonton AB T6G 2B7 Canada Alberta Health Services Edmonton AB T6G 2B7 Canada Alberta Health Services Calgary AB T2N 4N2 Canada Division of Gastroenterology Western University London ON N6A 5A5 Canada Department of Medicine University of Alberta Edmonton AB T6G 2B7 Canada

AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold

关键词： Ganglioside Phospholipid Fatty acid Lipid Inflamma

Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Diabetes 2022年第3期13卷 260-271页

作者： Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot tom Yates jian Yeo Melanie j Davies jack A Sargeant Diabetes Research Centre University of LeicesterLeicester General HospitalLeicester LE54PWUnited Kingdom Department of Cardiovascular Sciences Glenfield HospitalUniversity of LeicesterLeicester LE39QPUnited Kingdom The Hanning Sleep Laboratory University Hospitals of Leicester NHS TrustUniversity of LeicesterLeicester LE54PWUnited Kingdom National Institute for Health Research Leicester Biomedical Research CentreLeicester LE54PWUnited Kingdom Leicester Diabetes Centre University Hospitals of Leicester NHS TrustLeicester LE54PWUnited Kingdom National Institute for Health Research Applied Research Collaboration East MidlandsLeicester LE54PWUnited Kingdom Department of Diabetes University Hospitals of Derby and Burton NHS Foundation TrustDerby DE223NEUnited Kingdom

BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger *** To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with *** A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 *** and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood *** and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk *** A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in *** diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older *** results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other *** age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and *** The diagnosis of T2D earlier in life is associated with a worse cardi

关键词： Type 2 diabetes mellitus Early-onset adult type 2 diabetes Age of onset Cardiovascular risk Young adults Glycaemic control Obesity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

歌剧中的旋律

丛书名：钢琴简单弹

2010年

作者： (美)汤姆(tom Gerou)改编

本书收录了《船歌》、《我将去远方》、《女人善变》、《饮酒歌》、《夜女王咏叹调》等21首歌剧改编成的钢琴版本。

ISBN: (纸本)9787807515128

本书收录了《船歌》、《我将去远方》、《女人善变》、《饮酒歌》、《夜女王咏叹调》等21首歌剧改编成的钢琴版本。

关键词：歌剧

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Visual j++ 精通java G